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Investigation of three-pulse photon echo in thick crystal using finite-difference time-domain method 被引量:1
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作者 马秀荣 徐林 +1 位作者 常世元 张双根 《Chinese Physics B》 SCIE EI CAS CSCD 2017年第4期190-197,共8页
This paper investigates the phenomenon of three-pulse photon echo in thick rare-earth ions doped crystal whose thickness is far larger than 0.002 cm which is adopted in previous works.The influence of thickness on the... This paper investigates the phenomenon of three-pulse photon echo in thick rare-earth ions doped crystal whose thickness is far larger than 0.002 cm which is adopted in previous works.The influence of thickness on the three-pulse photon echo's amplitude and efficiency is analyzed with the Maxwell-Bloch equations solved by finite-difference timedomain method.We demonstrate that the amplitude of three-pulse echo will increase with the increasing of thickness and the optimum thickness to generate three-pulse photon echo is 0.3 cm for Tm^(3+):YAG when the attenuation of the input pulse is taken into account.Meanwhile,we find the expression 0.09 exp(α'L),which is previously employed to describe the relationship between echo's efficiency and thickness,should be modified as 1.3 · 0.09 exp(2.4 ·α'L) with the propagation of echo considered. 展开更多
关键词 three-pulse photon echo Maxwell-Bloch equations finite-difference time-domain method
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利用ECHO模型评价药学质控对药物治疗管理服务的影响
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作者 刘坤 蒋欢欢 +10 位作者 李玉双 黄炎 张倩影 陈冬 谷秀林 封锦慧 王紫监 陈云飞 齐亚娟 戈艳蕾 付爱双 《中国药房》 北大核心 2025年第9期1123-1128,共6页
目的利用经济、临床、人文产出(ECHO)模型评价药学质控对冠心病患者实施标准化药物治疗管理(MTM)服务效率和产出的影响。方法收集2023年1-3月(质控实施前组,96例)和6-8月(质控实施后组,164例)接受MTM服务的冠心病患者病例资料,采用倾向... 目的利用经济、临床、人文产出(ECHO)模型评价药学质控对冠心病患者实施标准化药物治疗管理(MTM)服务效率和产出的影响。方法收集2023年1-3月(质控实施前组,96例)和6-8月(质控实施后组,164例)接受MTM服务的冠心病患者病例资料,采用倾向性评分匹配法,每组各纳入80例患者,比较匹配后两组患者药学服务的经济、临床和人文产出指标差异。结果匹配后两组患者的基线资料比较差异均无统计学意义(P>0.05)。与质控实施前组比较,质控实施后组患者的日均治疗总成本(16.26元vs.24.40元,P<0.001)、成本-效用比[23.12元/质量调整生命年(QALY)vs.32.32元/QALY,P<0.001]、一般的药品不良反应发生率(2.50%vs.10.00%,P=0.049)均显著降低,欧洲五维生存质量量表效用值(0.74±0.06 vs.0.71±0.07,P=0.003)、药物治疗相关问题减少数量(1.0个vs.0.5个,P<0.001)、用药依从性评分[(6.32±0.48)分vs.(6.10±0.37)分,P=0.001]和满意度评分[(92.56±1.52)分vs.(91.95±1.56)分,P=0.013)]均显著升高;两组患者均未发生严重的药品不良反应,新的药品不良反应发生率比较差异无统计学意义(1.25%vs.3.75%,P=0.310)。结论药学质控可提高药学服务工作质量;ECHO模型可对MTM服务效果进行量化评价,使药学服务更好计价,更能适应社会需求,值得推广。 展开更多
关键词 药物治疗管理 药学质控 echo模型 药学服务
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An adaptive continuous threshold wavelet denoising method for LiDAR echo signal
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作者 Dezhi Zheng Tianchi Qu +4 位作者 Chun Hu Shijia Lu Zhongxiang Li Guanyu Yang Xiaojun Yang 《Nanotechnology and Precision Engineering》 2025年第2期51-62,共12页
Atmospheric aerosols are the primary contributors to environmental pollution.As such aerosols are micro-to nanosized particles invisible to the naked eye,it is necessary to utilize LiDAR technology for their detection... Atmospheric aerosols are the primary contributors to environmental pollution.As such aerosols are micro-to nanosized particles invisible to the naked eye,it is necessary to utilize LiDAR technology for their detection.The laser radar echo signal is vulnerable to background light and electronic thermal noise.While single-photon LiDAR can effectively reduce background light interference,electronic thermal noise remains a significant challenge,especially at long distances and in environments with a low signal-to-noise ratio(SNR).However,conventional denoising methods cannot achieve satisfactory results in this case.In this paper,a novel adaptive continuous threshold wavelet denoising algorithm is proposed to filter out the noise.The algorithm features an adaptive threshold and a continuous threshold function.The adaptive threshold is dynamically adjusted according to the wavelet decomposition level,and the continuous threshold function ensures continuity with lower constant error,thus optimizing the denoising process.Simulation results show that the proposed algorithm has excellent performance in improving SNR and reducing root mean square error(RMSE)compared with other algorithms.Experimental results show that denoising of an actual LiDAR echo signal results in a 4.37 dB improvement in SNR and a 39.5%reduction in RMSE.The proposed method significantly enhances the ability of single-photon LiDAR to detect weak signals. 展开更多
关键词 Single-photon LiDAR echo signal Adaptive thresholding Wavelet transform
