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Underdetermined DOA estimation and blind separation of non-disjoint sources in time-frequency domain based on sparse representation method 被引量:9
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作者 Xiang Wang Zhitao Huang Yiyu Zhou 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2014年第1期17-25,共9页
This paper deals with the blind separation of nonstation-ary sources and direction-of-arrival (DOA) estimation in the under-determined case, when there are more sources than sensors. We assume the sources to be time... This paper deals with the blind separation of nonstation-ary sources and direction-of-arrival (DOA) estimation in the under-determined case, when there are more sources than sensors. We assume the sources to be time-frequency (TF) disjoint to a certain extent. In particular, the number of sources presented at any TF neighborhood is strictly less than that of sensors. We can identify the real number of active sources and achieve separation in any TF neighborhood by the sparse representation method. Compared with the subspace-based algorithm under the same sparseness assumption, which suffers from the extra noise effect since it can-not estimate the true number of active sources, the proposed algorithm can estimate the number of active sources and their cor-responding TF values in any TF neighborhood simultaneously. An-other contribution of this paper is a new estimation procedure for the DOA of sources in the underdetermined case, which combines the TF sparseness of sources and the clustering technique. Sim-ulation results demonstrate the validity and high performance of the proposed algorithm in both blind source separation (BSS) and DOA estimation. 展开更多
关键词 underdetermined blind source separation (UBSS)time-frequency (TF) domain sparse representation methoditerative adaptive approach direction-of-arrival (DOA) estimationclustering validation.
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Surface wave attenuation based polarization attributes in time-frequency domain for multicomponent seismic data 被引量:2
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作者 Kong Xuan-Lin Chen Hui +3 位作者 Hu Zhi-Quan Kang Jia-Xing Xu Tian-Ji and Li Lu-Ming 《Applied Geophysics》 SCIE CSCD 2018年第1期99-110,149,共13页
In the paper, we propose a surface wave suppression method in time-frequency domain based on the wavelet transform, considering the characteristic difference of polarization attributes, amplitude energy and apparent v... In the paper, we propose a surface wave suppression method in time-frequency domain based on the wavelet transform, considering the characteristic difference of polarization attributes, amplitude energy and apparent velocity between the effective signals and strong surface waves. First, we use the proposed method to obtain time-frequency spectra of seismic signals by using the wavelet transform and calculate the instantaneous polarizability at each point based on instantaneous polarization analysis. Then, we separate the surface wave area from the signal area based on the surface-wave apparent velocity and the average energy of the signal. Finally, we combine the polarizability, energy, and frequency characteristic to identify and suppress the signal noise. Model and field data are used to test the proposed filtering method. 展开更多
关键词 Vector seismic trace POLARIZATION time-frequency domain surface wave denoising
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A Recursive Method of Time-Frequency Analysis for the Signal Processing of Flutter Test with Progression Variable Speed 被引量:1
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作者 宋叔飚 裴承鸣 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2005年第3期213-217,共5页
Focused on the non-statlonarity and real-time analysis of signal in flutter test with progression variable speed (FTPVS), a new method of recursive time-frequency analysis is presented. The time-varying system is tr... Focused on the non-statlonarity and real-time analysis of signal in flutter test with progression variable speed (FTPVS), a new method of recursive time-frequency analysis is presented. The time-varying system is tracked on-line by building a time-varying parameter model, and then the relevant parameter spectrum can be obtained. The feasibility and advantages of the method are examined by digital simulation. The results of FTPVS at low-speed wind-tunnel promise the engineering application perspective of the method. 展开更多
关键词 flutter test with progression variable speed (FTPVS) non-stationary signal processing recursive time-frequency analysis (RTFA)
