Sentiment analysis,a cornerstone of natural language processing,has witnessed remarkable advancements driven by deep learning models which demonstrated impressive accuracy in discerning sentiment from text across vari...Sentiment analysis,a cornerstone of natural language processing,has witnessed remarkable advancements driven by deep learning models which demonstrated impressive accuracy in discerning sentiment from text across various domains.However,the deployment of such models in resource-constrained environments presents a unique set of challenges that require innovative solutions.Resource-constrained environments encompass scenarios where computing resources,memory,and energy availability are restricted.To empower sentiment analysis in resource-constrained environments,we address the crucial need by leveraging lightweight pre-trained models.These models,derived from popular architectures such as DistilBERT,MobileBERT,ALBERT,TinyBERT,ELECTRA,and SqueezeBERT,offer a promising solution to the resource limitations imposed by these environments.By distilling the knowledge from larger models into smaller ones and employing various optimization techniques,these lightweight models aim to strike a balance between performance and resource efficiency.This paper endeavors to explore the performance of multiple lightweight pre-trained models in sentiment analysis tasks specific to such environments and provide insights into their viability for practical deployment.展开更多
Trained immunity is a phenomenon in which brief exposure to an infectious agent or a vaccine can induce long-lasting changes in the host’s immune system,enhancing protection against subsequent infections.The concept ...Trained immunity is a phenomenon in which brief exposure to an infectious agent or a vaccine can induce long-lasting changes in the host’s immune system,enhancing protection against subsequent infections.The concept of trained immunity has a significant impact on the field of immunology and has the potential to revolutionize how we approach vaccination and infectious disease control.Investigations into trained immunity are rapidly advanc-ing and have led to the development of new vaccines and immunotherapeutic strategies that harness the power of this phenomenon.While more investigations are needed to fully understand the mechanisms of trained immunity and its potential limitations,the prospects for its future application in clinical practice are promising.Here,we describe trained immunity as a biological process and explore the innate cues,epigenetic changes,and metabolic reprogram-ming activities that affect how trained immunity is induced.展开更多
Objective:Trained immunity of natural killer(NK)cells has shown great potential in the treatment of cancers by eliciting enhanced effector responses to restimulation by cytokines or cancer cells for long time periods ...Objective:Trained immunity of natural killer(NK)cells has shown great potential in the treatment of cancers by eliciting enhanced effector responses to restimulation by cytokines or cancer cells for long time periods after preactivation.However,the human NK cells responsible for the generation and maintenance of trained immunity are largely unknown.We hypothesized that heterogeneous human NK cells would respond differentially to stimulation with a combination of IL-12,IL-15,and IL-18,and that an NK cell subset might exist that is mainly responsible for the induction of trained immunity.On the basis of our hypothesis,we aimed to identify the subset from which cytokine-trained human NK cells originate and to explore possible regulatory targets for drug intervention.Methods:Flow cytometry assays were performed to analyze the functions of cytokine-trained NK cells and examine cell division and protein expression in NK cell subsets.Single-cell RNA sequencing(scRNA-seq)plus TotalSeq™technology was used to track the heterogeneity of NK cells during the induction of trained immunity.Results:Traditional developmental markers for peripheral NK cells were unable to identify the precursors of human NK cells with trained immunity.Therefore,we used scRNA-seq plus TotalSeq™technology to track the heterogeneity of NK cells during the induction of trained immunity and identified a unique cluster of CD57−NKG2A+EZH2+IFNG+MKI67+IL12R+IL15R+IL18R+NK cells.Enrichment and pseudotime trajectory analyses suggested that this cluster of NK cells contained the precursor of trained NK cells.We then used flow cytometry to further investigate the role of EZH2 in trained NK precursors and found that CD57−NKG2A+EZH2+NK cells had faster cell cycles and an enhanced trained phenotype,and EZH2 inhibition significantly impaired the induction of trained immunity in NK cells.These results suggested that EZH2 is a unique epigenetic marker of precursors of human NK cells with trained immunity.Conclusions:Our work revealed human NK heterogeneity in the induction of trained immunity,identified the precursor subset for trained NK cells,and demonstrated the critical role of EZH2 in the induction of trained immunity in human NK cells.展开更多
Objective:To investigate the effect of using audible thinking combined with the case teaching method in the teaching of nursing checkups for regulation nurses.Methods:The period was April 2023–April 2024,and a random...Objective:To investigate the effect of using audible thinking combined with the case teaching method in the teaching of nursing checkups for regulation nurses.Methods:The period was April 2023–April 2024,and a randomized controlled group study was carried out in which 76 regulation nurses in our hospital were randomly divided into a research group and a control group,with 38 regulation nurses in each group.The control group used conventional teaching methods,and the research group used audible thinking combined with the case teaching method,comparing the two groups’independent learning ability scores,assessment scores,and teaching satisfaction.Results:Independent learning ability score:after teaching,the research group was significantly higher than the control group(P<0.05);Assessment results:the research group was considerably higher than the control group(P<0.05);Teaching satisfaction:the research group was significantly higher than the control group(P<0.05).Conclusion:The use of audible thinking combined with the case teaching method in the teaching of nursing room visits for trained nurses can improve independent learning ability and assessment results and increase teaching satisfaction.展开更多
The crossed micro-bands in the martensite variant pairs of a thermomechanically trained Cu25.66Zn-4.02Al (wt-%) alloy have been studied. It was found that the micro-bands pass through the interface from one martensite...The crossed micro-bands in the martensite variant pairs of a thermomechanically trained Cu25.66Zn-4.02Al (wt-%) alloy have been studied. It was found that the micro-bands pass through the interface from one martensite variant to another and their orientation inside different variants is distinct, which would remain in the parent phase after the reverse transformation and play an important role in the formation of preferential martensite. In fact, the crossed micro-bands are micro-twins for accommodating the stress fields generated during thermomechanically training展开更多
