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A kinetic model for austenite grain growth during continuous casting considering massive type peritectic transformation
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作者 Peng Lan Hua-song Liu Jia-quan Zhang 《Journal of Iron and Steel Research International》 2025年第4期920-934,共15页
The continuous growth behavior of austenite grain in 20Cr peritectic steel was analyzed by experiment and theoretical modeling.The peculiar casting experiment with different cooling rates was achieved by multigradient... The continuous growth behavior of austenite grain in 20Cr peritectic steel was analyzed by experiment and theoretical modeling.The peculiar casting experiment with different cooling rates was achieved by multigradient operation scheme,and different morphologies in austenite grain were observed at the target location.The increase in austenite grain size with increasing cooling rate was firstly revealed in steels.The anomalous grain growth theoretically results from the mechanism of peritectic transformation transiting from the diffusional to massive type,and the additional energy storage stimulates the grain boundary migration.A new kinetic model to predict the growth behavior of austenite grain during continuous cooling process was developed,and the energy storage induced by massive type peritectic transformation was novelly taken into account.The parameters in the model were fitted by multiphase field modeling and experimental results.The kinetic model was finally verified by austenite grain size in laboratory test as well as the trial data at different locations in continuously cast bloom.The coarsening behavior of austenite grain during continuous casting was predicted based on the simulated temperature history.It is found that the grain coarsening occurs generally in the mold zone at high temperature for 20Cr steel and then almost levels off in the following process.The austenite finish transformation temperature Tγand primary cooling intensity show great influence on the grain coarsening.As Tγdecreases by 1℃,the austenite grain size decreases by 4μm linearly.However,the variation of Tγagainst heat flux is in a nonlinear relationship,suggesting that low cooling rate is much more harmful for austenite grain coarsening in continuous casting. 展开更多
关键词 Austenite grain growth Continuous casting Massive type transformation Kinetic model Peritectic steel
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Interference of Y-27632 on the signal transduction of transforming growth factor beta type 1 in ocular Tenon capsule fibroblasts 被引量:7
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作者 Xiao-Hui Zhang, Jian-Ming Wang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2012年第5期576-581,共6页
AIM: To investigate the interfering effect of Y-27632, a ROCK-I selective inhibitor, on the signal transduction pathway of transforming growth factor-beta 1 (TGF-beta 1) in ocular Tenon capsule fibroblasts (OTFS) in v... AIM: To investigate the interfering effect of Y-27632, a ROCK-I selective inhibitor, on the signal transduction pathway of transforming growth factor-beta 1 (TGF-beta 1) in ocular Tenon capsule fibroblasts (OTFS) in vitro. METHODS: After OTFS from passages 4 to 6 47 vitro were induced by TGF-beta 1 and then treated by Y-27632, the changes of the OTFS cell cycles were analyzed via flow cytometry, and the proteins expression of the alpha -smooth muscular actin (alpha -SMA), connective tissue growth factor (CTGF), collagen I were calculated by Western blot. After OTFS treated by the different concentrations of Y-27632, the expression levels of the alpha -SMA, CTGF and collagen I mRNA were assayed by RT-PCR. RESULTS: Y-27632 had no markedly effect on the OTFS cell cycles. After treated by TGF-beta 1, OTFS in G1 period significantly increased. The cell cycles distribution by both TGF-beta 1 and Y-27632 had no remarkable difference from that in control group. Y-27632 significantly inhibited the proteins expressions of both alpha -SMA and CTGF, while to some extent inhibited that of collagen I. TGF-beta 1 significantly promoted the proteins expressions of alpha -SMA, CTGF and collagen I. After OTFS treated by both TGF-beta 1 and Y-27632, of alpha -SMA, the protein expression was similar with that in control group (P=0.066>0.05), but the protein expression of CTGF or collagen I, respectively, was significantly different from that in control group (P=0.000<0.01). The differences of expressions of the alpha -SMA, CTGF and collagen I mRNA in 30, 150, 750 mu mol/L Y-27632 group were statistically significant, compared with those in control group, respectively (alpha -SMA, P=0.002, 0.000, 0.000; CTGF, P=0.014, 0.002, 0.001; collagen I,P=0.003, 0.002, 0.000). CONCLUSION: Blocking the Rho/ROCK signaling pathway by using of Y-27632 could inhibit the cellular proliferation and the expression of both CTGF and alpha -SMA whatever OTFS induced by TGF-beta 1 or not. Y-27632 suppressed the expression of collagen I mRNA without induction. 展开更多
关键词 Y-27632 ocular Tenon's capsule fibroblasts transforming growth factor beta type 1 α-smooth muscular actin connective tissue growth factor collagen I
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THE INTEGRAL TYPE GAUGE TRANSFORMATION AND THE ADDITIONAL SYMMETRY FOR THE CONSTRAINED KP HIERARCHY 被引量:2
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作者 程纪鹏 贺劲松 《Acta Mathematica Scientia》 SCIE CSCD 2015年第5期1111-1121,共11页
In this paper, the compatibility between the integral type gauge transformation and the additional symmetry of the constrained KP hierarchy is given. And the string-equation constraint in matrix models is also derived.
