Energy poverty in developing countries is a critical issue characterized by the lack of access to modern energy services,such as electricity and clean cooking facilities,as marked in SDG 7.This study explores the corr...Energy poverty in developing countries is a critical issue characterized by the lack of access to modern energy services,such as electricity and clean cooking facilities,as marked in SDG 7.This study explores the correlations between energy poverty,energy intensity,resource abundance,and income inequality,as these factors have been theorized to play important roles in influencing energy poverty in developing countries.By observing that the dataset is heterogeneous across the countries and over the time frame,we use the Method of Moments Quantile Regression(MMQR)to analyze our developing countries’data from 2000 to 2019.Our findings indicate that energy intensity is a significant factor influencing energy poverty,suggesting that higher energy consumption relative to the sample countries can exacerbate this issue.Additionally,we observe that income inequality within the sample countries is a critical determinant of energy poverty levels,highlighting the dynamics between economic disparity and access to energy resources.Interestingly,our study reveals that resource abundance acts as a blessing rather than a curse in terms of energy poverty,implying that countries rich in natural resources may have better opportunities to combat energy deprivation.Finally,we emphasize the vital role of financial markets in addressing energy poverty on a global scale,suggesting that robust financial systems can facilitate investments and innovations aimed at improving energy access for vulnerable populations.The results from the robustness analysis support the empirical results obtained from the main estimation.The empirical findings of the present study advance important comprehensions for policymakers to adopt energy policies that address the complex challenges of energy poverty and promote inclusive energy access.展开更多
Foreign-funded overseas industrial parks(OIPs)are crucial for attracting foreign investment and promoting globalization in developing countries.However,large-scale land acquisition for these parks generates conflicts ...Foreign-funded overseas industrial parks(OIPs)are crucial for attracting foreign investment and promoting globalization in developing countries.However,large-scale land acquisition for these parks generates conflicts between developers and local stakeholders,increasing development costs.A qualitative multicase study was conducted in this study to analyze the land transaction trajectories of China's OIPs.Four OIPs were selected to reveal the underlying mechanisms from the perspectives of institutional arrangements,governance mechanisms,and enterprise heterogeneity.The findings indicate that in host countries with insufficient institutional development,local governments are more inclined to directly engage in OIP land acquisition.High-level intergovernmental mechanisms facilitate land acquisition processes,although their efficacy depends largely on administrative power allocation across parks in host countries.The results also indicate that enterprise characteristics significantly influence land acquisition,where microscale private enterprises lacking political connections often employ low-cost,bottom-up strategies by leveraging international experience.In summary,policy-makers in developing countries should prioritize enhancing OIP governance to mitigate transaction costs,promote diversified land supply,and optimize land allocation.By depicting China's OIP land acquisition processes,this study deepens the academic understanding of OIP governance in developing countries and related international land transactions,offering practical OIP management insights for governments in both host and parent countries.展开更多
The suburbs surrounding metropolitan areas are the priority area for urban-rural integration development where functional optimization is essential to reconcile growing urban demands with sustainable rural development...The suburbs surrounding metropolitan areas are the priority area for urban-rural integration development where functional optimization is essential to reconcile growing urban demands with sustainable rural development.Rural functions are changing substantially and vary significantly across areas in the practice of high-quality urban-rural integration development era.How to make use of the advantages of different rural functions and achieve optimized combination of functions are actual problems that urgently need to be solved.The paper analyzed the process of urban-rural integration through the identification of urban-rural integration interfaces and evaluated the multifunctional transformation of rural areas in the Chengdu-Chongqing Economic Circle(CCEC)with a fixed weight evaluation model.The differences in rural functions analyzed with the Theil index reveals the characteristics and sources of differences in the“production-living-ecology-culture”functional areas in the CCEC.The research results show that:(1)The spatial distribution characteristics of rural functions in the CCEC are obvious,and agricultural production clusters dominate the Chengdu Plain and eastern Chongqing,contrasting with ecological conservation zones along the Yangtze River system,while cultural heritage hubs concentrate in economically vibrant tourism corridors.(2)The overall regional differences in rural functions are mainly due to intra-regional differences;in terms of the contribution rate,the contribution rate of intra-regional differences in agricultural production,ecological conservation,and cultural heritage functions is much larger than that of inter-regional differences,whereas the inter-regional differences in human living functions are larger than those of intra-regional differences.(3)Based on the research results,the study area is divided into 14 functional types,which can provide scientific basis for improving the spatial layout and high-quality development of rural functions in the CCEC.These insights advance theoretical understanding of mountainous-urban transitional areas while informing practical strategies for high-quality integrated development.展开更多
High-quality standards serve as the value scale for consensus on the conversion of green benefits.Taking carbon emissions in production cycle and carbon footprints in life cycle as examples,it is arduous work to signi...High-quality standards serve as the value scale for consensus on the conversion of green benefits.Taking carbon emissions in production cycle and carbon footprints in life cycle as examples,it is arduous work to significantly improve their comparability,credibility,and manageability.At present,there are over 1,400 ISO standards in the dual carbon field.In China,there are over 1,400 relevant national standards,over 3,000 sectoral standards,over 1,900 local standards,and over 800 association standards,forming a comprehensive supporting system.展开更多
