以传统药用植物意大利牛舌草(Anchusa italica Retz.)的临床功效和现代药理学研究为基础,通过构建体外抑郁症模型,系统研究牛舌草的药理作用及物质基础.HPLC检测不同产地(新疆、巴基斯坦、海南)牛舌草总黄酮(TFAI)的化学成分;然后用海...以传统药用植物意大利牛舌草(Anchusa italica Retz.)的临床功效和现代药理学研究为基础,通过构建体外抑郁症模型,系统研究牛舌草的药理作用及物质基础.HPLC检测不同产地(新疆、巴基斯坦、海南)牛舌草总黄酮(TFAI)的化学成分;然后用海马细胞(HT-22)通过皮质酮诱导建立神经细胞损伤模型,MTT法检测了5种牛舌草对HT-22细胞活力的影响,并计算其EC_(50).结果表明不同产地TFAI在500µg/mL浓度下对HT-22细胞均未表现出明显的细胞毒性作用,且对HT-22细胞具有显著的增殖作用,对过量皮质酮诱导的海马细胞损伤具有明显的细胞保护作用,比较5批牛舌草中的总黄酮含量和EC_(50)值,海南产地的牛舌草中的黄酮类含量最高,且对HT-22细胞的增殖作用EC_(50)值最低,具有较高的效价.研究结果说明五批TFAI提取物对皮质酮诱导的HT-22海马细胞损伤均具有保护作用,可以不同程度地增加HT-22细胞活力,具有显著的神经保护作用.展开更多
As antibiotic pollutants cannot be incompletely removed by conventional wastewater treatment plants,ultraviolet(UV)based advanced oxidation processes(AOPs)such as UV/persulfate(UV/PS)and UV/chlorine are increasingly c...As antibiotic pollutants cannot be incompletely removed by conventional wastewater treatment plants,ultraviolet(UV)based advanced oxidation processes(AOPs)such as UV/persulfate(UV/PS)and UV/chlorine are increasingly concerned for the effective removal of antibiotics from wastewaters.However,the specific mechanisms involving degradation kinetics and transformation mechanisms are not well elucidated.Here we report a detailed examination of SO_(4)•−/Cl•-mediated degradation kinetics,products,and toxicities of sulfathiazole(ST),sarafloxacin(SAR),and lomefloxacin(LOM)in the two processes.Both SO_(4)•−/Cl•-mediated transformation kinetics were found to be dependent on pH(P<0.05),which was attributed to the disparate reactivities of their individual dissociated forms.Based on competition kinetic experiments and matrix calculations,the cationic forms(H_(2)ST^(+),H_(2)SAR^(+),and H_(2)LOM^(+))were more highly reactive towards SO_(4)•−in most cases,while the neutral forms(e.g.,HSAR^(0)and HLOM^(0))reacted the fastest with Cl•for the most of the antibiotics tested.Based on the identification of 31 key intermediates using tandem mass spectrometry,these reactions generated different products,of which the majority still retained the core chemical structure of the parent compounds.The corresponding diverse transformation pathways were proposed,involving S−N breaking,hydroxylation,defluorination,and chlorination reactions.Furthermore,the toxicity changes of their reaction solutions as well as the toxicity of each intermediate were evaluated by the vibrio fischeri and ECOSAR model,respectively.Many primary by-products were proven to be more toxic than the parent chemicals,raising the wider issue of extended potency for these compounds with regards to their ecotoxicity.These results have implications for assessing the degradative fate and risk of these chemicals during the AOPs.展开更多
(Ti_(8)Zr_(6)Nb_(4)V_(5)Cr_(4))_(100−x)Al_(x)(x=0,0.1,0.2,0.3,0.4 at.%)lightweight high-entropy alloys with different contents of Al were prepared via vacuum non-consumable arc melting method.Effects of adding varying...(Ti_(8)Zr_(6)Nb_(4)V_(5)Cr_(4))_(100−x)Al_(x)(x=0,0.1,0.2,0.3,0.4 at.%)lightweight high-entropy alloys with different contents of Al were prepared via vacuum non-consumable arc melting method.Effects of adding varying Al contents on phase constitution,microstructure characteristics and mechanical properties of the lightweight alloys were studied.Results show that Ti_(8)Zr_(6)Nb_(4)V_(5)Cr_(4)alloy is composed of body-centered cubic(BCC)phase and C15 Laves phase,while(Ti_(8)Zr_(6)Nb_(4)V_(5)Cr_(4))_(100−x)Al_(x)lightweight high-entropy alloys by addition of Al are composed of BCC phase and C14 Laves phase.Addition of Al into Ti_(8)Zr_(6)Nb_(4)V_(5)Cr_(4)lightweight high-entropy alloy can transform C15 Laves phase to C14 Laves phase.With further addition of Al,BCC phase of alloys is significantly refined,and the volume fraction of C14 Laves phase is raised obviously.Meanwhile,the dimension of BCC phase in the alloy by addition of 0.3 at.%Al is the most refined and that of Laves phase is also obviously refined.Adding Al to Ti_(8)Zr_(6)Nb_(4)V_(5)Cr_(4)alloy can not only reduce the density of(Ti_(8)Zr_(6)Nb_(4)V_(5)Cr_(4))_(100−x)Al_(x)alloy,but also improve strength of(Ti_(8)Zr_(6)Nb_(4)V_(5)Cr_(4))_(100−x)Al_(x)alloy.As Al content increased from 0 to 0.4 at.%,the density of the alloy decreased from 6.22±0.875 to 5.79±0.679 g cm^(−3).Moreover,compressive strength of the alloy by 0.3 at.%Al addition is the highest to 1996.9 MPa,while fracture strain of the alloy is 16.82%.Strength improvement of alloys mainly results from microstructure refinement and precipitation of C14 Laves by Al addition into Ti_(8)Zr_(6)Nb_(4)V_(5)Cr_(4)lightweight high-entropy alloy.展开更多
