The 21^(st) century has started with several innovations in the medical sciences,with wide applications in health care management.This development has taken in the field of medicines(newer drugs/molecules),various too...The 21^(st) century has started with several innovations in the medical sciences,with wide applications in health care management.This development has taken in the field of medicines(newer drugs/molecules),various tools and technology which has completely changed the patient management including abdominal surgery.Surgery for abdominal diseases has moved from maximally invasive to minimally invasive(laparoscopic and robotic)surgery.Some of the newer medicines have its impact on need for surgical intervention.This article focuses on the development of these emerging molecules,tools,and technology and their impact on present surgical form and its future effects on the surgical intervention in gastroenterological diseases.展开更多
Over the past decade,artificial intelligence has transformed from a mere technological tool into a formidable force that is redefining global power relations.Its impact extends deeply into areas such as social governa...Over the past decade,artificial intelligence has transformed from a mere technological tool into a formidable force that is redefining global power relations.Its impact extends deeply into areas such as social governance,economic systems,and national security.The AI Index highlights this transformation:in 2016,only one country had enacted AI-specific legislation,but by 2022,the number had grown to 37.This rapid increase reflects a growing international consensus on the strategic importance of AI.展开更多
Aero-engines,the core of air travel,rely on advanced high strength-toughness alloys(THSAs)such as titanium alloys,nickel-based superalloys,intermetallics,and ultra-high strength steel.The precision of cutting techniqu...Aero-engines,the core of air travel,rely on advanced high strength-toughness alloys(THSAs)such as titanium alloys,nickel-based superalloys,intermetallics,and ultra-high strength steel.The precision of cutting techniques is crucial for the manufacture of key components,including blades,discs,shafts,and gears.However,machining THSAs pose significant challenges,including high cutting forces and temperatures,which lead to rapid tool wear,reduced efficiency,and compromised surface integrity.This review thoroughly explores the current landscape and future directions of cutting techniques for THSAs in aero-engines.It examines the principles,mechanisms,and benefits of energy-assisted cutting technologies like laser-assisted machining and cryogenic cooling.The review assesses various tool preparation methods,their effects on tool performance,and strategies for precise shape and surface integrity control.It also outlines intelligent monitoring technologies for machining process status,covering aspects such as tool wear,surface roughness,and chatter,contributing to intelligent manufacturing.Additionally,it highlights emerging trends and potential future developments,including multi-energy assisted cutting mechanisms,advanced cutting tools,and collaborative control of structure shape and surface integrity,alongside intelligent monitoring software and hardware.This review serves as a reference for achieving efficient and high-quality manufacturing of THSAs in aero-engines.展开更多
The presented work will show the highest relevance of solving all the issues related to this problem and present the results of the analysis of the main expected potential problems,which may occur in the implementatio...The presented work will show the highest relevance of solving all the issues related to this problem and present the results of the analysis of the main expected potential problems,which may occur in the implementation of the INDUSTRY-4.0 reform.It is proved that the pace and level of development of this reform will be determined to a large extent by the effectiveness of the individual nodes used and the entire mechatronic system.It has also been established that as a result of systematic miniaturization of the nodes of radio-electronic equipment and microelectronic equipment and microelectronic technology,the main problem of these reforms and the implementation of complex technological processes is instrumental and technological support,especially with cutting micro-tools and equipment.Therefore,on the example of these investigations,methods for improving their performance are shown.展开更多
This study presents an in-depth examination of the impact of educational gamification on middle school students’learning motivation through a mixed-methods approach.The integration of quantitative survey data and qua...This study presents an in-depth examination of the impact of educational gamification on middle school students’learning motivation through a mixed-methods approach.The integration of quantitative survey data and qualitative interviews and observations revealed that gamification significantly enhances intrinsic motivation by increasing interest and engagement in a learning environment.The study also found that gamification indirectly boosts extrinsic motivation through the augmentation of social interaction and learning engagement.Structural equation modeling underscored the direct and indirect effects of gamification on learning motivation.The findings suggest that educators should integrate gamification elements into their teaching designs,focus on fulfilling students’psychological needs for autonomy,competence,and relatedness,and leverage social interactions to foster motivation.The study’s contributions to the educational field include empirical evidence of gamification’s impact and a multidimensional perspective that strengthens the depth of understanding in the application of gamification.However,the study acknowledges limitations such as potential biases and a non-representative sample,calling for future research to address these issues through broader and longitudinal studies.展开更多
Disodium 5′-ribonucleotide,which is composed of disodium 5′-inosine(IMP)and disodium 5′-guanosine(GMP),is an important food additive.The lack of kinetic studies of it causes a lack of clarity in understanding the c...Disodium 5′-ribonucleotide,which is composed of disodium 5′-inosine(IMP)and disodium 5′-guanosine(GMP),is an important food additive.The lack of kinetic studies of it causes a lack of clarity in understanding the complicated multi-solute crystallization of IMP+GMP in ethanol-water.In this work,process analytical technology tools were used to obtain the thermodynamics and kinetic data from the experiments,the kinetic parameters of anti-solvent and cooling crystallization were investigated.The crystal form of IMP+GMP mixed crystal was determined,which was consistent with the IMP whether crystallized from pure water or ethanol-water.The effects of different anti-solvent addition rates and cooling rates on the metastable zone widths were studied,and the opposite effect on metastable zone width was found.The modified exponential empirical function was developed to correlate nucleation and growth kinetic equations under different conditions.The kinetic data were well fitted with adjusted correlation coefficient(adj-R^(2)>0.7),which is sufficient to provide a valid reference for process design and control.展开更多
文摘The 21^(st) century has started with several innovations in the medical sciences,with wide applications in health care management.This development has taken in the field of medicines(newer drugs/molecules),various tools and technology which has completely changed the patient management including abdominal surgery.Surgery for abdominal diseases has moved from maximally invasive to minimally invasive(laparoscopic and robotic)surgery.Some of the newer medicines have its impact on need for surgical intervention.This article focuses on the development of these emerging molecules,tools,and technology and their impact on present surgical form and its future effects on the surgical intervention in gastroenterological diseases.