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Flexible organic artificial synapse with ultrashort-term plasticity for tunable time-frequency signal processing
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作者 Yao Ni Lu Liu +2 位作者 Jiulong Feng Lu Yang Wentao Xu 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第12期236-240,共5页
A flexible organic artificial synapse(OAS)for tunable time-frequency signal processing was fabricated using a tri-blend film that had been fabricated using a one-step solution method.When combined with a chitosan film... A flexible organic artificial synapse(OAS)for tunable time-frequency signal processing was fabricated using a tri-blend film that had been fabricated using a one-step solution method.When combined with a chitosan film,this OAS can achieve an ultrashort-term retention time of only 49 ms for instant electricalcomputing applications;this is the shortest retention time yet achieved by a two-terminal artificial synapse.An array of these flexible OASs can withstand a high bending strain of 5%for 10^(4) cycles;this deformation endurance is a new record.The OAS was also sensitive to the number and frequency of electrical inputs;a tunable cut-off frequency enables dynamic filtering for use in image detail enhancement.This work provides a new resource for development of future neuromorphic computing devices。 展开更多
关键词 Flexible organic artificial synapse Tri-blend film time-frequency signal processing Ultrashort-term plasticity Dynamic filtering
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TVAR Time-frequency Analysis for Non-stationary Vibration Signals of Spacecraft 被引量:7
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作者 杨海 程伟 朱虹 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2008年第5期423-432,共10页
Predicting the time-varying auto-spectral density of a spacecraft in high-altitude orbits requires an accurate model for the non-stationary random vibration signals with densely spaced modal frequency. The traditional... Predicting the time-varying auto-spectral density of a spacecraft in high-altitude orbits requires an accurate model for the non-stationary random vibration signals with densely spaced modal frequency. The traditional time-varying algorithm limits prediction accuracy, thus affecting a number of operational decisions. To solve this problem, a time-varying auto regressive (TVAR) model based on the process neural network (PNN) and the empirical mode decomposition (EMD) is proposed. The time-varying system is tracked on-line by establishing a time-varying parameter model, and then the relevant parameter spectrum is obtained. Firstly, the EMD method is utilized to decompose the signal into several intrinsic mode functions (IMFs). Then for each IMF, the PNN is established and the time-varying auto-spectral density is obtained. Finally, the time-frequency distribution of the signals can be reconstructed by linear superposition. The simulation and the analytical results from an example demonstrate that this approach possesses simplicity, effectiveness, and feasibility, as well as higher frequency resolution. 展开更多
关键词 non-stationary random vibration time-frequency distribution process neural network empirical mode decomposition
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Direct data domain approach to space-time adaptive processing 被引量:2
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作者 Wen Xiaoqin Han Chongzhao 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2006年第1期59-64,共6页
In non-homogeneous environment, traditional space-time adaptive processing doesn't effectively suppress interference and detect target, because the secondary data don' t exactly reflect the statistical characteristi... In non-homogeneous environment, traditional space-time adaptive processing doesn't effectively suppress interference and detect target, because the secondary data don' t exactly reflect the statistical characteristic of the range cell under test. A ravel methodology utilizing the direct data domain approach to space-time adaptive processing ( STAP ) in airbome radar non-homogeneous environments is presented. The deterministic least squares adaptive signal processing technique operates on a "snapshot-by-snapshot" basis to dethrone the adaptive adaptive weights for nulling interferences and estimating signal of interest (SOI). Furthermore, this approach eliminates the requirement for estimating the covariance through the data of neighboring range cell, which eliminates calculating the inverse of covariance, and can be implemented to operate in real-time. Simulation results illustrate the efficiency of interference suppression in non-homogeneous environment. 展开更多
关键词 space-time adaptive processing direct data domain interference suppression.