Purpose–This paper aims to provide a comprehensive analysis of the strategic adjustments in China’s transportation structure,with a particular focus on the pivotal role of railway freight and its integration into th...Purpose–This paper aims to provide a comprehensive analysis of the strategic adjustments in China’s transportation structure,with a particular focus on the pivotal role of railway freight and its integration into the modern logistics system.It seeks to address the need for a more nuanced understanding of the“road to rail”policy,emphasizing the importance of intermodal collaboration and service of fragmented market demands.Design/methodology/approach–The study employs a transport economics perspective to evaluate the achievements and shortcomings of China’s transportation structure optimization.It bases its assessment of the current state of railway freight logistics,multi-modal transportation and the broader implications for the transportation service market on data analysis.The methodology includes a review of existing policies,an examination of industry practices and a comparative analysis with global trends in railway logistics.Findings–The research underscores the importance of focusing on the development of non-bulk materials,noting the insufficiency in the development of China’s rail multi-modal transportation and highlighting the instructive value of successful cases in open-top container road-rail intermodal transportation.The study posits that the railway sector must enhance cooperation with other market entities,aligning with the lead enterprises in the logistics chain that are characterized by speed,high value and strong coordination capabilities,in order to better serve the transportation market.This approach moves away from a reliance on the railway’s own capabilities alone.Originality/value–This paper offers original insights into the transformation of railway freight in China,contributing to the body of knowledge on transportation economics and logistics.It provides valuable recommendations for policymakers and industry practitioners,emphasizing the strategic importance of railway logistics in the context of China’s economic development and intense competition in the supply chain.The value of the article lies in its comprehensive understanding of the complexities involved in the adjustment of transportation structures,providing direction for the market-oriented reform of China’s railway freight sector.展开更多
In this paper,we propose a new full-Newton step feasible interior-point algorithm for the special weighted linear complementarity problems.The proposed algorithm employs the technique of algebraic equivalent transform...In this paper,we propose a new full-Newton step feasible interior-point algorithm for the special weighted linear complementarity problems.The proposed algorithm employs the technique of algebraic equivalent transformation to derive the search direction.It is shown that the proximity measure reduces quadratically at each iteration.Moreover,the iteration bound of the algorithm is as good as the best-known polynomial complexity for these types of problems.Furthermore,numerical results are presented to show the efficiency of the proposed algorithm.展开更多
ChuanWu(CW),the dried mother root of Aconitum carmichaelii Debx.,is a well-known traditional Chinese medicine(TCM)recognized for its potent efficacy but inherent toxicity,primarily due to its alkaloid content.Traditio...ChuanWu(CW),the dried mother root of Aconitum carmichaelii Debx.,is a well-known traditional Chinese medicine(TCM)recognized for its potent efficacy but inherent toxicity,primarily due to its alkaloid content.Traditional and modern detoxification methods for CW include proper processing,rational compatibility,and specialized decoction techniques,among which honey-boiled CW is particularly distinctive.However,research on the detoxification mechanism of honey-boiled CW remains limited.This study investigated this mechanism by analyzing alkaloid transformation and supramolecular aggregation.Honey-boiled and water-boiled CW preparations were compared.Ultra-high-performance liquid chromatography-tandem mass spectrometry was used to analyze CW alkaloids,specifically diester alkaloids(DDAs),monoester alkaloids(MDAs),and non-esterified diterpenoid alkaloids(NDAs).Transmission electron microscopy was employed to observe and identify supramolecular aggregates in the honey-boiled CW decoction.In vivo absorption of water-boiled,honey-boiled,and NADES-boiled CW was compared.Median lethal dose(LD_(50))tests assessed toxicity,including hepatotoxicity and nephrotoxicity.In vitro experiments evaluated the safety,anti-inflammatory,and analgesic effects of CWmedicated serum on RAW264.7 cells,with in vivo validation in mice.Results showed that honey promoted the conversion of highly toxic DDAs to less toxic MDAs and prevented MDAs from hydrolyzing into NDAs.Honey-boiled CW formed approximately 250 nm supramolecular aggregates that encapsulated MDAs,inhibiting their conversion to NDAs.These encapsulated MDAs acted as a stable delivery system with higher bioavailability than free benzoylmesaconine.Subsequent mouse experiments confirmed that honey-boiled CW significantly increased the LD_(50)of CW while reducing hepatotoxicity and nephrotoxicity.Additionally,honey-boiled CW significantly improved cell safety and enhanced anti-inflammatory and analgesic effects.Our findings reveal that honey-boiled CW exhibits a potent detoxification mechanism by influencing alkaloid transformation and facilitating the formation of supramolecular aggregates.This study lays the groundwork for developing detoxification or synergistic strategies within honey-boiled TCM.展开更多