关键词 constrained KP hierarchy integral type gauge transformation additional symmetry.
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On the Proximate Type of Analytic Function Represented by Laplace-Stieltjes Transformation 被引量:3
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作者 Wanchun LU 《Journal of Mathematical Research with Applications》 CSCD 2015年第1期97-102,共6页
In present paper, we study precisely the growth of analytic functions defined by zero order Laplace-Stieltjes transformation converging in right plane. The coefficient characterizations of generalized logarithmic p-ty... In present paper, we study precisely the growth of analytic functions defined by zero order Laplace-Stieltjes transformation converging in right plane. The coefficient characterizations of generalized logarithmic p-type and generalized lower logarithmic p-type are obtained, which improve the results of logarithmic type and lower logarithmic type. 展开更多
关键词 Laplace-Stieltjes transform zero order logarithmic p-type lower logarithmic p-type
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Inhibition of Ubiquitin-specific Protease 4 Attenuates Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells via Transforming Growth Factor Beta Receptor Type Ⅰ
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作者 Jin-yun PU Yu ZHANG +2 位作者 Li-xia WANG Jie WANG Jian-hua ZHOU 《Current Medical Science》 SCIE CAS 2022年第5期1000-1006,共7页
Objective Ubiquitin-specific protease 4(USP4)facilitates the development of transforming growth factor-beta 1(TGF-β1)-induced epithelial-mesenchymal transition(EMT)in various cancer cells.Moreover,EMT of renal tubula... Objective Ubiquitin-specific protease 4(USP4)facilitates the development of transforming growth factor-beta 1(TGF-β1)-induced epithelial-mesenchymal transition(EMT)in various cancer cells.Moreover,EMT of renal tubular epithelial cells(RTECs)is required for the progression of renal interstitial fibrosis.However,the role of USP4 in EMT of RTECs remains unknown.The present study aimed to explore the effect of USP4 on the EMT of RTECs as well as the involved mechanism.Methods In established unilateral ureteral obstruction(UUO)rats and NRK-52E cells,immunohistochemistry and Western blot assays were performed.Results USP4 expression was increased significantly with obstruction time.In NRK-52E cells stimulated by TGF-β1,USP4 expression was increased in a time-dependent manner.In addition,USP4 silencing with specific siRNA indicated that USP4 protein was suppressed effectively.Meanwhile,USP4 siRNA treatment restored E-cadherin and weakened alpha smooth muscle actin(α-SMA)expression,indicating that USP4 may promote EMT.After treatment with USP4 siRNA and TGF-β1 for 24 h,the expression of TGF-β1 receptor type I(TβRI)was decreased.Conclusion USP4 promotes the EMT of RTECs through upregulating TβRI,thereby facilitating renal interstitial fibrosis.These findings may provide a potential target of USP4 in the treatment of renal fibrosis. 展开更多
关键词 ubiquitin-specific protease 4 renal tubular epithelial cells epithelial-mesenchymal transition transforming growth factor-beta 1 receptor type I renal interstitial fibrosis
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Separate-Type Estimators for Estimating Population Ratio in Post-Stratified Sampling Using Variable Transformation
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作者 Aloy Chijioke Onyeka Chinyeaka Hostensia Izunobi Iheanyi Sylvester Iwueze 《Open Journal of Statistics》 2015年第1期27-34,共8页
