Stable tissue integration is important to keratoprosthesis （KPro）. The aim of this study was to evaluate the tissue bonding ability of hydroxyapatite （HAp）-coated titanium KPro. The samples were divided into three...Stable tissue integration is important to keratoprosthesis （KPro）. The aim of this study was to evaluate the tissue bonding ability of hydroxyapatite （HAp）-coated titanium KPro. The samples were divided into three groups： test groups （IBAD group and AD group） and Ti control. The coated samples had a HAp layer created by ion beam assisted deposition （IBAD） or aerosol deposition （AD）. The surface characteristics were analyzed with SEM, AFM, and XRD. The samples were surgically inserted into the muscles of rabbits. Eight weeks after healing, the attachment to the tissue was tested with a universal test device. The three samples exhibited distinctive surface morphology. The force to remove the HAp implants from the muscles was significantly greater than that of Ti group （P〈0.01）, with the AD samples requiring the greatest force （P〈0.01）. After removal, SEM showed that the tissue was firmly attached to the surface of AD samples. Photomicrographs of the peri-implant muscles showed a layer of aligned fibrous tissue without severe inflammation. The AD samples had more fibroblasts. Results indicate that because of enhanced mechanical adhesion of soft tissue to the implants, HAp-coated Ti by AD is a suitable KPro skirt material.展开更多
Dental and orthopedic titanium implants are successfully and widely used but still face challenges due to complications leading to high treatment cost,morbidity,and even mortality.This review focuses on the hybrid coa...Dental and orthopedic titanium implants are successfully and widely used but still face challenges due to complications leading to high treatment cost,morbidity,and even mortality.This review focuses on the hybrid coatings designed to prevent and mitigate implant failure by integrating multiple strategies and materials.The forms of manufacturing and synthesizing hybrid coatings were first discussed.We then categorize these coatings based on their biological functions:antibacterial coatings,which are essential for preventing difficult-to-treat infection;coatings designed to promote osseointegration,crucial for the mechanical stability of implants;coatings that encourage soft tissue attachment,contributing to the overall success and esthetics of implant.We summarize the state of the art in multifunctional coatings that integrate multiple biological functions as an alternative,holistic approach for reducing implant complications.The review culminates in a discussion on future di-rections in the field,emphasizing the potential and notable challenges these biofunctional hybrid coatings face toward obtaining commercial success in patients.Together,our article provides a comprehensive overview of current developments and a glimpse into the future of hybrid coatings for potentially revolutionizing dental and orthopedic implants.展开更多
文摘Stable tissue integration is important to keratoprosthesis （KPro）. The aim of this study was to evaluate the tissue bonding ability of hydroxyapatite （HAp）-coated titanium KPro. The samples were divided into three groups： test groups （IBAD group and AD group） and Ti control. The coated samples had a HAp layer created by ion beam assisted deposition （IBAD） or aerosol deposition （AD）. The surface characteristics were analyzed with SEM, AFM, and XRD. The samples were surgically inserted into the muscles of rabbits. Eight weeks after healing, the attachment to the tissue was tested with a universal test device. The three samples exhibited distinctive surface morphology. The force to remove the HAp implants from the muscles was significantly greater than that of Ti group （P〈0.01）, with the AD samples requiring the greatest force （P〈0.01）. After removal, SEM showed that the tissue was firmly attached to the surface of AD samples. Photomicrographs of the peri-implant muscles showed a layer of aligned fibrous tissue without severe inflammation. The AD samples had more fibroblasts. Results indicate that because of enhanced mechanical adhesion of soft tissue to the implants, HAp-coated Ti by AD is a suitable KPro skirt material.
基金This study was supported by the IADR Innovation in Oral Care Awards to Z.Y.,the National Natural Science Foundation of China[grant number 82160190 to T.S.]the Jiangxi Provincial Department of Science and Technology,China[grant number 20203BBGL73156 to T.S.].
文摘Dental and orthopedic titanium implants are successfully and widely used but still face challenges due to complications leading to high treatment cost,morbidity,and even mortality.This review focuses on the hybrid coatings designed to prevent and mitigate implant failure by integrating multiple strategies and materials.The forms of manufacturing and synthesizing hybrid coatings were first discussed.We then categorize these coatings based on their biological functions:antibacterial coatings,which are essential for preventing difficult-to-treat infection;coatings designed to promote osseointegration,crucial for the mechanical stability of implants;coatings that encourage soft tissue attachment,contributing to the overall success and esthetics of implant.We summarize the state of the art in multifunctional coatings that integrate multiple biological functions as an alternative,holistic approach for reducing implant complications.The review culminates in a discussion on future di-rections in the field,emphasizing the potential and notable challenges these biofunctional hybrid coatings face toward obtaining commercial success in patients.Together,our article provides a comprehensive overview of current developments and a glimpse into the future of hybrid coatings for potentially revolutionizing dental and orthopedic implants.
