为解决文本类地铁应急处置流程存在的流程顺序关系不明确、流程执行人员模糊等问题,提出了基于BiLSTM-CRF(Bidirectional Long Short-Term Memory-Conditional Random Field)的地铁应急处置知识抽取与推理方法。首先,利用BiLSTM-CRF方...为解决文本类地铁应急处置流程存在的流程顺序关系不明确、流程执行人员模糊等问题,提出了基于BiLSTM-CRF(Bidirectional Long Short-Term Memory-Conditional Random Field)的地铁应急处置知识抽取与推理方法。首先,利用BiLSTM-CRF方法对地铁应急处置流程的文本资料进行命名实体识别,完成文本资料的知识抽取;其次,选用TransD模型对识别后实体数据进行知识推理,从而完成以实体和属性对为节点、关系对为边的知识图谱构建;最后,利用Neo4j图数据库对构建的地铁应急处置流程知识图谱进行了可视化展示和案例分析。研究结果表明,基于BiLSTM-CRF的知识抽取模型的精确率、召回率和F1值均达到了90%以上,且基于BiLSTM-CRF的TransD模型的推理结果准确率提升了22.92%,保证了知识图谱构建的准确性,可为地铁应急管理提供决策支持。展开更多
Cellular pathways are ordinarily diagnosed with pathway inhibitors,related gene regulation,or fuorescent protein markers.They are also suggested to be diagnosed with pathway activation modulation of photobiomod ulatio...Cellular pathways are ordinarily diagnosed with pathway inhibitors,related gene regulation,or fuorescent protein markers.They are also suggested to be diagnosed with pathway activation modulation of photobiomod ulation(PBM)in this paper.A PBM on a biosystem function depends on whether the biosystem is in its function-specific homeostasis(FSH).An FSH,a negative feedback response for the function to be performed perfectly,is maintained by its FSH-essential subfunctions and its FSH-non-essential subfunctions(FNSs).A function in its FSH or far from its FSH is called a normal or dysfunctional function.A direct PBM may self-adaptatively modulate a dysfunctional function until it is normal so that it can be used to discover the optimum pathways for an FSH to be established.An indirect PBM may self adaptatively modulate a dysfunctional FNS of a normal function until the FNS is normal,and the normal function is then upgraded so that it can be used to discover the redundant pathways for a normal function to be upgraded.展开更多
Being sessile,plants have evolved sophisticated mechanisms to balance between growth and defense to survive in the harsh environment.The transition from growth to defense is commonly achieved by factors,such as protei...Being sessile,plants have evolved sophisticated mechanisms to balance between growth and defense to survive in the harsh environment.The transition from growth to defense is commonly achieved by factors,such as protein kinases(PKs)and transcription factors,that initiate signal transduction and regulate specialized metabolism.Plants produce an array of lineage-specific specialized metabolites for chemical defense and stress tolerance.Some of these molecules are also used by humans as drugs.However,many of these defense-responsive metabolites are toxic to plant cells and inhibitory to growth and development.Plants have,thus,evolved complex regulatory networks to balance the accumulation of the toxic metabolites.Perception of external stimuli is a vital part of the regulatory network.Protein kinase-mediated signaling activates a series of defense responses by phosphorylating the target pro-teins and translating the stimulus into downstream cellular signaling.As biosynthesis of specialized metabolites is triggered when plants perceive stimuli,a possible connection between PKs and spe-cial ized meta bolism is well recognized.However,the roles of PKs in plant specialized metabolism have not received much attention until recently.Here,we summarize the recent advances in understanding PKs in plant specialized metabolism.We aim to highlight how the stimulatory signals are transduced,leading to the biosynthesis of corresponding metabolites.We discuss the post-translational regulation of specialized metabolism and provide insights into the mechanisms by which plants respond to the external signals.In addition,we propose possible strategies to increase the production of plant spe-cial ized metabolites in biotechnological applications using PKs.展开更多
文摘为解决文本类地铁应急处置流程存在的流程顺序关系不明确、流程执行人员模糊等问题,提出了基于BiLSTM-CRF(Bidirectional Long Short-Term Memory-Conditional Random Field)的地铁应急处置知识抽取与推理方法。首先,利用BiLSTM-CRF方法对地铁应急处置流程的文本资料进行命名实体识别,完成文本资料的知识抽取;其次,选用TransD模型对识别后实体数据进行知识推理,从而完成以实体和属性对为节点、关系对为边的知识图谱构建;最后,利用Neo4j图数据库对构建的地铁应急处置流程知识图谱进行了可视化展示和案例分析。研究结果表明,基于BiLSTM-CRF的知识抽取模型的精确率、召回率和F1值均达到了90%以上,且基于BiLSTM-CRF的TransD模型的推理结果准确率提升了22.92%,保证了知识图谱构建的准确性,可为地铁应急管理提供决策支持。
基金supported by the National Science Foundation of China(60878061)Doctoral Fund of Ministry of Education of China(20124407110013)Guang-dong Scientic Project(2012B031600004).
文摘Cellular pathways are ordinarily diagnosed with pathway inhibitors,related gene regulation,or fuorescent protein markers.They are also suggested to be diagnosed with pathway activation modulation of photobiomod ulation(PBM)in this paper.A PBM on a biosystem function depends on whether the biosystem is in its function-specific homeostasis(FSH).An FSH,a negative feedback response for the function to be performed perfectly,is maintained by its FSH-essential subfunctions and its FSH-non-essential subfunctions(FNSs).A function in its FSH or far from its FSH is called a normal or dysfunctional function.A direct PBM may self-adaptatively modulate a dysfunctional function until it is normal so that it can be used to discover the optimum pathways for an FSH to be established.An indirect PBM may self adaptatively modulate a dysfunctional FNS of a normal function until the FNS is normal,and the normal function is then upgraded so that it can be used to discover the redundant pathways for a normal function to be upgraded.
文摘Being sessile,plants have evolved sophisticated mechanisms to balance between growth and defense to survive in the harsh environment.The transition from growth to defense is commonly achieved by factors,such as protein kinases(PKs)and transcription factors,that initiate signal transduction and regulate specialized metabolism.Plants produce an array of lineage-specific specialized metabolites for chemical defense and stress tolerance.Some of these molecules are also used by humans as drugs.However,many of these defense-responsive metabolites are toxic to plant cells and inhibitory to growth and development.Plants have,thus,evolved complex regulatory networks to balance the accumulation of the toxic metabolites.Perception of external stimuli is a vital part of the regulatory network.Protein kinase-mediated signaling activates a series of defense responses by phosphorylating the target pro-teins and translating the stimulus into downstream cellular signaling.As biosynthesis of specialized metabolites is triggered when plants perceive stimuli,a possible connection between PKs and spe-cial ized meta bolism is well recognized.However,the roles of PKs in plant specialized metabolism have not received much attention until recently.Here,we summarize the recent advances in understanding PKs in plant specialized metabolism.We aim to highlight how the stimulatory signals are transduced,leading to the biosynthesis of corresponding metabolites.We discuss the post-translational regulation of specialized metabolism and provide insights into the mechanisms by which plants respond to the external signals.In addition,we propose possible strategies to increase the production of plant spe-cial ized metabolites in biotechnological applications using PKs.