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Enhanced Nowcasting Through a Novel Radar Echo Extrapolation Algorithm:Integrating Recurrent Convolutional Neural Networks with Optical Flow Methods
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作者 Xugang LI Zhiyuan SHU +4 位作者 Shaoyu HOU Feng LV Wuyi WANG Rong MAI Haipeng ZHU 《Meteorological and Environmental Research》 2025年第3期51-56,共6页
This study proposes a novel radar echo extrapolation algorithm,OF-ConvGRU,which integrates Optical Flow(OF)and Convolutional Gated Recurrent Unit(ConvGRU)methods for improved nowcasting.Using the Standardized Radar Da... This study proposes a novel radar echo extrapolation algorithm,OF-ConvGRU,which integrates Optical Flow(OF)and Convolutional Gated Recurrent Unit(ConvGRU)methods for improved nowcasting.Using the Standardized Radar Dataset of the Guangdong-Hong Kong-Macao Greater Bay Area,the performance of OF-ConvGRU was evaluated against OF and ConvGRU methods.Threat Score(TS)and Bias Score(BIAS)were employed to assess extrapolation accuracy across various echo intensities(20-50 dBz)and weather phenomena.Results demonstrate that OF-ConvGRU significantly enhances prediction accuracy for moderate-intensity echoes(30-40 dBz),effectively combining OF s precise motion estimation with ConvGRU s nonlinear learning capabilities.However,challenges persist in low-intensity(20 dBz)and high-intensity(50 dBz)echo predictions.The study reveals distinct advantages of each method in specific contexts,highlighting the importance of multi-method approaches in operational nowcasting.OF-ConvGRU shows promise in balancing short-term accuracy with long-term stability,particularly for complex weather systems. 展开更多
关键词 Radar echo extrapolation NOWCASTING Optical flow Deep learning
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A Correntropy-Based Echo State Network With Application to Time Series Prediction
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作者 Xiufang Chen Zhenming Su +1 位作者 Long Jin Shuai Li 《IEEE/CAA Journal of Automatica Sinica》 2025年第2期425-435,共11页
As a category of recurrent neural networks,echo state networks(ESNs)have been the topic of in-depth investigations and extensive applications in a diverse array of fields,with spectacular triumphs achieved.Nevertheles... As a category of recurrent neural networks,echo state networks(ESNs)have been the topic of in-depth investigations and extensive applications in a diverse array of fields,with spectacular triumphs achieved.Nevertheless,the traditional ESN and the majority of its variants are devised in the light of the second-order statistical information of data(e.g.,variance and covariance),while more information is neglected.In the context of information theoretic learning,correntropy demonstrates the capacity to grab more information from data.Therefore,under the guidelines of the maximum correntropy criterion,this paper proposes a correntropy-based echo state network(CESN)in which the first-order and higher-order information of data is captured,promoting robustness to noise.Furthermore,an incremental learning algorithm for the CESN is presented,which has the expertise to update the CESN when new data arrives,eliminating the need to retrain the network from scratch.Finally,experiments on benchmark problems and comparisons with existing works are provided to verify the effectiveness and superiority of the proposed CESN. 展开更多
关键词 Correntropy echo state network(ESN) noise time series prediction
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A Time-Domain Irregular Wave Model with Different Random Numbers for FOWT Support Structures
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作者 Shen-Haw Ju Yi-Chen Huang 《Computer Modeling in Engineering & Sciences》 2025年第8期1631-1654,共24页
This study focuses on determining the second-order irregular wave loads in the time domain without using the Inverse Fast Fourier Transform(IFFT).Considering the substantial displacement effects that Floating Offshore... This study focuses on determining the second-order irregular wave loads in the time domain without using the Inverse Fast Fourier Transform(IFFT).Considering the substantial displacement effects that Floating Offshore Wind Turbine(FOWT)support structures undergo when subjected to wave loads,the time-domain wave method is more suitable,while the frequency-domain method requiring IFFT cannot be used for moving bodies.Nonetheless,the computational challenges posed by the considerable computer time