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Effects of Microencapsulated Compound Acidifier on Acidity and Development of Gastrointestinal Tract in Weaning Piglets 被引量:4
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作者 JIA Gang YAN Jia-you WANG Kang-ning 《Animal Husbandry and Feed Science》 CAS 2009年第6期34-37,共4页
The effects of different types of compound acidifiers (encapsulated and non-encapsulated) in maize-soybean basic diets on acidity and development of the gastrointestinal tract in weaning piglets were investigated in... The effects of different types of compound acidifiers (encapsulated and non-encapsulated) in maize-soybean basic diets on acidity and development of the gastrointestinal tract in weaning piglets were investigated in this study. 64 28-day-old weaned Landrace x Yorkshire hybrid piglets with average weight of (7.00 ±0.10) kg were selected and grouped into four treatments with four pigs ( half boars and half sows) in each repeat of four repeats in each treatment based on single-factor test design principles, and the pre-test period was 3 days but the test period was 35 days. The results showed that compared with acid-free diet group, encapsulated compound acidifier could reduce pH of stomach and intestinal in weaning piglets significantly (P 〈 0.01 ), while Test group 1 could also increase the relative weight of stomach and intestinal in piglets significantly (P 〈 0.05 ). Compared with non-encapsulated acidifier, encapsulated compound acidifier could greatly decrease pH in jejunum and ileum of weaning piglets ( P 〈 0.05) or relative weight of stomach in piglets ( P〈0.05), while Test group 1 could also enhance the relative weight of intestinal in piglets significantly ( P 〈0.01 ). In addition, encapsulated compound acidifiers significantly increased the ratio between the villus height and crypt depth of jejunum ( P 〈0.01 ). Accordingly, the microencapsulated compound acidifier in diets of weaning piglets can promote the development of gastrointestinal tracts for piglets by reducing pH of gastrointestinal tracts. 展开更多
关键词 Microencapsulated compound Acidifier Weaning piglet Digestive tract acidity Digestive tract development
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Developmental process of the arcuate fasciculus from infancy to adolescence: a diffusion tensor imaging study 被引量:3
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作者 Hyeong Jun Tak Jin Hyun Kim Su Min Son 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第6期937-943,共7页