Simple cubic black phosphorus(BP)has been recognized as a strategic material due to its exceptional structural stability under extreme conditions.In this investigation,simple cubic BP was successfully synthesized thro...Simple cubic black phosphorus(BP)has been recognized as a strategic material due to its exceptional structural stability under extreme conditions.In this investigation,simple cubic BP was successfully synthesized through shock-induced phase transformation,utilizing amorphous red phosphorus as the precursor material.The phase evolution process was systematically investigated using plane shock loading apparatus,with shock pressure and temperature parameters being precisely controlled to optimize transformation kinetics.Comprehensive phase characterization revealed the correlation between thermodynamic loading profiles and cubic BP formation efficiency.Precursor modification strategies were implemented through orthorhombic BP utilization,resulting in enhanced cubic phase yield and crystallinity.The synthesized cubic BP variants are considered promising candidates for advanced protective material systems,particularly where combinations of mechanical resilience and thermal stability are required under extreme operational conditions.This research provides critical insights into shock-induced phase transformation mechanics,while establishing foundational protocols for manufacturing non-equilibrium materials with potential applications in next-generation defensive technologies.展开更多
Accurate time delay estimation of target echo signals is a critical component of underwater target localization.In active sonar systems,echo signal processing is vulnerable to the effects of reverberation and noise in...Accurate time delay estimation of target echo signals is a critical component of underwater target localization.In active sonar systems,echo signal processing is vulnerable to the effects of reverberation and noise in the maritime environment.This paper proposes a novel method for estimating target time delay using multi-bright spot echoes,assuming the target’s size and depth are known.Aiming to effectively enhance the extraction of geometric features from the target echoes and mitigate the impact of reverberation and noise,the proposed approach employs the fractional order Fourier transform-frequency sliced wavelet transform to extract multi-bright spot echoes.Using the highlighting model theory and the target size information,an observation matrix is constructed to represent multi-angle incident signals and obtain the theoretical scattered echo signals from different angles.Aiming to accurately estimate the target’s time delay,waveform similarity coefficients and mean square error values between the theoretical return signals and received signals are computed across various incident angles and time delays.Simulation results show that,compared to the conventional matched filter,the proposed algorithm reduces the relative error by 65.9%-91.5%at a signal-to noise ratio of-25 dB,and by 66.7%-88.9%at a signal-to-reverberation ratio of−10 dB.This algorithm provides a new approach for the precise localization of submerged targets in shallow water environments.展开更多
Images taken in dim environments frequently exhibit issues like insufficient brightness,noise,color shifts,and loss of detail.These problems pose significant challenges to dark image enhancement tasks.Current approach...Images taken in dim environments frequently exhibit issues like insufficient brightness,noise,color shifts,and loss of detail.These problems pose significant challenges to dark image enhancement tasks.Current approaches,while effective in global illumination modeling,often struggle to simultaneously suppress noise and preserve structural details,especially under heterogeneous lighting.Furthermore,misalignment between luminance and color channels introduces additional challenges to accurate enhancement.In response to the aforementioned difficulties,we introduce a single-stage framework,M2ATNet,using the multi-scale multi-attention and Transformer architecture.First,to address the problems of texture blurring and residual noise,we design a multi-scale multi-attention denoising module(MMAD),which is applied separately to the luminance and color channels to enhance the structural and texture modeling capabilities.Secondly,to solve the non-alignment problem of the luminance and color channels,we introduce the multi-channel feature fusion Transformer(CFFT)module,which effectively recovers the dark details and corrects the color shifts through cross-channel alignment and deep feature interaction.To guide the model to learn more stably and efficiently,we also fuse multiple types of loss functions to form a hybrid loss term.We extensively evaluate the proposed method on various standard datasets,including LOL-v1,LOL-v2,DICM,LIME,and NPE.Evaluation in terms of numerical metrics and visual quality demonstrate that M2ATNet consistently outperforms existing advanced approaches.Ablation studies further confirm the critical roles played by the MMAD and CFFT modules to detail preservation and visual fidelity under challenging illumination-deficient environments.展开更多
