背景:新型生物材料不仅提供必要的机械支撑,还能促进细胞增殖和分化、诱导骨再生,从而改善治疗效果,为骨再生技术的发展提供了新的视角和方法。目的:通过文献计量学方法可视化分析生物材料在骨再生领域的研究状况及发展前景。方法:在Web...背景:新型生物材料不仅提供必要的机械支撑,还能促进细胞增殖和分化、诱导骨再生,从而改善治疗效果,为骨再生技术的发展提供了新的视角和方法。目的:通过文献计量学方法可视化分析生物材料在骨再生领域的研究状况及发展前景。方法:在Web of Science核心数据库中,精选了数据库建库至2024-09-24关于骨再生和生物材料领域最具影响力的文献500篇,运用VOSviewer和CiteSpace两款工具进行深入的计量学可视化分析,以揭示该领域的研究趋势和核心文献结果与结论:在所选的500篇文献中,中国和美国在发表论文数量和被引用率方面均占据领先地位,而常江是发文最多的作者,发表文章最多的期刊为Acta Biomaterialia。骨再生和材料学是一个跨学科的研究范畴,涵盖了材料科学、生物医学工程、细胞生物学、分子生物学等多个学科领域。骨修复材料的研究正从传统的生物惰性材料向生物活性材料转变,这些材料不仅提供机械支撑,还能促进细胞增殖和分化,诱导骨再生。合成骨修复材料因丰富的来源、可调节的物理化学特性以及较低的免疫排斥和疾病传播风险,正逐渐替代传统材料,成为临床骨移植手术的首选。研究者们正在不断改进这些材料的生物相容性、仿生特性、骨传导性和骨诱导性,使其更接近天然骨,前沿主要集中在生物活性陶瓷、3D打印、水凝胶、壳聚糖、羟基磷灰石等材料。新型材料在骨再生领域中的作用至关重要,随着材料科学技术的不断进步,这些新型材料在骨再生领域的应用前景非常广阔,有望为骨缺损治疗提供更为有效和个性化的治疗方案。展开更多
Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels,often leading to stroke and dementia.Due to its diverse etiologies and complex pathological me...Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels,often leading to stroke and dementia.Due to its diverse etiologies and complex pathological mechanisms,preventing and treating cerebral small vessel vasculopathy is challenging.Recent studies have shown that the glymphatic system plays a crucial role in interstitial solute clearance and the maintenance of brain homeostasis.Increasing evidence also suggests that dysfunction in glymphatic clearance is a key factor in the progression of cerebral small vessel disease.This review begins with a comprehensive introduction to the structure,function,and driving factors of the glymphatic system,highlighting its essential role in brain waste clearance.Afterwards,cerebral small vessel disease was reviewed from the perspective of the glymphatic system,after which the mechanisms underlying their correlation were summarized.Glymphatic dysfunction may lead to the accumulation of metabolic waste in the brain,thereby exacerbating the pathological processes associated with cerebral small vessel disease.The review also discussed the direct evidence of glymphatic dysfunction in patients and animal models exhibiting two subtypes of cerebral small vessel disease:arteriolosclerosis-related cerebral small vessel disease and amyloid-related cerebral small vessel disease.Diffusion tensor image analysis along the perivascular space is an important non-invasive tool for assessing the clearance function of the glymphatic system.However,the effectiveness of its parameters needs to be enhanced.Among various nervous system diseases,including cerebral small vessel disease,glymphatic failure may be a common final pathway toward dementia.Overall,this review summarizes prevention and treatment strategies that target glymphatic drainage and will offer valuable insight for developing novel treatments for cerebral small vessel disease.展开更多