We investigated the radiologic developmental process of the arcuate fasciculus(AF) using subcomponent diffusion tensor imaging(DTI) analysis in typically developing volunteers. DTI data were acquired from 96 conse... We investigated the radiologic developmental process of the arcuate fasciculus(AF) using subcomponent diffusion tensor imaging(DTI) analysis in typically developing volunteers. DTI data were acquired from 96 consecutive typically developing children, aged 0–14 years. AF subcomponents, including the posterior, anterior, and direct AF tracts were analyzed. Success rates of analysis(AR) and fractional anisotropy(FA) values of each subcomponent tract were measured and compared. AR of all subcomponent tracts, except the posterior, showed a significant increase with aging(P 〈 0.05). Subcomponent tracts had a specific developmental sequence: First, the posterior AF tract, second, the anterior AF tract, and last, the direct AF tract in identical hemispheres. FA values of all subcomponent tracts, except right direct AF tract, showed correlation with subject's age(P 〈 0.05). Increased AR and FA values were observed in female subjects in young age(0–2 years) group compared with males(P 〈 0.05). The direct AF tract showed leftward hemispheric asymmetry and this tendency showed greater consolidation in older age(3–14 years) groups(P 〈 0.05). These findings demonstrated the radiologic developmental patterns of the AF from infancy to adolescence using subcomponent DTI analysis. The AF showed a specific developmental sequence, sex difference in younger age, and hemispheric asymmetry in older age. 展开更多
关键词 tracts tensor younger older developmental maturation typically asymmetry anisotropy fractional
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Analysis on the Relationship between Socio-economy and Development of Science and Technology in Jiaxing City
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作者 Huang Kunming Fu Xiaofeng Chen Changjie 《Chinese Journal of Population,Resources and Environment》 北大核心 2007年第3期57-62,共6页
Currently, the progress of science and technology has become a key factor in promoting economic development. And the backwardness of science and technology at the grassroots level has undoubtedly restricted the proces... Currently, the progress of science and technology has become a key factor in promoting economic development. And the backwardness of science and technology at the grassroots level has undoubtedly restricted the process of China’s construction of socialist new countryside. Taking socio-economy and the devel- opment of science and technology in Jiaxing as a breakthrough point, and based