The purpose of the present study was to examine the effect of circuit training (CT) on resting heart rate variability (HRV) and other cardiovascular disease (CVD) risk factors such as blood lipids and blood glucose an...The purpose of the present study was to examine the effect of circuit training (CT) on resting heart rate variability (HRV) and other cardiovascular disease (CVD) risk factors such as blood lipids and blood glucose and on fitness components. Twenty-four healthy untrained adults (age 26.5 ± 5.1 years;height 1.67 ± 8.4 m;weight 66.8 ± 15.1 kg;26.3% ± 5.2%;maximum oxygen uptake (VO<sub>2max</sub>) 48.5 ± 10.0 ml.kg<sup>-1</sup>.min<sup>-1</sup>) were assigned to either CT (n = 12) involving bodyweight exercises, or control (CON, n = 12) groups. Prior to the start and following the end of the six-week training period, time-, frequency-domain and nonlinear measures of resting HRV, arterial blood pressure, body composition, fasting blood lipids, lipoproteins and glucose, VO<sub>2max</sub>, upper body muscular endurance (UBME) and abdominal and hip flexor (AHFME), back strength (BS) and handgrip were assessed. None of the resting HRV measures (P > 0.05) were affected by the CT intervention. However, diastolic blood pressure decreased (P = 0.03), lean body weight (P = 0.03) increased, VO<sub>2max</sub> (P = 0.03), UBME (P = 0.001), AHFME (P = 0.04), and BS (P = 0.03) were significantly higher following CT, whereas the other variables were not influenced by the CT. Six-week of CT involving bodyweight exercises has no significant impact on resting HRV. However, this type of training might decrease the risk for development of CVD by reducing arterial blood pressure and by improving body composition, aerobic capacity, muscular endurance and strength.展开更多
Both fuzzy temporal constraint and flexible resource constraint are considered in project scheduling. In order to obtain an optimal schedule, we propose a genetic algorithm integrated with concepts on fuzzy set theory...Both fuzzy temporal constraint and flexible resource constraint are considered in project scheduling. In order to obtain an optimal schedule, we propose a genetic algorithm integrated with concepts on fuzzy set theory as well as specialized coding and decoding mechanism. An example demonstrates that the proposed approach can assist the project managers to obtain the optimal schedule effectively and make the correct decision on skill training before a project begins.展开更多
Microorganisms have been essential in the natural world for millions of years,contributing significantly to environmental interaction.It has been disoverd that some bacteria are potential in geotechnical and environme...Microorganisms have been essential in the natural world for millions of years,contributing significantly to environmental interaction.It has been disoverd that some bacteria are potential in geotechnical and environmental engineering due to their outstanding ability of biomineralization.Therefore,how to train bacteria as special and professional“workers”for biomineralization is increasingly a key topic in related research fields.This article briefly introduces the methods that are commonly utilized to improve the environmental adaptability and mineralization efficiency of bacteria,including microbial domestication,microbial mutation breeding,microbial targeted screening,and bio-stimulation,which make great implications to advance the field of biomineralization.展开更多
Distance effect has been regarded as the best established marker of basic numerical magnitude processes and is related to individual mathematical abilities. A larger behavioral distance effect is suggested to be conco...Distance effect has been regarded as the best established marker of basic numerical magnitude processes and is related to individual mathematical abilities. A larger behavioral distance effect is suggested to be concomitant with lower mathematical achievement in children. However, the relationship between distance effect and superior mathematical abilities is unclear. One could get superior mathematical abilities by acquiring the skill of abacus-based mental calculation （AMC）, which can be used to solve calculation problems with exceptional speed and high accuracy. In the current study, we explore the relationship between distance effect and superior mathematical abilities by examining whether and how the AMC training modifies numerical magnitude processing. Thus, mathematical competencies were tested in 18 abacus-trained children （who accepted the AMC training） and 18 non-trained children. Electroencephalography （EEG） waveforms were recorded when these children executed numerical comparison tasks in both Arabic digit and dot array forms. We found that： （a） the abacus-trained group had superior mathematical abilities than their peers; （b） distance effects were found both in behavioral results and on EEG wave- forms; （c） the distance effect size of the average amplitude on the late negative-going component was different between groups in the digit task, with a larger effect size for abacus-trained children; （d） both the behavioral and EEG distance effects were modulated by the notation. These results revealed that the neural substrates of magnitude processing were modified by AMC training, and suggested that the mechanism of the representation of numerical magnitude for children with superior mathematical abilities was different from their peers. In addition, the results provide evidence for a view of non-abstract numerical representation.展开更多
Four “cuajada” type fresh cheeses were evaluated by two trained panels in different regions from Oaxaca in Mexico (Instituto Tecnológico de Comitancillo (ITC) and Universidad del Mar (UMAR)). Each panel was int...Four “cuajada” type fresh cheeses were evaluated by two trained panels in different regions from Oaxaca in Mexico (Instituto Tecnológico de Comitancillo (ITC) and Universidad del Mar (UMAR)). Each panel was integrated by six judges. Analysis of variance (ANOVA) in conjunction with principal component analysis (PCA) and the Rv coefficient were used to identify similarities and consensus among trained judges and panels. The ANOVA results revealed that the judges from ITC performed significantly better (P < 0.05) in discrimination and repetitivity, while both panels showed a similar effect in discrimination. The PCA determined some similarities in the position of cheeses in the sensory space, while Rv revealed that judges and panels were consensual. In conclusion, statistical resources determined that both panels were discriminating and that similarities in the positioning of cheeses in the sensory space were found.展开更多