The study proposes, along the line of [1], six separate-type estimators for estimating the population ratio of two variables in post-stratified sampling, using variable transformation. Properties of the proposed estim... The study proposes, along the line of [1], six separate-type estimators for estimating the population ratio of two variables in post-stratified sampling, using variable transformation. Properties of the proposed estimators were obtained up to first order approximations, both for achieved sample configurations (conditional argument) and over repeated samples of fixed size n (unconditional argument). Efficiency conditions, under which the proposed separate-type estimators would perform better than the associated customary separate-type estimators in terms of having smaller mean squared errors, were obtained. Furthermore, conditions under which some of the proposed separate-type estimators would perform better than other proposed separate-type estimators were also obtained. The optimum estimators among the proposed separate-type estimators were obtained and an empirical illustration confirmed the theoretical results. 展开更多
关键词 Variable transformation Separate-type ESTIMATOR OPTIMUM ESTIMATORS Ratio Product and Regression-type ESTIMATORS Mean Squared Error
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Boundedness of Commutators Generated by Campanato-type Functions and Riesz Transforms Associated with Schrdinger Operators
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作者 Mo Hui-xia Yu Dong-yan +1 位作者 Sui Xin Ji You-qing 《Communications in Mathematical Research》 CSCD 2015年第4期289-297,共9页
Abstract: Let L=-△+V be a SchrSdinger operator on Rn, n 〉 3, where △ is the Laplacian on Rn and V ≠ 0 is a nonnegative function satisfying the reverse HSlder's inequality. Let [b, T] be the commutator generated... Abstract: Let L=-△+V be a SchrSdinger operator on Rn, n 〉 3, where △ is the Laplacian on Rn and V ≠ 0 is a nonnegative function satisfying the reverse HSlder's inequality. Let [b, T] be the commutator generated by the Campanatotype function b ∈∧Lβ and the Riesz transform associated with SchrSdinger operator T =△↓(-△ + V)-1/2. In the paper, we establish the boundedness of [b, T] on Lebesgue spaces and Campanato-type spaces. 展开更多
关键词 COMMUTATOR Campanato-type space Riesz transform SchrSdinger op-erator
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ENHANCEMENT OF MORPHOLOGICAL AND ONCOGENIC TRANSFORMATION OF MOUSE CELLS WITH 12-O-TETRADECANOYL PHORBOL- 13-ACETATE FOLLOWING HERPES SINPLEX VIRUS TYPE 2 INFECTION
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作者 陈敏诲 陈道平 +1 位作者 陈晓 林雨霖 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 1994年第3期191-199,共9页
Sequential exposure of mouse embryo cells to HSV-2 and TPA gave rise to a synergistic enhancement of the transformation frequency. The transformants were selected for their ability to form dense foci of cells in me... Sequential exposure of mouse embryo cells to HSV-2 and TPA gave rise to a synergistic enhancement of the transformation frequency. The transformants were selected for their ability to form dense foci of cells in medium containing 10% or 1%(low) fetal bovine serum. The average number of foci induced with HSV -2 followed by TPA was about 3 or 5(in low serum) fold greater than that induced with HSV- 2 alone. HSV- 2 antigen could be detected in about 10% of transformed cells before 27th passage with immunofluorescence technique. Of two cell lines established from single focus , one designated BL which was preferable to form foci in subcultures was tumorigenic after 21th passage. All of the tumors were sarcomas with interlacing bundles of pleomorphic fibroblasts. The other,designated NP was nontumorigenic until 50th passage. The BL cell line was composed of two distict cell types, i. e.,pigmented and unpigmented. No viral DNA sequences weredetected in the cells of tumors derived from BL cell line. 展开更多
关键词 Herpes simplex virus type 2 Oncogenic transformation TPA Mouse cell.