We do so much to prepare our children for the future,but are we doing enough to prepare the future for our children?To do so we must seek sustainability.Sustainability is a new way of thinking about an age-old concern...We do so much to prepare our children for the future,but are we doing enough to prepare the future for our children?To do so we must seek sustainability.Sustainability is a new way of thinking about an age-old concern:ensuring that our children and grandchildren inherit a tomorrow that is at least as good as today,preferably better.We want to make sure that the way we live our lives is sustainable that can continue and keep improving for long time.And since buildings produce half of all greenhouse gases and account for one-sixth of the world's freshwater withdrawals,one-quarter of its wood harvest and two fifths of its material and energy flows.By several estimates,we will double the size of the built environment over the next twenty to forty years.Therefore,there is a critical and immediate need to shift thinking on how the built environment is designed.To reduce environmental impact,protect public health and improve environmental equity and justice,we must change principles for building practice.Designers in general and architects in particular should play a high-profile leadership role in this transformation.展开更多
This study examined the relationship between transformational leadership and employee bootleg innovation through the mediating role of creative self-efficacy and the moderating role of leader-member exchange(LMX).Data...This study examined the relationship between transformational leadership and employee bootleg innovation through the mediating role of creative self-efficacy and the moderating role of leader-member exchange(LMX).Data were collected from 279 employees and 56 matched supervisors within a large Chinese digital transformation group.A moderated mediation model analysis found that transformational leadership predicts higher employee bootleg innovation.Creative self-efficacy mediated the positive relationship between transformational leadership and employee bootleg.Additionally,leader-member exchange significantly moderated the relationship between transformational leadership and creative self-efficacy,for a further enhancement of bootleg innovation.Thesefindings underscore the importance of transformative leadership in fostering digital employee innovation.This study provides further evidence of the relevance of self-determination theory in explaining the leadership and employee innovation,relationship within the context of digital transformation.By implication,creative self-efficacy and leader-member exchange are modifiable factors by digital transformation entities seeking a competitive advantage.展开更多
Building Information Modelling(BIM)technology can solve construction issues from multiple perspectives,including technical and managerial.While existing research has primarily focused on BIM’s benefits and framework ...Building Information Modelling(BIM)technology can solve construction issues from multiple perspectives,including technical and managerial.While existing research has primarily focused on BIM’s benefits and framework development,few studies discussed whether BIM can be successfully applied in developing countries.This paper examines the current status and key obstacles hindering BIM adoption in developing countries,analyzing their underlying causes.Notably,the study reveals that high BIM awareness does not directly lead to high BIM usage.The findings aim to provide theoretical support for enhancing the BIM environment and increasing implementation feasibility in developing countries.Additionally,the research identifies critical barriers for governments to address in promoting BIM adoption,offering a foundation for policy formulation.展开更多
The oxytocin receptor(OXTR)has garnered increasing attention for its role in regulating both mature behaviors and brain development.It has been established that OXTR mediates a range of effects that are regionspecifc ...The oxytocin receptor(OXTR)has garnered increasing attention for its role in regulating both mature behaviors and brain development.It has been established that OXTR mediates a range of effects that are regionspecifc or period-specifc.However,the current studies of OXTR expression patterns in mice only provide limited help due to limitations in resolution.Therefore,our objective was to generate a comprehensive,high-resolution spatiotemporal expression map of Oxtr mRNA across the entire developing mouse brain.We applied RNAscope in situ hybridization to investigate the spatiotemporal expression pattern of Oxtr in the brains of male mice at six distinct postnatal developmental stages(P7,P14,P21,P28,P42,P56).We provide detailed descriptions of Oxtr expression patterns in key brain regions,including the cortex,basal forebrain,hippocampus,and amygdaloid complex,with a focus on the precise localization of Oxtr+cells and the variance of expression between diferent neurons.Furthermore,we identifed some neuronal populations with high Oxtr expression levels that have been little studied,including glutamatergic neurons in the ventral dentate gyrus,Vgat+Oxtr+cells in the basal forebrain,and GABAergic neurons in layers 4/5 of the cortex.Our study provides a novel perspective for understanding the distribution of Oxtr and encourages further investigations into its functions.展开更多
This paper examines the transformation and development of the Xinhui Chenpi industry under the rural revitalization strategy in China.The study highlights the significant growth of the industry,with the annual product...This paper examines the transformation and development of the Xinhui Chenpi industry under the rural revitalization strategy in China.The study highlights the significant growth of the industry,with the annual production of chenpi reaching approximately 7,000 tons and the total output value surpassing 26 billion yuan in 2024.The paper proposes strategies to foster sustainable growth in industries facing challenges such as inefficient production processes,inconsistent product quality,and a lack of policy awareness among operators.These strategies include optimizing support policies,enhancing regulatory frameworks,and leveraging digital technologies for brand building and market expansion.The research contributes to understanding the development trajectory of the Xinhui Chenpi industry and provides insights for policymakers and industry practitioners.展开更多
Litchi has great economic significance as a global fruit crop.However,the advancement of litchi functional genomics has encountered substantial obstacles due to its recalcitrance to stable transformation.Here,we prese...Litchi has great economic significance as a global fruit crop.However,the advancement of litchi functional genomics has encountered substantial obstacles due to its recalcitrance to stable transformation.Here,we present an efficacious Agrobacterium tumefaciens-mediated transformation system in somatic embryos of‘Heiye'litchi.This system was developed through the optimization of key variables encompassing explant selection,A.tumefaciens strain delineation,bacterium concentration,infection duration,and infection methodology.The subsequent validation of the transformation technique in litchi was realized through the ectopic expression of LcMYB1,resulting in the generation of transgenic calli.However,the differentiation of transgenic calli into somatic embryos encountered substantial challenges.To delineate the intricate molecular underpinnings of LcMYB1's inhibitory role in somatic embryo induction,a comprehensive transcriptome analysis was conducted that encompassed embryogenic calli(C),globular embryos(G),and transgenic calli(TC).A total of 1,166 common differentially expressed genes(DEGs)were identified between C-vs.-G and C-vs.-TC.Gene Ontology(GO)annotation and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis revealed that these common DEGs were mostly related to plant hormone signal transduction pathways.Furthermore,RT-qPCR corroborated the pronounced down-regulation of numerous genes that are associated with somatic embryo induction within the transgenic calli.The development of this transformation system provides valuable support for functional genomics research in litchi.展开更多