on the related data of Jiaxing during 1998?2004, this paper analyzes thoroughly the interactive relationship be- tween socio-economy and the development of science and tech- nology. This paper strives to summarize the development track and model of the grassroots work of science and technology so as to provide local governments with references and grounds for drawing up policies for the local work of science and technology. 展开更多
关键词 socio-economy development of science and technology development tract development model
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先天性糖基化障碍Ⅰa型伴反复呼吸道感染一家系分析并文献复习 被引量:1
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作者 张振坤 谢振华 +6 位作者 刘菁 肖梦君 李娴 张强 张耀东 王海军 李东晓 《山西医科大学学报》 2025年第2期193-199,共7页
目的 探讨PMM2基因变异相关先天性糖基化障碍(CDG)伴反复呼吸道感染患者的临床及遗传学特征。方法 收集1例PMM2基因变异致先天性糖基化障碍伴反复呼吸道感染患儿的临床资料,对先证者及其家系成员的可疑致病突变片段进行家系成员Sanger... 目的 探讨PMM2基因变异相关先天性糖基化障碍(CDG)伴反复呼吸道感染患者的临床及遗传学特征。方法 收集1例PMM2基因变异致先天性糖基化障碍伴反复呼吸道感染患儿的临床资料,对先证者及其家系成员的可疑致病突变片段进行家系成员Sanger测序。以“PMM2-CDG”“congenital disorder of glycosylation typeⅠa”“先天性糖基化障碍”或“PMM2基因”为关键词,分别检索PubMed数据库、中国知网、万方数据库收录的文献,总结PMM2基因变异所致CDG患者的临床表型、影像学及遗传学特点。结果 患儿,男,3岁,主要表现为语言及运动发育落后、眼球震颤、双眼内斜视、双下肢肌张力高,伴反复呼吸道感染。头颅MRI(2岁11月龄)结果示后颅窝囊性病变,小脑下蚓部及半球发育不全。家系全外显子组测序提示先证者PMM2基因存在父源性c.385G>A(p.Val129Met)与母源性c.395T>C(p.Ile132Thr)复合杂合变异,诊断为先天性糖基化障碍Ⅰa型(CDG-Ⅰa);姐姐在两个位点均为野生型。共检索到国内相关病例文献15篇26例患者,结合本例患者,共27例。国内CDG-Ⅰa患者的主要临床表现为发育落后(92.6%)、肌张力异常(77.8%)、小脑萎缩/发育不全(63.0%)、眼球内斜视(48.1%)、乳头内陷(33.3%)、臀部脂肪垫(22.2%)、癫痫/抽搐(14.8%)等。3例为PMM2基因纯合变异,24例为PMM2基因复合杂合变异。共包含23个基因变异位点,18种错义变异,4种移码变异及1种剪接变异。结论 PMM2基因致病变异可导致神经系统、心脏和免疫系统等多系统异常,对可疑CDG患者应及时行PMM2基因检测,以尽早明确诊断。 展开更多
关键词 PMM2基因 先天性糖基化障碍 呼吸道感染 基因变异 全面发育迟缓
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不同发育阶段湖羊生殖器官脂联素受体与睾酮分泌关键基因表达模式及相关性研究 被引量:3
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作者 姚晓磊 黄欣爱 +7 位作者 肖慎华 郑临枫 范丽洁 金宇月 刘孜斐 张艳丽 王洁 王锋 《畜牧兽医学报》 CAS CSCD 北大核心 2018年第8期1642-1650,共9页
旨在探究不同发育阶段湖羊生殖器官中脂联素受体(adiponectin receptor,AdpR)及睾酮(testosterone,T)分泌相关基因mRNA的表达变化及相关性分析。选取3、9、24月龄(M)湖羊各5只,颈静脉采血并收集血清,屠宰后,采集下丘脑、垂体、睾丸、附... 旨在探究不同发育阶段湖羊生殖器官中脂联素受体(adiponectin receptor,AdpR)及睾酮(testosterone,T)分泌相关基因mRNA的表达变化及相关性分析。选取3、9、24月龄(M)湖羊各5只,颈静脉采血并收集血清,屠宰后,采集下丘脑、垂体、睾丸、附睾头、体、尾组织;ELISA技术检测各月龄湖羊血清中脂联素(adiponectin,Adp)、T、促性腺激素释放激素(gonadotropin releasing hormone,GnRH)、促性腺激素抑制激素(gonadotropin inhibitory hormone,GnIH)浓度;qRT-PCT技术检测不同发育阶段湖羊下丘脑-垂体-性腺轴(hypothalamus-pituitary-gonad axis,HPG)中AdpR1和AdpR2及T分泌关键基因mRNA表达规律;免疫组化技术对AdpR1在湖羊睾丸和附睾中进行定位分析。结果表明:不同发育阶段湖羊血清中Adp、GnRH、GnIH浓度呈现不同的变化趋势,其中Adp含量在性成熟后(9和24月龄)显著高于性成熟前(3月龄)(P<0.05)。AdpR1mRNA表达量在各个月龄睾丸和附睾尾中均显著高于AdpR2(P<0.05),其中AdpR1mRNA表达量在二者中呈上升趋势,且差异显著(P<0.05),而在附睾头、体差异不显著(P>0.05)。AdpR1存在于睾丸间质细胞、生精细胞、曲精细管管壁肌样细胞、精子细胞以及附睾头、体、尾的上皮细胞。血清中Adp与T含量呈显著正相关(P<0.05);Adp含量与GnIH负相关以及与GnRH正相关,但差异不显著(P>0.05);AdpR1mRNA表达水平与StAR、3β-HSD mRNA表达水平呈显著正相关(P<0.05)。综上表明,在湖羊生殖器官发育过程中,Adp通过与其受体AdpR1结合,促进T的产生,进而影响湖羊睾丸发育。 展开更多