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The Dual Functionals for the Generalized Ball Basis of Wang-Said Type and Basis Transformation Formulas 被引量:2
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作者 Ping Jiang Hongyi Wu Jieqing Tan 《Numerical Mathematics A Journal of Chinese Universities(English Series)》 SCIE 2006年第3期248-256,共9页
The generalized Ball curves of Wang-Said type with a position parameter L not only unify the Wang-Ball curves and the Said-Ball curves, but also include several useful intermediate curves. This paper presents the dual... The generalized Ball curves of Wang-Said type with a position parameter L not only unify the Wang-Ball curves and the Said-Ball curves, but also include several useful intermediate curves. This paper presents the dual functionals for the generalized Ball basis of Wang-Said type. The relevant basis transformation formulae are also worked out. 展开更多
关键词 双功能 基本变形 算法 Wang-Said型 伯恩斯坦原理
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Studies on the Photosynthetic Characteristics andAssimilate's Accumulation and Transformation inHeavy Panicle Type of Rice 被引量:3
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作者 MAJun ZHUQing-sen +3 位作者 MAWen-bo TIANYan-hua YangJian-chang ZHOUKai-da 《Agricultural Sciences in China》 CAS CSCD 2003年第6期602-608,共7页
Using 18 indica rice varieties with different panicle weight, the photosynthetic characteristics and assimilate's accumulation and transformation in heavy panicle type of rice(HPT)were studied. The results showed ... Using 18 indica rice varieties with different panicle weight, the photosynthetic characteristics and assimilate's accumulation and transformation in heavy panicle type of rice(HPT)were studied. The results showed that the net photosynthetic rate of the flag leaf in HPT after heading was obviously higher than that in medium panicle type(MPT)and light panicle type(LPT). The reason for the high net photosynthetic rate in HPT was the increase of Rubisco activities and chlorophyll content, and keeping high assimilate ability to CO2 under high and low light intensity, high temperature and low CO2 content, and light midday depression and wide adaptability to environmental conditions. The high net photosynthetic rate of HPT might be also the results of its excellent stomatal characteristics and higher total quantity of stomatal opening degrees(stomatal density X stomatal opening degrees). There was a large amount of dry matter production after heading and obvious high assimilate's transformation to panicle in HPT. 展开更多
关键词 RICE Heavy panicle type Photosynthetic characteristics Assimilate's accumulation Assimilate's transformation High yield breeding
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Solution of Modified Equations of Emden-Type by Differential Transform Method
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作者 Supriya Mukherjee Banamali Roy Pratik Kumar Chatterjee 《Journal of Modern Physics》 2011年第6期559-563,共5页
