Histone methylation is one of the most widely studied post-transcriptional modifications. It is thought to be an important epigenetic event that is closely associated with cell fate determination and differentiation. ...Histone methylation is one of the most widely studied post-transcriptional modifications. It is thought to be an important epigenetic event that is closely associated with cell fate determination and differentiation. To explore the spatiotemporal expression of histone H3 lysine 4trimethylation（H3K4me3） and histone H3 lysine 27 trimethylation（H3K27me3） epigenetic marks and methylation or demethylation transferases in tooth organ development, we measured the expression of SET7, EZH2, KDM5 B and JMJD3 via immunohistochemistry and quantitative polymerase chain reaction（qP CR） analysis in the first molar of BALB/c mice embryos at E13.5, E15.5, E17.5, P0 and P3, respectively. We also measured the expression of H3K4me3 and H3K27me3 with immunofluorescence staining. During murine tooth germ development, methylation or demethylation transferases were expressed in a spatial–temporal manner. The bivalent modification characterized by H3K4me3 and H3K27me3 can be found during the tooth germ development, as shown by immunofluorescence. The expression of SET7, EZH2 as methylation transferases and KDM5 B and JMJD3 as demethylation transferases indicated accordingly with the expression of H3K4me3 and H3K27me3 respectively to some extent. The bivalent histone may play a critical role in tooth organ development via the regulation of cell differentiation.展开更多
Tooth modification technique is widely used in gear industry to improve the meshing performance of gearings. However, few of the present studies on tooth modification considers the influence of inevitable random error...Tooth modification technique is widely used in gear industry to improve the meshing performance of gearings. However, few of the present studies on tooth modification considers the influence of inevitable random errors on gear modification effects. In order to investigate the uncertainties of tooth modification amount variations on system＇s dynamic behaviors of a helical planetary gears, an analytical dynamic model including tooth modification parameters is proposed to carry out a deterministic analysis on the dynamics of a helical planetary gear. The dynamic meshing forces as well as the dynamic transmission errors of the sun-planet 1 gear pair with and without tooth modifications are computed and compared to show the effectiveness of tooth modifications on gear dynamics enhancement. By using response surface method, a fitted regression model for the dynamic transmission error（DTE） fluctuations is established to quantify the relationship between modification amounts and DTE fluctuations. By shifting the inevitable random errors arousing from manufacturing and installing process to tooth modification amount variations, a statistical tooth modification model is developed and a methodology combining Monte Carlo simulation and response surface method is presented for uncertainty analysis of tooth modifications. The uncertainly analysis reveals that the system＇s dynamic behaviors do not obey the normal distribution rule even though the design variables are normally distributed. In addition, a deterministic modification amount will not definitely achieve an optimal result for both static and dynamic transmission error fluctuation reduction simultaneously.展开更多
To reduce vibration and noise and increase transmission efficiency, a three segment method for modifying the pinion profile was proposed. Cutter surface equations were deduced by changing the shape of the cutter-edge,...To reduce vibration and noise and increase transmission efficiency, a three segment method for modifying the pinion profile was proposed. Cutter surface equations were deduced by changing the shape of the cutter-edge, substituting three segment parabolas for the line. The influence of longitudinal tooth modifications on tooth surface load distributions was discussed. Transmission error minimization and uniformity of tooth surface load distribution were chosen as optimization goals and the modified parameters were obtained by applying the complex method. Finally, an experiment comparing the loaded transmission error, vibration, and noise both before and after modifications was carried out. The results indicate that the modified design is reliable.展开更多
Gear assembly errors can lead to the increase of vibration and noise of the system,which affect the stability of system.The influence can be compensated by tooth modification.Firstly,an improved three-dimensional load...Gear assembly errors can lead to the increase of vibration and noise of the system,which affect the stability of system.The influence can be compensated by tooth modification.Firstly,an improved three-dimensional loaded tooth contact analysis(3D-LTCA)method which can consider tooth modification and coupling assembly errors is proposed,and mesh stiffness calculated by proposed method is verified by MASTA software.Secondly,based on neural network,the surrogate model(SM)that maps the relationship between modification parameters and mesh mechanical parameters is established,and its accuracy is verified.Finally,SM is introduced to establish an optimization model with the target of minimizing mesh stiffness variations and obtaining more even load distribution on mesh surface.The results show that even considering training time,the efficiency of gear pair optimization by surrogate model is still much higher than that by LTCA method.After optimization,the mesh stiffness fluctuation of gear pair with coupling assembly error is reduced by 34.10%,and difference in average contact stresses between left and right regions of the mesh surface is reduced by 62.84%.展开更多
