The purpose of the present study is to evaluate the uncertainties of in vivo dosimetry measured with diode detectors for conformal radiation therapy techniques in order to define appropriate tolerance levels for pelvi...The purpose of the present study is to evaluate the uncertainties of in vivo dosimetry measured with diode detectors for conformal radiation therapy techniques in order to define appropriate tolerance levels for pelvis and breast treatment in MEIH （Middle East Institute of Health）. The present work is carried out on 30-472 and 30-473 diode detectors irradiated by 4 and 15MV photon beams of a medical linear accelerator Synergy from ELEKTA. Dose computation is performed with Pinnacle 7.4 k treatment planning system. First, an estimation of the uncertainties in a simple geometric case, using a water-equivalent solid phantom is done. Secondly, each treatment parameter such as field size, beam angle, beam modifiers and source-skin distance is evaluated in order to simulate the conformal radiation treatments used in the present institution for the main anatomical sites. Interpretation of entrance dose in-vivo measurements requires the determination of appropriate tolerance levels. Indeed, the authors found that the 5% action level proposed in the literature underestimates the uncertainties in the treatment process. A method for the evaluation of tolerance/action levels related to the different anatomical sites is developed. By the end of the present study the authors have developed an integrated monitoring system that offers accurate information about the dose received by patients.展开更多
Women have been stereotyped as better multitaskers when compared to their male counterparts. The purpose of this study is to investigate whether there are differences in gender performance when performing cognitive co...Women have been stereotyped as better multitaskers when compared to their male counterparts. The purpose of this study is to investigate whether there are differences in gender performance when performing cognitive combined tasks. Twenty-four graduate students （twelve females and twelve males） volunteered to participate in the study. The task requires participants to indicate when they perceive a change in the intensity of an auditory signal while simultaneously solving algebraic problems. Multivariate Analysis of Variance （MANOVA） results reveal no significant differences between genders when performing the combined tasks （p = 0.1831 and 2 = 0.7891） although the average number of false alarms made during the combined tasks by males is nearly 11% higher than the average number of false alarms made by females. However, （Multivariate Analysis of Variance） ANOVA results for the combined tasks show that males outperform females on the computational task while listening for changes in the auditory signal F（1, 22） - 5.09, p 〈 0.03, but there are no significant differences in their ability to detect noise intensity variation or in the number of false alarms made while multitasking. For the single task analysis the ANOVAs indicate no significant differences in signal detection task performance, computational task performance, or the number of false alarms made by males and females.展开更多
The conjugation of SUMO （small ubiquitin-like modifier） to protein substrates is a reversible process （SUMOylation/deSUMOylation） that regulates plant devel- opment and stress responses. The essential metal copper...The conjugation of SUMO （small ubiquitin-like modifier） to protein substrates is a reversible process （SUMOylation/deSUMOylation） that regulates plant devel- opment and stress responses. The essential metal copper （Cu） is required for normal plant growth, but excess amounts are toxic. The SUMO E3 ligase, SIZI, and SIZ1- mediated SUMOylation function in plant tolerance to excess Cu. It is unknown whether deSUMOylation also contributes to Cu tolerance in plants. Here, we report that OTSI, a protease that cleaves SUMO from its substrate proteins, participates in Cu tolerance in Arabidopsis thaliana （Arabi- dopsis）. OTS1 loss-of-function mutants （otsl-2 and otsl-3） displayed increased sensitivity to excess Cu. Redox homeostasis and the balance between SUMOylation and deSUMOylation were disrupted in the otsl-3 mutant under excess Cu conditions, The otsl-3 mutant accumulated higher levels of Cu in both shoots and roots compared to wild type. Specific Cu-related metal transporter genes were upregu- lated due to the loss-of-function of OTS% which might explain the high Cu levels in otsl-3. These results suggest that the SUMOylation/deSUMOylation machinery is acti- vated in response to excess Cu, and modulates Cu homeostasis and tolerance by regulating both Cu uptake and detoxification. Together, our findings provide insight into the biological function and regulatory role of SUMOylation/deSUMOylation in plant tolerance to Cu.展开更多