In this paper the Modified Equations of Emden type (MEE), χ+αχχ+βχ 3 is solved numerically by the differential transform method. This technique doesn’t require any discretization, linearization or small perturb... In this paper the Modified Equations of Emden type (MEE), χ+αχχ+βχ 3 is solved numerically by the differential transform method. This technique doesn’t require any discretization, linearization or small perturbations and therefore it reduces significantly the numerical computation. The current results of this paper are in excellent agreement with those provided by Chandrasekar et al. [1] and thereby illustrate the reliability and the performance of the differential transform method. We have also compared the results with the classical Runge-Kutta 4 (RK4) Method. 展开更多
关键词 Modified EQUATIONS of Emden type DIFFERENTIAL transforms METHOD RUNGE-KUTTA 4 (RK4) METHOD
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Relativistic effect of pseudospin symmetry and tensor coupling on the Mie-type potential via Laplace transformation method
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作者 M.Eshghi S.M.Ikhdair 《Chinese Physics B》 SCIE EI CAS CSCD 2014年第12期44-49,共6页
A relativistic Mie-type potential for spin-1/2 particles is studied. The Dirac Hamiltonian contains a scalar S(r) and a vector V(r) Mie-type potential in the radial coordinates, as well as a tensor potential U(r... A relativistic Mie-type potential for spin-1/2 particles is studied. The Dirac Hamiltonian contains a scalar S(r) and a vector V(r) Mie-type potential in the radial coordinates, as well as a tensor potential U(r) in the form of Coulomb potential. In the pseudospin(p-spin) symmetry setting Σ = Cps and Δ = V(r), an analytical solution for exact bound states of the corresponding Dirac equation is found. The eigenenergies and normalized wave functions are presented and particular cases are discussed with any arbitrary spin–orbit coupling number κ. Special attention is devoted to the caseΣ = 0 for which p-spin symmetry is exact. The Laplace transform approach(LTA) is used in our calculations. Some numerical results are obtained and compared with those of other methods. 展开更多
关键词 Dirac equation Mie-type potential Laplace transform approach tensor interaction p-spin symmetry
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Study on the Effect of Multi-Type Current Transformers Hybrid Operation on Differential Protection of the Bus Based on Dynamic Simulation
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作者 Wenbiao Liao Zexin Zhou +2 位作者 Rongrong Zhan Yanjun Li Zhengguang Chen 《Energy and Power Engineering》 2017年第4期1-11,共11页
This paper analyzes characteristics of multi type current transformers hybrid operation for each branch of the bus and their effects on differential protection of the bus. By theoretically analyzing transmission chara... This paper analyzes characteristics of multi type current transformers hybrid operation for each branch of the bus and their effects on differential protection of the bus. By theoretically analyzing transmission characteristics of multi type current transformers and their influence factors, we study the dynamic model testing method of multi type current transformers for the bus, and design 3 kinds of testing schemes by making the equivalent model based on the field of P-level current transformer, TPY-level current transformer and electronic current transformer, and build the hybrid operation testing platform of multi type current transformers. Finally, we compare and analyze the transmission characteristics difference of multi type current transformers on the same branch and the characteristics difference of hybrid operation in two successive external faults, analyze the cause behind the differences, and put forward the corresponding improvement measures. 展开更多