In order to analyze the lubricating characteristics at different meshing points in the cycloid pin wheel transmission process,the cycloid gear teeth were discretized,combined with the kinematic analysis of the cycloid...In order to analyze the lubricating characteristics at different meshing points in the cycloid pin wheel transmission process,the cycloid gear teeth were discretized,combined with the kinematic analysis of the cycloid pin gear transmission and the contact analysis of the gear teeth.The progressive mesh densification method(PMD)was used to numerically solve the film thickness.The influence of the design parameters and process parameters on the lubrication characteristics was analyzed.The elastohydrodynamic lubrication and mixed lubrication characteristics at different contact points were obtained.The optimal meshing area of the cycloid gear tooth was determined,and the film thickness ratio,contact load ratio,maximum contact pressure at different points,average film thickness and roughness after contact deformation were analyzed.The conclusion of this study provides effective guidance for the research on the modification of cycloid gear teeth.展开更多
Gears are important mechanical parts for transmitting power and play an increasingly important role in the machinery industry.The electric vehicle industry developed rapidly and became a vital development field of the...Gears are important mechanical parts for transmitting power and play an increasingly important role in the machinery industry.The electric vehicle industry developed rapidly and became a vital development field of the automotive industry over the past few years.The conversion of energy increases the requirements for electric vehicle transmissions,which promotes the development of high-speed and low-noise transmission gear.This paper elaborates on the research progress of high-speed and low-noise gear finishing methods.Firstly,this review analyses the machining requirements,finishing,and specific machining technologies of high-speed and low-noise gears.The importance of gear grinding and honing in high-speed and low-noise gear machining is highlighted.Secondly,the applications of gear grinding and honing in gear modification,error compensation,and texture control are analyzed.Furthermore,the role of precision machining technology in improving gear performance is clarified.Finally,the design and processing methods of the modified tooth flank for gear modification are summarized.In addition,the influence of tooth surface texture on noise is described,and the texture change methods are explored.The well-known open problems of gear finishing are finally identified,and some new research interests are also pointed out.This review will provide valuable references for further research on gear finishing.展开更多
Based on the study of the meshing theory of a new silent chain and sprockets, and the rolling cutting theory of sprocket and hob, the harmonious relations of dominating dimensions among the new silent chain, sprocket ...Based on the study of the meshing theory of a new silent chain and sprockets, and the rolling cutting theory of sprocket and hob, the harmonious relations of dominating dimensions among the new silent chain, sprocket and hob is build, the meshing conditions are expatiated, and the resolved expression, which can instruct design and calculation, is educed. The tests show that the meshing design method is feasible.展开更多
基金supported by National Science Foundation of China (Grant No. 81371136) to Xue-Dong ZhouNational Science Foundation of China (Grant No. 81200760 and 81470711) to Li-Wei Zheng
文摘Histone methylation is one of the most widely studied post-transcriptional modifications. It is thought to be an important epigenetic event that is closely associated with cell fate determination and differentiation. To explore the spatiotemporal expression of histone H3 lysine 4trimethylation（H3K4me3） and histone H3 lysine 27 trimethylation（H3K27me3） epigenetic marks and methylation or demethylation transferases in tooth organ development, we measured the expression of SET7, EZH2, KDM5 B and JMJD3 via immunohistochemistry and quantitative polymerase chain reaction（qP CR） analysis in the first molar of BALB/c mice embryos at E13.5, E15.5, E17.5, P0 and P3, respectively. We also measured the expression of H3K4me3 and H3K27me3 with immunofluorescence staining. During murine tooth germ development, methylation or demethylation transferases were expressed in a spatial–temporal manner. The bivalent modification characterized by H3K4me3 and H3K27me3 can be found during the tooth germ development, as shown by immunofluorescence. The expression of SET7, EZH2 as methylation transferases and KDM5 B and JMJD3 as demethylation transferases indicated accordingly with the expression of H3K4me3 and H3K27me3 respectively to some extent. The bivalent histone may play a critical role in tooth organ development via the regulation of cell differentiation.
基金Supported by National Natural Science Foundation of China(Grant No.51375013)Anhui Provincial Natural Science Foundation of China(Grant No.1208085ME64)
文摘Tooth modification technique is widely used in gear industry to improve the meshing performance of gearings. However, few of the present studies on tooth modification considers the influence of inevitable random errors on gear modification effects. In order to investigate the uncertainties of tooth modification amount variations on system＇s dynamic behaviors of a helical planetary gears, an analytical dynamic model including tooth modification parameters is proposed to carry out a deterministic analysis on the dynamics of a helical planetary gear. The dynamic meshing forces as well as the dynamic transmission errors of the sun-planet 1 gear pair with and without tooth modifications are computed and compared to show the effectiveness of tooth modifications on gear dynamics enhancement. By using response surface method, a fitted regression model for the dynamic transmission error（DTE） fluctuations is established to quantify the relationship between modification amounts and DTE fluctuations. By shifting the inevitable random errors arousing from manufacturing and installing process to tooth modification amount variations, a statistical tooth modification model is developed and a methodology combining Monte Carlo simulation and response surface method is presented for uncertainty analysis of tooth modifications. The uncertainly analysis reveals that the system＇s dynamic behaviors do not obey the normal distribution rule even though the design variables are normally distributed. In addition, a deterministic modification amount will not definitely achieve an optimal result for both static and dynamic transmission error fluctuation reduction simultaneously.