The roll motions of ships advancing in heavy seas have severe impacts on the safety of crews,vessels,and cargoes;thus,it must be damped.This study presents the design of a rudder roll damping autopilot by utilizing th...The roll motions of ships advancing in heavy seas have severe impacts on the safety of crews,vessels,and cargoes;thus,it must be damped.This study presents the design of a rudder roll damping autopilot by utilizing the dual extended Kalman filter(DEKF)trained radial basis function neural networks(RBFNN)for the surface vessels.The autopilot system constitutes the roll reduction controller and the yaw motion controller implemented in parallel.After analyzing the advantages of the DEKF-trained RBFNN control method theoretically,the ship’s nonlinear model with environmental disturbances was employed to verify the performance of the proposed stabilization system.Different sailing scenarios were conducted to investigate the motion responses of the ship in waves.The results demonstrate that the DEKF RBFNN based control system is efficient and practical in reducing roll motions and following the path for the ship sailing in waves only through rudder actions.展开更多
<span style="font-family:Verdana;"><strong>Objective:</strong></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span sty...<span style="font-family:Verdana;"><strong>Objective:</strong></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> To investigate whether a physical therapist trained through the Mechanical Diagnosis and Therapy (MDT) diploma program could guess psychological Patient Reported Outcome Measure (PROM) scores of individuals with low back pain (LBP) by taking patient history and completing a physical evaluation.</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Methods: </span></b></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">Ten participants with LBP completed PROMs immediately before history taking and again after a physical evaluation. PROMs included the Pain Catastrophizing Scale (PCS), Tampa Scale for Kinesiophobia (TSK), Hospital Anxiety and Depression Scale, and Pain Coping Strategy Questionnaire. A physical therapist who completed the MDT diploma program took the patients’ history and completed their physical evaluation. The therapist completed the same PROMs immediately after both history taking and physical evaluation. Correlations between patient and therapist scores were calculated using Spearman’s </span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;">. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> Statistically significant positive correlations were detected in </span></span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">the PCS (</span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;"> = 0.65) and TSK (</span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;"> = 0.78) before history taking, and in the PCS (</span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;"> = 0.81) and TSK (</span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;"> = 0.74) after physical evaluation.</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Discussion: </span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">The results are based on one MDT therapist and generalizability of the findings is limited. However, the current preliminary findings justify the need for further studies to explore effective post-graduate training to promote a patient centered approach.</span></span></span>展开更多
Objectives Assessing physical activity and cardiometabolic risk in masters athletes as an example of very high physical activity at old age.Methods Forty-three men were studied in full factorial design,either as sprin...Objectives Assessing physical activity and cardiometabolic risk in masters athletes as an example of very high physical activity at old age.Methods Forty-three men were studied in full factorial design,either as sprint or jump-trained masters athletes(MA,n=10,age 60–75 years),as young sprint or jump-trained athletes(YA,n=10,age 20–35 years),older control participants(OC,n=11,age 60–75 years)or as young control participants(AC,n=12,age 20–35 years).We performed bio-electrical impedance analysis and assessed serum markers of lipids and glucose metabolism and C-reactive protein,structured training hours,and habitual activity via mobile actimetry.Results Body fat was greater in OC than in MA(23.9[SD 4.2]%vs.14.0[SD 5.7]%,p<0.001),and also greater than in YA and YC(both p<0.001).Weekly training hours were comparable between MA and YA(7.9[SD3.3]hours vs.11.1[SD 4.8]hours,p=0.69).Habitual walking distance was greater in MA than in OC(7,387[SD 4,923]m/day vs.4,110[SD 1,772]m/day,p=0.039),and so was habitual running distance(667[SD690]m/day vs.132[427]m/day,p<0.001).HOMA-index was greater in OC than in MA(2.07[SD 1.39]vs.0.80[SD 0.41],p=0.0039),and so was C-reactive protein(1.35[SD 1.74]mg/l vs.0.58[SD 0.27]mg/ml,p=0.018),whereas serum lipids showed only moderate or no effect(all p between 0.036 and 0.07).Conclusions Improved body composition and physical activity levels in MA are associated with lower cardiometabolic risk,which seems more pronounced for insulin sensitivity and inflammaging than for lipid metabolism.展开更多
Modulating trained immunity while simultaneously initiating regenerative cues presents a significant challenge in large bone defect therapy.This study introduces a cell-free approach utilizing a 3D microenvironment-re...Modulating trained immunity while simultaneously initiating regenerative cues presents a significant challenge in large bone defect therapy.This study introduces a cell-free approach utilizing a 3D microenvironment-responsive scaffold to orchestrate immune reprogramming.To mitigate maladaptive trained immunity and activate regenerative signaling,a composite fibrous scaffold is functionalized with immune-engineered exosomes derived from inflammation-primed mesenchymal stem cells(PSS-iEXO)in a reactive oxygen species(ROS)-responsive manner.The PSS-iEXO scaffolds incorporate boronic ester linkages as ROS-sensitive moieties,enabling rapid,dynamic,and“on-demand”exosome release in response to elevated ROS levels characteristic of the early inflammatory phase post-injury,thereby initiating regeneration.In vitro and in vivo analyses reveal that these scaffolds precisely target and modulate maladaptive trained immunity,reprogramming immune responses by shifting macrophage polarization from a hyperactivated type I phenotype to a balanced state while promoting CD4+regulatory T cell activation—both critical for coupling angiogenesis and osteogenesis.Mechanistic insights highlight the role of engineered exosomes in enhancing mitochondrial function and oxidative phosphorylation in macrophages,establishing a cell-free immune-regenerative niche for large bone defect therapy.展开更多
Correction:Advanced Fiber Materials(2025)7:1423-1445.https://doi.org/10.1007/s42765-025-00548-3.Fig.4b and Fig.9k were identified with improper use of images and thus require a correction.Original Fig.4.
