Viburnum tinus L.is a shrub native to the Mediterranean basin.Because of its sedative and antispasmodic activities,it is often used as a folk medicine in Europe.Phytochemical researches have shown that numerous chemic...Viburnum tinus L.is a shrub native to the Mediterranean basin.Because of its sedative and antispasmodic activities,it is often used as a folk medicine in Europe.Phytochemical researches have shown that numerous chemical components,including iridoid glycosides,diterpenes,triterpenes,coumarin,flavonoids and anthocyanidins have been isolated from Viburnum tinus L..This study reviewed the chemical constituents and pharmacological activities of Viburnum tinus L.to provide a reference for further researches.展开更多
<strong><u>Introduction:</u></strong> Tubular and interstitial nephropathy syndrome with uveitis or TINU syndrome is a rare association. <strong><u>Patients and methods:</u>&l...<strong><u>Introduction:</u></strong> Tubular and interstitial nephropathy syndrome with uveitis or TINU syndrome is a rare association. <strong><u>Patients and methods:</u></strong> We have listed cases in which the clinical-biological picture and histology were consistent with this syndrome. <strong><u>Results:</u></strong> Two cases were retained: These were two female patients whose mean age at diagnosis was 16 years. The inaugural symptoms were bilateral anterior uveitis in two cases. The time to onset of renal signs: was 4 to 2 weeks months. Acute kidney failure was reported in both cases with a mean creatinine of 36.4 mg/l. An average proteinuria of 1.1 g/24 h associated with aseptic leukocyturia in one case/2 and glycosuria normoglycemic in 1 case/2. Non inflammatory syndrome specific with inflammatory anemia is reported in both cases. Kidney puncture biopsy confirmed the diagnosis with nephropathy diffuse polymorphic tubulointerstitial and immunofluorescence negative in both cases. Oral corticosteroid therapy (1 mg/kg per day) was started for 4 to 6 months. Both patients received initial local corticosteroid therapy for uveitis. The outcome was favorable under treatment with remission complete. Kidney function recovered after 6 months with an average serum creatinine of 6 mg/l. <strong><u>Discussion:</u></strong> The incidence of TINU syndrome appears to be underestimated in the literature. It is believed to be an autoimmune disease. The positive diagnosis is based on clinical, biological and histological. An etiological investigation in search of disease systemic is necessary before making the diagnosis. There is no codified treatment. The prognosis is favorable in the majority of cases. <strong><u>Conclusion:</u></strong> Investigation of renal function is necessary for any patient.展开更多
肾小管间质性肾炎-葡萄膜炎(tubulointerstitial nephritis and uveitis,TINU)综合征是一类以特发性肾小管间质性肾炎(tubulointerstitial nephritis,TIN)和眼部葡萄膜炎为主要特征的疾病,常伴有非特异系统性表现,1975年被Dobrin首次报...肾小管间质性肾炎-葡萄膜炎(tubulointerstitial nephritis and uveitis,TINU)综合征是一类以特发性肾小管间质性肾炎(tubulointerstitial nephritis,TIN)和眼部葡萄膜炎为主要特征的疾病,常伴有非特异系统性表现,1975年被Dobrin首次报道。2001年Mandeville等[1]报道世界范围内133例TINU患者的中位年龄为15岁(9~74岁),女性与男性的比例为3∶1。国内儿科病例报道少[2,3,4]。该病多以非特异性症状为首发表现,且眼葡萄膜炎与肾小管间质性肾炎发生时间多不同步,临床容易忽视,现将我院收治的1例TINU综合征患儿临床资料报道如下,以加强对该病的认识。展开更多
小管间质肾炎-葡萄膜炎（tubulointerstitial nephritis and uveitis,TINU）综合征是急性间质肾炎中一种少见的亚型.1975年首先由Dobrin等报道[1].至2014年全球共报道约250例病例[2-3].大部分TINU综合征患者为青少年和年轻女性,年龄中...小管间质肾炎-葡萄膜炎（tubulointerstitial nephritis and uveitis,TINU）综合征是急性间质肾炎中一种少见的亚型.1975年首先由Dobrin等报道[1].至2014年全球共报道约250例病例[2-3].大部分TINU综合征患者为青少年和年轻女性,年龄中位数为15岁[4],目前病例以眼科、成人肾内科的个案报道为主,无大规模流行病学调查.尤其儿科报道甚少,截止至2014年检索CNKI、万方、维普数据库显示国内16岁以下儿科病例报道仅3例[5].儿童、青少年较低的诊断率与疾病特点有关,也与临床肾内科（儿童和成人）、眼科医师对于本病的认识不足有关.为提高对本病的认识,避免漏诊及延误诊断,现重点就TINU综合征的临床特点、诊断、治疗及相关进展等进行综述.展开更多
文摘Viburnum tinus L.is a shrub native to the Mediterranean basin.Because of its sedative and antispasmodic activities,it is often used as a folk medicine in Europe.Phytochemical researches have shown that numerous chemical components,including iridoid glycosides,diterpenes,triterpenes,coumarin,flavonoids and anthocyanidins have been isolated from Viburnum tinus L..This study reviewed the chemical constituents and pharmacological activities of Viburnum tinus L.to provide a reference for further researches.
