Spectrofluorometric titration and continuous variation were used to study supramolecular inclusion complexes of β-CD and its derivatives with 2-p-toluidinglnaphthalene-6-sulfonate(TNS).The stoichiometry,stability con...Spectrofluorometric titration and continuous variation were used to study supramolecular inclusion complexes of β-CD and its derivatives with 2-p-toluidinglnaphthalene-6-sulfonate(TNS).The stoichiometry,stability constants and configuration of supramolecular inclusion complexes were discussed.The results suggest that β-CD and its derivatives form 1∶1 supramolecular inclusion complexes with TNS in aqueous solutions.The hydrophobic interactions and van der Waals forces determine the stability of supramolecular inclusion complexes.The size fit between the hosts and the vip plays important roles in the formation of the supramolecular inclusion complexes.展开更多
本文于2025年07月发表于《Blood》杂志,发表后引起业内广泛关注,Blood发布述评文章(Thrombopoiesis comes full circle,Amelia A Rodolf,Owen J T McCarty,2025,10,23)。本文题录为:Wu H,Lu Y,Sun D,et al.circFUT8promotes proplatelet...本文于2025年07月发表于《Blood》杂志,发表后引起业内广泛关注,Blood发布述评文章(Thrombopoiesis comes full circle,Amelia A Rodolf,Owen J T McCarty,2025,10,23)。本文题录为:Wu H,Lu Y,Sun D,et al.circFUT8promotes proplatelet formation by interacting with IGF2BP2 and stabilizing TNS1 mRNA in megakaryocytes.Blood.2025;146(17):2119-2132.该研究首次揭示了环状RNA circFUT8促进血小板生成的重要作用,阐明了circFUT8通过与IGF2BP2相互作用促进巨核细胞中TNS1 mRNA的稳定,进而调控巨核细胞肌动蛋白骨架重排的作用机制。本研究揭示了血小板生成调控的新机制,拓宽了环形RNA的生物学功能,为血小板减少症提供了潜在的治疗靶点,也为血小板体外生成策略提供了新的理论依据。现在作者将再次通过佳文解读的方式来阐述这一研究。展开更多
文摘Spectrofluorometric titration and continuous variation were used to study supramolecular inclusion complexes of β-CD and its derivatives with 2-p-toluidinglnaphthalene-6-sulfonate(TNS).The stoichiometry,stability constants and configuration of supramolecular inclusion complexes were discussed.The results suggest that β-CD and its derivatives form 1∶1 supramolecular inclusion complexes with TNS in aqueous solutions.The hydrophobic interactions and van der Waals forces determine the stability of supramolecular inclusion complexes.The size fit between the hosts and the vip plays important roles in the formation of the supramolecular inclusion complexes.
文摘本文于2025年07月发表于《Blood》杂志,发表后引起业内广泛关注,Blood发布述评文章(Thrombopoiesis comes full circle,Amelia A Rodolf,Owen J T McCarty,2025,10,23)。本文题录为:Wu H,Lu Y,Sun D,et al.circFUT8promotes proplatelet formation by interacting with IGF2BP2 and stabilizing TNS1 mRNA in megakaryocytes.Blood.2025;146(17):2119-2132.该研究首次揭示了环状RNA circFUT8促进血小板生成的重要作用,阐明了circFUT8通过与IGF2BP2相互作用促进巨核细胞中TNS1 mRNA的稳定,进而调控巨核细胞肌动蛋白骨架重排的作用机制。本研究揭示了血小板生成调控的新机制,拓宽了环形RNA的生物学功能,为血小板减少症提供了潜在的治疗靶点,也为血小板体外生成策略提供了新的理论依据。现在作者将再次通过佳文解读的方式来阐述这一研究。