在整体式车辆稳定性轨迹跟踪控制架构的基础之上,设计了一种引入预瞄曲率信息的自适应预测时域非线性模型预测控制(NMPC).基于预瞄的参考路径曲率点列指导控制维度变化,提升控制器对于路径曲率的动态响应能力;进一步地,引入状态协调优...在整体式车辆稳定性轨迹跟踪控制架构的基础之上,设计了一种引入预瞄曲率信息的自适应预测时域非线性模型预测控制(NMPC).基于预瞄的参考路径曲率点列指导控制维度变化,提升控制器对于路径曲率的动态响应能力;进一步地,引入状态协调优化机制,使控制器显示耦合至上一控制周期的车辆状态空间,有效避免预测时域变化造成的多步优化问题解耦效应,抑制因控制输入突变对轨迹跟踪控制任务的影响.结合两种优化方法,有效改善固定预测时域策略在高曲率轨迹跟踪中因累计误差造成的跟踪精度下降问题.最后,基于MATLAB/Simulink-CarSim联合仿真平台对算法进行了验证.经计算,高速单移线工况下,该方法在侧向偏差均值/峰值、纵向偏差均值/峰值、航向偏差均值/峰值指标中,相较于固定预测时域NMPC同比降低36.17%/15.25%、11.55%/38.58%、6.13%/25.27%;高速双移线工况下,同比降低30.28%/29.77%、25.07%/3.85%、11.02%/2.68%.此外,在高速低附着工况中,该方法仍能保证良好的控制精度及侧向稳定性,其峰值侧向偏差为0.2017 m、峰值纵向偏差为0.9744 km h^(-1)、峰值航向偏差为1.1936°、峰值质心侧偏角为1.9074°.展开更多
The excessive buildup of neurotoxicα-synuclein plays a pivotal role in the pathogenesis of Parkinson's disease,highlighting the urgent need for innovative therapeutic strategies to promoteα-synuclein clearance,p...The excessive buildup of neurotoxicα-synuclein plays a pivotal role in the pathogenesis of Parkinson's disease,highlighting the urgent need for innovative therapeutic strategies to promoteα-synuclein clearance,particularly given the current lack of disease-modifying treatments.The glymphatic system,a recently identified perivascular fluid transport network,is crucial for clearing neurotoxic proteins.This review aims to synthesize current knowledge on the role of the glymphatic system inα-synuclein clearance and its implications for the pathology of Parkinson's disease while emphasizing potential therapeutic strategies and areas for future research.The review begins with an overview of the glymphatic system and details its anatomical structure and physiological functions that facilitate cerebrospinal fluid circulation and waste clearance.It summarizes emerging evidence from neuroimaging and experimental studies that highlight the close correlation between the glymphatic system and clinical symptom severity in patients with Parkinson's disease,as well as the effect of glymphatic dysfunction onα-synuclein accumulation in Parkinson's disease models.Subsequently,the review summarizes the mechanisms of glymphatic system impairment in Parkinson's disease,including sleep disturbances,aquaporin-4 impairment,and mitochondrial dysfunction,all of which diminish glymphatic system efficiency.This creates a vicious cycle that exacerbatesα-synuclein accumulation and worsens Parkinson's disease.The therapeutic perspectives section outlines strategies for enhancing glymphatic activity,such as improving sleep quality and pharmacologically targeting aquaporin-4 or its subcellular localization.Promising interventions include deep brain stimulation,melatonin supplementation,γ-aminobutyric acid modulation,and non-invasive methods(such as exercise and bright-light therapy),multisensoryγstimulation,and ultrasound therapy.Moreover,identifying neuroimaging biomarkers to assess glymphatic flow as an indicator ofα-synuclein burden could refine Parkinson's disease diagnosis and track disease progression.In conclusion,the review highlights the critical role of the glymphatic system inα-synuclein clearance and its potential as a therapeutic target in Parkinson's disease.It advocates for further research to elucidate the specific mechanisms by which the glymphatic system clears misfoldedα-synuclein and the development of imaging biomarkers to monitor glymphatic activity in patients with Parkinson's disease.Findings from this review suggest that enhancing glymphatic clearance is a promising strategy for reducingα-synuclein deposits and mitigating the progression of Parkinson's disease.展开更多
