Purpose:This study investigated the effects of obesity on breast size,thoracic spine structure and function,upper torso musculoskeletal pain and physical activity participation in women living independently in the com...Purpose:This study investigated the effects of obesity on breast size,thoracic spine structure and function,upper torso musculoskeletal pain and physical activity participation in women living independently in the community.Methods:A total of 378 women were divided into 3 groups(Not Overweight:body mass index(BMI)=22.5±0.2 kg/m^2(mean±SE);Overweight:BMI=27.4±0.3 kg/m^2;Obese:BMI=35.4±0.3 kg/m^2).Outcome variables of breast volume(mL),thoracic flexion torque(N·m),thoracic kyphosis(degrees),upper torso musculoskeletal pain(score) and time spent in physical activity(min) were calculated and compared among the 3 groups,adjusting for between-group differences in age.Results:There was a significant main effect of BMI on all outcome variables.Participants classified as Obese displayed significantly larger breasts,had greater thoracic flexion torques and reported less time participating in physical activity relative to the participants who were classified as Not Overweight and Overweight.Participants in the Obese group also displayed significantly more thoracic kyphosis and reported significantly more upper torso musculoskeletal pain compared to their counterparts who were classified as Not Overweight.Conclusion:This study is the first to demonstrate that increased obesity levels were associated with compromised kyphosis and loading of the thoracic spine,as well as increased symptoms of upper torso musculoskeletal pain and reduced time spent in physical activity in women living in the community.We recommend further research to determine whether evidence-based interventions designed to reduce the flexion torque generated on the thoracic spine can improve these symptoms of upper torso musculoskeletal pain and the ability of women with obesity to participate in physical activity.展开更多
This paper constructs a concentric ellipsoid torso-heart model by boundary element method and investigates the impacts of model structures on the cardiac magnetic fields generated by both equivalent primary source--a ...This paper constructs a concentric ellipsoid torso-heart model by boundary element method and investigates the impacts of model structures on the cardiac magnetic fields generated by both equivalent primary source--a current dipole and volume currents. Then by using the simulated magnetic fields based on torso-heart model as input, the cardiac current sources--an array of current dipoles by optimal constrained linear inverse method are constructed. Next, the current dipole array reconstruction considering boundaries is compared with that in an unbounded homogeneous medium. Furthermore, the influence of random noise on reconstruction is also considered and the reconstructing effect is judged by several reconstructing parameters.展开更多
Background: In combat operations, patients with traumatic injuries require expeditious evacuation to improve survival. Studies have shown that long transport times are associated with increased morbidity and mortality...Background: In combat operations, patients with traumatic injuries require expeditious evacuation to improve survival. Studies have shown that long transport times are associated with increased morbidity and mortality. Limited data exist on the influence of transport time on patient outcomes with specific injury types. The objective of this study was to determine the impact of the duration of time from the initial request for medical evacuation to arrival at a medical treatment facility on morbidity and mortality in casualties with traumatic extremity amputation and noncompressible torso injury(NCTI).Methods: We completed a retrospective review of MEDEVAC patient care records for United States military personnel who sustained traumatic amputations and NCTI during Operation Enduring Freedom between January 2011 and March 2014. We grouped patients as traumatic amputation and NCTI(AMP+NCTI), traumatic amputation only(AMP),and neither AMP nor NCTI(Non-AMP/NCTI). Analysis was performed using chi-squared tests, Fisher's exact tests,Cochran-Armitage Trend tests, Shapiro-Wilks tests, Wilcoxon and Kruskal-Wallis techniques and Cox proportional hazards regression modeling.Results: We reviewed 1267 records, of which 669 had an injury severity score(ISS) of 10 or greater and were included in the analysis. In the study population, 15.5% sustained only amputation injuries(n=104, AMP only), 10.8% sustained amputation and NCTI(n=72, AMP+NCTI), and 73.7% did not sustain either an amputation or an NCTI(n=493,Non-AMP/NCTI). AMP+NCTI had the highest mortality(16.7%) with transport time greater than 60 min. While the AMP+NCTI group had decreasing survival with longer transport times, AMP and Non-AMP/NCTI did not exhibit the same trend.Conclusions: A decreased transport time from the point of injury to a medical treatment facility was associated with decreased mortality in patients who suffered a combination of amputation injury and NCTI. No significant association between transport time and outcomes was found in patients who did not sustain NCTI. Priority for rapid evacuation of combat casualties should be given to those with NCTI.展开更多
