In a recent study published in Cell,1 Wu et al.reveal that glucose restriction,a promising anti-cancer metabolic therapy,paradoxically promotes lung metastasis by compelling tumor cells to secrete exosomal TRAIL,which...In a recent study published in Cell,1 Wu et al.reveal that glucose restriction,a promising anti-cancer metabolic therapy,paradoxically promotes lung metastasis by compelling tumor cells to secrete exosomal TRAIL,which establishes an immunosuppressive pre-metastatic niche.This work offers critical new insight into the systemic risks and complex immunological consequences of targeting cancer metabolism and expands our understanding of how primary tumors remotely reshape the microenvironment of distant organs to facilitate metastatic colonization.展开更多
基金supported by grants from the Ministry of Food and Drug Safety(25192MFDS004)the National Research Foundation of Korea(NRF)funded by the Korea government(MSIT)(RS-2023-00207904).
文摘In a recent study published in Cell,1 Wu et al.reveal that glucose restriction,a promising anti-cancer metabolic therapy,paradoxically promotes lung metastasis by compelling tumor cells to secrete exosomal TRAIL,which establishes an immunosuppressive pre-metastatic niche.This work offers critical new insight into the systemic risks and complex immunological consequences of targeting cancer metabolism and expands our understanding of how primary tumors remotely reshape the microenvironment of distant organs to facilitate metastatic colonization.
