The developing olfactory system - merging of the periph- eral and central nervous systems： The olfactory system is responsible for the sense of smell and is comprised of a complex topographic map that regenerates thr...The developing olfactory system - merging of the periph- eral and central nervous systems： The olfactory system is responsible for the sense of smell and is comprised of a complex topographic map that regenerates throughout life. In rodents each olfactory sensory neuron expresses one of N 1,300 odorant receptors with the neurons being distributed mosaically within the epithelium. The axons of the sensory neurons do not maintain near-neighbour relationships and instead project to disparate topographic targets in the olfac- tory bulb within the central nervous system. The develop- ment of the targets relies on the intermingling of the sensory axons with the interneurons, glia and second order neurons of the olfactory bulb. Thus the formation of the olfactory system involves the coordinated integration of the axons of the peripheral olfactory sensory neurons with the cells of the olfactory bulb.展开更多
The People’s Bank of China（PBOC）recently issued the regulations on QR code payment service（Trial）and two other relevant technical specifications to regulate payments by scanning two-dimensional barcode,which are ...The People’s Bank of China（PBOC）recently issued the regulations on QR code payment service（Trial）and two other relevant technical specifications to regulate payments by scanning two-dimensional barcode,which are to take effect on April 1,2018.Payment institutions must obtain proper permits to offer barcode-based payment services by then.Payments with QR codes are increasingly common in China for purchases in large or small shops,展开更多
China’s first general standard for stem cells officially released on November 22,2017 is expected to lay a foundation for regulating the application of stem cells technology.Stem cells are a group of self-renewal cel...China’s first general standard for stem cells officially released on November 22,2017 is expected to lay a foundation for regulating the application of stem cells technology.Stem cells are a group of self-renewal cells that can differentiate into specialized cells.They are now used for the treatment of many diseases.Despite a series of documents for regulating basic research and achievement transformation of stem cells,展开更多
Summary In Arabidopsis, both the membrane-anchored receptor-like kinase （RLK） BAK1 and the receptor-like cytoplasmic kinase （RLCK） BIK1 are important mediators of transmembrane signal transduction that regulate pl...Summary In Arabidopsis, both the membrane-anchored receptor-like kinase （RLK） BAK1 and the receptor-like cytoplasmic kinase （RLCK） BIK1 are important mediators of transmembrane signal transduction that regulate plant development and immunity. However, little attention has been paid to their genetic association. This study found the bak1 bik1 double mutant of Arabidopsis displayed a severe dwarfism phenotype due to constitutive immunity and cell death in developing plants. These data suggest that BIK1 cooperates with BAK1 to regulate constitutive immunity and cell death.展开更多
Chloroplast genes are transcribed by the plastidencoded RNA polymerase（PEP） or nucleus-encoded RNA polymerase. FRUCTOKINASE-LIKE PROTEINS（FLNs） are phosphofructokinase-B（Pfk B）-type carbohydrate kinases that act...Chloroplast genes are transcribed by the plastidencoded RNA polymerase（PEP） or nucleus-encoded RNA polymerase. FRUCTOKINASE-LIKE PROTEINS（FLNs） are phosphofructokinase-B（Pfk B）-type carbohydrate kinases that act as part of the PEP complex; however, the molecular mechanisms underlying FLN activity in rice remain elusive.Previously, we identified and characterized a heat-stress sensitive albino（hsa_1） mutant in rice. Map-based cloning revealed that HSA_1 encodes a putative OsFLN_2. Here, we further demonstrated that knockdown or knockout of the OsFLN_1, a close homolog of HSA_1/OsFLN_2, considerably inhibits chloroplast biogenesis and the fln_1 knockout mutants, created by clustered regularly interspaced short palindromic repeats（CRISPR） and CRISPR-associate protein_9, exhibit severe albino phenotype and seedling lethality. Moreover, OsFLN_1 localizes to the chloroplast.Yeast two-hybrid, pull-down and bimolecular fluorescencecomplementation experiments revealed that OsFLN_1 and HSA_1/OsFLN_2 interact with THIOREDOXINZ（OsTRXz） to regulate chloroplast development. In agreement with this,knockout of OsTRXz resulted in a similar albino and seedling lethality phenotype to that of the fln_1 mutants. Quantitative reverse transcription polymerase chain reaction and immunoblot analysis revealed that the transcription and translation of PEP-dependent genes were strongly inhibited in fln_1 and trxz mutants, indicating that loss of OsFLN_1, HSA_1/OsFLN_2, or OsTRXz function perturbs the stability of the transcriptionally active chromosome complex and PEP activity. These results show that OsFLN_1 and HSA_1/OsFLN_2 contribute to chloroplast biogenesis and plant growth.展开更多