文摘The purpose of the present study is to evaluate the uncertainties of in vivo dosimetry measured with diode detectors for conformal radiation therapy techniques in order to define appropriate tolerance levels for pelvis and breast treatment in MEIH （Middle East Institute of Health）. The present work is carried out on 30-472 and 30-473 diode detectors irradiated by 4 and 15MV photon beams of a medical linear accelerator Synergy from ELEKTA. Dose computation is performed with Pinnacle 7.4 k treatment planning system. First, an estimation of the uncertainties in a simple geometric case, using a water-equivalent solid phantom is done. Secondly, each treatment parameter such as field size, beam angle, beam modifiers and source-skin distance is evaluated in order to simulate the conformal radiation treatments used in the present institution for the main anatomical sites. Interpretation of entrance dose in-vivo measurements requires the determination of appropriate tolerance levels. Indeed, the authors found that the 5% action level proposed in the literature underestimates the uncertainties in the treatment process. A method for the evaluation of tolerance/action levels related to the different anatomical sites is developed. By the end of the present study the authors have developed an integrated monitoring system that offers accurate information about the dose received by patients.
文摘Women have been stereotyped as better multitaskers when compared to their male counterparts. The purpose of this study is to investigate whether there are differences in gender performance when performing cognitive combined tasks. Twenty-four graduate students （twelve females and twelve males） volunteered to participate in the study. The task requires participants to indicate when they perceive a change in the intensity of an auditory signal while simultaneously solving algebraic problems. Multivariate Analysis of Variance （MANOVA） results reveal no significant differences between genders when performing the combined tasks （p = 0.1831 and 2 = 0.7891） although the average number of false alarms made during the combined tasks by males is nearly 11% higher than the average number of false alarms made by females. However, （Multivariate Analysis of Variance） ANOVA results for the combined tasks show that males outperform females on the computational task while listening for changes in the auditory signal F（1, 22） - 5.09, p 〈 0.03, but there are no significant differences in their ability to detect noise intensity variation or in the number of false alarms made while multitasking. For the single task analysis the ANOVAs indicate no significant differences in signal detection task performance, computational task performance, or the number of false alarms made by males and females.
基金supported by the National Transgenic Major Project of China (2016ZX08009-003-002 to H.L.)the National Natural Science Foundation of China (31600201 to H.Z+1 种基金 31470342 and 31670235 to H.L.)the National Basic Research Program of China (2015CB150100 to H.L)
文摘The conjugation of SUMO （small ubiquitin-like modifier） to protein substrates is a reversible process （SUMOylation/deSUMOylation） that regulates plant devel- opment and stress responses. The essential metal copper （Cu） is required for normal plant growth, but excess amounts are toxic. The SUMO E3 ligase, SIZI, and SIZ1- mediated SUMOylation function in plant tolerance to excess Cu. It is unknown whether deSUMOylation also contributes to Cu tolerance in plants. Here, we report that OTSI, a protease that cleaves SUMO from its substrate proteins, participates in Cu tolerance in Arabidopsis thaliana （Arabi- dopsis）. OTS1 loss-of-function mutants （otsl-2 and otsl-3） displayed increased sensitivity to excess Cu. Redox homeostasis and the balance between SUMOylation and deSUMOylation were disrupted in the otsl-3 mutant under excess Cu conditions, The otsl-3 mutant accumulated higher levels of Cu in both shoots and roots compared to wild type. Specific Cu-related metal transporter genes were upregu- lated due to the loss-of-function of OTS% which might explain the high Cu levels in otsl-3. These results suggest that the SUMOylation/deSUMOylation machinery is acti- vated in response to excess Cu, and modulates Cu homeostasis and tolerance by regulating both Cu uptake and detoxification. Together, our findings provide insight into the biological function and regulatory role of SUMOylation/deSUMOylation in plant tolerance to Cu.
