Background:Brain metastases are frequent complications for lung cancer patients.However,changes in the brain of lung cancer patients have received little attention.We aimed to explore whether alterations in brain gluc...Background:Brain metastases are frequent complications for lung cancer patients.However,changes in the brain of lung cancer patients have received little attention.We aimed to explore whether alterations in brain glucose uptake and brain texture occur in non-small cell lung cancer(NSCLC)patients and to investigate associations between brain alterations and NSCLC via the uEXPLORER positron emission tomography/computed tomography(PET/CT)system.Methods:In total,105 participants were enrolled,including 55 healthy con-trols and 50 NSCLC patients.Images were acquired using the PET/CT system.Standardized uptake values normalized by lean body mass were calculated as indicators of glucose uptake.Correlation analysis was conducted between aberrant brain glucose uptake,glucose uptake of cancer lesions,and con-centrations of serum lung cancer markers.Radiomics was used to investigate whether features extracted from regions with altered brain glucose uptake could serve as biomarkers of lung cancer progression.Results:Compared with healthy controls,NSCLC patients showed decreased standardized uptake values normalized by lean body mass in the left insula,medial frontal gyrus,and anterior cingulate.Correlation analysis demon-strated that glucose uptake of the anterior cingulate was negatively correlated with serum lung cancer marker concentrations.Radiomic features on PET/CT images of the above brain regions could classify NSCLC patients and healthy controls with an accuracy of 79%.Conclusions:NSCLC patients exhibited altered brain glucose uptake and changes in brain textures.These alterations may reflect alterations in behav-ioral domains in NSCLC and may be related to altered lung-brain interactions and potential brain metastasis of NSCLC.展开更多
Total-body positron emission tomography(TB-PET)has ultra-high sensitivity and the unique ability to conduct dynamic imaging of the entire body.Both the hardware configuration and the data acquired from a TB-PET scanne...Total-body positron emission tomography(TB-PET)has ultra-high sensitivity and the unique ability to conduct dynamic imaging of the entire body.Both the hardware configuration and the data acquired from a TB-PET scanner differ from those of the conventional short axial field-of-view scanners.Therefore,various aspects concerning data processing need careful consideration when implementing TB-PET in clinical settings.Additionally,advances in data analysis are needed to fully uncover the potential of these systems.Although some progress has been achieved,further research and innovation in scan data management are necessary.In this report,we provide a comprehensive overview of the current progress,challenges,and possible future directions for TB-PET data processing and analysis.For a review of clinical applications,please find the other review accompanying this paper.展开更多
基金Taishan Scholar Project of Shandong Province,Grant/Award Number:TS201712065Chinese Polar Environment Comprehensive Investigation and Assessment Programmes,Grant/Award Number:2021YFE0204600Science and Technology Development Plan of Shandong Province,Grant/Award。
文摘Background:Brain metastases are frequent complications for lung cancer patients.However,changes in the brain of lung cancer patients have received little attention.We aimed to explore whether alterations in brain glucose uptake and brain texture occur in non-small cell lung cancer(NSCLC)patients and to investigate associations between brain alterations and NSCLC via the uEXPLORER positron emission tomography/computed tomography(PET/CT)system.Methods:In total,105 participants were enrolled,including 55 healthy con-trols and 50 NSCLC patients.Images were acquired using the PET/CT system.Standardized uptake values normalized by lean body mass were calculated as indicators of glucose uptake.Correlation analysis was conducted between aberrant brain glucose uptake,glucose uptake of cancer lesions,and con-centrations of serum lung cancer markers.Radiomics was used to investigate whether features extracted from regions with altered brain glucose uptake could serve as biomarkers of lung cancer progression.Results:Compared with healthy controls,NSCLC patients showed decreased standardized uptake values normalized by lean body mass in the left insula,medial frontal gyrus,and anterior cingulate.Correlation analysis demon-strated that glucose uptake of the anterior cingulate was negatively correlated with serum lung cancer marker concentrations.Radiomic features on PET/CT images of the above brain regions could classify NSCLC patients and healthy controls with an accuracy of 79%.Conclusions:NSCLC patients exhibited altered brain glucose uptake and changes in brain textures.These alterations may reflect alterations in behav-ioral domains in NSCLC and may be related to altered lung-brain interactions and potential brain metastasis of NSCLC.
基金Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province,Grant/Award Number:2023B1212060052Shenzhen Science and Technology Innovation Committee,Grant/Award Number:20220531100209020Guangdong Science and Technology Department,Grant/Award Number:2022A1515110716。
文摘Total-body positron emission tomography(TB-PET)has ultra-high sensitivity and the unique ability to conduct dynamic imaging of the entire body.Both the hardware configuration and the data acquired from a TB-PET scanner differ from those of the conventional short axial field-of-view scanners.Therefore,various aspects concerning data processing need careful consideration when implementing TB-PET in clinical settings.Additionally,advances in data analysis are needed to fully uncover the potential of these systems.Although some progress has been achieved,further research and innovation in scan data management are necessary.In this report,we provide a comprehensive overview of the current progress,challenges,and possible future directions for TB-PET data processing and analysis.For a review of clinical applications,please find the other review accompanying this paper.
