Introduction:On August 6,2025,the Yiwu CDC received notification of a suspected mpox case.Subsequent laboratory testing confirmed mpox virus(MPXV,Clade Ib)infection,prompting the initiation of a comprehensive multi-le...Introduction:On August 6,2025,the Yiwu CDC received notification of a suspected mpox case.Subsequent laboratory testing confirmed mpox virus(MPXV,Clade Ib)infection,prompting the initiation of a comprehensive multi-level epidemiologic investigation.Methods:Between August 6–10,2025,provincial,municipal,and county expert teams conducted systematic case finding,interview-based exposure mapping,and linkage analysis of public security and border records to reconstruct contact trajectories.The investigation included comprehensive contact tracing,environmental sampling,and real-time PCR testing of lesion and oropharyngeal specimens for MPXV detection.Results:Six laboratory-confirmed cases were identified with symptom onset dates spanning July 23 through August 6.Five patients received treatment in Yiwu,while one was managed in Changzhou.The cases were predominantly male(5/6),with ages ranging from 22–43 years(median 30 years).Four of the six cases were foreign nationals.Investigators identified and monitored 52 core close contacts and 38 general contacts under 21-day health surveillance protocols.Environmental sampling(n=43)conducted at five case residences and personal items yielded 27 positive results(62.8%)for MPXV.Conclusions:This outbreak represents an imported mpox cluster with subsequent person-to-person transmission occurring primarily through intimate contact.We documented substantial household environmental contamination,emphasizing the critical importance of comprehensive decontamination measures.Rapid case detection,systematic contact management,and terminal disinfection protocols effectively contained further viral spread.展开更多
文摘Introduction:On August 6,2025,the Yiwu CDC received notification of a suspected mpox case.Subsequent laboratory testing confirmed mpox virus(MPXV,Clade Ib)infection,prompting the initiation of a comprehensive multi-level epidemiologic investigation.Methods:Between August 6–10,2025,provincial,municipal,and county expert teams conducted systematic case finding,interview-based exposure mapping,and linkage analysis of public security and border records to reconstruct contact trajectories.The investigation included comprehensive contact tracing,environmental sampling,and real-time PCR testing of lesion and oropharyngeal specimens for MPXV detection.Results:Six laboratory-confirmed cases were identified with symptom onset dates spanning July 23 through August 6.Five patients received treatment in Yiwu,while one was managed in Changzhou.The cases were predominantly male(5/6),with ages ranging from 22–43 years(median 30 years).Four of the six cases were foreign nationals.Investigators identified and monitored 52 core close contacts and 38 general contacts under 21-day health surveillance protocols.Environmental sampling(n=43)conducted at five case residences and personal items yielded 27 positive results(62.8%)for MPXV.Conclusions:This outbreak represents an imported mpox cluster with subsequent person-to-person transmission occurring primarily through intimate contact.We documented substantial household environmental contamination,emphasizing the critical importance of comprehensive decontamination measures.Rapid case detection,systematic contact management,and terminal disinfection protocols effectively contained further viral spread.