It is difficult to recover chrysocolla from sulfidation flotation which is closely related to the mineral surface composition.In this study,the effects of fluoride roasting on the surface composition of chrysocolla we...It is difficult to recover chrysocolla from sulfidation flotation which is closely related to the mineral surface composition.In this study,the effects of fluoride roasting on the surface composition of chrysocolla were investigated,its impact on sulfidation flotation was explored,and the mechanisms involved in both fluoride roasting and sulfidation flotation were discussed.With CaF_(2)as the roasting reagent,Na_(2)S·9H_(2)O as the sulfidation reagent,and sodium butyl xanthate(NaBX)as the collector,the results of the flotation experiments showed that fluoride roasting improved the floatability of chrysocolla,and the recovery rate increased from 16.87%to 82.74%.X-ray diffraction analysis revealed that after fluoride roasting,approximately all the Cu on the chrysocolla surface was exposed in the form of CuO,which could provide a basis for subsequent sulfidation flotation.The microscopy and elemental analyses revealed that large quantities of"pagoda-like"grains were observed on the sulfidation surface of the fluoride-roasted chrysocolla,indicating high crystallinity particles of copper sulfide.This suggests that the effect of sulfide formation on the chrysocolla surface was more pronounced.X-ray photoelectron spectroscopy revealed that fluoride roasting increased the relative contents of sulfur and copper on the surface and that both the Cu~+and polysulfide fractions on the surface of the minerals increased.This enhances the effect of sulfidation,which is conducive to flotation recovery.Therefore,fluoride roasting improved the effect of copper species transformation and sulfidation on the surface of chysocolla,promoted the adsorption of collectors,and improved the recovery of chrysocolla from sulfidation flotation.展开更多
Peanuts(Arachis hypogaea) are important sources of vegetable oil,protein,and forage.The genus Arachis comprises nine intrageneric taxonomic sections encompassing 84 species.Most Arachis species are wild plants that se...Peanuts(Arachis hypogaea) are important sources of vegetable oil,protein,and forage.The genus Arachis comprises nine intrageneric taxonomic sections encompassing 84 species.Most Arachis species are wild plants that serve widely as forage and turfgrass.Furthermore,wild Arachis species provide valuable gene resources for broadening the genetic diversity of cultivated peanuts.To date,several key genes have been identified through the use of recombinant inbred lines derived from interspecific crosses within Arachis.Despite this progress,the application of genetic engineering to enhance peanut traits remains limited.This limitation arises primarily from the absence of a robust and reliable genetic transformation protocol for Arachis species.Nevertheless,evidence indicates that successful genetic transformation of Arachis plants was first reported approximately 30 years ago.Thus,a notable discrepancy exists between early reports of transformation success and the ongoing challenges in stably transferring candidate genes into Arachis genotypes.This review summarizes existing methods for regeneration and genetic transformation in Arachis,aiming to advance understanding of transgenic technologies applicable to this genus.展开更多
The moment a media delegation from the Republic of the Congo arrived at the Othello Kitchenware Museum on 18 November 2025,they were greeted with a vivid show of Guangdong’s industrial strength.Standing before them w...The moment a media delegation from the Republic of the Congo arrived at the Othello Kitchenware Museum on 18 November 2025,they were greeted with a vivid show of Guangdong’s industrial strength.Standing before them was not a typical exhibition hall,but a building shaped like a gleaming stainless-steel cooking pot.展开更多
文摘以传统药用植物意大利牛舌草(Anchusa italica Retz.)的临床功效和现代药理学研究为基础,通过构建体外抑郁症模型,系统研究牛舌草的药理作用及物质基础.HPLC检测不同产地(新疆、巴基斯坦、海南)牛舌草总黄酮(TFAI)的化学成分;然后用海马细胞(HT-22)通过皮质酮诱导建立神经细胞损伤模型,MTT法检测了5种牛舌草对HT-22细胞活力的影响,并计算其EC_(50).结果表明不同产地TFAI在500µg/mL浓度下对HT-22细胞均未表现出明显的细胞毒性作用,且对HT-22细胞具有显著的增殖作用,对过量皮质酮诱导的海马细胞损伤具有明显的细胞保护作用,比较5批牛舌草中的总黄酮含量和EC_(50)值,海南产地的牛舌草中的黄酮类含量最高,且对HT-22细胞的增殖作用EC_(50)值最低,具有较高的效价.研究结果说明五批TFAI提取物对皮质酮诱导的HT-22海马细胞损伤均具有保护作用,可以不同程度地增加HT-22细胞活力,具有显著的神经保护作用.