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CPS Modeling of CNC Machine Tool Work Processes Using an Instruction-Domain Based Approach 被引量:19
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作者 Jihong Chen Jianzhong Yang +5 位作者 Huicheng Zhou Hua Xiang Zhihong Zhu Yesong Li Chen-Han Lee Guangda Xu 《Engineering》 SCIE EI 2015年第2期247-260,共14页
Building cyber-physical system(CPS) models of machine tools is a key technology for intelligent manufacturing. The massive electronic data from a computer numerical control(CNC) system during the work processes of a C... Building cyber-physical system(CPS) models of machine tools is a key technology for intelligent manufacturing. The massive electronic data from a computer numerical control(CNC) system during the work processes of a CNC machine tool is the main source of the big data on which a CPS model is established. In this work-process model, a method based on instruction domain is applied to analyze the electronic big data, and a quantitative description of the numerical control(NC) processes is built according to the G code of the processes. Utilizing the instruction domain, a work-process CPS model is established on the basis of the accurate, real-time mapping of the manufacturing tasks, resources, and status of the CNC machine tool. Using such models, case studies are conducted on intelligent-machining applications, such as the optimization of NC processing parameters and the health assurance of CNC machine tools. 展开更多
关键词 cyber-physical system (CPS) big data computer numerical control (CNC) machine tool electronic data of work processes instruction domain intelligent machining
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Early detection of sudden cardiac death by using classical linear techniques and time-frequency methods on electrocardiogram signals 被引量:2
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作者 Elias Ebrahimzadeh Mohammad Pooyan 《Journal of Biomedical Science and Engineering》 2011年第11期699-706,共8页
Early detection of sudden cardiac death may be used for surviving the life of cardiac patients. In this paper we have investigated an algorithm to detect and predict sudden cardiac death, by processing of heart rate v... Early detection of sudden cardiac death may be used for surviving the life of cardiac patients. In this paper we have investigated an algorithm to detect and predict sudden cardiac death, by processing of heart rate variability signal through the classical and time-frequency methods. At first, one minute of ECG signals, just before the cardiac death event are extracted and used to compute heart rate variability (HRV) signal. Five features in time domain and four features in frequency domain are extracted from the HRV signal and used as classical linear features. Then the Wigner Ville transform is applied to the HRV signal, and 11 extra features in the time-frequency (TF) domain are obtained. In order to improve the performance of classification, the principal component analysis (PCA) is applied to the obtained features vector. Finally a neural network classifier is applied to the reduced features. The obtained results show that the TF method can classify normal and SCD subjects, more efficiently than the classical methods. A MIT-BIH ECG database was used to evaluate the proposed method. The proposed method was implemented using MLP classifier and had 74.36% and 99.16% correct detection rate (accuracy) for classical features and TF method, respectively. Also, the accuracy of the KNN classifier were 73.87% and 96.04%. 展开更多
关键词 SUDDEN CARDIAC DEATH Heart Rate Variability time-frequency Transform ELECTROCARDIOGRAM Signal Linear processing
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A Novel Receiving Method for Baseband DSSS Signal based on Phase Domain Processing
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作者 Sha Xuejun Zhan Zongchao Tang Xun 《China Communications》 SCIE CSCD 2010年第1期57-64,共8页
In this paper, the phase characteristic disturbance model for baseband direct sequence spread spectrum (DSSS) signal in additive white Gaussian noise (AWGN) environment is established, and the probability density func... In this paper, the phase characteristic disturbance model for baseband direct sequence spread spectrum (DSSS) signal in additive white Gaussian noise (AWGN) environment is established, and the probability density function (PDF) of phase characteristic disturbance is obtained. Then a novel receiver model for baseband DSSS signal based on maximum likelihood (ML) criterion is proposed. The simulation results show that, comparing with correlation scheme, the performance of the proposed method for baseband DSSS signal is 1dB worse in AWGN environment. However, if there is narrow interference in the AWGN environment, the proposed method will show better performance up to 2.5dB, and it has good adaptive resistance to narrowband interference located in different frequency points. This method could be used as an alterative communication scheme for military circumstance when existing strong narrowband interference of various frequencies. 展开更多
