Amoenucles A-F(1-6),six previously undescribed nucleoside derivatives,and two known analogs(7 and 8)were isolated from the culture of Aspergillus amoenus TJ507.Their structures were elucidated through spectroscopic an...Amoenucles A-F(1-6),six previously undescribed nucleoside derivatives,and two known analogs(7 and 8)were isolated from the culture of Aspergillus amoenus TJ507.Their structures were elucidated through spectroscopic analysis,single-crystal X-ray crystallography,and chemical reactions.Notably,3 and 4 represent the first reported instances of nucleosides with an attached pyrrole moiety.Of particular significance,the absolute configuration of the sugar moiety of 1-4 was determined using nuclear magnetic resonance(NMR),electric circular dichroism(ECD)calculations,and a hydrolysis reaction,presenting a potentially valuable method for confirming nucleoside structures.Furthermore,1,2,and 5-8 exhibited potential tumor necrosis factorα(TNF-α)inhibitory activities,which may provide a novel chemical template for the development of agents targeting autoimmune and inflammatory diseases.展开更多
采用TJ-1模拟月壤作为试验材料,通过静力触探、静载荷试验的对比分析,探讨适合月壤承载力计算的经验公式,以期为未来载人登月时宇航员和着陆器登陆可能涉及到有关月面承载能力的问题提供必要的参考。首先,使用近255 t TJ-1模拟月壤人工...采用TJ-1模拟月壤作为试验材料,通过静力触探、静载荷试验的对比分析,探讨适合月壤承载力计算的经验公式,以期为未来载人登月时宇航员和着陆器登陆可能涉及到有关月面承载能力的问题提供必要的参考。首先,使用近255 t TJ-1模拟月壤人工制备出13 m×12 m×1.2 m试验用地基,后在试验地基均匀布置6个静力触探测点和2个静载荷试验测点进行测试。针对太沙基承载力计算半经验公式以及规范和国内外学者提出的12个适合中密实砂土静力触探承载力计算的经验公式,对试验结果进行探讨。发现直接运用太沙基提出的半经验公式计算月壤承载力结果明显偏小,而由联合试验小组提出的经验公式s[R]36 P 76.6能够用来近似计算月壤地基承载力。计算结果表明,该经验公式在计算承载力时能够与静载荷试验值较好的吻合。展开更多
基金supported by the National Natural Science Foundation for Distinguished Young Scholars (No. 81725021)the National Natural Science Foundation of China (Nos.82003633 and 82173705)。
文摘Amoenucles A-F(1-6),six previously undescribed nucleoside derivatives,and two known analogs(7 and 8)were isolated from the culture of Aspergillus amoenus TJ507.Their structures were elucidated through spectroscopic analysis,single-crystal X-ray crystallography,and chemical reactions.Notably,3 and 4 represent the first reported instances of nucleosides with an attached pyrrole moiety.Of particular significance,the absolute configuration of the sugar moiety of 1-4 was determined using nuclear magnetic resonance(NMR),electric circular dichroism(ECD)calculations,and a hydrolysis reaction,presenting a potentially valuable method for confirming nucleoside structures.Furthermore,1,2,and 5-8 exhibited potential tumor necrosis factorα(TNF-α)inhibitory activities,which may provide a novel chemical template for the development of agents targeting autoimmune and inflammatory diseases.
文摘采用TJ-1模拟月壤作为试验材料,通过静力触探、静载荷试验的对比分析,探讨适合月壤承载力计算的经验公式,以期为未来载人登月时宇航员和着陆器登陆可能涉及到有关月面承载能力的问题提供必要的参考。首先,使用近255 t TJ-1模拟月壤人工制备出13 m×12 m×1.2 m试验用地基,后在试验地基均匀布置6个静力触探测点和2个静载荷试验测点进行测试。针对太沙基承载力计算半经验公式以及规范和国内外学者提出的12个适合中密实砂土静力触探承载力计算的经验公式,对试验结果进行探讨。发现直接运用太沙基提出的半经验公式计算月壤承载力结果明显偏小,而由联合试验小组提出的经验公式s[R]36 P 76.6能够用来近似计算月壤地基承载力。计算结果表明,该经验公式在计算承载力时能够与静载荷试验值较好的吻合。