基金supported by the Key Research and Development Program of Shaanxi Province(No.2024SF-YBXM-567)the National Natural Science Foundation of China(Nos.21976045,22076112)the China Scholarship Council(CSC)Scholarship(No.202308610123).
文摘As antibiotic pollutants cannot be incompletely removed by conventional wastewater treatment plants,ultraviolet(UV)based advanced oxidation processes(AOPs)such as UV/persulfate(UV/PS)and UV/chlorine are increasingly concerned for the effective removal of antibiotics from wastewaters.However,the specific mechanisms involving degradation kinetics and transformation mechanisms are not well elucidated.Here we report a detailed examination of SO_(4)•−/Cl•-mediated degradation kinetics,products,and toxicities of sulfathiazole(ST),sarafloxacin(SAR),and lomefloxacin(LOM)in the two processes.Both SO_(4)•−/Cl•-mediated transformation kinetics were found to be dependent on pH(P<0.05),which was attributed to the disparate reactivities of their individual dissociated forms.Based on competition kinetic experiments and matrix calculations,the cationic forms(H_(2)ST^(+),H_(2)SAR^(+),and H_(2)LOM^(+))were more highly reactive towards SO_(4)•−in most cases,while the neutral forms(e.g.,HSAR^(0)and HLOM^(0))reacted the fastest with Cl•for the most of the antibiotics tested.Based on the identification of 31 key intermediates using tandem mass spectrometry,these reactions generated different products,of which the majority still retained the core chemical structure of the parent compounds.The corresponding diverse transformation pathways were proposed,involving S−N breaking,hydroxylation,defluorination,and chlorination reactions.Furthermore,the toxicity changes of their reaction solutions as well as the toxicity of each intermediate were evaluated by the vibrio fischeri and ECOSAR model,respectively.Many primary by-products were proven to be more toxic than the parent chemicals,raising the wider issue of extended potency for these compounds with regards to their ecotoxicity.These results have implications for assessing the degradative fate and risk of these chemicals during the AOPs.
基金supported by National Natural Science Foundation of China(Grant No.52001114)Program for Science and Technology Innovation Talents in Universities of Henan Province(No.23HASTIT022 and 2021GGJS064)Scientific Research Fund of State Key Laboratory of Materials Processing and Die and Mould Technology(Grant No.P2023-005).
文摘(Ti_(8)Zr_(6)Nb_(4)V_(5)Cr_(4))_(100−x)Al_(x)(x=0,0.1,0.2,0.3,0.4 at.%)lightweight high-entropy alloys with different contents of Al were prepared via vacuum non-consumable arc melting method.Effects of adding varying Al contents on phase constitution,microstructure characteristics and mechanical properties of the lightweight alloys were studied.Results show that Ti_(8)Zr_(6)Nb_(4)V_(5)Cr_(4)alloy is composed of body-centered cubic(BCC)phase and C15 Laves phase,while(Ti_(8)Zr_(6)Nb_(4)V_(5)Cr_(4))_(100−x)Al_(x)lightweight high-entropy alloys by addition of Al are composed of BCC phase and C14 Laves phase.Addition of Al into Ti_(8)Zr_(6)Nb_(4)V_(5)Cr_(4)lightweight high-entropy alloy can transform C15 Laves phase to C14 Laves phase.With further addition of Al,BCC phase of alloys is significantly refined,and the volume fraction of C14 Laves phase is raised obviously.Meanwhile,the dimension of BCC phase in the alloy by addition of 0.3 at.%Al is the most refined and that of Laves phase is also obviously refined.Adding Al to Ti_(8)Zr_(6)Nb_(4)V_(5)Cr_(4)alloy can not only reduce the density of(Ti_(8)Zr_(6)Nb_(4)V_(5)Cr_(4))_(100−x)Al_(x)alloy,but also improve strength of(Ti_(8)Zr_(6)Nb_(4)V_(5)Cr_(4))_(100−x)Al_(x)alloy.As Al content increased from 0 to 0.4 at.%,the density of the alloy decreased from 6.22±0.875 to 5.79±0.679 g cm^(−3).Moreover,compressive strength of the alloy by 0.3 at.%Al addition is the highest to 1996.9 MPa,while fracture strain of the alloy is 16.82%.Strength improvement of alloys mainly results from microstructure refinement and precipitation of C14 Laves by Al addition into Ti_(8)Zr_(6)Nb_(4)V_(5)Cr_(4)lightweight high-entropy alloy.