Background Cotton is an important crop providing the most natural fibers all over the world. The cotton genomics community has utilized whole genome sequencing data to construct an elite gene pool in which functional ...Background Cotton is an important crop providing the most natural fibers all over the world. The cotton genomics community has utilized whole genome sequencing data to construct an elite gene pool in which functional genes are related to agronomic traits. However, the functional validation of these genes is hindered by time-consuming and inefficient genetic transformation methods. Thus, establishing a transient transformation system of high efficiency is necessary for cotton genomics.Results To improve the efficiency of transient transformation, we used the protoplasts isolated from the etiolated cotyledon as recipient. The enzymatic digestion buffer comprised 1.5%(w/v) cellulase, 0.75%(w/v) macerozyme, and 1% hemicellulase, osmotically buffered with 0.4 mol·L^(-1) mannitol. After 5 h of dark incubation at 25℃, uniform cotton protoplasts were successfully isolated with a yield of 4.6 × 10^(6) protoplasts per gram(fresh weight) and 95% viability. We incubated 100 μL protoplasts(2.5 × 10^(5)·m L^(-1)) with 15 μg plasmid in the solution of 0.4 mol·L^(-1) mannitol and 40% PEG 4000 for 15 min, ultimately achieving an optimal transient transfection efficiency of 71.47%.Conclusions This transient system demonstrated effective utility in cellular biology research through successful applications in subcellular localization analyses, bimolecular fluorescence complementation(Bi FC) verification, and prime editing vector validation. Through systematic optimization, we established an efficient and expedited protoplast-based transient transformation system and successfully applied this platform to cotton functional genomics studies.展开更多
This study aims to understand the behavior of the Bugis community in developing vernacular house models in the coastal areas of South Sulawesi Province,along with the factors influencing this behavior,such as knowledg...This study aims to understand the behavior of the Bugis community in developing vernacular house models in the coastal areas of South Sulawesi Province,along with the factors influencing this behavior,such as knowledge,motivation,attitude,locus of control,commitment,concern,and income level.Bugis vernacular houses reflect local wisdom that is adapted to environmental,socio-cultural conditions,and the challenges of modernization.This correlational research was conducted in the regencies of Pangkajene and Kepulauan,Barru,and Bone,with a sample of 300 household heads.The variables analyzed include knowledge,motivation,attitude,locus of control,commitment,concern,and income level.Data were collected through knowledge tests and questionnaires and were analyzed using simple and multiple regression tech-niques.The results show that the Bugis community’s behavior in developing vernacular houses is moderate.Individually,motivation,locus of control,commitment,and concern significantly influence behavior,while knowledge,attitude,and income do not have a significant impact.However,collectively,all independent variables(knowledge,motivation,attitude,locus of control,commitment,concern,and income)affect the behavior of the Bugis community in developing vernacular houses in coastal areas.This study provides valuable insights into the environmental and social adaptations of the Bugis coastal community,as well as efforts to preserve culture through the sustainable development of vernacular houses.展开更多
BACKGROUND Helicobacter pylori(H.pylori)eradication treatment for primary gastric mucosaassociated lymphoid tissue(MALT)lymphoma has already been established.However,t(11;18)(q21;q21)/API2-MALT1 translocation-positive...BACKGROUND Helicobacter pylori(H.pylori)eradication treatment for primary gastric mucosaassociated lymphoid tissue(MALT)lymphoma has already been established.However,t(11;18)(q21;q21)/API2-MALT1 translocation-positive lesions are a type of primary gastric MALT lymphoma in which a response to eradication treatment is difficult to achieve.In addition,trisomy 18 may be associated with diffuse large B-cell lymphoma(DLBCL)transformation of gastric MALT lymphoma.CASE SUMMARY A 66-year-old man was diagnosed with MALT lymphoma in the ascending colon by colonoscopy and biopsy.Two years later,esophagogastroduodenoscopy revealed chronic atrophic gastritis that was positive for H.pylori,and eradication treatment was administered.Two years and nine months later(at the age of 70),a new ulcerative lesion suggestive of MALT lymphoma appeared in the gastric body,and six months later,a similar lesion was also found in the fundus.One year later(4 years and 3 months after H.pylori eradication),at the age of 72,the lesion in the gastric body had become deeper and had propagated.A biopsy revealed a pathological diagnosis of DLBCL.Both MALT lymphoma lesions in the ascending colon and DLBCL lesions in the stomach were positive for the t(11;18)(q21;q21)/API2-MALT1 translocation,and trisomy 18q21 was also detected.After 6 courses of R-CHOP(rituximab,cyclophosphamide,doxorubicin,vincristine and prednisone)chemotherapy,all of the above lesions disappeared[complete remission(CR)],and CR has been maintained for more than 3 years.In addition,both the colonic and gastric lesions were proven to have the same clonality.CONCLUSION Because the patient had a MALT1 translocation with trisomy 18q21,it was thought that this gastric MALT lymphoma developed independently of H.pylori infection and progressed.展开更多
River ethics,a significant advancement inspired by Chinese President XI Jinping's ecological civilization thought,embodies the philosophical essence of river governance and represents a legacy of innovation by gen...River ethics,a significant advancement inspired by Chinese President XI Jinping's ecological civilization thought,embodies the philosophical essence of river governance and represents a legacy of innovation by generations of water resources professionals.Rooted in river ecology,it offers a framework for advancing modern water governance systems and capabilities.This paper examines eight dimensions of river ethics to provide actionable recommendations:enhancing knowledge systems on water,rivers,and lakes;addressing critical challenges in water governance to strengthen the foundational role of water authorities in ensuring water security,resource management,ecological sustainability and environmental protection;optimizing water project planning to mitigate ecological impacts;ensuring high standards in the lifecycle management of water projects;refining water diversion strategies for precise scheduling;utilizing ecosystem complexity for river and lake restoration;implementing tiered management of water-related disasters;and driving reforms to modernize water governance systems and mechanisms.展开更多
