Background: Clinical decision support tools provide suggestions to support healthcare providers and clinicians, as they attend to patients. Clinicians use these tools to rapidly consult the evidence at the point of ca...Background: Clinical decision support tools provide suggestions to support healthcare providers and clinicians, as they attend to patients. Clinicians use these tools to rapidly consult the evidence at the point of care, a practice which has been found to reduce the time patients spend in hospitals, promote the quality of care and improve healthcare outcomes. Such tools include Medscape, VisualDx, Clinical Key, DynaMed, BMJ Best Practice and UpToDate. However, use of such tools has not yet been fully embraced in low-resource settings such as Uganda. Objective: This paper intends to collate data on the use and uptake of one such tool, UpToDate, which was provided at no cost to five medical schools in Uganda. Methods: Free access to UpToDate was granted through the IP addresses of five medical schools in Uganda in collaboration with Better Evidence at The Global Health Delivery Project at Harvard and Brigham and Women’s Hospital and Wolters Kluwer Health. Following the donation, medical librarians in the respective institutions conducted training sessions and created awareness of the tool. Usage data was aggregated, based on logins and content views, presented and analyzed using Excel tables and graphs. Results: The data shows similar trends in increased usage over the period of August 2022 to August 2023 across the five medical schools. The most common topics viewed, mode of access (using either the computer or the mobile app), total usage by institution, ratio of uses to eligible users by institution and ratio of uses to students by institution are shared. Conclusion: The study revealed that the tool was used by various user categories across the institutions with similar steady improved usage over the year. These results can inform the librarians as they encourage their respective institutions to continue using the tool to support uptake of point-of-care tools in clinical practice.展开更多
Base editing, as an expanded clustered regularly interspaced short palindromic repeats(CRISPR)-Cas genome editing strategy, permits precise and irreversible nucleotide conversion. SaKKH, an efficient variant of a Cas9...Base editing, as an expanded clustered regularly interspaced short palindromic repeats(CRISPR)-Cas genome editing strategy, permits precise and irreversible nucleotide conversion. SaKKH, an efficient variant of a Cas9 ortholog from Staphylococcus aureus(SaCas9), is important in genome editing because it can edit sites with HHHAAT protospacer adjacent motif(PAM) that the canonical Streptococcus pyogenes Cas9(SpCas9) or its variants(e.g. xCas9, Cas9-NG) cannot. However, several technical parameters of SaKKH involved base editors have not been well defined and this uncertainty limits their application. We developed an effective multiplex cytosine base editor(SaKKHn-pBE) and showed that it recognized NNARRT, NNCRRT, NNGRGT, and NNTRGT PAMs. Based on 27 targets tested, we defined technical parameters of SaKKHn-pBE including the editing window, the preferred sequence context, and the mutation type. The editing efficiency was further improved by modification of the SaKKH sgRNA. These advances can be applied in future research and molecular breeding in rice and other plants.展开更多
This paper outlines a framework to use computer and natural language techniques for various levels of learners to learn foreign languages in Computer-based Learning environment.We propose some ideas for using the comp...This paper outlines a framework to use computer and natural language techniques for various levels of learners to learn foreign languages in Computer-based Learning environment.We propose some ideas for using the computer as a practical tool for learning foreign language where the most of courseware is generated automatically.We then describe how to build Computer-based Learning tools,discuss its effectiveness,and conclude with some possibilities using on-line resources.展开更多
