Based on the China Meteorological Administration’s Tropical Regional Atmosphere Model for the South China Sea(CMA-TRAMS),the authors conducted a collaborative assimilation forecasting experiment utilizing both Beidou...Based on the China Meteorological Administration’s Tropical Regional Atmosphere Model for the South China Sea(CMA-TRAMS),the authors conducted a collaborative assimilation forecasting experiment utilizing both Beidou radiosonde and drone-dropped(HAIYAN-I)radiosonde data in September 2023.Three assimilation experimental groups were designed as follows:Beidou radiosonde assimilation,drone-dropped radiosonde assimilation,and collaborative assimilation of Beidou and drone-dropped radiosonde data(hereinafter referred to as“Beidoudrop”).Additionally,a control group of operational forecasts without these data assimilations was set up.The results indicate that the operational forecast path in the control group deviated northward from the actual path.Besides,the Beidou-drop group showed the most significant improvement in terms of forecasting the typhoon path at 60 to 90 h lead times.Specifically,the 72 h and 90 h path errors were reduced by 66.8 and 82.4 km,respectively,resulting in a much more accurate forecast of Typhoon Haikui’s landing point,at the coastal junction of Fujian and Guangdong.Furthermore,the collaborative assimilation revealed a notable impact on improving the forecast of wind and rain associated with Haikui’s landfall,aligning more closely with the real case.A marked rise was also seen in the precipitation score of the Beidou-drop group,where the 50 mm TS(threat score)of the 72 h lead time increased from 0.33 in the control experiment to 0.75,and the 100 mm TS rose from 0.18 to 0.39.展开更多
目的研究益气活血复方对脂多糖(LPS)诱导的人脐静脉内皮细胞(HUVECs)Toll样受体4(TLR4)及其下游信号转导通路元件髓样分化因子88(MyD88)、肿瘤坏死因子受体相关因子-6(TRAF-6)、Toll样受体相关分子(TRAM)、Toll样受体相关的干扰素活化子...目的研究益气活血复方对脂多糖(LPS)诱导的人脐静脉内皮细胞(HUVECs)Toll样受体4(TLR4)及其下游信号转导通路元件髓样分化因子88(MyD88)、肿瘤坏死因子受体相关因子-6(TRAF-6)、Toll样受体相关分子(TRAM)、Toll样受体相关的干扰素活化子(TRIF)表达的影响,探讨益气活血复方含药血清防治动脉粥样硬化(AS)的机制。方法选择新西兰大耳白兔20只,随机分为4组,即正常组、中药高浓度组、中药中浓度组、中药低浓度组,每组5只。以上各组白兔分别以生理盐水和高、中、低浓度益气活血复方连续灌胃7d。末次灌胃给药2h后,心脏采血,离心后分离血清。体外培养人脐静脉内皮细胞,用LPS刺激后,分别加入高、中、低浓度益气活血复方含药血清干预24h,收集细胞,用Real ti me PCR方法测定TLR4、MyD88、TRAF-6、TRAM及TRIF mRNA的表达。结果用LPS刺激人脐静脉内皮细胞后,引起TLR4、MyD88、TRAF-6、TRAM及TRIF mRNA的高表达(与空白对照组比较,P<0.01),用益气活血复方含药血清干预以后显著抑制TLR4、MyD88及TRAF-6 mRNA的高表达(与模型组比较P<0.05或P<0.01),对TRAM及TRIF作用不明显。结论益气活血复方可阻断TLR4高表达,同时阻断TLR4胞内信号转导的MyD88依赖性途径,而对MyD88非依赖性途径作用不明显,因此益气活血复方主要是通过阻断MyD88依赖性途径来发挥其抗动脉粥样硬化的作用。展开更多
文摘Based on the China Meteorological Administration’s Tropical Regional Atmosphere Model for the South China Sea(CMA-TRAMS),the authors conducted a collaborative assimilation forecasting experiment utilizing both Beidou radiosonde and drone-dropped(HAIYAN-I)radiosonde data in September 2023.Three assimilation experimental groups were designed as follows:Beidou radiosonde assimilation,drone-dropped radiosonde assimilation,and collaborative assimilation of Beidou and drone-dropped radiosonde data(hereinafter referred to as“Beidoudrop”).Additionally,a control group of operational forecasts without these data assimilations was set up.The results indicate that the operational forecast path in the control group deviated northward from the actual path.Besides,the Beidou-drop group showed the most significant improvement in terms of forecasting the typhoon path at 60 to 90 h lead times.Specifically,the 72 h and 90 h path errors were reduced by 66.8 and 82.4 km,respectively,resulting in a much more accurate forecast of Typhoon Haikui’s landing point,at the coastal junction of Fujian and Guangdong.Furthermore,the collaborative assimilation revealed a notable impact on improving the forecast of wind and rain associated with Haikui’s landfall,aligning more closely with the real case.A marked rise was also seen in the precipitation score of the Beidou-drop group,where the 50 mm TS(threat score)of the 72 h lead time increased from 0.33 in the control experiment to 0.75,and the 100 mm TS rose from 0.18 to 0.39.
文摘目的研究益气活血复方对脂多糖(LPS)诱导的人脐静脉内皮细胞(HUVECs)Toll样受体4(TLR4)及其下游信号转导通路元件髓样分化因子88(MyD88)、肿瘤坏死因子受体相关因子-6(TRAF-6)、Toll样受体相关分子(TRAM)、Toll样受体相关的干扰素活化子(TRIF)表达的影响,探讨益气活血复方含药血清防治动脉粥样硬化(AS)的机制。方法选择新西兰大耳白兔20只,随机分为4组,即正常组、中药高浓度组、中药中浓度组、中药低浓度组,每组5只。以上各组白兔分别以生理盐水和高、中、低浓度益气活血复方连续灌胃7d。末次灌胃给药2h后,心脏采血,离心后分离血清。体外培养人脐静脉内皮细胞,用LPS刺激后,分别加入高、中、低浓度益气活血复方含药血清干预24h,收集细胞,用Real ti me PCR方法测定TLR4、MyD88、TRAF-6、TRAM及TRIF mRNA的表达。结果用LPS刺激人脐静脉内皮细胞后,引起TLR4、MyD88、TRAF-6、TRAM及TRIF mRNA的高表达(与空白对照组比较,P<0.01),用益气活血复方含药血清干预以后显著抑制TLR4、MyD88及TRAF-6 mRNA的高表达(与模型组比较P<0.05或P<0.01),对TRAM及TRIF作用不明显。结论益气活血复方可阻断TLR4高表达,同时阻断TLR4胞内信号转导的MyD88依赖性途径,而对MyD88非依赖性途径作用不明显,因此益气活血复方主要是通过阻断MyD88依赖性途径来发挥其抗动脉粥样硬化的作用。