China’s Ministry of Land and Resources on Feb. 18 has issued an urgent notification on regulating the country’s real estate market. The notification has been already released to all of the Chinese provincial land an...China’s Ministry of Land and Resources on Feb. 18 has issued an urgent notification on regulating the country’s real estate market. The notification has been already released to all of the Chinese provincial land and resources bureaus, autonomous regions and municipalities, requires the strict control of land development for the building of commercial housing.展开更多
As multinationals flock to China, the counhy has become the world’s largest recipient of foreign direct investment. Undoubtedly, foreign investment has played an important and positive role in China’s development in...As multinationals flock to China, the counhy has become the world’s largest recipient of foreign direct investment. Undoubtedly, foreign investment has played an important and positive role in China’s development in many areas, including economic growth, social proyess,展开更多
The occurrence and development of liver cancer are essentially the most serious outcomes of uncontrolled liver regeneration. The progression of liver cancer is inevitably related to the abnormal microenvironment of li...The occurrence and development of liver cancer are essentially the most serious outcomes of uncontrolled liver regeneration. The progression of liver cancer is inevitably related to the abnormal microenvironment of liver regeneration. The deterioration observed in the microenvironment of liver regeneration is a necessary condition for the occurrence, development and metastasis of cancer. Therefore, the use of a technique to prevent and treat liver cancer via changes in the microenvironment of liver regeneration is a novel strategy. This strategy would be an effective way to delay, prevent or even reverse cancer occurrence, development and metastasis through an improvement in the liver regeneration microenvironment along with the integrated regulation of multiple components, targets, levels, channels and time sequences. In addition, the treatment of ＂tonifying Shen（Kidney） to regulate liver regeneration and repair by affecting stem cells and their microenvironment＂ can regulate ＂the dynamic imbalance between the normal liver regeneration and the abnormal liver regeneration＂; this would improve the microenvironment of liver regeneration, which is also a mechanism by which liver cancer may be prevented or treated.展开更多
基金supported by an Australian Postgraduate Award to D.A
文摘The developing olfactory system - merging of the periph- eral and central nervous systems： The olfactory system is responsible for the sense of smell and is comprised of a complex topographic map that regenerates throughout life. In rodents each olfactory sensory neuron expresses one of N 1,300 odorant receptors with the neurons being distributed mosaically within the epithelium. The axons of the sensory neurons do not maintain near-neighbour relationships and instead project to disparate topographic targets in the olfac- tory bulb within the central nervous system. The develop- ment of the targets relies on the intermingling of the sensory axons with the interneurons, glia and second order neurons of the olfactory bulb. Thus the formation of the olfactory system involves the coordinated integration of the axons of the peripheral olfactory sensory neurons with the cells of the olfactory bulb.
文摘The People’s Bank of China（PBOC）recently issued the regulations on QR code payment service（Trial）and two other relevant technical specifications to regulate payments by scanning two-dimensional barcode,which are to take effect on April 1,2018.Payment institutions must obtain proper permits to offer barcode-based payment services by then.Payments with QR codes are increasingly common in China for purchases in large or small shops,
文摘China’s first general standard for stem cells officially released on November 22,2017 is expected to lay a foundation for regulating the application of stem cells technology.Stem cells are a group of self-renewal cells that can differentiate into specialized cells.They are now used for the treatment of many diseases.Despite a series of documents for regulating basic research and achievement transformation of stem cells,
基金supported by the National Natural Science Foundation of China(31571249 and 31425003)
文摘Summary In Arabidopsis, both the membrane-anchored receptor-like kinase （RLK） BAK1 and the receptor-like cytoplasmic kinase （RLCK） BIK1 are important mediators of transmembrane signal transduction that regulate plant development and immunity. However, little attention has been paid to their genetic association. This study found the bak1 bik1 double mutant of Arabidopsis displayed a severe dwarfism phenotype due to constitutive immunity and cell death in developing plants. These data suggest that BIK1 cooperates with BAK1 to regulate constitutive immunity and cell death.