Low collateral damage weapons achieve controlled personnel injury through the coupling of shock waves and particle swarms,where the particle swarms arise from the high-explosive dispersion of compacted metal particle ...Low collateral damage weapons achieve controlled personnel injury through the coupling of shock waves and particle swarms,where the particle swarms arise from the high-explosive dispersion of compacted metal particle ring.To investigate the dynamic response of the human target under combined shock waves and particle swarms loading,a physical human surrogate torso model(HSTM)was developed,and the dynamic response test experiment was conducted under the combined loading.The effects of particle size on the loading parameters,the damage patterns of the ballistic plate and HSTM,and the dynamic response parameters of the HSTM with and without protection are mainly analyzed.Our findings revealed that particle swarms can effectively delay the shock wave attenuation,especially the best effect when the particle size was 0.28–0.45 mm.The ballistic plate mainly exhibited dense perforation of the outer fabric and impacted crater damage of ceramic plates,whereas the unprotected HSTM was mainly dominated by high-density and small-size ballistic cavity group damage.The peak values of the dynamic response parameters for the HSTM under combined loading were significantly larger than those under bare charge loading,with multiple peaks observed.Under unprotected conditions,the peak acceleration of skeletons and peak pressure of organs increased with the particle size.Under protected conditions,the particle size,the number of particles hit,and the fit of the ballistic plate to the HSTM together affected the dynamic response parameters of the HSTM.展开更多
With the widespread adoption of advanced tourniquets,the mortality rate of limb wound hemorrhage has decreased significantly,and non-compressible torso hemorrhage has gradually occupied the leading position of potenti...With the widespread adoption of advanced tourniquets,the mortality rate of limb wound hemorrhage has decreased significantly,and non-compressible torso hemorrhage has gradually occupied the leading position of potentially preventable death,both in military and civilian circumstances.With the emergence of novel hemostatic devices and materials,strategies for the management of non-compressible torso hemorrhage have changed significantly.This review summarizes the current treatment strategies and types of equipment for non-compressible torso hemorrhage and suggests future research directions,hoping to provide a comprehensive review for the medical personnel and researchers engaging in this field.展开更多
Human-like torso features are essential in humanoid robots. In this paper problems for design and operation of solutions for a robotic torso are discussed by referring to experiences and designs that have been develop...Human-like torso features are essential in humanoid robots. In this paper problems for design and operation of solutions for a robotic torso are discussed by referring to experiences and designs that have been developed at Laboratory of Robotics and Mechatronics （LARM） in Cassino, Italy. A new solution is presented with conceptual views as waist-trunk structure that makes a proper partition of the performance for walking and arm operations as sustained by a torso.展开更多
The torso plays an important role in the human-like operation of humanoids. In this paper, a method is proposed to analyze the behavior of the human torso by using inertial and magnetic sensing tools. Experiments are ...The torso plays an important role in the human-like operation of humanoids. In this paper, a method is proposed to analyze the behavior of the human torso by using inertial and magnetic sensing tools. Experiments are conducted to characterize the motion performance of the human torso during daily routine operations. Furthermore, the forces acting on the human body during these operations are evaluated to design and validate the performance of a humanoid robot.展开更多
Insect growth and development are precisely controlled by hormone homeostasis.The prothoracicotropic hormone(PTTH)receptor,Torso,is a member of the receptor tyrosine kinase family in insects.Activation of Torso by PTT...Insect growth and development are precisely controlled by hormone homeostasis.The prothoracicotropic hormone(PTTH)receptor,Torso,is a member of the receptor tyrosine kinase family in insects.Activation of Torso by PTTH triggers biosynthesis and release of the steroid hormone in the prothoracic gland(PG).Although numbers of genes functioning in steroid hormone synthesis and metabolism have been identified in insects,the PTTH transduction pathway via its receptor Torso is poorly understood.In the current study,we describe a loss-of-function analysis of Torso in the