文摘Over the past decade,artificial intelligence has transformed from a mere technological tool into a formidable force that is redefining global power relations.Its impact extends deeply into areas such as social governance,economic systems,and national security.The AI Index highlights this transformation:in 2016,only one country had enacted AI-specific legislation,but by 2022,the number had grown to 37.This rapid increase reflects a growing international consensus on the strategic importance of AI.
基金National Natural Science Foundation of China(Nos.92160301,92060203,52175415,and 52205475)Science Center for Gas Turbine Project(No.P2023-B-IV-003-001)+1 种基金Natural Science Foundation of Jiangsu Province(No.BK20210295)Fundamental Research Funds for the Central Universities(Nos.NS2023028 and NG2024015)。
文摘Aero-engines,the core of air travel,rely on advanced high strength-toughness alloys(THSAs)such as titanium alloys,nickel-based superalloys,intermetallics,and ultra-high strength steel.The precision of cutting techniques is crucial for the manufacture of key components,including blades,discs,shafts,and gears.However,machining THSAs pose significant challenges,including high cutting forces and temperatures,which lead to rapid tool wear,reduced efficiency,and compromised surface integrity.This review thoroughly explores the current landscape and future directions of cutting techniques for THSAs in aero-engines.It examines the principles,mechanisms,and benefits of energy-assisted cutting technologies like laser-assisted machining and cryogenic cooling.The review assesses various tool preparation methods,their effects on tool performance,and strategies for precise shape and surface integrity control.It also outlines intelligent monitoring technologies for machining process status,covering aspects such as tool wear,surface roughness,and chatter,contributing to intelligent manufacturing.Additionally,it highlights emerging trends and potential future developments,including multi-energy assisted cutting mechanisms,advanced cutting tools,and collaborative control of structure shape and surface integrity,alongside intelligent monitoring software and hardware.This review serves as a reference for achieving efficient and high-quality manufacturing of THSAs in aero-engines.
基金This work was supported by Shota Rustaveli National Science Foundation(SRNSF)[PHDF-19-2224,Improving the efficiency of mechatronic systems in order to ensure the reform of“Industry-4.0”].
文摘The presented work will show the highest relevance of solving all the issues related to this problem and present the results of the analysis of the main expected potential problems,which may occur in the implementation of the INDUSTRY-4.0 reform.It is proved that the pace and level of development of this reform will be determined to a large extent by the effectiveness of the individual nodes used and the entire mechatronic system.It has also been established that as a result of systematic miniaturization of the nodes of radio-electronic equipment and microelectronic equipment and microelectronic technology,the main problem of these reforms and the implementation of complex technological processes is instrumental and technological support,especially with cutting micro-tools and equipment.Therefore,on the example of these investigations,methods for improving their performance are shown.
文摘This study presents an in-depth examination of the impact of educational gamification on middle school students’learning motivation through a mixed-methods approach.The integration of quantitative survey data and qualitative interviews and observations revealed that gamification significantly enhances intrinsic motivation by increasing interest and engagement in a learning environment.The study also found that gamification indirectly boosts extrinsic motivation through the augmentation of social interaction and learning engagement.Structural equation modeling underscored the direct and indirect effects of gamification on learning motivation.The findings suggest that educators should integrate gamification elements into their teaching designs,focus on fulfilling students’psychological needs for autonomy,competence,and relatedness,and leverage social interactions to foster motivation.The study’s contributions to the educational field include empirical evidence of gamification’s impact and a multidimensional perspective that strengthens the depth of understanding in the application of gamification.However,the study acknowledges limitations such as potential biases and a non-representative sample,calling for future research to address these issues through broader and longitudinal studies.
基金Financial supports from the National Natural Science Foundation of China (Nos.22178121 and 21908254)are greatly appreciated.
文摘Disodium 5′-ribonucleotide,which is composed of disodium 5′-inosine(IMP)and disodium 5′-guanosine(GMP),is an important food additive.The lack of kinetic studies of it causes a lack of clarity in understanding the complicated multi-solute crystallization of IMP+GMP in ethanol-water.In this work,process analytical technology tools were used to obtain the thermodynamics and kinetic data from the experiments,the kinetic parameters of anti-solvent and cooling crystallization were investigated.The crystal form of IMP+GMP mixed crystal was determined,which was consistent with the IMP whether crystallized from pure water or ethanol-water.The effects of different anti-solvent addition rates and cooling rates on the metastable zone widths were studied,and the opposite effect on metastable zone width was found.The modified exponential empirical function was developed to correlate nucleation and growth kinetic equations under different conditions.The kinetic data were well fitted with adjusted correlation coefficient(adj-R^(2)>0.7),which is sufficient to provide a valid reference for process design and control.