关键词 DIFFERENTIAL Protection of the BUS Multi-type Current transformer Hybrid Operation DYNAMIC SIMULATION TEST Method DYNAMIC SIMULATION TEST PLATFORM
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On <i>q</i>-Analogues of Laplace Type Integral Transforms of <i>q</i><sup>2</sup>-Bessel Functions
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作者 Arwa Alshibani Reem Alkhairy 《Applied Mathematics》 2019年第5期301-311,共11页
The present paper deals with the evaluation of the q-Analogues of Laplece transforms of a product of basic analogues of q2-special functions. We apply these transforms to three families of q-Bessel functions. Several ... The present paper deals with the evaluation of the q-Analogues of Laplece transforms of a product of basic analogues of q2-special functions. We apply these transforms to three families of q-Bessel functions. Several special cases have been deducted. 展开更多
关键词 q-Extensions of Bessel Functions q-Analogues of LAPLACE type Integrals transforms q-Analogues of Gamma Function q-Shift Factorials
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scTransformer:一种基于深度学习的单细胞类型识别方法
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作者 袁佳欣 刘宏德 《生物信息学》 2025年第2期96-110,共15页
细胞类型注释是单细胞RNA测序(scRNA-Seq)分析的基本任务。为了解决处理稀疏数据时出现的性能下降以及计算复杂度较高的问题,本文提出了一种基于深度学习模型Transformer的scRNA-seq数据的细胞类型识别和注释工具,scTransformer。模型... 细胞类型注释是单细胞RNA测序(scRNA-Seq)分析的基本任务。为了解决处理稀疏数据时出现的性能下降以及计算复杂度较高的问题,本文提出了一种基于深度学习模型Transformer的scRNA-seq数据的细胞类型识别和注释工具,scTransformer。模型包含四个模块,即基因嵌入、位置编码、变换编码器和分类层;基因嵌入过程将K个高变异基因(HVG)(K=2000)处理为N个子向量;以未分配率、F1分数、准确度、kappa分数、AUR指标作为评判标准,系统评估模型和其他9种工具的性能。结果表明:在数据集内,scTransformer的准确度达到96.59%,高于其他工具,未分配率达到了0.18%;可能因为样本的不均衡,其平均F1分数为93.46%,低于CHETAH,Clustifyr和SciBet;在跨平台相同组织间测试和完全不同组织间测试中(胰腺、血液),scTransformer的准确率、F1分数和kappa系数均是最好的(>0.99);在小鼠大脑、胰腺、肺组织中,scTransformer的AUR和未分配率仅次于Seurat工具和Clustifyr工具。scTransformer源代码和数据位于https://github.com/nanjingyuanbao/scTransformer。综上,本文提出并系统评估了一种新的基于Transformer的细胞类型注释工具。 展开更多
关键词 细胞类型注释 变换器模型 单细胞RNA测序
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伸展盆地中的变换走滑构造及其油气地质意义
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作者 刘晓林 景安语 +1 位作者 武云云 李伟 《海洋地质前沿》 北大核心 2026年第1期11-24,共14页
变换构造在伸展盆地内普遍发育,变换走滑构造作为其中的一种特殊类型,是为保持区域或局部应变守恒、传递伸展断层之间的位移,发育在不同伸展断层域之间的具有明显水平位移的被动走滑构造,形成于非走滑应力体制下。变换走滑构造在中国东... 变换构造在伸展盆地内普遍发育,变换走滑构造作为其中的一种特殊类型,是为保持区域或局部应变守恒、传递伸展断层之间的位移,发育在不同伸展断层域之间的具有明显水平位移的被动走滑构造,形成于非走滑应力体制下。变换走滑构造在中国东部伸展盆地中普遍发育、类型多样,依据是否形成明显的走滑断裂可划分为变换走滑断层和变换走滑带,其类型与两侧断层伸展差异大小有关,进一步依据两侧断层的倾向,每类又可划分为倾向相反型、倾向相同型和倾向复杂型3个亚类。变换走滑构造对油气成藏具有重要的控制作用,可以为伸展盆地内构造圈闭解释判识提供依据,变换走滑构造导致局部地层的弯曲变形,控制了古地貌或微古地貌的分布,进而对沉积储层的发育展布具有一定的控制作用;变换走滑构造可以作为有利的油气聚集区带,也可以对油气分布起到分隔作用。 展开更多
关键词 变换走滑构造 类型划分 控藏作用 伸展盆地
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基于GRU和Transformer的跨组织业务流程异常检测
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作者 杨凡 方娜 《计算机应用研究》 北大核心 2025年第11期3307-3315,共9页
