To the Editor:Mechanotransduction is crucial for cellular and tissue adaptation to mechanical stimuli.Piezo1 channels,key mechanosensitive ion channels,confer sensitivity to these cues.Bone remodels in response to mec...To the Editor:Mechanotransduction is crucial for cellular and tissue adaptation to mechanical stimuli.Piezo1 channels,key mechanosensitive ion channels,confer sensitivity to these cues.Bone remodels in response to mechanical stimuli,maintaining homeostasis.Accumulated scientific evidence underscores the mechanosensitivity of both skeletal lineage cells and osteoclasts,marked by their robust expression of Piezo1 channels.Furthermore,insights garnered from bone-related studies have illuminated the indispensable function of Piezo1 in orchestrating bone development,repair processes,and other mechanobiologydriven activities.展开更多
基金supported by grants from the Research Fund from the National Natural Science Foundation of China(Nos.81971777,12132012,32100952).
文摘To the Editor:Mechanotransduction is crucial for cellular and tissue adaptation to mechanical stimuli.Piezo1 channels,key mechanosensitive ion channels,confer sensitivity to these cues.Bone remodels in response to mechanical stimuli,maintaining homeostasis.Accumulated scientific evidence underscores the mechanosensitivity of both skeletal lineage cells and osteoclasts,marked by their robust expression of Piezo1 channels.Furthermore,insights garnered from bone-related studies have illuminated the indispensable function of Piezo1 in orchestrating bone development,repair processes,and other mechanobiologydriven activities.