文摘背景:新型生物材料不仅提供必要的机械支撑,还能促进细胞增殖和分化、诱导骨再生,从而改善治疗效果,为骨再生技术的发展提供了新的视角和方法。目的:通过文献计量学方法可视化分析生物材料在骨再生领域的研究状况及发展前景。方法:在Web of Science核心数据库中,精选了数据库建库至2024-09-24关于骨再生和生物材料领域最具影响力的文献500篇,运用VOSviewer和CiteSpace两款工具进行深入的计量学可视化分析,以揭示该领域的研究趋势和核心文献结果与结论:在所选的500篇文献中,中国和美国在发表论文数量和被引用率方面均占据领先地位,而常江是发文最多的作者,发表文章最多的期刊为Acta Biomaterialia。骨再生和材料学是一个跨学科的研究范畴,涵盖了材料科学、生物医学工程、细胞生物学、分子生物学等多个学科领域。骨修复材料的研究正从传统的生物惰性材料向生物活性材料转变,这些材料不仅提供机械支撑,还能促进细胞增殖和分化,诱导骨再生。合成骨修复材料因丰富的来源、可调节的物理化学特性以及较低的免疫排斥和疾病传播风险,正逐渐替代传统材料,成为临床骨移植手术的首选。研究者们正在不断改进这些材料的生物相容性、仿生特性、骨传导性和骨诱导性,使其更接近天然骨,前沿主要集中在生物活性陶瓷、3D打印、水凝胶、壳聚糖、羟基磷灰石等材料。新型材料在骨再生领域中的作用至关重要,随着材料科学技术的不断进步,这些新型材料在骨再生领域的应用前景非常广阔,有望为骨缺损治疗提供更为有效和个性化的治疗方案。
基金supported by the National Natural Science Foundation of China,No.82274304(to YH)the Major Clinical Study Projects of Shanghai Shenkang Hospital Development Center,No.SHDC2020CR2046B(to YH)Shanghai Municipal Health Commission Talent Plan,No.2022LJ010(to YH).
文摘Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels,often leading to stroke and dementia.Due to its diverse etiologies and complex pathological mechanisms,preventing and treating cerebral small vessel vasculopathy is challenging.Recent studies have shown that the glymphatic system plays a crucial role in interstitial solute clearance and the maintenance of brain homeostasis.Increasing evidence also suggests that dysfunction in glymphatic clearance is a key factor in the progression of cerebral small vessel disease.This review begins with a comprehensive introduction to the structure,function,and driving factors of the glymphatic system,highlighting its essential role in brain waste clearance.Afterwards,cerebral small vessel disease was reviewed from the perspective of the glymphatic system,after which the mechanisms underlying their correlation were summarized.Glymphatic dysfunction may lead to the accumulation of metabolic waste in the brain,thereby exacerbating the pathological processes associated with cerebral small vessel disease.The review also discussed the direct evidence of glymphatic dysfunction in patients and animal models exhibiting two subtypes of cerebral small vessel disease:arteriolosclerosis-related cerebral small vessel disease and amyloid-related cerebral small vessel disease.Diffusion tensor image analysis along the perivascular space is an important non-invasive tool for assessing the clearance function of the glymphatic system.However,the effectiveness of its parameters needs to be enhanced.Among various nervous system diseases,including cerebral small vessel disease,glymphatic failure may be a common final pathway toward dementia.Overall,this review summarizes prevention and treatment strategies that target glymphatic drainage and will offer valuable insight for developing novel treatments for cerebral small vessel disease.