The exploration of the coupling and coordination between urban innovation capability(IC)and industrial transformation(IF)serves as a novel perspective for interpreting the increasingly severe phenomenon of population ...The exploration of the coupling and coordination between urban innovation capability(IC)and industrial transformation(IF)serves as a novel perspective for interpreting the increasingly severe phenomenon of population shrinkage during the industrialization process.This study investigated the evolutionary characteristics of IC and IF in shrinking and growing cities in Northeast China from 2010 to 2020.It uses entropy weighted model,coupling coordination degree,the Dagum Gini coefficient,and geographic detectors to analyze the coordinated development of IC and IF in the context of population shrinkage.The study analyzed the spatiotemporal patterns and driving mechanisms for their coordinated development.The results show that:1)both urban IC and IF exhibited an overall positive trend during the study period.Shrinking cities depend more on IF to address the challenges of population shrinkage,while growing cities mainly rely on innovation-driven development.2)The coupling gap between IC and IF in shrinking and growing cities has widened over time,with the coordination level of shrinking cities steadily decreasing.Cities with serious disorder are concentrated in northern Heilongjiang Province,while most cities in Jilin Province experience moderate disorder.Liaoning Province,however,shows generally good coupling coordination.3)Human capital is the key factor driving coupling coordination in both types of cities.Shrinking cities rely on economic and financial development,with the‘repair-type’logic that emphasizes short-term economic growth and resource compensation.In contrast,the coupling of growing cities relies on basic support capabilities,with the‘optimization-type’logic focused on enhancing endogenous resilience and systemic coordination.Exploring the coordination between urban innovation capabilities and industrial transformation can provide a new perspective for research on population shrinkage,which holds certain theoretical and practical significance for implementing the new round of revitalization strategy in Northeast China.展开更多
Objectives:Electronic health records(EHRs)offer valuable real-world data(RWD)for Chinese medicine research.However,significant methodological challenges remain in developing integrative Chinese-Western medicine(ICWM)d...Objectives:Electronic health records(EHRs)offer valuable real-world data(RWD)for Chinese medicine research.However,significant methodological challenges remain in developing integrative Chinese-Western medicine(ICWM)databases.This study aims to establish a best-practice methodological framework,referred to as BRIDGE,to guide the construction of ICWM databases using EHRs.Methods:We developed the methodological framework through a comprehensive process,including systematic literature review,synthesis of empirical experiences,thematic expert discussions,and consultation with an external panel to reach consensus.Results:The BRIDGE framework outlines 6 core components for ICWM-EHR database development:Overall design,database architecture,data extraction and linkage,data governance,data verification,and data quality evaluation.Key data elements include variables related to study population,treatment or exposure,outcomes,and confounders.These databases support various research applications,particularly in evaluating the effectiveness and safety of integrative therapies.To demonstrate its practical value,we developed an ICWM-EHR database on women’s reproductive lifespan,encompassing 2,064,482 patients.This database captures women’s health conditions across the life course,from reproductive age to older adulthood.Conclusions:The BRIDGE methodological framework provides a standardized approach to building high-quality ICWM-EHR databases.It offers a unique opportunity to strengthen the methodological rigor and real-world relevance of Chinese medicine research in integrated healthcare settings.展开更多
With the first rays of dawn peeking through the rainforest at Shiti Village,Dehong Dai and Jingpo Autonomous Prefecture,Yunnan Province,Xu Xiaolong,a bird-watching guide from the Jingpo ethnic group,led a German bird-...With the first rays of dawn peeking through the rainforest at Shiti Village,Dehong Dai and Jingpo Autonomous Prefecture,Yunnan Province,Xu Xiaolong,a bird-watching guide from the Jingpo ethnic group,led a German bird-watching group into the jungle.His great-grandfather made a living by hunting“weird-looking birds”in the mountains.Today,the birds(Great Hornbill)are attracting tourist dollars from other parts of the world without dodging bullets.In Shiti Village,bird-watchers can enjoy the chirping of Great Hornbills and feel the rumbling in the air as the birds fly past.The village on the Chinese border with Myanmar was formerly poverty-stricken,with an average annual income of barely 2,000 yuan(US$305)per household 10 years ago.Today,the average annual income has grown to 150,000 yuan(US$23,075).It is a shining example of the successful practice of the notion that“lucid waters and lush mountains are invaluable assets.”展开更多
The Emerging Markets and Developing Countries Forum on Bridging the AI Divide and Opening Ceremony of AIM Global CoE were held on July 27 in Minhang district,Shanghai.The event was hosted by AIM Global CoE,and co-orga...The Emerging Markets and Developing Countries Forum on Bridging the AI Divide and Opening Ceremony of AIM Global CoE were held on July 27 in Minhang district,Shanghai.The event was hosted by AIM Global CoE,and co-organized by Shanghai Artificial Intelligence Research Institute(SAIRI),Shanghai Technology Innovation Center,Shanghai Grand Neobay Investment Development Group,and Organizing Committee of AI Journey Conference.Asian Association of Business Incubation(AABI)and SAIRI served as the international partners.展开更多
文摘Energy poverty in developing countries is a critical issue characterized by the lack of access to modern energy services,such as electricity and clean cooking facilities,as marked in SDG 7.This study explores the correlations between energy poverty,energy intensity,resource abundance,and income inequality,as these factors have been theorized to play important roles in influencing energy poverty in developing countries.By observing that the dataset is heterogeneous across the countries and over the time frame,we use the Method of Moments Quantile Regression(MMQR)to analyze our developing countries’data from 2000 to 2019.Our findings indicate that energy intensity is a significant factor influencing energy poverty,suggesting that higher energy consumption relative to the sample countries can exacerbate this issue.Additionally,we observe that income inequality within the sample countries is a critical determinant of energy poverty levels,highlighting the dynamics between economic disparity and access to energy resources.Interestingly,our study reveals that resource abundance acts as a blessing rather than a curse in terms of energy poverty,implying that countries rich in natural resources may have better opportunities to combat energy deprivation.Finally,we emphasize the vital role of financial markets in addressing energy poverty on a global scale,suggesting that robust financial systems can facilitate investments and innovations aimed at improving energy access for vulnerable populations.The results from the robustness analysis support the empirical results obtained from the main estimation.The empirical findings of the present study advance important comprehensions for policymakers to adopt energy policies that address the complex challenges of energy poverty and promote inclusive energy access.