基金supported by the Yuxiu Innovation Project of NCUT(Grant No.2024NCUTYXCX211).
文摘Purpose–This paper aims to provide a comprehensive analysis of the strategic adjustments in China’s transportation structure,with a particular focus on the pivotal role of railway freight and its integration into the modern logistics system.It seeks to address the need for a more nuanced understanding of the“road to rail”policy,emphasizing the importance of intermodal collaboration and service of fragmented market demands.Design/methodology/approach–The study employs a transport economics perspective to evaluate the achievements and shortcomings of China’s transportation structure optimization.It bases its assessment of the current state of railway freight logistics,multi-modal transportation and the broader implications for the transportation service market on data analysis.The methodology includes a review of existing policies,an examination of industry practices and a comparative analysis with global trends in railway logistics.Findings–The research underscores the importance of focusing on the development of non-bulk materials,noting the insufficiency in the development of China’s rail multi-modal transportation and highlighting the instructive value of successful cases in open-top container road-rail intermodal transportation.The study posits that the railway sector must enhance cooperation with other market entities,aligning with the lead enterprises in the logistics chain that are characterized by speed,high value and strong coordination capabilities,in order to better serve the transportation market.This approach moves away from a reliance on the railway’s own capabilities alone.Originality/value–This paper offers original insights into the transformation of railway freight in China,contributing to the body of knowledge on transportation economics and logistics.It provides valuable recommendations for policymakers and industry practitioners,emphasizing the strategic importance of railway logistics in the context of China’s economic development and intense competition in the supply chain.The value of the article lies in its comprehensive understanding of the complexities involved in the adjustment of transportation structures,providing direction for the market-oriented reform of China’s railway freight sector.
基金Supported by the Optimisation Theory and Algorithm Research Team(Grant No.23kytdzd004)University Science Research Project of Anhui Province(Grant No.2024AH050631)the General Programs for Young Teacher Cultivation of Educational Commission of Anhui Province(Grant No.YQYB2023090).
文摘In this paper,we propose a new full-Newton step feasible interior-point algorithm for the special weighted linear complementarity problems.The proposed algorithm employs the technique of algebraic equivalent transformation to derive the search direction.It is shown that the proximity measure reduces quadratically at each iteration.Moreover,the iteration bound of the algorithm is as good as the best-known polynomial complexity for these types of problems.Furthermore,numerical results are presented to show the efficiency of the proposed algorithm.
基金supported by National Natural Science Foundation of China(Grant Nos.:82230117,82474195,and 82173992)Youth Medical Innovation Research Project of China(Grant No.:P24021887623)+1 种基金Nanjing Medical University(Grant Nos.:TZKY20230104,and 2024KF0292)Science and Technology Support Projectof Taizhou(Grant No.:TS202420).