关键词 PHASE domain processING PHASE characteristic DISTURBANCE ML criterion anti-narrow-band interference
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TIME DOMAIN PROCESSING MODE SPREAD SPECTRUM SYSTEM
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作者 何世平 《Journal of Electronics(China)》 1995年第3期276-283,共8页
The construction and specifications of a surface acoustic wave storage correlator are described. A time domain processing mode spread spectrum system is presented. An analysis of the interference rejection for this sy... The construction and specifications of a surface acoustic wave storage correlator are described. A time domain processing mode spread spectrum system is presented. An analysis of the interference rejection for this system is provided. The formula for calculating the probability of error of the system is given. The experimental results agree with the theoretical analysis. 展开更多
关键词 Time domain processing SPREAD SPECTRUM system STORAGE CORRELATOR
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A NEW QUADRATIC TIME-FREQUENCY DISTRIBUTIONAND A COMPARATIVE STUDY OF SEVERAL POPULARQUADRATIC TIME-FREQUENCY DISTRIBUTIONS
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作者 Liu Guizhong Liu Zhimei(information Engineering Institute, Xi’an Jiaotong University, Xi’an 710049) 《Journal of Electronics(China)》 1997年第2期104-111,共8页
A new quadratic time-frequency distribution (TFD) with a compound kernel is proposed and a comparative study of several popular quadratic TFD is carried out. It is shown that the new TFD with compound kernel has stron... A new quadratic time-frequency distribution (TFD) with a compound kernel is proposed and a comparative study of several popular quadratic TFD is carried out. It is shown that the new TFD with compound kernel has stronger ability than the exponential distribution (ED) and the cone-shaped kernel distribution (CKD) in reducing cross terms, meanwhile almost not decreasing the time-frequency resolution of ED or CKD. 展开更多
关键词 SIGNAL processing time-frequency analysis time-frequency distribution of Cohen’s CLASS
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Human Brain Microwave Imaging Signal Processing: Frequency Domain (S-parameters) to Time Domain Conversion
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作者 Kim Mey Chew Rubita Sudirman +2 位作者 Nasrul Humaimi Mahmood Norhudah Seman Ching Yee Yong 《Engineering(科研)》 2013年第5期31-36,共6页
The paper presents the microwave signal processing method using MATLAB based on the result of microwave imaging system simulation developed using Computer Simulation Technology (CST). The simulation system contains a ... The paper presents the microwave signal processing method using MATLAB based on the result of microwave imaging system simulation developed using Computer Simulation Technology (CST). The simulation system contains a transmitting/receiving antenna, human brain and a tumor inside the brain model. The source signal, microwave signal operates from 1 to 10 GHz. The generated scattering parameters (S-parameters) are in frequency domain form. This paper describes in detail regarding the signal conversion from frequency domain to time domain through proposed Inverse Fast Fourier Transform (IFFT) method as well as the noise filtering process. Peaks detection process was performed in order to identify the time delay of the reflection points at different Y-axis 展开更多
关键词 Microwave SIGNAL SIGNAL processing SCATTERING Parameters Time domain IFFT
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Building a Productive Domain-Specific Cloud for Big Data Processing and Analytics Service
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作者 Yuzhong Yan Mahsa Hanifi +1 位作者 Liqi Yi Lei Huang 《Journal of Computer and Communications》 2015年第5期107-117,共11页