基金Philosophy and Social Science Planning Projects in Yunnan Province,No.QN202428China Postdoctoral Science Foundation,No.2024M752918。
文摘Foreign-funded overseas industrial parks(OIPs)are crucial for attracting foreign investment and promoting globalization in developing countries.However,large-scale land acquisition for these parks generates conflicts between developers and local stakeholders,increasing development costs.A qualitative multicase study was conducted in this study to analyze the land transaction trajectories of China's OIPs.Four OIPs were selected to reveal the underlying mechanisms from the perspectives of institutional arrangements,governance mechanisms,and enterprise heterogeneity.The findings indicate that in host countries with insufficient institutional development,local governments are more inclined to directly engage in OIP land acquisition.High-level intergovernmental mechanisms facilitate land acquisition processes,although their efficacy depends largely on administrative power allocation across parks in host countries.The results also indicate that enterprise characteristics significantly influence land acquisition,where microscale private enterprises lacking political connections often employ low-cost,bottom-up strategies by leveraging international experience.In summary,policy-makers in developing countries should prioritize enhancing OIP governance to mitigate transaction costs,promote diversified land supply,and optimize land allocation.By depicting China's OIP land acquisition processes,this study deepens the academic understanding of OIP governance in developing countries and related international land transactions,offering practical OIP management insights for governments in both host and parent countries.
基金funded by the National Natural Science Foundation of China(Grant Nos.T2261129477,42101202 and 42401261)Fundamental Research Funds for the Central Universities(2024CDJSKXYGG06)the Science and Technology Research Program of Chongqing Municipal Education Commission(Grant No.KJQN202400528).
文摘The suburbs surrounding metropolitan areas are the priority area for urban-rural integration development where functional optimization is essential to reconcile growing urban demands with sustainable rural development.Rural functions are changing substantially and vary significantly across areas in the practice of high-quality urban-rural integration development era.How to make use of the advantages of different rural functions and achieve optimized combination of functions are actual problems that urgently need to be solved.The paper analyzed the process of urban-rural integration through the identification of urban-rural integration interfaces and evaluated the multifunctional transformation of rural areas in the Chengdu-Chongqing Economic Circle(CCEC)with a fixed weight evaluation model.The differences in rural functions analyzed with the Theil index reveals the characteristics and sources of differences in the“production-living-ecology-culture”functional areas in the CCEC.The research results show that:(1)The spatial distribution characteristics of rural functions in the CCEC are obvious,and agricultural production clusters dominate the Chengdu Plain and eastern Chongqing,contrasting with ecological conservation zones along the Yangtze River system,while cultural heritage hubs concentrate in economically vibrant tourism corridors.(2)The overall regional differences in rural functions are mainly due to intra-regional differences;in terms of the contribution rate,the contribution rate of intra-regional differences in agricultural production,ecological conservation,and cultural heritage functions is much larger than that of inter-regional differences,whereas the inter-regional differences in human living functions are larger than those of intra-regional differences.(3)Based on the research results,the study area is divided into 14 functional types,which can provide scientific basis for improving the spatial layout and high-quality development of rural functions in the CCEC.These insights advance theoretical understanding of mountainous-urban transitional areas while informing practical strategies for high-quality integrated development.
文摘High-quality standards serve as the value scale for consensus on the conversion of green benefits.Taking carbon emissions in production cycle and carbon footprints in life cycle as examples,it is arduous work to significantly improve their comparability,credibility,and manageability.At present,there are over 1,400 ISO standards in the dual carbon field.In China,there are over 1,400 relevant national standards,over 3,000 sectoral standards,over 1,900 local standards,and over 800 association standards,forming a comprehensive supporting system.
文摘We do so much to prepare our children for the future,but are we doing enough to prepare the future for our children?To do so we must seek sustainability.Sustainability is a new way of thinking about an age-old concern:ensuring that our children and grandchildren inherit a tomorrow that is at least as good as today,preferably better.We want to make sure that the way we live our lives is sustainable that can continue and keep improving for long time.And since buildings produce half of all greenhouse gases and account for one-sixth of the world's freshwater withdrawals,one-quarter of its wood harvest and two fifths of its material and energy flows.By several estimates,we will double the size of the built environment over the next twenty to forty years.Therefore,there is a critical and immediate need to shift thinking on how the built environment is designed.To reduce environmental impact,protect public health and improve environmental equity and justice,we must change principles for building practice.Designers in general and architects in particular should play a high-profile leadership role in this transformation.
