Dear Editor,Patient-derived organoids(PDOs)are directly established via in vitro culture of patients’tumor samples,with the capacity to highly recapitulate the physiological traits,pathological states,and biological ...Dear Editor,Patient-derived organoids(PDOs)are directly established via in vitro culture of patients’tumor samples,with the capacity to highly recapitulate the physiological traits,pathological states,and biological behaviors of the original tumor tissues.As an optimal bridge connecting in vitro and in vivo models,PDOs have been successfully constructed from tumor tissues of multiple organs,including the brain,breast,kidney,liver,lung,pancreas,and small intestine,and are currently applied across a broad spectrum of fields such as basic research,tumor model construction,drug development,biobank establishment,and personalized therapy[1].展开更多
基金supported by the National Natural Science Foundation of China(grant Nos.82570757,82270662)Sichuan Provincial Science and Technology Program(grant No.2024CDZG-25)Sanming Project of Medicine in Shenzhen(grant No.SZSM202411031).
文摘Dear Editor,Patient-derived organoids(PDOs)are directly established via in vitro culture of patients’tumor samples,with the capacity to highly recapitulate the physiological traits,pathological states,and biological behaviors of the original tumor tissues.As an optimal bridge connecting in vitro and in vivo models,PDOs have been successfully constructed from tumor tissues of multiple organs,including the brain,breast,kidney,liver,lung,pancreas,and small intestine,and are currently applied across a broad spectrum of fields such as basic research,tumor model construction,drug development,biobank establishment,and personalized therapy[1].