silkworm,Bombyx mori,by targeted gene disruption using the transgenic CRISPR/Cas9(clustered regularly interspaced short palindromic repeats/RNA-guided Cas9 nucleases)system.Depletion of B.mori Torso(BmTorso)did not eventually affect larval ecdysis and metamorphosis processes.Instead,BmTorso deficiency resulted in significant extension of developing time during larval and pupal stages with increased pupa and cocoon sizes.The eedysteriod titers in the hemolymph of BmTorso mutants sharpy declined.Transcriptional levels of genes involved in ecdysone biosynthesis and eedysteroid signaling pathways were significantly reduced in BniTorso-defic'iQnt animals.Additionally,RNA-Seq analysis revealed that genes involved in the longevity pathway and protein processing in the endoplasmic reticulum pathway were affected after BmTorso deletion.These results indicate that Torso is critical for maintaining steroid hormone homeostasis in insects.展开更多
BACKGROUND:Resuscitative endovascular balloon occlusion of the aorta(REBOA)can temporarily control traumatic bleeding.However,its prolonged use potentially leads to ischemia-reperfusion injury(IRI).Partial REBOA(pREBO...BACKGROUND:Resuscitative endovascular balloon occlusion of the aorta(REBOA)can temporarily control traumatic bleeding.However,its prolonged use potentially leads to ischemia-reperfusion injury(IRI).Partial REBOA(pREBOA)can alleviate ischemic burden;however,its security and eff ectiveness prior to operative hemorrhage control remains unknown.Hence,we aimed to estimate the effi cacy of pREBOA in a swine model of liver injury using an experimental sliding-chamber ballistic gun.METHODS:Twenty Landrace pigs were randomized into control(no aortic occlusion)(n=5),intervention with complete REBOA(cREBOA)(n=5),continuous pREBOA(C-pREBOA)(n=5),and sequential pREBOA(S-pREBOA)(n=5)groups.In the cREBOA and C-pREBOA groups,the balloon was inflated for 60 min.The hemodynamic and laboratory values were compared at various observation time points.Tissue samples immediately after animal euthanasia from the myocardium,liver,kidneys,and duodenum were collected for histological assessment using hematoxylin and eosin staining.RESULTS:Compared with the control group,the survival rate of the REBOA groups was prominently improved(all P<0.05).The total volume of blood loss was markedly lower in the cREBOA group(493.14±127.31 mL)compared with other groups(P<0.01).The pH was significantly lower at 180 min in the cREBOA and S-pREBOA groups(P<0.05).At 120 min,the S-pREBOA group showed higher alanine aminotransferase(P<0.05)but lower blood urea nitrogen compared with the cREBOA group(P<0.05).CONCLUSION:In this trauma model with liver injury,a 60-minute pREBOA resulted in improved survival rate and was effective in maintaining reliable aortic pressure,despite persistent hemorrhage.Extended tolerance time for aortic occlusion in Zone I for non-compressible torso hemorrhage was feasible with both continuous partial and sequential partial measures,and the significant improvement in the severity of acidosis and distal organ injury was observed in the sequential pREBOA.展开更多
基金support of the Australian Government Research Training Program Scholarshipthe Sports Medicine Australia Research Foundation,which providcd partial funding towards this study。
文摘Purpose:This study investigated the effects of obesity on breast size,thoracic spine structure and function,upper torso musculoskeletal pain and physical activity participation in women living independently in the community.Methods:A total of 378 women were divided into 3 groups(Not Overweight:body mass index(BMI)=22.5±0.2 kg/m^2(mean±SE);Overweight:BMI=27.4±0.3 kg/m^2;Obese:BMI=35.4±0.3 kg/m^2).Outcome variables of breast volume(mL),thoracic flexion torque(N·m),thoracic kyphosis(degrees),upper torso musculoskeletal pain(score) and time spent in physical activity(min) were calculated and compared among the 3 groups,adjusting for between-group differences in age.Results:There was a significant main effect of BMI on all outcome variables.Participants classified as Obese displayed significantly larger breasts,had greater thoracic flexion torques and reported less time participating in physical activity relative to the participants who were classified as Not Overweight and Overweight.Participants in the Obese group also displayed significantly more thoracic kyphosis and reported significantly more upper torso musculoskeletal pain compared to their counterparts who were classified as Not Overweight.Conclusion:This study is the first to demonstrate that increased obesity levels were associated with compromised kyphosis and loading of the thoracic spine,as well as increased symptoms of upper torso musculoskeletal pain and reduced time spent in physical activity in women living in the community.We recommend further research to determine whether evidence-based interventions designed to reduce the flexion torque generated on the thoracic spine can improve these symptoms of upper torso musculoskeletal pain and the ability of women with obesity to participate in physical activity.