文摘ChuanWu(CW),the dried mother root of Aconitum carmichaelii Debx.,is a well-known traditional Chinese medicine(TCM)recognized for its potent efficacy but inherent toxicity,primarily due to its alkaloid content.Traditional and modern detoxification methods for CW include proper processing,rational compatibility,and specialized decoction techniques,among which honey-boiled CW is particularly distinctive.However,research on the detoxification mechanism of honey-boiled CW remains limited.This study investigated this mechanism by analyzing alkaloid transformation and supramolecular aggregation.Honey-boiled and water-boiled CW preparations were compared.Ultra-high-performance liquid chromatography-tandem mass spectrometry was used to analyze CW alkaloids,specifically diester alkaloids(DDAs),monoester alkaloids(MDAs),and non-esterified diterpenoid alkaloids(NDAs).Transmission electron microscopy was employed to observe and identify supramolecular aggregates in the honey-boiled CW decoction.In vivo absorption of water-boiled,honey-boiled,and NADES-boiled CW was compared.Median lethal dose(LD_(50))tests assessed toxicity,including hepatotoxicity and nephrotoxicity.In vitro experiments evaluated the safety,anti-inflammatory,and analgesic effects of CWmedicated serum on RAW264.7 cells,with in vivo validation in mice.Results showed that honey promoted the conversion of highly toxic DDAs to less toxic MDAs and prevented MDAs from hydrolyzing into NDAs.Honey-boiled CW formed approximately 250 nm supramolecular aggregates that encapsulated MDAs,inhibiting their conversion to NDAs.These encapsulated MDAs acted as a stable delivery system with higher bioavailability than free benzoylmesaconine.Subsequent mouse experiments confirmed that honey-boiled CW significantly increased the LD_(50)of CW while reducing hepatotoxicity and nephrotoxicity.Additionally,honey-boiled CW significantly improved cell safety and enhanced anti-inflammatory and analgesic effects.Our findings reveal that honey-boiled CW exhibits a potent detoxification mechanism by influencing alkaloid transformation and facilitating the formation of supramolecular aggregates.This study lays the groundwork for developing detoxification or synergistic strategies within honey-boiled TCM.
基金supported by the Youth Project of the Independent Subject of the State Key Laboratory of Explosion Science and Safety Protection,Beijing Institute of Technology(Grant Nos.QNKT25-13 and QNKT24-02)the 76th batch of Project funded by China Postdoctoral Science Foundation(Grant No.2024M764116)+3 种基金the National Natural Science Foundation of China(Grant Nos.12002048,12072037,12102050,and 12202067)the Science and Technology Commission,China(Grant No.2019-jcjc-zd-011-00)the Project supported by the Open Funds of Kui Yuan Laboratory(Grant No.KY202431)the State Key Laboratory of Explosion Science and Safety Protection(Grant No.KFJJ25-21M)。
文摘Simple cubic black phosphorus(BP)has been recognized as a strategic material due to its exceptional structural stability under extreme conditions.In this investigation,simple cubic BP was successfully synthesized through shock-induced phase transformation,utilizing amorphous red phosphorus as the precursor material.The phase evolution process was systematically investigated using plane shock loading apparatus,with shock pressure and temperature parameters being precisely controlled to optimize transformation kinetics.Comprehensive phase characterization revealed the correlation between thermodynamic loading profiles and cubic BP formation efficiency.Precursor modification strategies were implemented through orthorhombic BP utilization,resulting in enhanced cubic phase yield and crystallinity.The synthesized cubic BP variants are considered promising candidates for advanced protective material systems,particularly where combinations of mechanical resilience and thermal stability are required under extreme operational conditions.This research provides critical insights into shock-induced phase transformation mechanics,while establishing foundational protocols for manufacturing non-equilibrium materials with potential applications in next-generation defensive technologies.
基金Supported by the State Key Laboratory of Acoustics and Marine Information Chinese Academy of Sciences(SKL A202507).
文摘Accurate time delay estimation of target echo signals is a critical component of underwater target localization.In active sonar systems,echo signal processing is vulnerable to the effects of reverberation and noise in the maritime environment.This paper proposes a novel method for estimating target time delay using multi-bright spot echoes,assuming the target’s size and depth are known.Aiming to effectively enhance the extraction of geometric features from the target echoes and mitigate the impact of reverberation and noise,the proposed approach employs the fractional order Fourier transform-frequency sliced wavelet transform to extract multi-bright spot echoes.Using the highlighting model theory and the target size information,an observation matrix is constructed to represent multi-angle incident signals and obtain the theoretical scattered echo signals from different angles.Aiming to accurately estimate the target’s time delay,waveform similarity coefficients and mean square error values between the theoretical return signals and received signals are computed across various incident angles and time delays.Simulation results show that,compared to the conventional matched filter,the proposed algorithm reduces the relative error by 65.9%-91.5%at a signal-to noise ratio of-25 dB,and by 66.7%-88.9%at a signal-to-reverberation ratio of−10 dB.This algorithm provides a new approach for the precise localization of submerged targets in shallow water environments.
