目的探究食管胃结合部腺癌(adenocarcinoma of esophagogastric junction,AEG)腹腔镜全胃切除术(laparoscopic total gastrectomy,LTG)后消化道重建吻合方式及与胃肠功能障碍的关系。方法选择2019年1月至2023年6月于上海中医药大学附属...目的探究食管胃结合部腺癌(adenocarcinoma of esophagogastric junction,AEG)腹腔镜全胃切除术(laparoscopic total gastrectomy,LTG)后消化道重建吻合方式及与胃肠功能障碍的关系。方法选择2019年1月至2023年6月于上海中医药大学附属曙光医院行LTG治疗的AEG患者(n=100)为研究对象;根据腹腔镜手术中吻合方式不同,分为Overlap组(n=35)和Roux-en-Y组(n=65)。对比分析两组患者的临床资料。采用广义估计方程(generalized estimating equations,GEE)评估两组患者各胃肠道激素的改善情况。结果与Roux-en-Y组相比,Overlap组患者的术中出血量更少、术后住院时间更短、并发症发生率更低(P<0.05)。与Roux-en-Y组相比,Overlap组患者术后1个月、3个月ALB及HGB水平均更高(P<0.05),主观综合营养评估法(subjective global assessement,SGA)评分更低(P<0.05);与Roux-en-Y组相比,Overlap组患者术后3个月TP水平更高(P<0.05)。与Roux-en-Y组相比,Overlap组患者术后3个月GAS、MTL及SS水平均更高(P<0.05),CCK水平更低(P<0.05)。GEE分析结果显示,与Roux-en-Y组相比,Overlap组各胃肠道激素的改善情况均更优(P<0.05)。结论对行LTG的AEG患者开展Overlap吻合,能更好改善术后营养状况,且对胃肠功能影响更小,安全性更高。展开更多
Background Scant information is currently available on the use of insect oils in ruminant diets.Insect oils could be used as alternatives to certain conventional plant lipid sources that are considered no longer susta...Background Scant information is currently available on the use of insect oils in ruminant diets.Insect oils could be used as alternatives to certain conventional plant lipid sources that are considered no longer sustainable.This trial aims at evaluating the effects of the dietary inclusion of Hermetia illucens oil(HIO)vs.hydrogenated palm fat(HPF)on digestive parameters,oxidative stress,and milk production performance of dairy cows.Results Twenty-six Valdostana Red Pied cows were randomly divided into two groups and fed with hay ad libitum and a concentrate containing 3%(as fed)of either HPF or HIO.The trial lasted 50 d,including two weeks of diet adaptation.Individual feed intake and milk yield were monitored three and four times a week,respectively.Fecal samples were collected at the end(d 50)of the trial to determine total-tract nutrients apparent digestibility.Individual blood samples were collected to evaluate blood plasma metabolites(d 0 and d 50)and oxidative stress parameters(d 0,d 26 and d 50).Milk samples were collected at d 0,d 14,d 26,d 38 and d 50 for chemical composition analysis.Feed efficiency was estimated through feed conversion ratio and residual feed intake(RFI).Data were analyzed by SAS software using a mixed model.The diet had no effect on nutrients intake and apparent total-tract digestibility.However,the dietary inclusion of HIO led to higher milk production(+0.82 kg/cow/d;P<0.05)and slightly lower RFI(−0.008;P<0.001)when compared to the HPF diet.Milk composition and the nutritional metabolic status of the cows remained unaffected by diet.Serum antioxidant capacity was comparable between the two groups,while lower derivatives of reactive oxygen metabolite concentrations were observed in the HIO-fed cows when compared to the HPF-fed ones(−37.13 Carratelli Units;P<0.001).Conclusions The dietary inclusion of HIO instead of HPF did not negatively affect feed palatability and total-tract apparent digestibility of nutrients in dairy cows.Furthermore,it increased feed efficiency by supporting a higher milk production together with an improved antioxidant status.The results suggest that HIO could be an eligible option as an innovative energy source for dairy cows.展开更多