After spinal cord injury,impairment of the sensorimotor circuit can lead to dysfunction in the motor,sensory,proprioceptive,and autonomic nervous systems.Functional recovery is often hindered by constraints on the tim...After spinal cord injury,impairment of the sensorimotor circuit can lead to dysfunction in the motor,sensory,proprioceptive,and autonomic nervous systems.Functional recovery is often hindered by constraints on the timing of interventions,combined with the limitations of current methods.To address these challenges,various techniques have been developed to aid in the repair and reconstruction of neural circuits at different stages of injury.Notably,neuromodulation has garnered considerable attention for its potential to enhance nerve regeneration,provide neuroprotection,restore neurons,and regulate the neural reorganization of circuits within the cerebral cortex and corticospinal tract.To improve the effectiveness of these interventions,the implementation of multitarget early interventional neuromodulation strategies,such as electrical and magnetic stimulation,is recommended to enhance functional recovery across different phases of nerve injury.This review concisely outlines the challenges encountered following spinal cord injury,synthesizes existing neurostimulation techniques while emphasizing neuroprotection,repair,and regeneration of impaired connections,and advocates for multi-targeted,task-oriented,and timely interventions.展开更多
BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking rec...BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking recovery.OBJECTIVE:To determine whether early suspension-protected training with a personal assistant machine for stroke patients enhances walking ability and prevents muscle spasms.METHODS:Thirty-two early-stage stroke patients from Shenzhen University General Hospital and the China Rehabilitation Research Center were randomly assigned to the experimental group(n=16)and the control group(n=16).Both groups underwent 4 weeks of gait training under the suspension protection system for 30 minutes daily,5 days a week.The experimental group used the personal assistant machine during training.Three-dimensional gait analysis(using the Cortex motion capture system),Brunnstrom staging,Fugl-Meyer Assessment for lower limb motor function,Fugl-Meyer balance function,and the modified Ashworth Scale were evaluated within 1 week before the intervention and after 4 weeks of intervention.RESULTS AND CONCLUSION:After the 4-week intervention,all outcome measures showed significant changes in each group.The experimental group had a small but significant increase in the modified Ashworth Scale score(P<0.05,d=|0.15|),while the control group had a large significant increase(P<0.05,d=|1.48|).The experimental group demonstrated greater improvements in walking speed(16.5 to 38.44 cm/s,P<0.05,d=|4.01|),step frequency(46.44 to 64.94 steps/min,P<0.05,d=|2.32|),stride length(15.50 to 29.81 cm,P<0.05,d=|3.44|),and peak hip and knee flexion(d=|1.82|to|2.17|).After treatment,the experimental group showed significantly greater improvements than the control group in walking speed(38.44 vs.26.63 cm/s,P<0.05,d=|2.75|),stride length,peak hip and knee flexion(d=|1.31|to|1.45|),step frequency(64.94 vs.59.38 steps/min,P<0.05,d=|0.85|),and a reduced support phase(bilateral:24.31%vs.28.38%,P<0.05,d=|0.88|;non-paretic:66.19%vs.70.13%,P<0.05,d=|0.94|).For early hemiplegia,personal assistant machine-assisted gait training under the suspension protection system helps establish a correct gait pattern,prevents muscle spasms,and improves motor function.展开更多
Virus-induced asthma is prevalent among children,but its underlying mechanisms are unclear.Accumulated evidence indicates that early-life respiratory virus infection increases susceptibility to allergic asthma.Nonethe...Virus-induced asthma is prevalent among children,but its underlying mechanisms are unclear.Accumulated evidence indicates that early-life respiratory virus infection increases susceptibility to allergic asthma.Nonetheless,the relationship between systemic virus infections,such as enterovirus infection,and the ensuing effects on allergic asthma development is unknown.Early-life enterovirus infection was correlated with higher risks of allergic diseases in children.Adult mice exhibited exacerbated mite allergen-induced airway inflammation following recovery from EV-A71 infection in the neonatal period.Bone marrow-derived macrophages(BMDMs)from recovered EV-A71-infected mice showed sustained innate immune memory(trained immunity)that could drive naïve T helper cells toward Th2 and Th17 cell differentiation when in contact with mites.Adoptive transfer of EV-A71-trained BMDMs induced augmented allergic inflammation in naïve recipient mice,which was inhibited by 2-deoxy-D-glucose(2-DG)pretreatment,suggesting that trained macrophages following enterovirus infection are crucial in the progression of allergic asthma later in life.展开更多
BACKGROUND Orthopaedic surgical education has traditionally depended on the apprenticeship model of“see one,do one,teach one”.However,reduced operative exposure,stricter work-hour regulations,medicolegal constraints...BACKGROUND Orthopaedic surgical education has traditionally depended on the apprenticeship model of“see one,do one,teach one”.However,reduced operative exposure,stricter work-hour regulations,medicolegal constraints,and patient safety concerns have constrained its practicality.Simulation-based training has become a reliable,safe,and cost-efficient alternative.Dry lab techniques,especially virtual and augmented reality,make up 78%of current dry lab research,whereas wet labs still set the standard for anatomical realism.AIM To evaluate the effectiveness,limitations,and future directions of wet and dry lab simulation in orthopaedic training.METHODS A scoping review was carried out across four databases-PubMed,Cochrane Library,Web of Science,and EBSCOhost-up to 2025.Medical Subject Headings included:"Orthopaedic Education","Wet Lab","Dry Lab","Simulation Training","Virtual Reality",and"Surgical Procedure".Eligible studies focused on orthopaedic or spinal surgical education,employed wet or dry lab techniques,and assessed training effectiveness.Exclusion criteria consisted of non-English publications,abstracts only,non-orthopaedic research,and studies unrelated to simulation.Two reviewers independently screened titles,abstracts,and full texts,resolving discrepancies with a third reviewer.RESULTS From 1851 records,101 studies met inclusion:78 on dry labs,7 on wet labs,4 on both.Virtual reality(VR)simulations were most common,with AI increasingly used for feedback and assessment.Cadaveric training remains the gold standard for accuracy and tactile feedback,while dry labs-especially VR-offer scalability,lower cost(40%-60%savings in five studies),and accessibility for novices.Senior residents prefer wet labs for complex tasks;juniors favour dry labs for basics.Challenges include limited transferability data,lack of standard outcome metrics,and ethical concerns about cadaver use and AI assessment.CONCLUSION Wet and dry labs each have unique strengths in orthopaedic training.A hybrid approach combining both,supported by standardised assessments and outcome studies,is most effective.Future efforts should aim for uniform reporting,integrating new technologies,and policy support for hybrid curricula to enhance skills and patient care.展开更多
In infrastructure as a service(IaaS)cloud mode equipment simulated training,to keep the resource utilization ratio in a rational high level,improve the training effect and reduce the system running cost,the problem of...In infrastructure as a service(IaaS)cloud mode equipment simulated training,to keep the resource utilization ratio in a rational high level,improve the training effect and reduce the system running cost,the problem of training virtual machine(TVM)placement needs to be resolved first.We make analysis to the problem and give the mathematical formulation to the problem.Then,we figure out the principle and target of the TVM placement.Based on above analysis,we propose a constrained immune memory and immunodominance clone(CIMIC)TVM placement optimization algorithm.By reverse optimization of the initial antibody population,the searching range is reduced.The common antibody population and the immunodominance antibody population evolve simultaneously,which realizes the simultaneous progressing of global searching and local searching of solutions.Further,local optimal is avoided by this means.Memory antibody makes ful use of the unfeasible solutions and the diversity of antibody population is maintained.The constraint information of the problem is utilized to improve the optimization effect.Experiment results show that the CIMIC algorithm improves the overall optimization effect of TVM placement,reduces the server number and improves the resource utilization and system stability.展开更多
文摘Sentiment analysis,a cornerstone of natural language processing,has witnessed remarkable advancements driven by deep learning models which demonstrated impressive accuracy in discerning sentiment from text across various domains.However,the deployment of such models in resource-constrained environments presents a unique set of challenges that require innovative solutions.Resource-constrained environments encompass scenarios where computing resources,memory,and energy availability are restricted.To empower sentiment analysis in resource-constrained environments,we address the crucial need by leveraging lightweight pre-trained models.These models,derived from popular architectures such as DistilBERT,MobileBERT,ALBERT,TinyBERT,ELECTRA,and SqueezeBERT,offer a promising solution to the resource limitations imposed by these environments.By distilling the knowledge from larger models into smaller ones and employing various optimization techniques,these lightweight models aim to strike a balance between performance and resource efficiency.This paper endeavors to explore the performance of multiple lightweight pre-trained models in sentiment analysis tasks specific to such environments and provide insights into their viability for practical deployment.