基金Project supported by the State Key Development Program for Basic Research of China(Grant No.2006CB601007)the National Natural Science Foundation of China(Grant No.10674006)the National High Technology Research and Development Program of China(Grant No.2007AA03Z238)
文摘This paper constructs a concentric ellipsoid torso-heart model by boundary element method and investigates the impacts of model structures on the cardiac magnetic fields generated by both equivalent primary source--a current dipole and volume currents. Then by using the simulated magnetic fields based on torso-heart model as input, the cardiac current sources--an array of current dipoles by optimal constrained linear inverse method are constructed. Next, the current dipole array reconstruction considering boundaries is compared with that in an unbounded homogeneous medium. Furthermore, the influence of random noise on reconstruction is also considered and the reconstructing effect is judged by several reconstructing parameters.
基金Department of Defense Joint Program Committee(JPC-6)
文摘Background: In combat operations, patients with traumatic injuries require expeditious evacuation to improve survival. Studies have shown that long transport times are associated with increased morbidity and mortality. Limited data exist on the influence of transport time on patient outcomes with specific injury types. The objective of this study was to determine the impact of the duration of time from the initial request for medical evacuation to arrival at a medical treatment facility on morbidity and mortality in casualties with traumatic extremity amputation and noncompressible torso injury(NCTI).Methods: We completed a retrospective review of MEDEVAC patient care records for United States military personnel who sustained traumatic amputations and NCTI during Operation Enduring Freedom between January 2011 and March 2014. We grouped patients as traumatic amputation and NCTI(AMP+NCTI), traumatic amputation only(AMP),and neither AMP nor NCTI(Non-AMP/NCTI). Analysis was performed using chi-squared tests, Fisher's exact tests,Cochran-Armitage Trend tests, Shapiro-Wilks tests, Wilcoxon and Kruskal-Wallis techniques and Cox proportional hazards regression modeling.Results: We reviewed 1267 records, of which 669 had an injury severity score(ISS) of 10 or greater and were included in the analysis. In the study population, 15.5% sustained only amputation injuries(n=104, AMP only), 10.8% sustained amputation and NCTI(n=72, AMP+NCTI), and 73.7% did not sustain either an amputation or an NCTI(n=493,Non-AMP/NCTI). AMP+NCTI had the highest mortality(16.7%) with transport time greater than 60 min. While the AMP+NCTI group had decreasing survival with longer transport times, AMP and Non-AMP/NCTI did not exhibit the same trend.Conclusions: A decreased transport time from the point of injury to a medical treatment facility was associated with decreased mortality in patients who suffered a combination of amputation injury and NCTI. No significant association between transport time and outcomes was found in patients who did not sustain NCTI. Priority for rapid evacuation of combat casualties should be given to those with NCTI.
文摘Low collateral damage weapons achieve controlled personnel injury through the coupling of shock waves and particle swarms,where the particle swarms arise from the high-explosive dispersion of compacted metal particle ring.To investigate the dynamic response of the human target under combined shock waves and particle swarms loading,a physical human surrogate torso model(HSTM)was developed,and the dynamic response test experiment was conducted under the combined loading.The effects of particle size on the loading parameters,the damage patterns of the ballistic plate and HSTM,and the dynamic response parameters of the HSTM with and without protection are mainly analyzed.Our findings revealed that particle swarms can effectively delay the shock wave attenuation,especially the best effect when the particle size was 0.28–0.45 mm.The ballistic plate mainly exhibited dense perforation of the outer fabric and impacted crater damage of ceramic plates,whereas the unprotected HSTM was mainly dominated by high-density and small-size ballistic cavity group damage.The peak values of the dynamic response parameters for the HSTM under combined loading were significantly larger than those under bare charge loading,with multiple peaks observed.Under unprotected conditions,the peak acceleration of skeletons and peak pressure of organs increased with the particle size.Under protected conditions,the particle size,the number of particles hit,and the fit of the ballistic plate to the HSTM together affected the dynamic response parameters of the HSTM.
基金This work was supported by research funding of Clinical Technology Innovation Cultivation Program of Army Medical University(CX2019JS109)Innovation Developing Program of Army Medical Center(2019CXJX018).
文摘With the widespread adoption of advanced tourniquets,the mortality rate of limb wound hemorrhage has decreased significantly,and non-compressible torso hemorrhage has gradually occupied the leading position of potentially preventable death,both in military and civilian circumstances.With the emergence of novel hemostatic devices and materials,strategies for the management of non-compressible torso hemorrhage have changed significantly.This review summarizes the current treatment strategies and types of equipment for non-compressible torso hemorrhage and suggests future research directions,hoping to provide a comprehensive review for the medical personnel and researchers engaging in this field.