In recent decades, many additives with different characteristics have been applied to strengthen and toughen Al2O3-based ceramic cutting tool materials. Among them, SiC whiskers and SiC nanoparticles showed excellent ...In recent decades, many additives with different characteristics have been applied to strengthen and toughen Al2O3-based ceramic cutting tool materials. Among them, SiC whiskers and SiC nanoparticles showed excellent performance in improving the material properties. While no attempts have been made to add SiC whiskers and SiC nanoparticles together into the ceramic matrix and the synergistically toughening effects of them have not been studied. An Al2O3-SiCw-SiC np advanced ceramic cutting tool material is fabricated by adding both one-dimensional SiC whiskers and zero-dimensional SiC nanoparticles into the Al2O3 matrix with an effective dispersing and mixing process. The composites with 25 vol% SiC whiskers and 25 vol% SiC nanoparticles alone are also investegated for comparison purposes. Results show that the Al2O3-SiCw-SiCnp composite with both 20 vo1% SiC whiskers and 5 vol% SiC nanoparticles additives have much improved mechanical properties. The flexural strength of Al2O3-SiCw-SiCnp is 730＋ 95 MPa and fracture toughness is 5.6 ± 0.6 MPa.m1/2. The toughening and strengthening mechanisms of SiC whiskers and nanoparticles are studied when they are added either individually or in combination. It is indicated that when SiC whiskers and nanoparticles are added together, the grains are further refined and homogenized, so that the microstructure and fracture mode ratio is modified. The SiC nanoparticles are found helpful to enhance the toughening effects of the SiC whiskers. The proposed research helps to enrich the types of ceramic cutting tool and is benefit to expand the application range of ceramic cutting tool.展开更多
On the basis of theoretical analyses and calculations of high speed continuous impact force and tool notch surface temperature acted upon by burr and serrated chip edge, a notch wear model of low stress value and temp...On the basis of theoretical analyses and calculations of high speed continuous impact force and tool notch surface temperature acted upon by burr and serrated chip edge, a notch wear model of low stress value and temperature impact fatigue was established. Saw-tooth-shaped burr and fin-shaped chip edge continuously impacts the rake face and flank face at high speed and high fre-quency, which results in a V-shaped notch wear. An experiment was done to validate that the saw-tooth-shaped burr does affect the notch wear. This model can be utilized to solve reasonably many problems that cannot be explained by any other theoretical assumptions.展开更多
Case Based Reasoning(CBR)is one of the artificial intelligent methodologies that is widely used in problem solving by reusing the most similar previous experiences stored in the library.A framework of ECO-CBR for Life...Case Based Reasoning(CBR)is one of the artificial intelligent methodologies that is widely used in problem solving by reusing the most similar previous experiences stored in the library.A framework of ECO-CBR for Life Cycle Assessment data collection has been used and the process was carried out using SolidWorks program.The practicality of the tool has been validated using case study,which then provides solution.The output enable researchers to determine forecast error and forecast accuracy,by valuing the calculation from Total Carbon Footprint,Energy Consumption,Air Acidification,and Water Eutrophication.ECO-CBR is able to assist designers in product design.Due to the limitation of environmental impact consideration in product sustainability,there is a demand to propose a tool that can assist designers to reduce environmental impact of product design at early stage.The model works as an essential guideline to lessen repeated mistakes in the product development process and help designers measure the risks before concluding ideal decisions.Minor errors that occur through the study showed that ECO-CBR is reliable to be implemented in order to find a better solution.展开更多
Chlorophyll-a (Chl-a) concentration in lakes can tell a lot about a lake’s water quality and ecosystem. It is a measure of the amount of algae growing in a waterbody and can be used to monitor the trophic condition o...Chlorophyll-a (Chl-a) concentration in lakes can tell a lot about a lake’s water quality and ecosystem. It is a measure of the amount of algae growing in a waterbody and can be used to monitor the trophic condition of a waterbody. We studied the pre and post effects of marine ranch construction in Chl-a concentration in Zhelin Bay, Southern China using Normalized Difference Chlorophyll Index (NDCI) and a web-based tool (https://mapcoordinates.info/). We used 8 day composite MODIS image collections of 500 m resolution and randomly selected two stations to extract the chlorophyll-a concentration values through the web-based tool. We recorded the slight increase in NDCI values in all stations after the construction of marine ranch which is a good indicator of the marine organisms’ reproduction and survival.展开更多