文摘Trained immunity is a phenomenon in which brief exposure to an infectious agent or a vaccine can induce long-lasting changes in the host’s immune system,enhancing protection against subsequent infections.The concept of trained immunity has a significant impact on the field of immunology and has the potential to revolutionize how we approach vaccination and infectious disease control.Investigations into trained immunity are rapidly advanc-ing and have led to the development of new vaccines and immunotherapeutic strategies that harness the power of this phenomenon.While more investigations are needed to fully understand the mechanisms of trained immunity and its potential limitations,the prospects for its future application in clinical practice are promising.Here,we describe trained immunity as a biological process and explore the innate cues,epigenetic changes,and metabolic reprogram-ming activities that affect how trained immunity is induced.
基金This work was supported by grants from The National Key R&D Program(Grant Nos.2018YFC1313400,2018YFC1313000,and 2018YFC1313002)The National Natural Science Foundation of China(Grant Nos.81872166,U20A20375,31600705,81974416,and 81702405)The Tianjin Natural Science Foundation(Grant No.17JCQNJC09000)。
文摘Objective:Trained immunity of natural killer(NK)cells has shown great potential in the treatment of cancers by eliciting enhanced effector responses to restimulation by cytokines or cancer cells for long time periods after preactivation.However,the human NK cells responsible for the generation and maintenance of trained immunity are largely unknown.We hypothesized that heterogeneous human NK cells would respond differentially to stimulation with a combination of IL-12,IL-15,and IL-18,and that an NK cell subset might exist that is mainly responsible for the induction of trained immunity.On the basis of our hypothesis,we aimed to identify the subset from which cytokine-trained human NK cells originate and to explore possible regulatory targets for drug intervention.Methods:Flow cytometry assays were performed to analyze the functions of cytokine-trained NK cells and examine cell division and protein expression in NK cell subsets.Single-cell RNA sequencing(scRNA-seq)plus TotalSeq™technology was used to track the heterogeneity of NK cells during the induction of trained immunity.Results:Traditional developmental markers for peripheral NK cells were unable to identify the precursors of human NK cells with trained immunity.Therefore,we used scRNA-seq plus TotalSeq™technology to track the heterogeneity of NK cells during the induction of trained immunity and identified a unique cluster of CD57−NKG2A+EZH2+IFNG+MKI67+IL12R+IL15R+IL18R+NK cells.Enrichment and pseudotime trajectory analyses suggested that this cluster of NK cells contained the precursor of trained NK cells.We then used flow cytometry to further investigate the role of EZH2 in trained NK precursors and found that CD57−NKG2A+EZH2+NK cells had faster cell cycles and an enhanced trained phenotype,and EZH2 inhibition significantly impaired the induction of trained immunity in NK cells.These results suggested that EZH2 is a unique epigenetic marker of precursors of human NK cells with trained immunity.Conclusions:Our work revealed human NK heterogeneity in the induction of trained immunity,identified the precursor subset for trained NK cells,and demonstrated the critical role of EZH2 in the induction of trained immunity in human NK cells.
文摘Objective:To investigate the effect of using audible thinking combined with the case teaching method in the teaching of nursing checkups for regulation nurses.Methods:The period was April 2023–April 2024,and a randomized controlled group study was carried out in which 76 regulation nurses in our hospital were randomly divided into a research group and a control group,with 38 regulation nurses in each group.The control group used conventional teaching methods,and the research group used audible thinking combined with the case teaching method,comparing the two groups’independent learning ability scores,assessment scores,and teaching satisfaction.Results:Independent learning ability score:after teaching,the research group was significantly higher than the control group(P<0.05);Assessment results:the research group was considerably higher than the control group(P<0.05);Teaching satisfaction:the research group was significantly higher than the control group(P<0.05).Conclusion:The use of audible thinking combined with the case teaching method in the teaching of nursing room visits for trained nurses can improve independent learning ability and assessment results and increase teaching satisfaction.