Cloud Computing as a disruptive technology, provides a dynamic, elastic and promising computing climate to tackle the challenges of big data processing and analytics. Hadoop and MapReduce are the widely used open sour... Cloud Computing as a disruptive technology, provides a dynamic, elastic and promising computing climate to tackle the challenges of big data processing and analytics. Hadoop and MapReduce are the widely used open source frameworks in Cloud Computing for storing and processing big data in the scalable fashion. Spark is the latest parallel computing engine working together with Hadoop that exceeds MapReduce performance via its in-memory computing and high level programming features. In this paper, we present our design and implementation of a productive, domain-specific big data analytics cloud platform on top of Hadoop and Spark. To increase user’s productivity, we created a variety of data processing templates to simplify the programming efforts. We have conducted experiments for its productivity and performance with a few basic but representative data processing algorithms in the petroleum industry. Geophysicists can use the platform to productively design and implement scalable seismic data processing algorithms without handling the details of data management and the complexity of parallelism. The Cloud platform generates a complete data processing application based on user’s kernel program and simple configurations, allocates resources and executes it in parallel on top of Spark and Hadoop. 展开更多
关键词 BUILDING a Productive domain-Specific CLOUD for BIG Data processING and ANALYTICS SERVICE
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Domain adaptation method inspired by quantum convolutional neural network
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作者 Chunhui Wu Junhao Pei +2 位作者 Yihua Wu Anqi Zhang Shengmei Zhao 《Chinese Physics B》 2025年第7期185-195,共11页
Quantum machine learning is an important application of quantum computing in the era of noisy intermediate-scale quantum devices.Domain adaptation(DA)is an effective method for addressing the distribution discrepancy ... Quantum machine learning is an important application of quantum computing in the era of noisy intermediate-scale quantum devices.Domain adaptation(DA)is an effective method for addressing the distribution discrepancy problem between the training data and the real data when the neural network model is deployed.In this paper,we propose a variational quantum domain adaptation method inspired by the quantum convolutional neural network,named variational quantum domain adaptation(VQDA).The data are first uploaded by a‘quantum coding module',then the feature information is extracted by several‘quantum convolution layers'and‘quantum pooling layers',which is named‘Feature Extractor'.Subsequently,the labels and the domains of the samples are obtained by the‘quantum fully connected layer'.With a gradient reversal module,the trained‘Feature Extractor'can extract the features that cannot be distinguished from the source and target domains.The simulations on the local computer and IBM Quantum Experience(IBM Q)platform by Qiskit show the effectiveness of the proposed method.The results show that VQDA(with 8 quantum bits)has 91.46%average classification accuracy for DA task between MNIST→USPS(USPS→MNIST),achieves 91.16%average classification accuracy for gray-scale and color images(with 10 quantum bits),and has 69.25%average classification accuracy on the DA task for color images(also with 10 quantum bits).VQDA achieves a 9.14%improvement in average classification accuracy compared to its corresponding classical domain adaptation method with the same parameter scale for different DA tasks.Simultaneously,the parameters scale is reduced to 43%by using VQDA when both quantum and classical DA methods have similar classification accuracies. 展开更多
关键词 quantum image processing domain adaptation quantum convolutional neural network IBM quantum experience
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DNEFNET: Denoising and Frequency Domain Feature Enhancement Event Fusion Network for Image Deblurring
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作者 Kangkang Zhao Yaojie Chen Jianbo Li 《Computers, Materials & Continua》 2025年第7期745-762,共18页
Traditional cameras inevitably suffer from motion blur when facing high-speed moving objects.Event cameras,as high temporal resolution bionic cameras,record intensity changes in an asynchronous manner,and their record... Traditional cameras inevitably suffer from motion blur when facing high-speed moving objects.Event cameras,as high temporal resolution bionic cameras,record intensity changes in an asynchronous manner,and their recorded high temporal resolution information can effectively solve the problem of time information loss in motion blur.Existing event-based deblurring methods still face challenges when facing high-speed moving objects.We conducted an in-depth study of the imaging principle of event cameras.We found that the event stream contains excessive noise.The valid information is sparse.Invalid event features hinder the