The performances of mixed ceramic and sialon ceramic tools in machining nickel based alloy are tested.The negative cutting edge inclination and small tool lead angle are recommended for reducing ceramic tool failure....The performances of mixed ceramic and sialon ceramic tools in machining nickel based alloy are tested.The negative cutting edge inclination and small tool lead angle are recommended for reducing ceramic tool failure. So called“notching at depth of cut”is not actually at the depth of cutting line, but out of cutting area。 The real reason of notching is caused by shocking of “sawtooth”on sawtooth- shaped burr and fin- shaped edges of chip展开更多
目的系统评价慢性病患者自我倡权评估工具的测量学属性和方法学质量。方法计算机检索PubMed、CINAHL、Embase、Web of Science、万方、维普、中国知网及中国生物医学文献数据库中有关慢性病患者自我倡权评估工具的相关研究,检索时限为...目的系统评价慢性病患者自我倡权评估工具的测量学属性和方法学质量。方法计算机检索PubMed、CINAHL、Embase、Web of Science、万方、维普、中国知网及中国生物医学文献数据库中有关慢性病患者自我倡权评估工具的相关研究,检索时限为建库至2024年7月31日。由2名研究者分别对文献进行筛选和资料的提取,运用基于共识选择健康测量工具的标准(consensus-based standards for the selection of healthmeasurement instruments,COSMIN)对纳入的评估工具进行评价。结果共纳入10项研究,包含7种慢性病患者自我倡权测量工具,均存在偏倚风险,推荐等级为B级;10项研究均未评价测量误差及反应度,仅2项研究评价结构效度指标未满足要求,7项研究未行多组验证性因子分析或项目功能差异分析,仅2项研究计算了组内相关系数,6项研究未行假设检验。结论女性癌症幸存者自我倡权量表的各测量属性的评价较全面,信效度较好,可暂推荐使用。未来可根据COSMIN指南优化研究设计与报告标准,完善自我倡权测量工具,以便更全面精确地评估慢性病患者自我倡权水平。展开更多
文摘Background: Clinical decision support tools provide suggestions to support healthcare providers and clinicians, as they attend to patients. Clinicians use these tools to rapidly consult the evidence at the point of care, a practice which has been found to reduce the time patients spend in hospitals, promote the quality of care and improve healthcare outcomes. Such tools include Medscape, VisualDx, Clinical Key, DynaMed, BMJ Best Practice and UpToDate. However, use of such tools has not yet been fully embraced in low-resource settings such as Uganda. Objective: This paper intends to collate data on the use and uptake of one such tool, UpToDate, which was provided at no cost to five medical schools in Uganda. Methods: Free access to UpToDate was granted through the IP addresses of five medical schools in Uganda in collaboration with Better Evidence at The Global Health Delivery Project at Harvard and Brigham and Women’s Hospital and Wolters Kluwer Health. Following the donation, medical librarians in the respective institutions conducted training sessions and created awareness of the tool. Usage data was aggregated, based on logins and content views, presented and analyzed using Excel tables and graphs. Results: The data shows similar trends in increased usage over the period of August 2022 to August 2023 across the five medical schools. The most common topics viewed, mode of access (using either the computer or the mobile app), total usage by institution, ratio of uses to eligible users by institution and ratio of uses to students by institution are shared. Conclusion: The study revealed that the tool was used by various user categories across the institutions with similar steady improved usage over the year. These results can inform the librarians as they encourage their respective institutions to continue using the tool to support uptake of point-of-care tools in clinical practice.
基金supported by the Beijing Scholars Program[BSP041]。
文摘Base editing, as an expanded clustered regularly interspaced short palindromic repeats(CRISPR)-Cas genome editing strategy, permits precise and irreversible nucleotide conversion. SaKKH, an efficient variant of a Cas9 ortholog from Staphylococcus aureus(SaCas9), is important in genome editing because it can edit sites with HHHAAT protospacer adjacent motif(PAM) that the canonical Streptococcus pyogenes Cas9(SpCas9) or its variants(e.g. xCas9, Cas9-NG) cannot. However, several technical parameters of SaKKH involved base editors have not been well defined and this uncertainty limits their application. We developed an effective multiplex cytosine base editor(SaKKHn-pBE) and showed that it recognized NNARRT, NNCRRT, NNGRGT, and NNTRGT PAMs. Based on 27 targets tested, we defined technical parameters of SaKKHn-pBE including the editing window, the preferred sequence context, and the mutation type. The editing efficiency was further improved by modification of the SaKKH sgRNA. These advances can be applied in future research and molecular breeding in rice and other plants.
文摘This paper outlines a framework to use computer and natural language techniques for various levels of learners to learn foreign languages in Computer-based Learning environment.We propose some ideas for using the computer as a practical tool for learning foreign language where the most of courseware is generated automatically.We then describe how to build Computer-based Learning tools,discuss its effectiveness,and conclude with some possibilities using on-line resources.