文摘The crossed micro-bands in the martensite variant pairs of a thermomechanically trained Cu25.66Zn-4.02Al (wt-%) alloy have been studied. It was found that the micro-bands pass through the interface from one martensite variant to another and their orientation inside different variants is distinct, which would remain in the parent phase after the reverse transformation and play an important role in the formation of preferential martensite. In fact, the crossed micro-bands are micro-twins for accommodating the stress fields generated during thermomechanically training
文摘The purpose of the present study was to examine the effect of circuit training (CT) on resting heart rate variability (HRV) and other cardiovascular disease (CVD) risk factors such as blood lipids and blood glucose and on fitness components. Twenty-four healthy untrained adults (age 26.5 ± 5.1 years;height 1.67 ± 8.4 m;weight 66.8 ± 15.1 kg;26.3% ± 5.2%;maximum oxygen uptake (VO<sub>2max</sub>) 48.5 ± 10.0 ml.kg<sup>-1</sup>.min<sup>-1</sup>) were assigned to either CT (n = 12) involving bodyweight exercises, or control (CON, n = 12) groups. Prior to the start and following the end of the six-week training period, time-, frequency-domain and nonlinear measures of resting HRV, arterial blood pressure, body composition, fasting blood lipids, lipoproteins and glucose, VO<sub>2max</sub>, upper body muscular endurance (UBME) and abdominal and hip flexor (AHFME), back strength (BS) and handgrip were assessed. None of the resting HRV measures (P > 0.05) were affected by the CT intervention. However, diastolic blood pressure decreased (P = 0.03), lean body weight (P = 0.03) increased, VO<sub>2max</sub> (P = 0.03), UBME (P = 0.001), AHFME (P = 0.04), and BS (P = 0.03) were significantly higher following CT, whereas the other variables were not influenced by the CT. Six-week of CT involving bodyweight exercises has no significant impact on resting HRV. However, this type of training might decrease the risk for development of CVD by reducing arterial blood pressure and by improving body composition, aerobic capacity, muscular endurance and strength.
基金Supported by the National Natural Science Foundation of China(No.71272146)
文摘Both fuzzy temporal constraint and flexible resource constraint are considered in project scheduling. In order to obtain an optimal schedule, we propose a genetic algorithm integrated with concepts on fuzzy set theory as well as specialized coding and decoding mechanism. An example demonstrates that the proposed approach can assist the project managers to obtain the optimal schedule effectively and make the correct decision on skill training before a project begins.
基金support from the National Natural Science Foundation of China(Grant No.52078085)Chongqing Planning and Natural Resources Bureau(No.KJ-2021048).
文摘Microorganisms have been essential in the natural world for millions of years,contributing significantly to environmental interaction.It has been disoverd that some bacteria are potential in geotechnical and environmental engineering due to their outstanding ability of biomineralization.Therefore,how to train bacteria as special and professional“workers”for biomineralization is increasingly a key topic in related research fields.This article briefly introduces the methods that are commonly utilized to improve the environmental adaptability and mineralization efficiency of bacteria,including microbial domestication,microbial mutation breeding,microbial targeted screening,and bio-stimulation,which make great implications to advance the field of biomineralization.
基金supported by the National High-Tech R&D Program(863)of China(Nos.2012AA011603 and 2012AA011602)the National Natural Science Foundation of China(Nos.30900389 and 31270026)
文摘Distance effect has been regarded as the best established marker of basic numerical magnitude processes and is related to individual mathematical abilities. A larger behavioral distance effect is suggested to be concomitant with lower mathematical achievement in children. However, the relationship between distance effect and superior mathematical abilities is unclear. One could get superior mathematical abilities by acquiring the skill of abacus-based mental calculation （AMC）, which can be used to solve calculation problems with exceptional speed and high accuracy. In the current study, we explore the relationship between distance effect and superior mathematical abilities by examining whether and how the AMC training modifies numerical magnitude processing. Thus, mathematical competencies were tested in 18 abacus-trained children （who accepted the AMC training） and 18 non-trained children. Electroencephalography （EEG） waveforms were recorded when these children executed numerical comparison tasks in both Arabic digit and dot array forms. We found that： （a） the abacus-trained group had superior mathematical abilities than their peers; （b） distance effects were found both in behavioral results and on EEG wave- forms; （c） the distance effect size of the average amplitude on the late negative-going component was different between groups in the digit task, with a larger effect size for abacus-trained children; （d） both the behavioral and EEG distance effects were modulated by the notation. These results revealed that the neural substrates of magnitude processing were modified by AMC training, and suggested that the mechanism of the representation of numerical magnitude for children with superior mathematical abilities was different from their peers. In addition, the results provide evidence for a view of non-abstract numerical representation.
文摘Four “cuajada” type fresh cheeses were evaluated by two trained panels in different regions from Oaxaca in Mexico (Instituto Tecnológico de Comitancillo (ITC) and Universidad del Mar (UMAR)). Each panel was integrated by six judges. Analysis of variance (ANOVA) in conjunction with principal component analysis (PCA) and the Rv coefficient were used to identify similarities and consensus among trained judges and panels. The ANOVA results revealed that the judges from ITC performed significantly better (P < 0.05) in discrimination and repetitivity, while both panels showed a similar effect in discrimination. The PCA determined some similarities in the position of cheeses in the sensory space, while Rv revealed that judges and panels were consensual. In conclusion, statistical resources determined that both panels were discriminating and that similarities in the positioning of cheeses in the sensory space were found.
基金This research is a part of the project titled‘Intelligent Control for Surface Vessels Based on Kalman Filter Variants Trained Radial Basis Function Neural Networks’partially funded by the Institutional Grants Scheme(TGRS 060515)of Tasmania,Australia.
文摘The roll motions of ships advancing in heavy seas have severe impacts on the safety of crews,vessels,and cargoes;thus,it must be damped.This study presents the design of a rudder roll damping autopilot by utilizing the dual extended Kalman filter(DEKF)trained radial basis function neural networks(RBFNN)for the surface vessels.The autopilot system constitutes the roll reduction controller and the yaw motion controller implemented in parallel.After analyzing the advantages of the DEKF-trained RBFNN control method theoretically,the ship’s nonlinear model with environmental disturbances was employed to verify the performance of the proposed stabilization system.Different sailing scenarios were conducted to investigate the motion responses of the ship in waves.The results demonstrate that the DEKF RBFNN based control system is efficient and practical in reducing roll motions and following the path for the ship sailing in waves only through rudder actions.