文摘目的探究食管胃结合部腺癌(adenocarcinoma of esophagogastric junction,AEG)腹腔镜全胃切除术(laparoscopic total gastrectomy,LTG)后消化道重建吻合方式及与胃肠功能障碍的关系。方法选择2019年1月至2023年6月于上海中医药大学附属曙光医院行LTG治疗的AEG患者(n=100)为研究对象;根据腹腔镜手术中吻合方式不同,分为Overlap组(n=35)和Roux-en-Y组(n=65)。对比分析两组患者的临床资料。采用广义估计方程(generalized estimating equations,GEE)评估两组患者各胃肠道激素的改善情况。结果与Roux-en-Y组相比,Overlap组患者的术中出血量更少、术后住院时间更短、并发症发生率更低(P<0.05)。与Roux-en-Y组相比,Overlap组患者术后1个月、3个月ALB及HGB水平均更高(P<0.05),主观综合营养评估法(subjective global assessement,SGA)评分更低(P<0.05);与Roux-en-Y组相比,Overlap组患者术后3个月TP水平更高(P<0.05)。与Roux-en-Y组相比,Overlap组患者术后3个月GAS、MTL及SS水平均更高(P<0.05),CCK水平更低(P<0.05)。GEE分析结果显示,与Roux-en-Y组相比,Overlap组各胃肠道激素的改善情况均更优(P<0.05)。结论对行LTG的AEG患者开展Overlap吻合,能更好改善术后营养状况,且对胃肠功能影响更小,安全性更高。
基金funded by the HiGa project,supported within the Green Era Hub call by the Green Development and Demonstration Programme,GUDP,under the Ministry of Food,Agriculture and Fisheries of Denmark,the Flanders Innovation&Entrepreneurship(VLAIO)the Italian Ministry of Agriculture,Food Sovereignty and Forests(CUP:D23 C23000570005).
文摘Background Scant information is currently available on the use of insect oils in ruminant diets.Insect oils could be used as alternatives to certain conventional plant lipid sources that are considered no longer sustainable.This trial aims at evaluating the effects of the dietary inclusion of Hermetia illucens oil(HIO)vs.hydrogenated palm fat(HPF)on digestive parameters,oxidative stress,and milk production performance of dairy cows.Results Twenty-six Valdostana Red Pied cows were randomly divided into two groups and fed with hay ad libitum and a concentrate containing 3%(as fed)of either HPF or HIO.The trial lasted 50 d,including two weeks of diet adaptation.Individual feed intake and milk yield were monitored three and four times a week,respectively.Fecal samples were collected at the end(d 50)of the trial to determine total-tract nutrients apparent digestibility.Individual blood samples were collected to evaluate blood plasma metabolites(d 0 and d 50)and oxidative stress parameters(d 0,d 26 and d 50).Milk samples were collected at d 0,d 14,d 26,d 38 and d 50 for chemical composition analysis.Feed efficiency was estimated through feed conversion ratio and residual feed intake(RFI).Data were analyzed by SAS software using a mixed model.The diet had no effect on nutrients intake and apparent total-tract digestibility.However,the dietary inclusion of HIO led to higher milk production(+0.82 kg/cow/d;P<0.05)and slightly lower RFI(−0.008;P<0.001)when compared to the HPF diet.Milk composition and the nutritional metabolic status of the cows remained unaffected by diet.Serum antioxidant capacity was comparable between the two groups,while lower derivatives of reactive oxygen metabolite concentrations were observed in the HIO-fed cows when compared to the HPF-fed ones(−37.13 Carratelli Units;P<0.001).Conclusions The dietary inclusion of HIO instead of HPF did not negatively affect feed palatability and total-tract apparent digestibility of nutrients in dairy cows.Furthermore,it increased feed efficiency by supporting a higher milk production together with an improved antioxidant status.The results suggest that HIO could be an eligible option as an innovative energy source for dairy cows.