基金funded by the National Natural Science Foundation of China,grant numbers 52374156 and 62476005。
文摘Images taken in dim environments frequently exhibit issues like insufficient brightness,noise,color shifts,and loss of detail.These problems pose significant challenges to dark image enhancement tasks.Current approaches,while effective in global illumination modeling,often struggle to simultaneously suppress noise and preserve structural details,especially under heterogeneous lighting.Furthermore,misalignment between luminance and color channels introduces additional challenges to accurate enhancement.In response to the aforementioned difficulties,we introduce a single-stage framework,M2ATNet,using the multi-scale multi-attention and Transformer architecture.First,to address the problems of texture blurring and residual noise,we design a multi-scale multi-attention denoising module(MMAD),which is applied separately to the luminance and color channels to enhance the structural and texture modeling capabilities.Secondly,to solve the non-alignment problem of the luminance and color channels,we introduce the multi-channel feature fusion Transformer(CFFT)module,which effectively recovers the dark details and corrects the color shifts through cross-channel alignment and deep feature interaction.To guide the model to learn more stably and efficiently,we also fuse multiple types of loss functions to form a hybrid loss term.We extensively evaluate the proposed method on various standard datasets,including LOL-v1,LOL-v2,DICM,LIME,and NPE.Evaluation in terms of numerical metrics and visual quality demonstrate that M2ATNet consistently outperforms existing advanced approaches.Ablation studies further confirm the critical roles played by the MMAD and CFFT modules to detail preservation and visual fidelity under challenging illumination-deficient environments.
基金financially supported by the National Natural Science Foundation of China(No.52374259)the Open Fund of the State Key Laboratory of Mineral Processing Science and Technology,China(No.BGRIMM-KJSKL-2023-11)the Major Science and Technology Projects in Yunnan Province,China(No.202302 AF080004)。
文摘It is difficult to recover chrysocolla from sulfidation flotation which is closely related to the mineral surface composition.In this study,the effects of fluoride roasting on the surface composition of chrysocolla were investigated,its impact on sulfidation flotation was explored,and the mechanisms involved in both fluoride roasting and sulfidation flotation were discussed.With CaF_(2)as the roasting reagent,Na_(2)S·9H_(2)O as the sulfidation reagent,and sodium butyl xanthate(NaBX)as the collector,the results of the flotation experiments showed that fluoride roasting improved the floatability of chrysocolla,and the recovery rate increased from 16.87%to 82.74%.X-ray diffraction analysis revealed that after fluoride roasting,approximately all the Cu on the chrysocolla surface was exposed in the form of CuO,which could provide a basis for subsequent sulfidation flotation.The microscopy and elemental analyses revealed that large quantities of"pagoda-like"grains were observed on the sulfidation surface of the fluoride-roasted chrysocolla,indicating high crystallinity particles of copper sulfide.This suggests that the effect of sulfide formation on the chrysocolla surface was more pronounced.X-ray photoelectron spectroscopy revealed that fluoride roasting increased the relative contents of sulfur and copper on the surface and that both the Cu~+and polysulfide fractions on the surface of the minerals increased.This enhances the effect of sulfidation,which is conducive to flotation recovery.Therefore,fluoride roasting improved the effect of copper species transformation and sulfidation on the surface of chysocolla,promoted the adsorption of collectors,and improved the recovery of chrysocolla from sulfidation flotation.
基金funded by the Key R&D Program of Shandong Province,China (2024LZGC035)the Start-up Foundation for High Talents of Qingdao Agricultural University,China (665/1120012)。
文摘Peanuts(Arachis hypogaea) are important sources of vegetable oil,protein,and forage.The genus Arachis comprises nine intrageneric taxonomic sections encompassing 84 species.Most Arachis species are wild plants that serve widely as forage and turfgrass.Furthermore,wild Arachis species provide valuable gene resources for broadening the genetic diversity of cultivated peanuts.To date,several key genes have been identified through the use of recombinant inbred lines derived from interspecific crosses within Arachis.Despite this progress,the application of genetic engineering to enhance peanut traits remains limited.This limitation arises primarily from the absence of a robust and reliable genetic transformation protocol for Arachis species.Nevertheless,evidence indicates that successful genetic transformation of Arachis plants was first reported approximately 30 years ago.Thus,a notable discrepancy exists between early reports of transformation success and the ongoing challenges in stably transferring candidate genes into Arachis genotypes.This review summarizes existing methods for regeneration and genetic transformation in Arachis,aiming to advance understanding of transgenic technologies applicable to this genus.
文摘The moment a media delegation from the Republic of the Congo arrived at the Othello Kitchenware Museum on 18 November 2025,they were greeted with a vivid show of Guangdong’s industrial strength.Standing before them was not a typical exhibition hall,but a building shaped like a gleaming stainless-steel cooking pot.