基金supported by the China Association of Trade in Services(CATIS-PR-250225).
文摘This study examined the relationship between transformational leadership and employee bootleg innovation through the mediating role of creative self-efficacy and the moderating role of leader-member exchange(LMX).Data were collected from 279 employees and 56 matched supervisors within a large Chinese digital transformation group.A moderated mediation model analysis found that transformational leadership predicts higher employee bootleg innovation.Creative self-efficacy mediated the positive relationship between transformational leadership and employee bootleg.Additionally,leader-member exchange significantly moderated the relationship between transformational leadership and creative self-efficacy,for a further enhancement of bootleg innovation.Thesefindings underscore the importance of transformative leadership in fostering digital employee innovation.This study provides further evidence of the relevance of self-determination theory in explaining the leadership and employee innovation,relationship within the context of digital transformation.By implication,creative self-efficacy and leader-member exchange are modifiable factors by digital transformation entities seeking a competitive advantage.
文摘Building Information Modelling(BIM)technology can solve construction issues from multiple perspectives,including technical and managerial.While existing research has primarily focused on BIM’s benefits and framework development,few studies discussed whether BIM can be successfully applied in developing countries.This paper examines the current status and key obstacles hindering BIM adoption in developing countries,analyzing their underlying causes.Notably,the study reveals that high BIM awareness does not directly lead to high BIM usage.The findings aim to provide theoretical support for enhancing the BIM environment and increasing implementation feasibility in developing countries.Additionally,the research identifies critical barriers for governments to address in promoting BIM adoption,offering a foundation for policy formulation.
基金supported by the National Science Fund for Distinguished Young Scholars(32325025)the STI2030-Major Projects(2021ZD0202500)+2 种基金the National Key Research and Development Program of China(2021YFA1101801)the National Natural Science Foundation of China(32171148,and 31770929)the Beijing Municipal Science and Technology Commission(Z181100001518001 and Z161100000216154).
文摘The oxytocin receptor(OXTR)has garnered increasing attention for its role in regulating both mature behaviors and brain development.It has been established that OXTR mediates a range of effects that are regionspecifc or period-specifc.However,the current studies of OXTR expression patterns in mice only provide limited help due to limitations in resolution.Therefore,our objective was to generate a comprehensive,high-resolution spatiotemporal expression map of Oxtr mRNA across the entire developing mouse brain.We applied RNAscope in situ hybridization to investigate the spatiotemporal expression pattern of Oxtr in the brains of male mice at six distinct postnatal developmental stages(P7,P14,P21,P28,P42,P56).We provide detailed descriptions of Oxtr expression patterns in key brain regions,including the cortex,basal forebrain,hippocampus,and amygdaloid complex,with a focus on the precise localization of Oxtr+cells and the variance of expression between diferent neurons.Furthermore,we identifed some neuronal populations with high Oxtr expression levels that have been little studied,including glutamatergic neurons in the ventral dentate gyrus,Vgat+Oxtr+cells in the basal forebrain,and GABAergic neurons in layers 4/5 of the cortex.Our study provides a novel perspective for understanding the distribution of Oxtr and encourages further investigations into its functions.
基金Research on the Digital Transformation of the Xinhui Dried Tangerine Peel Industry under the Rural Revitalization Strategy(2023HSQX100)。
文摘This paper examines the transformation and development of the Xinhui Chenpi industry under the rural revitalization strategy in China.The study highlights the significant growth of the industry,with the annual production of chenpi reaching approximately 7,000 tons and the total output value surpassing 26 billion yuan in 2024.The paper proposes strategies to foster sustainable growth in industries facing challenges such as inefficient production processes,inconsistent product quality,and a lack of policy awareness among operators.These strategies include optimizing support policies,enhancing regulatory frameworks,and leveraging digital technologies for brand building and market expansion.The research contributes to understanding the development trajectory of the Xinhui Chenpi industry and provides insights for policymakers and industry practitioners.
基金supported by the National Natural Science Foundation of China(31872066 and 32272663)the Science and Technology Planning Project of Guangzhou,China(2023B01J2002)+2 种基金the Key Research and Development Program of Hainan,China(ZDYF2023XDNY052)the Seed Industry Engineering Project of Department of Agriculture and Rural Affairs of Guangdong,China(2022-NPY-00-004 and 2022-NBH00-001)the Litchi Industry Science and Technology Special Mission of Yunnan,China(202204BI090021)。
文摘Litchi has great economic significance as a global fruit crop.However,the advancement of litchi functional genomics has encountered substantial obstacles due to its recalcitrance to stable transformation.Here,we present an efficacious Agrobacterium tumefaciens-mediated transformation system in somatic embryos of‘Heiye'litchi.This system was developed through the optimization of key variables encompassing explant selection,A.tumefaciens strain delineation,bacterium concentration,infection duration,and infection methodology.The subsequent validation of the transformation technique in litchi was realized through the ectopic expression of LcMYB1,resulting in the generation of transgenic calli.However,the differentiation of transgenic calli into somatic embryos encountered substantial challenges.To delineate the intricate molecular underpinnings of LcMYB1's inhibitory role in somatic embryo induction,a comprehensive transcriptome analysis was conducted that encompassed embryogenic calli(C),globular embryos(G),and transgenic calli(TC).A total of 1,166 common differentially expressed genes(DEGs)were identified between C-vs.-G and C-vs.-TC.Gene Ontology(GO)annotation and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis revealed that these common DEGs were mostly related to plant hormone signal transduction pathways.Furthermore,RT-qPCR corroborated the pronounced down-regulation of numerous genes that are associated with somatic embryo induction within the transgenic calli.The development of this transformation system provides valuable support for functional genomics research in litchi.