基金Supported by the National Natural Science Foundation under Grant No. 50875211
文摘To reduce vibration and noise and increase transmission efficiency, a three segment method for modifying the pinion profile was proposed. Cutter surface equations were deduced by changing the shape of the cutter-edge, substituting three segment parabolas for the line. The influence of longitudinal tooth modifications on tooth surface load distributions was discussed. Transmission error minimization and uniformity of tooth surface load distribution were chosen as optimization goals and the modified parameters were obtained by applying the complex method. Finally, an experiment comparing the loaded transmission error, vibration, and noise both before and after modifications was carried out. The results indicate that the modified design is reliable.
基金Project(11972112)supported by the National Natural Science Foundation of ChinaProject(N2103024)supported by the Fundamental Research Funds for the Central Universities,ChinaProject(J2019-IV-0018-0086)supported by the National Science and Technology Major Project,China。
文摘Gear assembly errors can lead to the increase of vibration and noise of the system,which affect the stability of system.The influence can be compensated by tooth modification.Firstly,an improved three-dimensional loaded tooth contact analysis(3D-LTCA)method which can consider tooth modification and coupling assembly errors is proposed,and mesh stiffness calculated by proposed method is verified by MASTA software.Secondly,based on neural network,the surrogate model(SM)that maps the relationship between modification parameters and mesh mechanical parameters is established,and its accuracy is verified.Finally,SM is introduced to establish an optimization model with the target of minimizing mesh stiffness variations and obtaining more even load distribution on mesh surface.The results show that even considering training time,the efficiency of gear pair optimization by surrogate model is still much higher than that by LTCA method.After optimization,the mesh stiffness fluctuation of gear pair with coupling assembly error is reduced by 34.10%,and difference in average contact stresses between left and right regions of the mesh surface is reduced by 62.84%.
基金Project(E2019209153)supported by the Natural Science Foundation of Hebei Province,China。
文摘In order to analyze the lubricating characteristics at different meshing points in the cycloid pin wheel transmission process,the cycloid gear teeth were discretized,combined with the kinematic analysis of the cycloid pin gear transmission and the contact analysis of the gear teeth.The progressive mesh densification method(PMD)was used to numerically solve the film thickness.The influence of the design parameters and process parameters on the lubrication characteristics was analyzed.The elastohydrodynamic lubrication and mixed lubrication characteristics at different contact points were obtained.The optimal meshing area of the cycloid gear tooth was determined,and the film thickness ratio,contact load ratio,maximum contact pressure at different points,average film thickness and roughness after contact deformation were analyzed.The conclusion of this study provides effective guidance for the research on the modification of cycloid gear teeth.
基金Supported by National Natural Science Foundation of China(Grant Nos.52275483,52075142,and U22B2084)the Fundamental Research Funds for the Central Universities of China(Grant No.JZ2023HGPA0292).
文摘Gears are important mechanical parts for transmitting power and play an increasingly important role in the machinery industry.The electric vehicle industry developed rapidly and became a vital development field of the automotive industry over the past few years.The conversion of energy increases the requirements for electric vehicle transmissions,which promotes the development of high-speed and low-noise transmission gear.This paper elaborates on the research progress of high-speed and low-noise gear finishing methods.Firstly,this review analyses the machining requirements,finishing,and specific machining technologies of high-speed and low-noise gears.The importance of gear grinding and honing in high-speed and low-noise gear machining is highlighted.Secondly,the applications of gear grinding and honing in gear modification,error compensation,and texture control are analyzed.Furthermore,the role of precision machining technology in improving gear performance is clarified.Finally,the design and processing methods of the modified tooth flank for gear modification are summarized.In addition,the influence of tooth surface texture on noise is described,and the texture change methods are explored.The well-known open problems of gear finishing are finally identified,and some new research interests are also pointed out.This review will provide valuable references for further research on gear finishing.
基金This project is supported by National Natural Science Foundation of China (No.50275062)National Machine Industry Technique Development Foundation of China(No.99JA0002).
文摘Based on the study of the meshing theory of a new silent chain and sprockets, and the rolling cutting theory of sprocket and hob, the harmonious relations of dominating dimensions among the new silent chain, sprocket and hob is build, the meshing conditions are expatiated, and the resolved expression, which can instruct design and calculation, is educed. The tests show that the meshing design method is feasible.