expression of valid features due to the uncertainty of the global threshold.To address this problem,a denoising-based long and short-term memory module(DTM)is designed in this paper.The DTM suppressed the original event information by noise reduction process.Invalid features in the event stream and solves the problem of sparse valid information in the event stream,and it also combines with the long short-term memory module(LSTM),which further enhances the event feature information in the time scale.In addition,through the in-depth understanding of the unique characteristics of event features,it is found that the high-frequency information recorded by event features does not effectively guide the fusion feature deblurring process in the spatial-domain-based feature processing,and for this reason,we introduce the residual fast fourier transform module(RES-FFT)to further enhance the high-frequency characteristics of the fusion features by performing the feature extraction of the fusion features from the perspective of the frequency domain.Ultimately,our proposed event image fusion network based on event denoising and frequency domain feature enhancement(DNEFNET)achieved Peak Signal-to-Noise Ratio(PSNR)/Structural Similarity Index Measure(SSIM)scores of 35.55/0.972 on the GoPro dataset and 38.27/0.975 on the REBlur dataset,achieving the state of the art(SOTA)effect. 展开更多
关键词 Image deblurring event camera DENOISING frequency domain Algorithm 1:DNEFNET image processing
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Simulation of pavement roughness based on time domain model 被引量:2
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作者 钮凯健 李昶 《Journal of Southeast University(English Edition)》 EI CAS 2010年第3期475-479,共5页
In order to describe pavement roughness more intuitively and effectively, a method of pavement roughness simulation, i.e., the stochastic sinusoidal wave, is introduced. The method is based on the primary idea that pa... In order to describe pavement roughness more intuitively and effectively, a method of pavement roughness simulation, i.e., the stochastic sinusoidal wave, is introduced. The method is based on the primary idea that pavement roughness is denoted as the sum of numerous sines or cosines with stochastic phases, and uses the discrete spectrum to approach the target stochastic process. It is a discrete numerical method used to simulate pavement roughness. According to a given pavement power spectral density (PSD) coefficient, under the condition that the character of displacement frequency based on the time domain model is in accordance with the given pavement surface spectrum, the pavement roughness is optimized to stochastic equivalent vibrations by computer simulation, and the curves that describe pavement roughness under each grade are obtained. The results show that the stochastic sinusoidal wave is suitable for simulation of measured pavement surface spectra based on the time domain model. The method of the stochastic sinusoidal wave is important to the research on vehicle ride comfort due to its rigorous mathematical derivation, extensive application range and intuitive simulation curve. Finally, a roughness index defined as the nominal roughness index (NRI) is introduced, and it has correlation with the PSD coefficient. 展开更多
关键词 pavement roughness stochastic sinusoidal wave stochastic process power spectral density (PSD) coefficient time domain nominal roughness index (NRI)
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基于深度学习的双域信息CT金属伪影抑制方法
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作者 海潮 田鑫 +4 位作者 张宏 谭大龙 何一新 孟凡勇 杨民 《北京航空航天大学学报》 北大核心 2026年第1期232-243,共12页
当CT扫描视野中出现金属时,重建图像不可避免地会产生金属伪影,严重影响图像质量。为了抑制金属伪影,提出一种新的深度学习CT金属伪影抑制(MAR)方法,结合正弦图域和图像域的双域信息,采用自适应最优阈值分割方法分割CT图像中的金属,并... 当CT扫描视野中出现金属时,重建图像不可避免地会产生金属伪影,严重影响图像质量。为了抑制金属伪影,提出一种新的深度学习CT金属伪影抑制(MAR)方法,结合正弦图域和图像域的双域信息,采用自适应最优阈值分割方法分割CT图像中的金属,并在正弦图中去除金属污染区域,使用线性插值(LI)初步修复缺失的金属区域,采用正弦图修补网络修复受金属污染的正弦图,利用编码器-解码器网络结构恢复缺失的图像信息。网络输出的正弦图经过滤波反投影(FBP)算法生成CT重建图像。对于初步校正后存在的正弦图信息不一致性问题,使用非局部细化网络在图像域进行修复,减少二次伪影产生。模拟和真实数据实验结果表明:所提方法能有效减少金属伪影,同时保留图像细节信息,显著提高重建图像质量。 展开更多
关键词 图像处理 深度学习 金属伪影抑制 双域信息 Pix2Pix 非局部细化网络
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A Synthetic Speech Detection Model Combining Local-Global Dependency
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作者 Jiahui Song Yuepeng Zhang Wenhao Yuan 《Computers, Materials & Continua》 2026年第1期1312-1326,共15页