基金Supported by National Natural Science Foundation of China(Grant No.51175305)
文摘In recent decades, many additives with different characteristics have been applied to strengthen and toughen Al2O3-based ceramic cutting tool materials. Among them, SiC whiskers and SiC nanoparticles showed excellent performance in improving the material properties. While no attempts have been made to add SiC whiskers and SiC nanoparticles together into the ceramic matrix and the synergistically toughening effects of them have not been studied. An Al2O3-SiCw-SiC np advanced ceramic cutting tool material is fabricated by adding both one-dimensional SiC whiskers and zero-dimensional SiC nanoparticles into the Al2O3 matrix with an effective dispersing and mixing process. The composites with 25 vol% SiC whiskers and 25 vol% SiC nanoparticles alone are also investegated for comparison purposes. Results show that the Al2O3-SiCw-SiCnp composite with both 20 vo1% SiC whiskers and 5 vol% SiC nanoparticles additives have much improved mechanical properties. The flexural strength of Al2O3-SiCw-SiCnp is 730＋ 95 MPa and fracture toughness is 5.6 ± 0.6 MPa.m1/2. The toughening and strengthening mechanisms of SiC whiskers and nanoparticles are studied when they are added either individually or in combination. It is indicated that when SiC whiskers and nanoparticles are added together, the grains are further refined and homogenized, so that the microstructure and fracture mode ratio is modified. The SiC nanoparticles are found helpful to enhance the toughening effects of the SiC whiskers. The proposed research helps to enrich the types of ceramic cutting tool and is benefit to expand the application range of ceramic cutting tool.
文摘On the basis of theoretical analyses and calculations of high speed continuous impact force and tool notch surface temperature acted upon by burr and serrated chip edge, a notch wear model of low stress value and temperature impact fatigue was established. Saw-tooth-shaped burr and fin-shaped chip edge continuously impacts the rake face and flank face at high speed and high fre-quency, which results in a V-shaped notch wear. An experiment was done to validate that the saw-tooth-shaped burr does affect the notch wear. This model can be utilized to solve reasonably many problems that cannot be explained by any other theoretical assumptions.
文摘Case Based Reasoning(CBR)is one of the artificial intelligent methodologies that is widely used in problem solving by reusing the most similar previous experiences stored in the library.A framework of ECO-CBR for Life Cycle Assessment data collection has been used and the process was carried out using SolidWorks program.The practicality of the tool has been validated using case study,which then provides solution.The output enable researchers to determine forecast error and forecast accuracy,by valuing the calculation from Total Carbon Footprint,Energy Consumption,Air Acidification,and Water Eutrophication.ECO-CBR is able to assist designers in product design.Due to the limitation of environmental impact consideration in product sustainability,there is a demand to propose a tool that can assist designers to reduce environmental impact of product design at early stage.The model works as an essential guideline to lessen repeated mistakes in the product development process and help designers measure the risks before concluding ideal decisions.Minor errors that occur through the study showed that ECO-CBR is reliable to be implemented in order to find a better solution.
文摘Chlorophyll-a (Chl-a) concentration in lakes can tell a lot about a lake’s water quality and ecosystem. It is a measure of the amount of algae growing in a waterbody and can be used to monitor the trophic condition of a waterbody. We studied the pre and post effects of marine ranch construction in Chl-a concentration in Zhelin Bay, Southern China using Normalized Difference Chlorophyll Index (NDCI) and a web-based tool (https://mapcoordinates.info/). We used 8 day composite MODIS image collections of 500 m resolution and randomly selected two stations to extract the chlorophyll-a concentration values through the web-based tool. We recorded the slight increase in NDCI values in all stations after the construction of marine ranch which is a good indicator of the marine organisms’ reproduction and survival.
文摘The performances of mixed ceramic and sialon ceramic tools in machining nickel based alloy are tested.The negative cutting edge inclination and small tool lead angle are recommended for reducing ceramic tool failure. So called“notching at depth of cut”is not actually at the depth of cutting line, but out of cutting area。 The real reason of notching is caused by shocking of “sawtooth”on sawtooth- shaped burr and fin- shaped edges of chip
文摘目的系统评价慢性病患者自我倡权评估工具的测量学属性和方法学质量。方法计算机检索PubMed、CINAHL、Embase、Web of Science、万方、维普、中国知网及中国生物医学文献数据库中有关慢性病患者自我倡权评估工具的相关研究,检索时限为建库至2024年7月31日。由2名研究者分别对文献进行筛选和资料的提取,运用基于共识选择健康测量工具的标准(consensus-based standards for the selection of healthmeasurement instruments,COSMIN)对纳入的评估工具进行评价。结果共纳入10项研究,包含7种慢性病患者自我倡权测量工具,均存在偏倚风险,推荐等级为B级;10项研究均未评价测量误差及反应度,仅2项研究评价结构效度指标未满足要求,7项研究未行多组验证性因子分析或项目功能差异分析,仅2项研究计算了组内相关系数,6项研究未行假设检验。结论女性癌症幸存者自我倡权量表的各测量属性的评价较全面,信效度较好,可暂推荐使用。未来可根据COSMIN指南优化研究设计与报告标准,完善自我倡权测量工具,以便更全面精确地评估慢性病患者自我倡权水平。