基金supported by National Natural Science Foundation of China (31371606, 31601284, 31661143006)The Transgenic Plant Research and Commercialization Project of the Ministry of Agriculture of China (2016ZX08001003-002)+2 种基金Zhejiang Province Outstanding Youth Fund (LR16C130001)The Collaborative Innovation Project of the Chinese Academy of Agricultural Sciences (Y2016XT05)State Key Laboratory of Rice Biology Research Project (2017ZZKT10103)
文摘Chloroplast genes are transcribed by the plastidencoded RNA polymerase（PEP） or nucleus-encoded RNA polymerase. FRUCTOKINASE-LIKE PROTEINS（FLNs） are phosphofructokinase-B（Pfk B）-type carbohydrate kinases that act as part of the PEP complex; however, the molecular mechanisms underlying FLN activity in rice remain elusive.Previously, we identified and characterized a heat-stress sensitive albino（hsa_1） mutant in rice. Map-based cloning revealed that HSA_1 encodes a putative OsFLN_2. Here, we further demonstrated that knockdown or knockout of the OsFLN_1, a close homolog of HSA_1/OsFLN_2, considerably inhibits chloroplast biogenesis and the fln_1 knockout mutants, created by clustered regularly interspaced short palindromic repeats（CRISPR） and CRISPR-associate protein_9, exhibit severe albino phenotype and seedling lethality. Moreover, OsFLN_1 localizes to the chloroplast.Yeast two-hybrid, pull-down and bimolecular fluorescencecomplementation experiments revealed that OsFLN_1 and HSA_1/OsFLN_2 interact with THIOREDOXINZ（OsTRXz） to regulate chloroplast development. In agreement with this,knockout of OsTRXz resulted in a similar albino and seedling lethality phenotype to that of the fln_1 mutants. Quantitative reverse transcription polymerase chain reaction and immunoblot analysis revealed that the transcription and translation of PEP-dependent genes were strongly inhibited in fln_1 and trxz mutants, indicating that loss of OsFLN_1, HSA_1/OsFLN_2, or OsTRXz function perturbs the stability of the transcriptionally active chromosome complex and PEP activity. These results show that OsFLN_1 and HSA_1/OsFLN_2 contribute to chloroplast biogenesis and plant growth.
文摘China’s Ministry of Land and Resources on Feb. 18 has issued an urgent notification on regulating the country’s real estate market. The notification has been already released to all of the Chinese provincial land and resources bureaus, autonomous regions and municipalities, requires the strict control of land development for the building of commercial housing.
文摘As multinationals flock to China, the counhy has become the world’s largest recipient of foreign direct investment. Undoubtedly, foreign investment has played an important and positive role in China’s development in many areas, including economic growth, social proyess,
基金Supported by the National Natural Science Foundation of China(No.81373513)Research Projects of Key Diseases of the National Traditional Chinese Medicine Clinical Research Center,Hubei Province(No.JDZX2012054,JDZX2015172)
文摘The occurrence and development of liver cancer are essentially the most serious outcomes of uncontrolled liver regeneration. The progression of liver cancer is inevitably related to the abnormal microenvironment of liver regeneration. The deterioration observed in the microenvironment of liver regeneration is a necessary condition for the occurrence, development and metastasis of cancer. Therefore, the use of a technique to prevent and treat liver cancer via changes in the microenvironment of liver regeneration is a novel strategy. This strategy would be an effective way to delay, prevent or even reverse cancer occurrence, development and metastasis through an improvement in the liver regeneration microenvironment along with the integrated regulation of multiple components, targets, levels, channels and time sequences. In addition, the treatment of ＂tonifying Shen（Kidney） to regulate liver regeneration and repair by affecting stem cells and their microenvironment＂ can regulate ＂the dynamic imbalance between the normal liver regeneration and the abnormal liver regeneration＂; this would improve the microenvironment of liver regeneration, which is also a mechanism by which liver cancer may be prevented or treated.