文摘在整体式车辆稳定性轨迹跟踪控制架构的基础之上,设计了一种引入预瞄曲率信息的自适应预测时域非线性模型预测控制(NMPC).基于预瞄的参考路径曲率点列指导控制维度变化,提升控制器对于路径曲率的动态响应能力;进一步地,引入状态协调优化机制,使控制器显示耦合至上一控制周期的车辆状态空间,有效避免预测时域变化造成的多步优化问题解耦效应,抑制因控制输入突变对轨迹跟踪控制任务的影响.结合两种优化方法,有效改善固定预测时域策略在高曲率轨迹跟踪中因累计误差造成的跟踪精度下降问题.最后,基于MATLAB/Simulink-CarSim联合仿真平台对算法进行了验证.经计算,高速单移线工况下,该方法在侧向偏差均值/峰值、纵向偏差均值/峰值、航向偏差均值/峰值指标中,相较于固定预测时域NMPC同比降低36.17%/15.25%、11.55%/38.58%、6.13%/25.27%;高速双移线工况下,同比降低30.28%/29.77%、25.07%/3.85%、11.02%/2.68%.此外,在高速低附着工况中,该方法仍能保证良好的控制精度及侧向稳定性,其峰值侧向偏差为0.2017 m、峰值纵向偏差为0.9744 km h^(-1)、峰值航向偏差为1.1936°、峰值质心侧偏角为1.9074°.
基金supported by the National Natural Science Foundation of China,No.81971031(to ZL)the National Key Research and Development Program of China,No.2022YFE0210100(to JFC)+7 种基金the National Natural Science Foundation of China(Original Exploration Project),No.82151308(to JFC)the National Natural Science Foundation of China(Research Fund for International Senior Scientists),No.82150710558(to JFC)Science&Technology Initiative STI2030-Major Projects,No.2021ZD0203400(to JFC)Key Research and Development Program of Zhejiang Province,No.2023C03079(to JFC)Scientific Research Starting Foundation of Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine,Vision and Brain Health),No.OJQDSP2022007(to JFC)Project of State Key Laboratory of Ophthalmology,Optometry and Visual Science,Wenzhou Medical University,No.J01-20190101(to JFC)Scientific Research Starting Foundation of Wenzhou Medical University,No.QTJ12003(to JFC)Department of Science and Technology of Zhejiang Province,No.2023ZY1011(to JFC)。
文摘The excessive buildup of neurotoxicα-synuclein plays a pivotal role in the pathogenesis of Parkinson's disease,highlighting the urgent need for innovative therapeutic strategies to promoteα-synuclein clearance,particularly given the current lack of disease-modifying treatments.The glymphatic system,a recently identified perivascular fluid transport network,is crucial for clearing neurotoxic proteins.This review aims to synthesize current knowledge on the role of the glymphatic system inα-synuclein clearance and its implications for the pathology of Parkinson's disease while emphasizing potential therapeutic strategies and areas for future research.The review begins with an overview of the glymphatic system and details its anatomical structure and physiological functions that facilitate cerebrospinal fluid circulation and waste clearance.It summarizes emerging evidence from neuroimaging and experimental studies that highlight the close correlation between the glymphatic system and clinical symptom severity in patients with Parkinson's disease,as well as the effect of glymphatic dysfunction onα-synuclein accumulation in Parkinson's disease models.Subsequently,the review summarizes the mechanisms of glymphatic system impairment in Parkinson's disease,including sleep disturbances,aquaporin-4 impairment,and mitochondrial dysfunction,all of which diminish glymphatic system efficiency.This creates a vicious cycle that exacerbatesα-synuclein accumulation and worsens Parkinson's disease.The therapeutic perspectives section outlines strategies for enhancing glymphatic activity,such as improving sleep quality and pharmacologically targeting aquaporin-4 or its subcellular localization.Promising interventions include deep brain stimulation,melatonin supplementation,γ-aminobutyric acid modulation,and non-invasive methods(such as exercise and bright-light therapy),multisensoryγstimulation,and ultrasound therapy.Moreover,identifying neuroimaging biomarkers to assess glymphatic flow as an indicator ofα-synuclein burden could refine Parkinson's disease diagnosis and track disease progression.In conclusion,the review highlights the critical role of the glymphatic system inα-synuclein clearance and its potential as a therapeutic target in Parkinson's disease.It advocates for further research to elucidate the specific mechanisms by which the glymphatic system clears misfoldedα-synuclein and the development of imaging biomarkers to monitor glymphatic activity in patients with Parkinson's disease.Findings from this review suggest that enhancing glymphatic clearance is a promising strategy for reducingα-synuclein deposits and mitigating the progression of Parkinson's disease.