基金supported by Biological Breeding of Early Maturing and Disease Resistant Cotton Varieties (NO.2023ZD04041)the Project of China Agriculture Research System (Grant No. CARS-15-06)+2 种基金Natural Science Foundation of Henan Province (Grant No. 232300421041 and 222300420382)National Natural Science Foundation of China (Grant No. U21 A20213)the Central Public-interest Scientific Institution Basal Research Fund (Grant No. 1610162023017 and 1610162023028)。
文摘Background Cotton is an important crop providing the most natural fibers all over the world. The cotton genomics community has utilized whole genome sequencing data to construct an elite gene pool in which functional genes are related to agronomic traits. However, the functional validation of these genes is hindered by time-consuming and inefficient genetic transformation methods. Thus, establishing a transient transformation system of high efficiency is necessary for cotton genomics.Results To improve the efficiency of transient transformation, we used the protoplasts isolated from the etiolated cotyledon as recipient. The enzymatic digestion buffer comprised 1.5%(w/v) cellulase, 0.75%(w/v) macerozyme, and 1% hemicellulase, osmotically buffered with 0.4 mol·L^(-1) mannitol. After 5 h of dark incubation at 25℃, uniform cotton protoplasts were successfully isolated with a yield of 4.6 × 10^(6) protoplasts per gram(fresh weight) and 95% viability. We incubated 100 μL protoplasts(2.5 × 10^(5)·m L^(-1)) with 15 μg plasmid in the solution of 0.4 mol·L^(-1) mannitol and 40% PEG 4000 for 15 min, ultimately achieving an optimal transient transfection efficiency of 71.47%.Conclusions This transient system demonstrated effective utility in cellular biology research through successful applications in subcellular localization analyses, bimolecular fluorescence complementation(Bi FC) verification, and prime editing vector validation. Through systematic optimization, we established an efficient and expedited protoplast-based transient transformation system and successfully applied this platform to cotton functional genomics studies.
基金The cost of this research comes from a grant from the government of the Republic of Indonesia,through the Ministry of Education and Culture,Research and Technology with contract number:1225/UN36.11/LP2M/2024。
文摘This study aims to understand the behavior of the Bugis community in developing vernacular house models in the coastal areas of South Sulawesi Province,along with the factors influencing this behavior,such as knowledge,motivation,attitude,locus of control,commitment,concern,and income level.Bugis vernacular houses reflect local wisdom that is adapted to environmental,socio-cultural conditions,and the challenges of modernization.This correlational research was conducted in the regencies of Pangkajene and Kepulauan,Barru,and Bone,with a sample of 300 household heads.The variables analyzed include knowledge,motivation,attitude,locus of control,commitment,concern,and income level.Data were collected through knowledge tests and questionnaires and were analyzed using simple and multiple regression tech-niques.The results show that the Bugis community’s behavior in developing vernacular houses is moderate.Individually,motivation,locus of control,commitment,and concern significantly influence behavior,while knowledge,attitude,and income do not have a significant impact.However,collectively,all independent variables(knowledge,motivation,attitude,locus of control,commitment,concern,and income)affect the behavior of the Bugis community in developing vernacular houses in coastal areas.This study provides valuable insights into the environmental and social adaptations of the Bugis coastal community,as well as efforts to preserve culture through the sustainable development of vernacular houses.
文摘BACKGROUND Helicobacter pylori(H.pylori)eradication treatment for primary gastric mucosaassociated lymphoid tissue(MALT)lymphoma has already been established.However,t(11;18)(q21;q21)/API2-MALT1 translocation-positive lesions are a type of primary gastric MALT lymphoma in which a response to eradication treatment is difficult to achieve.In addition,trisomy 18 may be associated with diffuse large B-cell lymphoma(DLBCL)transformation of gastric MALT lymphoma.CASE SUMMARY A 66-year-old man was diagnosed with MALT lymphoma in the ascending colon by colonoscopy and biopsy.Two years later,esophagogastroduodenoscopy revealed chronic atrophic gastritis that was positive for H.pylori,and eradication treatment was administered.Two years and nine months later(at the age of 70),a new ulcerative lesion suggestive of MALT lymphoma appeared in the gastric body,and six months later,a similar lesion was also found in the fundus.One year later(4 years and 3 months after H.pylori eradication),at the age of 72,the lesion in the gastric body had become deeper and had propagated.A biopsy revealed a pathological diagnosis of DLBCL.Both MALT lymphoma lesions in the ascending colon and DLBCL lesions in the stomach were positive for the t(11;18)(q21;q21)/API2-MALT1 translocation,and trisomy 18q21 was also detected.After 6 courses of R-CHOP(rituximab,cyclophosphamide,doxorubicin,vincristine and prednisone)chemotherapy,all of the above lesions disappeared[complete remission(CR)],and CR has been maintained for more than 3 years.In addition,both the colonic and gastric lesions were proven to have the same clonality.CONCLUSION Because the patient had a MALT1 translocation with trisomy 18q21,it was thought that this gastric MALT lymphoma developed independently of H.pylori infection and progressed.