文摘<span style="font-family:Verdana;"><strong>Objective:</strong></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> To investigate whether a physical therapist trained through the Mechanical Diagnosis and Therapy (MDT) diploma program could guess psychological Patient Reported Outcome Measure (PROM) scores of individuals with low back pain (LBP) by taking patient history and completing a physical evaluation.</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Methods: </span></b></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">Ten participants with LBP completed PROMs immediately before history taking and again after a physical evaluation. PROMs included the Pain Catastrophizing Scale (PCS), Tampa Scale for Kinesiophobia (TSK), Hospital Anxiety and Depression Scale, and Pain Coping Strategy Questionnaire. A physical therapist who completed the MDT diploma program took the patients’ history and completed their physical evaluation. The therapist completed the same PROMs immediately after both history taking and physical evaluation. Correlations between patient and therapist scores were calculated using Spearman’s </span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;">. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> Statistically significant positive correlations were detected in </span></span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">the PCS (</span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;"> = 0.65) and TSK (</span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;"> = 0.78) before history taking, and in the PCS (</span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;"> = 0.81) and TSK (</span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;"> = 0.74) after physical evaluation.</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Discussion: </span></b></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">The results are based on one MDT therapist and generalizability of the findings is limited. However, the current preliminary findings justify the need for further studies to explore effective post-graduate training to promote a patient centered approach.</span></span></span>
文摘Objectives Assessing physical activity and cardiometabolic risk in masters athletes as an example of very high physical activity at old age.Methods Forty-three men were studied in full factorial design,either as sprint or jump-trained masters athletes(MA,n=10,age 60–75 years),as young sprint or jump-trained athletes(YA,n=10,age 20–35 years),older control participants(OC,n=11,age 60–75 years)or as young control participants(AC,n=12,age 20–35 years).We performed bio-electrical impedance analysis and assessed serum markers of lipids and glucose metabolism and C-reactive protein,structured training hours,and habitual activity via mobile actimetry.Results Body fat was greater in OC than in MA(23.9[SD 4.2]%vs.14.0[SD 5.7]%,p<0.001),and also greater than in YA and YC(both p<0.001).Weekly training hours were comparable between MA and YA(7.9[SD3.3]hours vs.11.1[SD 4.8]hours,p=0.69).Habitual walking distance was greater in MA than in OC(7,387[SD 4,923]m/day vs.4,110[SD 1,772]m/day,p=0.039),and so was habitual running distance(667[SD690]m/day vs.132[427]m/day,p<0.001).HOMA-index was greater in OC than in MA(2.07[SD 1.39]vs.0.80[SD 0.41],p=0.0039),and so was C-reactive protein(1.35[SD 1.74]mg/l vs.0.58[SD 0.27]mg/ml,p=0.018),whereas serum lipids showed only moderate or no effect(all p between 0.036 and 0.07).Conclusions Improved body composition and physical activity levels in MA are associated with lower cardiometabolic risk,which seems more pronounced for insulin sensitivity and inflammaging than for lipid metabolism.
基金the Natural Science Foundation of Chongqing,China(CSTB2022NSCQ-BHX0683)National Natural Science Foundation of China-Joint Fund Project(U22A20284)+2 种基金National Natural Science Foundation of China(12472320)Postdoctoral Special Funding Project of Chongqing Human Resources and Social Security Bureau(2112012726787861)Innovative Project for Doctoral Students of the First Affiliated Hospital of Chongqing Medical University(CYYY-BSYJSCXXM-202308).
文摘Modulating trained immunity while simultaneously initiating regenerative cues presents a significant challenge in large bone defect therapy.This study introduces a cell-free approach utilizing a 3D microenvironment-responsive scaffold to orchestrate immune reprogramming.To mitigate maladaptive trained immunity and activate regenerative signaling,a composite fibrous scaffold is functionalized with immune-engineered exosomes derived from inflammation-primed mesenchymal stem cells(PSS-iEXO)in a reactive oxygen species(ROS)-responsive manner.The PSS-iEXO scaffolds incorporate boronic ester linkages as ROS-sensitive moieties,enabling rapid,dynamic,and“on-demand”exosome release in response to elevated ROS levels characteristic of the early inflammatory phase post-injury,thereby initiating regeneration.In vitro and in vivo analyses reveal that these scaffolds precisely target and modulate maladaptive trained immunity,reprogramming immune responses by shifting macrophage polarization from a hyperactivated type I phenotype to a balanced state while promoting CD4+regulatory T cell activation—both critical for coupling angiogenesis and osteogenesis.Mechanistic insights highlight the role of engineered exosomes in enhancing mitochondrial function and oxidative phosphorylation in macrophages,establishing a cell-free immune-regenerative niche for large bone defect therapy.
文摘Correction:Advanced Fiber Materials(2025)7:1423-1445.https://doi.org/10.1007/s42765-025-00548-3.Fig.4b and Fig.9k were identified with improper use of images and thus require a correction.Original Fig.4.
基金supported by the National Key Research and Development Program of China,No.2023YFC3603705(to DX)the National Natural Science Foundation of China,No.82302866(to YZ).
文摘After spinal cord injury,impairment of the sensorimotor circuit can lead to dysfunction in the motor,sensory,proprioceptive,and autonomic nervous systems.Functional recovery is often hindered by constraints on the timing of interventions,combined with the limitations of current methods.To address these challenges,various techniques have been developed to aid in the repair and reconstruction of neural circuits at different stages of injury.Notably,neuromodulation has garnered considerable attention for its potential to enhance nerve regeneration,provide neuroprotection,restore neurons,and regulate the neural reorganization of circuits within the cerebral cortex and corticospinal tract.To improve the effectiveness of these interventions,the implementation of multitarget early interventional neuromodulation strategies,such as electrical and magnetic stimulation,is recommended to enhance functional recovery across different phases of nerve injury.This review concisely outlines the challenges encountered following spinal cord injury,synthesizes existing neurostimulation techniques while emphasizing neuroprotection,repair,and regeneration of impaired connections,and advocates for multi-targeted,task-oriented,and timely interventions.