文摘Human-like torso features are essential in humanoid robots. In this paper problems for design and operation of solutions for a robotic torso are discussed by referring to experiences and designs that have been developed at Laboratory of Robotics and Mechatronics （LARM） in Cassino, Italy. A new solution is presented with conceptual views as waist-trunk structure that makes a proper partition of the performance for walking and arm operations as sustained by a torso.
文摘The torso plays an important role in the human-like operation of humanoids. In this paper, a method is proposed to analyze the behavior of the human torso by using inertial and magnetic sensing tools. Experiments are conducted to characterize the motion performance of the human torso during daily routine operations. Furthermore, the forces acting on the human body during these operations are evaluated to design and validate the performance of a humanoid robot.
基金supported by grants from National Postdoctoral Program for Innovative Talents Grant(BX20190350)China Postdoctoral Science Foundation Grant(2019M661654).
文摘Insect growth and development are precisely controlled by hormone homeostasis.The prothoracicotropic hormone(PTTH)receptor,Torso,is a member of the receptor tyrosine kinase family in insects.Activation of Torso by PTTH triggers biosynthesis and release of the steroid hormone in the prothoracic gland(PG).Although numbers of genes functioning in steroid hormone synthesis and metabolism have been identified in insects,the PTTH transduction pathway via its receptor Torso is poorly understood.In the current study,we describe a loss-of-function analysis of Torso in the silkworm,Bombyx mori,by targeted gene disruption using the transgenic CRISPR/Cas9(clustered regularly interspaced short palindromic repeats/RNA-guided Cas9 nucleases)system.Depletion of B.mori Torso(BmTorso)did not eventually affect larval ecdysis and metamorphosis processes.Instead,BmTorso deficiency resulted in significant extension of developing time during larval and pupal stages with increased pupa and cocoon sizes.The eedysteriod titers in the hemolymph of BmTorso mutants sharpy declined.Transcriptional levels of genes involved in ecdysone biosynthesis and eedysteroid signaling pathways were significantly reduced in BniTorso-defic'iQnt animals.Additionally,RNA-Seq analysis revealed that genes involved in the longevity pathway and protein processing in the endoplasmic reticulum pathway were affected after BmTorso deletion.These results indicate that Torso is critical for maintaining steroid hormone homeostasis in insects.
基金supported by military logistics scientific research project(AHJ16J004)。
文摘BACKGROUND:Resuscitative endovascular balloon occlusion of the aorta(REBOA)can temporarily control traumatic bleeding.However,its prolonged use potentially leads to ischemia-reperfusion injury(IRI).Partial REBOA(pREBOA)can alleviate ischemic burden;however,its security and eff ectiveness prior to operative hemorrhage control remains unknown.Hence,we aimed to estimate the effi cacy of pREBOA in a swine model of liver injury using an experimental sliding-chamber ballistic gun.METHODS:Twenty Landrace pigs were randomized into control(no aortic occlusion)(n=5),intervention with complete REBOA(cREBOA)(n=5),continuous pREBOA(C-pREBOA)(n=5),and sequential pREBOA(S-pREBOA)(n=5)groups.In the cREBOA and C-pREBOA groups,the balloon was inflated for 60 min.The hemodynamic and laboratory values were compared at various observation time points.Tissue samples immediately after animal euthanasia from the myocardium,liver,kidneys,and duodenum were collected for histological assessment using hematoxylin and eosin staining.RESULTS:Compared with the control group,the survival rate of the REBOA groups was prominently improved(all P<0.05).The total volume of blood loss was markedly lower in the cREBOA group(493.14±127.31 mL)compared with other groups(P<0.01).The pH was significantly lower at 180 min in the cREBOA and S-pREBOA groups(P<0.05).At 120 min,the S-pREBOA group showed higher alanine aminotransferase(P<0.05)but lower blood urea nitrogen compared with the cREBOA group(P<0.05).CONCLUSION:In this trauma model with liver injury,a 60-minute pREBOA resulted in improved survival rate and was effective in maintaining reliable aortic pressure,despite persistent hemorrhage.Extended tolerance time for aortic occlusion in Zone I for non-compressible torso hemorrhage was feasible with both continuous partial and sequential partial measures,and the significant improvement in the severity of acidosis and distal organ injury was observed in the sequential pREBOA.