基金Three Gorges Follow-up Work Fund,Grant/Award Number:WE0161A042024National Key Research Program of China,Grant/Award Number:2024YFC3210900。
文摘River ethics,a significant advancement inspired by Chinese President XI Jinping's ecological civilization thought,embodies the philosophical essence of river governance and represents a legacy of innovation by generations of water resources professionals.Rooted in river ecology,it offers a framework for advancing modern water governance systems and capabilities.This paper examines eight dimensions of river ethics to provide actionable recommendations:enhancing knowledge systems on water,rivers,and lakes;addressing critical challenges in water governance to strengthen the foundational role of water authorities in ensuring water security,resource management,ecological sustainability and environmental protection;optimizing water project planning to mitigate ecological impacts;ensuring high standards in the lifecycle management of water projects;refining water diversion strategies for precise scheduling;utilizing ecosystem complexity for river and lake restoration;implementing tiered management of water-related disasters;and driving reforms to modernize water governance systems and mechanisms.
基金Under the auspices of National Natural Science Foundation of China(No.42471227,42171198)。
文摘The exploration of the coupling and coordination between urban innovation capability(IC)and industrial transformation(IF)serves as a novel perspective for interpreting the increasingly severe phenomenon of population shrinkage during the industrialization process.This study investigated the evolutionary characteristics of IC and IF in shrinking and growing cities in Northeast China from 2010 to 2020.It uses entropy weighted model,coupling coordination degree,the Dagum Gini coefficient,and geographic detectors to analyze the coordinated development of IC and IF in the context of population shrinkage.The study analyzed the spatiotemporal patterns and driving mechanisms for their coordinated development.The results show that:1)both urban IC and IF exhibited an overall positive trend during the study period.Shrinking cities depend more on IF to address the challenges of population shrinkage,while growing cities mainly rely on innovation-driven development.2)The coupling gap between IC and IF in shrinking and growing cities has widened over time,with the coordination level of shrinking cities steadily decreasing.Cities with serious disorder are concentrated in northern Heilongjiang Province,while most cities in Jilin Province experience moderate disorder.Liaoning Province,however,shows generally good coupling coordination.3)Human capital is the key factor driving coupling coordination in both types of cities.Shrinking cities rely on economic and financial development,with the‘repair-type’logic that emphasizes short-term economic growth and resource compensation.In contrast,the coupling of growing cities relies on basic support capabilities,with the‘optimization-type’logic focused on enhancing endogenous resilience and systemic coordination.Exploring the coordination between urban innovation capabilities and industrial transformation can provide a new perspective for research on population shrinkage,which holds certain theoretical and practical significance for implementing the new round of revitalization strategy in Northeast China.
基金supported by the National Key Research&Development Program of China(No.2024YFC3505800)the National Natural Science Foundation of China(Nos.82474334,82474335 and 72174132)+3 种基金National Science Fund for Distinguished Young Scholars(No.82225049)the Key Research&Development Projects of Sichuan Provincial Department of Science and Technology(Nos.2024YFFK0174 and 2024YFFK0152)1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(Nos.ZYYC24010 and ZYGD23004)the Special Fund for Traditional Chinese Medicine of Sichuan Provincial Administration of Traditional Chinese Medicine(No.2024zd023).
文摘Objectives:Electronic health records(EHRs)offer valuable real-world data(RWD)for Chinese medicine research.However,significant methodological challenges remain in developing integrative Chinese-Western medicine(ICWM)databases.This study aims to establish a best-practice methodological framework,referred to as BRIDGE,to guide the construction of ICWM databases using EHRs.Methods:We developed the methodological framework through a comprehensive process,including systematic literature review,synthesis of empirical experiences,thematic expert discussions,and consultation with an external panel to reach consensus.Results:The BRIDGE framework outlines 6 core components for ICWM-EHR database development:Overall design,database architecture,data extraction and linkage,data governance,data verification,and data quality evaluation.Key data elements include variables related to study population,treatment or exposure,outcomes,and confounders.These databases support various research applications,particularly in evaluating the effectiveness and safety of integrative therapies.To demonstrate its practical value,we developed an ICWM-EHR database on women’s reproductive lifespan,encompassing 2,064,482 patients.This database captures women’s health conditions across the life course,from reproductive age to older adulthood.Conclusions:The BRIDGE methodological framework provides a standardized approach to building high-quality ICWM-EHR databases.It offers a unique opportunity to strengthen the methodological rigor and real-world relevance of Chinese medicine research in integrated healthcare settings.
文摘With the first rays of dawn peeking through the rainforest at Shiti Village,Dehong Dai and Jingpo Autonomous Prefecture,Yunnan Province,Xu Xiaolong,a bird-watching guide from the Jingpo ethnic group,led a German bird-watching group into the jungle.His great-grandfather made a living by hunting“weird-looking birds”in the mountains.Today,the birds(Great Hornbill)are attracting tourist dollars from other parts of the world without dodging bullets.In Shiti Village,bird-watchers can enjoy the chirping of Great Hornbills and feel the rumbling in the air as the birds fly past.The village on the Chinese border with Myanmar was formerly poverty-stricken,with an average annual income of barely 2,000 yuan(US$305)per household 10 years ago.Today,the average annual income has grown to 150,000 yuan(US$23,075).It is a shining example of the successful practice of the notion that“lucid waters and lush mountains are invaluable assets.”
文摘The Emerging Markets and Developing Countries Forum on Bridging the AI Divide and Opening Ceremony of AIM Global CoE were held on July 27 in Minhang district,Shanghai.The event was hosted by AIM Global CoE,and co-organized by Shanghai Artificial Intelligence Research Institute(SAIRI),Shanghai Technology Innovation Center,Shanghai Grand Neobay Investment Development Group,and Organizing Committee of AI Journey Conference.Asian Association of Business Incubation(AABI)and SAIRI served as the international partners.