跨组织流程作为现代业务协同的关键载体,其异常检测对保障系统稳定与业务连续性至关重要。针对现有方法多聚焦于单组织视角,难以识别组织间消息偏差、上下文对接异常及整体时序结构变化的问题,提出一种融合GRU与Transformer的跨组织异... 跨组织流程作为现代业务协同的关键载体,其异常检测对保障系统稳定与业务连续性至关重要。针对现有方法多聚焦于单组织视角,难以识别组织间消息偏差、上下文对接异常及整体时序结构变化的问题,提出一种融合GRU与Transformer的跨组织异常检测方法CoBPAD(cross-organizational business processes anomaly detection)。该方法利用GRU捕捉流程的时序依赖特征,并结合Transformer的多头注意力机制建模组织间交互模式。在训练过程中引入教师强制机制,从基于行为模式识别点异常、基于上下文规则匹配检测上下文异常和基于流程时序结构变化判断群体异常三个维度识别异常。在三个不同领域的数据集上的实验结果表明,CoBPAD在多类异常检测任务中均优于代表性方法BAnDIT,具备更强的检测能力与适应性,为后续的异常解释与实时监控提供支持方法。 展开更多
关键词 跨组织业务流程 多类异常检测 GRU transformER 注意力机制 教师强制机制
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基于Transformer和逐深度卷积的JPEG文件碎片识别
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作者 朱楠 皇智远 《数据与计算发展前沿(中英文)》 2025年第6期1-12,共12页
【目的】设计一种高准确率的JPEG文件碎片识别方法。【方法】构建基于Transformer和逐深度卷积的文件碎片识别深度网络,该网络以原始字节作为输入,首先通过嵌入层来降低数据维度并学习字节之间的关系,随后分别输入由Transformer编码器... 【目的】设计一种高准确率的JPEG文件碎片识别方法。【方法】构建基于Transformer和逐深度卷积的文件碎片识别深度网络,该网络以原始字节作为输入,首先通过嵌入层来降低数据维度并学习字节之间的关系,随后分别输入由Transformer编码器构成的全局特征提取分支网络和由Inception模块构成的局部特征提取分支网络,最终将提取到的全局特征和局部特征进行串接后输入到决策模块进行分类。【结果】在FFT-75数据集上对75类不同的文件碎片进行识别,能够取得70.7%(512字节)/83.3%(4,096字节)的整体分类准确率和91.8%(512字节)和94.2%(4,096字节)的JPEG文件碎片分类准确率。【结论】不论是在整体分类准确率上还是对JPEG文件碎片的分类准确率上,相较于对比方法均有所提升,验证了所提出的全局特征和局部特征融合的有效性。 展开更多
关键词 电子数据取证 文件碎片类型识别 JPEG文件 transformER 卷积神经网络
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配电网故障识别Transformer-联邦迁移学习算法设计
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作者 叶远波 王吉文 +1 位作者 邵庆祝 汪艳霞 《电力系统及其自动化学报》 北大核心 2025年第10期120-128,共9页
配电网故障类型识别是提高供电可靠性的重要保障之一。目前,人工智能算法在电力系统故障诊断领域具有广阔的应用前景。本文提出了一种面向配电网故障识别的Transformer-联邦迁移学习算法。通过改进Transformer编码器模块,有效捕捉输入... 配电网故障类型识别是提高供电可靠性的重要保障之一。目前,人工智能算法在电力系统故障诊断领域具有广阔的应用前景。本文提出了一种面向配电网故障识别的Transformer-联邦迁移学习算法。通过改进Transformer编码器模块,有效捕捉输入电气量所包含的全局信息,实现更加准确高效的故障辨识;其次,采用联邦学习传递客户端模型参数,解决了通信过程中数据出错、延时或者误码等问题;并利用深度迁移学习,基于一条线路的训练结果,有效识别同一配网中其他线路发生故障时的故障类型。仿真结果表明,本文算法在高阻接地故障情况下优于传统算法,并且具有很好的模型泛化能力。 展开更多
关键词 配电网 故障类型辨识 联邦学习 深度迁移学习 transformer网络
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基于转录组学和凋亡分析白藜芦醇对氧化应激诱导C2C12细胞肌纤维类型转化的影响
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作者 周雪玉 左惠心 +6 位作者 刘昀阁 宫本芝 梁荣蓉 杨啸吟 毛衍伟 张一敏 朱立贤 《肉类研究》 北大核心 2026年第2期7-15,共9页
探讨白藜芦醇对H_(2)O_(2)诱导氧化应激引起C2C12细胞肌纤维类型转化的影响。以未处理的C2C12细胞作为对照组,用H_(2)O_(2)(400μmol/L,24 h)处理C2C12细胞,构建氧化应激模型组(H_(2)O_(2)组),再用白藜芦醇(10μmol/L,24 h)和H_(2)O_(2)... 探讨白藜芦醇对H_(2)O_(2)诱导氧化应激引起C2C12细胞肌纤维类型转化的影响。以未处理的C2C12细胞作为对照组,用H_(2)O_(2)(400μmol/L,24 h)处理C2C12细胞,构建氧化应激模型组(H_(2)O_(2)组),再用白藜芦醇(10μmol/L,24 h)和H_(2)O_(2)(400μmol/L,24 h)构建白藜芦醇改善模型组(Res+H_(2)O_(2)组)。通过测定活性氧(reactive oxygen species,ROS)水平、细胞凋亡率、肌纤维类型(肌球蛋白重链(myosin heavy chain,MyHC)I、MyHC IIa、MyHC IIx和MyHC IIb)和凋亡相关因子(Caspase-9、Caspase-3、B淋巴细胞瘤-2(B-cell lymphoma-2,Bcl-2)和Bcl-2相关X蛋白质(Bcl-2-associated X protein,Bax))的mRNA和蛋白表达水平,同时利用转录组学,分析白藜芦醇对氧化应激诱导C2C12细胞肌纤维类型转化的影响。结果显示,白藜芦醇显著增加I型和IIa型肌纤维的mRNA表达(P<0.05),显著降低IIx型和IIb型肌纤维的mRNA表达(P<0.05),显著增加慢肌纤维蛋白的表达(P<0.05),显著降低快肌纤维蛋白的表达(P<0.05)。同时白藜芦醇可以显著降低ROS水平和细胞凋亡率(P<0.05),并显著降低凋亡相关蛋白Cleaved Caspase-3的相对表达量(P<0.05),显著增加Bcl-2/Bax(P<0.05)。转录组学结果表明,白藜芦醇参与了线粒体相关的凋亡抑制途径。上述结果表明,白藜芦醇可以通过线粒体介导的凋亡途径抑制氧化应激,减轻氧化应激对肌纤维类型转化的影响,增加慢肌纤维比例,减少快肌纤维比例。 展开更多
关键词 氧化应激 白藜芦醇 肌纤维类型转化 细胞凋亡 线粒体 活性氧
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