关键词 脂联素受体 生殖器官 不同发育阶段 湖羊
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全面性发育迟缓患儿大脑白质纤维束微结构异常的扩散峰度成像研究 被引量:4
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作者 张晓雪 赵鑫 +5 位作者 沈艳勇 程美英 王长浩 杨喆璇 冯占起 张小安 《磁共振成像》 CAS CSCD 北大核心 2024年第6期19-23,30,共6页
目的使用扩散峰度成像(diffusion kurtosis imaging,DKI)评估全面性发育迟缓(global developmental delay,GDD)患儿大脑白质纤维束微结构的改变。材料与方法这项前瞻性研究纳入了37例GDD儿童作为试验组和32例性别、年龄相匹配的健康儿... 目的使用扩散峰度成像(diffusion kurtosis imaging,DKI)评估全面性发育迟缓(global developmental delay,GDD)患儿大脑白质纤维束微结构的改变。材料与方法这项前瞻性研究纳入了37例GDD儿童作为试验组和32例性别、年龄相匹配的健康儿童作为对照组。对所有参与者进行了DKI序列扫描,经过后处理得到扩散张量和峰度张量参数。使用基于束的空间统计学方法(tract-based spatial statistics,TBSS)比较了这些参数在两组之间的差异,并将组间有显著差异纤维束内的参数值与GDD儿童的神经发育得分进行Spearman相关分析。结果与对照组相比,GDD组右侧皮质脊髓束和右侧丘脑前辐射的平均扩散率(mean diffusivity,MD)均显著升高(P均<0.05);双侧丘脑前辐射、双侧皮质脊髓束和右侧上纵束的径向扩散系数(radial diffusivity,RD)也显著升高(P均<0.05)。此外,GDD组的径向峰度(radial kurtosis,RK)则显著降低(P均<0.05),包括双侧丘脑前辐射、双侧皮质脊髓束、双侧下额枕束、双侧上纵束、双侧下纵束、小钳、左侧钩状束和右侧扣带回。相关性分析发现,左侧下纵束和左侧钩状束的平均RK值与适应性行为得分呈正相关(r=0.349、0.486,P均<0.05);左侧钩状束的平均RK值与精细动作得分和个人-社交行为得分均呈正相关(r=0.365、0.590,P均<0.05)。结论DKI技术能够检测到GDD儿童大脑白质纤维束微结构的异常,为探索GDD潜在病理机制提供了有用的价值。 展开更多
关键词 全面性发育迟缓 扩散峰度成像 磁共振成像 基于束的空间统计学方法 白质 儿童
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脑性瘫痪伴生长发育迟缓儿童胰岛素样生长因子1表达和肠道菌群特征及相关性
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作者 黄敏 余小塘 +6 位作者 周平 卢振盛 朱世华 聂韵 梁正中 伍利群 杨杰文 《中国学校卫生》 CAS 北大核心 2024年第9期1246-1250,1254,共6页
目的 探讨脑性瘫痪(简称“脑瘫”)伴生长发育迟缓儿童血清胰岛素样生长因子1(IGF-1)表达、肠道菌群特征及相关性,为促进脑瘫伴生长发育迟缓儿童身心健康提供参考依据。方法 2022年6月—2023年6月随机选取广州市某福利院的3~14岁112名脑... 目的 探讨脑性瘫痪(简称“脑瘫”)伴生长发育迟缓儿童血清胰岛素样生长因子1(IGF-1)表达、肠道菌群特征及相关性,为促进脑瘫伴生长发育迟缓儿童身心健康提供参考依据。方法 2022年6月—2023年6月随机选取广州市某福利院的3~14岁112名脑瘫儿童,按照WHO标准是否生长发育迟缓分为脑瘫伴生长发育迟缓组(80名)和脑瘫伴生长发育正常组(32名),并选取同院生活的健康儿童32名为对照组;对3组儿童进行血清IGF-1测定,并用16S rDNA测序技术测定肠道菌群,探究3组儿童IGF-1表达特点、肠道菌群群落组成和差异特征及相关性。结果 对3组儿童血清IGF-1水平进行比较,脑瘫伴生长发育迟缓组[97.70(66.35,139.50)ng/mL]、脑瘫伴生长发育正常组[149.00(68.30,233.00)ng/mL]均低于健康对照组[169.90(118.75,293.80)ng/mL],差异有统计学意义(H=20.13,P<0.05)。脑瘫伴生长发育迟缓组和脑瘫伴生长发育正常组肠道菌群Alpha多样性均高于健康对照组[Chao指数(482.50,489.90,396.10)、Shannon指数(6.29,6.44,5.89)和Simpson指数(0.97,0.97,0.96)](H值分别为17.20,7.01,6.41,P值均<0.05)。IGF-1与Eubacterium coprostanoligenes group、罕见小球菌属相对丰度均呈正相关(r值分别为0.38,0.33,P值均<0.05)。结论 脑瘫伴生长发育迟缓儿童血清IGF-1水平低下,同时肠道菌群群落多样、菌种差异。选择适合的肠道菌群作为脑瘫伴生长发育迟缓的潜在预测标志物,可为开展干预治疗提供新策略。 展开更多
关键词 脑性瘫痪 发育障碍 胰岛素样生长因子Ⅰ 胃肠道 细菌 儿童
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