Soft bioelectronics hold immense potential across diverse applications,notably in healthcare,human-machine interfaces,and conformal neural interfaces.A core driving force is the pursuit of high-fidelity,seamless integ...Soft bioelectronics hold immense potential across diverse applications,notably in healthcare,human-machine interfaces,and conformal neural interfaces.A core driving force is the pursuit of high-fidelity,seamless integration between electronic systems and biological tissues,enabling the long-term stable monitoring of biosignals and precise diagnosis and therapy within closed-loop configurations.The past decade has seen transformative growth in this field,yielding numerous novel conformal integration strategies.These include seminal developments such as ultra-thin epidermal electronics[1,2],conformal bioelectronics fabrication or encapsulation using viscoplastic effect[3,4],and a“drop-printing”strategy for damage-free,conformal wrapping of bioelectronic interfaces through dynamic stress release[5].However,a fundamental trade-off in the clinical translation of bioelectronics lies between practical handleability ex vivo(pre-implantation)and the demand for mechanical conformability in vivo[6].To realize imperceptible biointerfaces-platforms avoiding mechanical stress or chronic tissue compression-devices must be nanoscale-thin and ultrasoft.Yet,such nanofilms are fragile and difficult to manipulate during conventional microfabrication and transfer steps,impeding their clinical translation and scalability.展开更多
文摘Soft bioelectronics hold immense potential across diverse applications,notably in healthcare,human-machine interfaces,and conformal neural interfaces.A core driving force is the pursuit of high-fidelity,seamless integration between electronic systems and biological tissues,enabling the long-term stable monitoring of biosignals and precise diagnosis and therapy within closed-loop configurations.The past decade has seen transformative growth in this field,yielding numerous novel conformal integration strategies.These include seminal developments such as ultra-thin epidermal electronics[1,2],conformal bioelectronics fabrication or encapsulation using viscoplastic effect[3,4],and a“drop-printing”strategy for damage-free,conformal wrapping of bioelectronic interfaces through dynamic stress release[5].However,a fundamental trade-off in the clinical translation of bioelectronics lies between practical handleability ex vivo(pre-implantation)and the demand for mechanical conformability in vivo[6].To realize imperceptible biointerfaces-platforms avoiding mechanical stress or chronic tissue compression-devices must be nanoscale-thin and ultrasoft.Yet,such nanofilms are fragile and difficult to manipulate during conventional microfabrication and transfer steps,impeding their clinical translation and scalability.