Synthetic speech detection is an essential task in the field of voice security,aimed at identifying deceptive voice attacks generated by text-to-speech(TTS)systems or voice conversion(VC)systems.In this paper,we propo... Synthetic speech detection is an essential task in the field of voice security,aimed at identifying deceptive voice attacks generated by text-to-speech(TTS)systems or voice conversion(VC)systems.In this paper,we propose a synthetic speech detection model called TFTransformer,which integrates both local and global features to enhance detection capabilities by effectively modeling local and global dependencies.Structurally,the model is divided into two main components:a front-end and a back-end.The front-end of the model uses a combination of SincLayer and two-dimensional(2D)convolution to extract high-level feature maps(HFM)containing local dependency of the input speech signals.The back-end uses time-frequency Transformer module to process these feature maps and further capture global dependency.Furthermore,we propose TFTransformer-SE,which incorporates a channel attention mechanism within the 2D convolutional blocks.This enhancement aims to more effectively capture local dependencies,thereby improving the model’s performance.The experiments were conducted on the ASVspoof 2021 LA dataset,and the results showed that the model achieved an equal error rate(EER)of 3.37%without data augmentation.Additionally,we evaluated the model using the ASVspoof 2019 LA dataset,achieving an EER of 0.84%,also without data augmentation.This demonstrates that combining local and global dependencies in the time-frequency domain can significantly improve detection accuracy. 展开更多
关键词 Synthetic speech detection transformer local-global time-frequency domain
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Argonaute protein as a linker to command center of physiological processes 被引量:2
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作者 Kaifa Wei Lingjuan Wu +4 位作者 Yanhui Chen Yina Lin Yanmei Wang Xiaoyao Liu Daoxin Xie 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2013年第4期430-441,共12页
MicroRNAs (miRNAs) post-transcriptionally regulate gene expression by binding to target mRNAs with perfect or imperfect complementarity, recruiting an Argonaute (AGO) protein complex that usually results in degrad... MicroRNAs (miRNAs) post-transcriptionally regulate gene expression by binding to target mRNAs with perfect or imperfect complementarity, recruiting an Argonaute (AGO) protein complex that usually results in degradation or translational repression of the target mRNA. AGO proteins function as the Slicer enzyme in miRNA and small interfering RNA (siRNA) pathways involved in human physiological and pathophysiological processes, such as antiviral responses and disease formation. Although the past decade has witnessed rapid advancement in studies of AGO protein functions, to further elucidate the molecular mechanism of AGO proteins in cellular function and biochemical process is really a challenging area for researchers. In order to understand the molecular causes underlying the pathological processes, we mainly focus on five fundamental problems of AGO proteins, including evolution, functional domain, subcellular location, post-translational modification and protein-protein interactions. Our discussion highlight their roles in early diagnosis, disease prevention, drug target identification, drug response, etc. 展开更多
关键词 Small RNA Argonaute (AGO) protein functional domain subcellular location post-translational modification pathological process
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Hierarchical Domain Assignment BaseC on Word-Gloss 被引量:1
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作者 朱朝勇 黄河燕 史树敏 《China Communications》 SCIE CSCD 2012年第3期19-27,共9页
This paper proposes a hierarchical word domain assignment algorithm to automatically build domain dictionaries from Machine-Readable Dictionary(MRD).The process for word domain assignment can be divided into three ste... This paper proposes a hierarchical word domain assignment algorithm to automatically build domain dictionaries from Machine-Readable Dictionary(MRD).The process for word domain assignment can be divided into three steps:1) Hierarchical structure constructing;2) Classifier training;3) Word domain assigning.Compared with the traditional methods,the hierarchical word domain assignment algorithm enhances the accuracy of word domain assignment while reducing human efforts on collecting corpus.Experiments on WordNet 2.0 show that 62.53% of the first domain labels are matched with the WordNet Domains 3.0 by using gloss-based word domain assignment,and the performance can be further improved by utilizing the hierarchical relationships among the domain sets. 展开更多
关键词 natural language processing domaindictionary hierarchical classification domain as-sigrmaent WORDNET MRD
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