文摘BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking recovery.OBJECTIVE:To determine whether early suspension-protected training with a personal assistant machine for stroke patients enhances walking ability and prevents muscle spasms.METHODS:Thirty-two early-stage stroke patients from Shenzhen University General Hospital and the China Rehabilitation Research Center were randomly assigned to the experimental group(n=16)and the control group(n=16).Both groups underwent 4 weeks of gait training under the suspension protection system for 30 minutes daily,5 days a week.The experimental group used the personal assistant machine during training.Three-dimensional gait analysis(using the Cortex motion capture system),Brunnstrom staging,Fugl-Meyer Assessment for lower limb motor function,Fugl-Meyer balance function,and the modified Ashworth Scale were evaluated within 1 week before the intervention and after 4 weeks of intervention.RESULTS AND CONCLUSION:After the 4-week intervention,all outcome measures showed significant changes in each group.The experimental group had a small but significant increase in the modified Ashworth Scale score(P<0.05,d=|0.15|),while the control group had a large significant increase(P<0.05,d=|1.48|).The experimental group demonstrated greater improvements in walking speed(16.5 to 38.44 cm/s,P<0.05,d=|4.01|),step frequency(46.44 to 64.94 steps/min,P<0.05,d=|2.32|),stride length(15.50 to 29.81 cm,P<0.05,d=|3.44|),and peak hip and knee flexion(d=|1.82|to|2.17|).After treatment,the experimental group showed significantly greater improvements than the control group in walking speed(38.44 vs.26.63 cm/s,P<0.05,d=|2.75|),stride length,peak hip and knee flexion(d=|1.31|to|1.45|),step frequency(64.94 vs.59.38 steps/min,P<0.05,d=|0.85|),and a reduced support phase(bilateral:24.31%vs.28.38%,P<0.05,d=|0.88|;non-paretic:66.19%vs.70.13%,P<0.05,d=|0.94|).For early hemiplegia,personal assistant machine-assisted gait training under the suspension protection system helps establish a correct gait pattern,prevents muscle spasms,and improves motor function.
基金This study was,in part,supported by the Centre of Allergy and Mucosal Immunity,Headquarters of University Advancement at the National Cheng Kung University,Ministry of Education,Taiwan.H.J.T is supported in part by a grant from the National Health Research Institutes(PI:Tsai,PH-101-PP-14,PH-101-SP-14,and PH-108-PP-08).
文摘Virus-induced asthma is prevalent among children,but its underlying mechanisms are unclear.Accumulated evidence indicates that early-life respiratory virus infection increases susceptibility to allergic asthma.Nonetheless,the relationship between systemic virus infections,such as enterovirus infection,and the ensuing effects on allergic asthma development is unknown.Early-life enterovirus infection was correlated with higher risks of allergic diseases in children.Adult mice exhibited exacerbated mite allergen-induced airway inflammation following recovery from EV-A71 infection in the neonatal period.Bone marrow-derived macrophages(BMDMs)from recovered EV-A71-infected mice showed sustained innate immune memory(trained immunity)that could drive naïve T helper cells toward Th2 and Th17 cell differentiation when in contact with mites.Adoptive transfer of EV-A71-trained BMDMs induced augmented allergic inflammation in naïve recipient mice,which was inhibited by 2-deoxy-D-glucose(2-DG)pretreatment,suggesting that trained macrophages following enterovirus infection are crucial in the progression of allergic asthma later in life.
文摘BACKGROUND Orthopaedic surgical education has traditionally depended on the apprenticeship model of“see one,do one,teach one”.However,reduced operative exposure,stricter work-hour regulations,medicolegal constraints,and patient safety concerns have constrained its practicality.Simulation-based training has become a reliable,safe,and cost-efficient alternative.Dry lab techniques,especially virtual and augmented reality,make up 78%of current dry lab research,whereas wet labs still set the standard for anatomical realism.AIM To evaluate the effectiveness,limitations,and future directions of wet and dry lab simulation in orthopaedic training.METHODS A scoping review was carried out across four databases-PubMed,Cochrane Library,Web of Science,and EBSCOhost-up to 2025.Medical Subject Headings included:"Orthopaedic Education","Wet Lab","Dry Lab","Simulation Training","Virtual Reality",and"Surgical Procedure".Eligible studies focused on orthopaedic or spinal surgical education,employed wet or dry lab techniques,and assessed training effectiveness.Exclusion criteria consisted of non-English publications,abstracts only,non-orthopaedic research,and studies unrelated to simulation.Two reviewers independently screened titles,abstracts,and full texts,resolving discrepancies with a third reviewer.RESULTS From 1851 records,101 studies met inclusion:78 on dry labs,7 on wet labs,4 on both.Virtual reality(VR)simulations were most common,with AI increasingly used for feedback and assessment.Cadaveric training remains the gold standard for accuracy and tactile feedback,while dry labs-especially VR-offer scalability,lower cost(40%-60%savings in five studies),and accessibility for novices.Senior residents prefer wet labs for complex tasks;juniors favour dry labs for basics.Challenges include limited transferability data,lack of standard outcome metrics,and ethical concerns about cadaver use and AI assessment.CONCLUSION Wet and dry labs each have unique strengths in orthopaedic training.A hybrid approach combining both,supported by standardised assessments and outcome studies,is most effective.Future efforts should aim for uniform reporting,integrating new technologies,and policy support for hybrid curricula to enhance skills and patient care.
基金Equipment Pre-research Fund of China under Grant No.9140A04030214JB34058.
文摘In infrastructure as a service(IaaS)cloud mode equipment simulated training,to keep the resource utilization ratio in a rational high level,improve the training effect and reduce the system running cost,the problem of training virtual machine(TVM)placement needs to be resolved first.We make analysis to the problem and give the mathematical formulation to the problem.Then,we figure out the principle and target of the TVM placement.Based on above analysis,we propose a constrained immune memory and immunodominance clone(CIMIC)TVM placement optimization algorithm.By reverse optimization of the initial antibody population,the searching range is reduced.The common antibody population and the immunodominance antibody population evolve simultaneously,which realizes the simultaneous progressing of global searching and local searching of solutions.Further,local optimal is avoided by this means.Memory antibody makes ful use of the unfeasible solutions and the diversity of antibody population is maintained.The constraint information of the problem is utilized to improve the optimization effect.Experiment results show that the CIMIC algorithm improves the overall optimization effect of TVM placement,reduces the server number and improves the resource utilization and system stability.
