Endogenous forces generated by living cells are essential for biological processes and physiological functions of cells and tissues.Over the last several decades,numerous methods for detecting traction forces have bee...Endogenous forces generated by living cells are essential for biological processes and physiological functions of cells and tissues.Over the last several decades,numerous methods for detecting traction forces have been developed.Here we review these methods and discuss their respective strengths and limitations.Being able to reliably quantify tractions in living cells and tissues are critical in understanding how forces drive and regulate cell and tissue functions in physiology and diseases.展开更多
基金support from National Natural Science Foundation of China grants(12422212,11902121 and 32071306 to JC)Huazhong University of Science and Technology Program for Academic Frontier Youth Team(2018QYTD01 to JC)+1 种基金the Fundamental Research Funds for the Central Universities(2024BRB004 to JC)National Natural Science Foundation of China grant(11902122 to FW).NW was supported by NIH R01 GM072744 and Northeastern University in Boston.
文摘Endogenous forces generated by living cells are essential for biological processes and physiological functions of cells and tissues.Over the last several decades,numerous methods for detecting traction forces have been developed.Here we review these methods and discuss their respective strengths and limitations.Being able to reliably quantify tractions in living cells and tissues are critical in understanding how forces drive and regulate cell and tissue functions in physiology and diseases.