文摘<strong><u>Introduction:</u></strong> Tubular and interstitial nephropathy syndrome with uveitis or TINU syndrome is a rare association. <strong><u>Patients and methods:</u></strong> We have listed cases in which the clinical-biological picture and histology were consistent with this syndrome. <strong><u>Results:</u></strong> Two cases were retained: These were two female patients whose mean age at diagnosis was 16 years. The inaugural symptoms were bilateral anterior uveitis in two cases. The time to onset of renal signs: was 4 to 2 weeks months. Acute kidney failure was reported in both cases with a mean creatinine of 36.4 mg/l. An average proteinuria of 1.1 g/24 h associated with aseptic leukocyturia in one case/2 and glycosuria normoglycemic in 1 case/2. Non inflammatory syndrome specific with inflammatory anemia is reported in both cases. Kidney puncture biopsy confirmed the diagnosis with nephropathy diffuse polymorphic tubulointerstitial and immunofluorescence negative in both cases. Oral corticosteroid therapy (1 mg/kg per day) was started for 4 to 6 months. Both patients received initial local corticosteroid therapy for uveitis. The outcome was favorable under treatment with remission complete. Kidney function recovered after 6 months with an average serum creatinine of 6 mg/l. <strong><u>Discussion:</u></strong> The incidence of TINU syndrome appears to be underestimated in the literature. It is believed to be an autoimmune disease. The positive diagnosis is based on clinical, biological and histological. An etiological investigation in search of disease systemic is necessary before making the diagnosis. There is no codified treatment. The prognosis is favorable in the majority of cases. <strong><u>Conclusion:</u></strong> Investigation of renal function is necessary for any patient.
文摘肾小管间质性肾炎-葡萄膜炎(tubulointerstitial nephritis and uveitis,TINU)综合征是一类以特发性肾小管间质性肾炎(tubulointerstitial nephritis,TIN)和眼部葡萄膜炎为主要特征的疾病,常伴有非特异系统性表现,1975年被Dobrin首次报道。2001年Mandeville等[1]报道世界范围内133例TINU患者的中位年龄为15岁(9~74岁),女性与男性的比例为3∶1。国内儿科病例报道少[2,3,4]。该病多以非特异性症状为首发表现,且眼葡萄膜炎与肾小管间质性肾炎发生时间多不同步,临床容易忽视,现将我院收治的1例TINU综合征患儿临床资料报道如下,以加强对该病的认识。
文摘小管间质肾炎-葡萄膜炎（tubulointerstitial nephritis and uveitis,TINU）综合征是急性间质肾炎中一种少见的亚型.1975年首先由Dobrin等报道[1].至2014年全球共报道约250例病例[2-3].大部分TINU综合征患者为青少年和年轻女性,年龄中位数为15岁[4],目前病例以眼科、成人肾内科的个案报道为主,无大规模流行病学调查.尤其儿科报道甚少,截止至2014年检索CNKI、万方、维普数据库显示国内16岁以下儿科病例报道仅3例[5].儿童、青少年较低的诊断率与疾病特点有关,也与临床肾内科（儿童和成人）、眼科医师对于本病的认识不足有关.为提高对本病的认识,避免漏诊及延误诊断,现重点就TINU综合征的临床特点、诊断、治疗及相关进展等进行综述.