requirements of the time-domain wave method remain a significant obstacle.Thus,the paper incorporates various numerical schemes,including parallel computing and extrapolation of wave forces during specific time steps to improve overall efficiency.Despite the effectiveness of these schemes,the computational difficulties associated with the time-domain wave method persist.This study then proposes an innovative approach utilizing different randomnumbers in distinct segments,significantly reducing the computation of second-order wave loads.This random number interpolation ensures a smooth curve transition between two segments,emphasizingminimizing errors near the end of the first segment.Numerical analyses demonstrate substantial decreases in total computer time for FOWT structural analyses while maintaining consistent steel design results.The proposed method is uncomplicated,requiring only a simple subprogram modification in a conventional wave load computer program. 展开更多
关键词 Fast fourier transform finite element method floating offshore wind turbine irregular wave parallel computing time-domain wave loads
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Iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL-IQ) for evaluation of early bone mass changes in ageing osteoporosis patients
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作者 Yonggui Yang Fang Chen +2 位作者 Xiufen Wu Xinyu Xu Pu-Yeh Wu 《Magnetic Resonance Letters》 2025年第2期11-18,共8页
This study explored the application value of iterative decomposition of water and fatwith echo asymmetry and least-squares estimation(IDEAL-IQ)technology in the early diagnosis of ageing osteoporosis(OP).172 participa... This study explored the application value of iterative decomposition of water and fatwith echo asymmetry and least-squares estimation(IDEAL-IQ)technology in the early diagnosis of ageing osteoporosis(OP).172 participants were enrolled and underwentmagnetic resonance imaging(MRI)examinations on a 3.0T scanner.100 cases were included in the normal group(50 males and 50 females;mean age:45 years;age range:20e84 years).33 cases were included in the osteopenia group(17 males and 16 females;mean age:55 years;age range:43e83 years).39 caseswere includedintheOP group(19males and20females;meanage:58years;age range:48 e82 years).Conventional T1WI and T2WI were first obtained,followed by 3D-IDEAL-IQ-acqui-sition.Fat fraction(FF)and apparent transverse relaxation rate(R2*)resultswere automatically calculated from IDEAL-IQ-images on the console.Based on T1Wand T2W-images,300 ROIs for each participantweremanually delineated in L1-L5 vertebral bodies of five middle slices.In each age group of all normal subjects,each parameter was significantly correlated with gender.In male participants from the normal,osteopenia,and OP groups,statistical analysis revealed F values of 11319.292 and 180.130 for comparisons involving FF and R2*values,respectively(all p<0.0001).The sensitivity and specificity of FF values were 0.906 and 0.950,0.994 and 0.997,0.865 and 0.820,respectively.For R2*,they were 0.665 and 0.616,0.563 and 0.519,0.571 and 0.368,respectively.In female participants from the normal,osteopenia,and OP-groups,statis-tical analysis revealed F values of 12461.658 and 548.274 for comparisons involving FF and R2*values,respectively(all p<0.0001).The sensitivity and specificity of FF values were 0.985 and 0.991,0.996 and 0.996,0.581 and 0.678,respectively.For R2*,they were 0.698 and 0.730,0.603 and 0.665,0.622 and 0.525,respectively.Significant differences were indicated in the quanti-tative values among the three groups.FF value had good performance,while R2*value had poor performance indiscriminatingosteopenia andOP-groups.Overall,the IDEAL-IQ techniqueoffers specific reference indices that enable noninvasive and quantitative assessment of lumbar vertebrae bone metabolism,thereby providing diagnostic information for OP. 展开更多
关键词 Magnetic resonance imaging Iterative decomposition of water and fat with echo asymmetry and least-squares estimation Bone mineral density OSTEOPOROSIS Osteopenia
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连云港市一起ECHO_(30)病毒性脑膜炎爆发流行病学调查 被引量:11
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作者 朱磷扬 张廷禄 +4 位作者 朱凤东 许雷 孙波 潘红星 赵玉良 《疾病监测》 CAS 2007年第6期384-387,共4页
目的分析2006年江苏省连云港市病毒性脑膜炎爆发的流行特征、影响因素和病因。方法采用统一的流行病学调查表对病例进行调查,收集2004年以来全市各县区病毒性脑膜炎住院病例资料,采用1:2配比病例对照研究的方法分析流行因素;24份脑脊液... 目的分析2006年江苏省连云港市病毒性脑膜炎爆发的流行特征、影响因素和病因。方法采用统一的流行病学调查表对病例进行调查,收集2004年以来全市各县区病毒性脑膜炎住院病例资料,采用1:2配比病例对照研究的方法分析流行因素;24份脑脊液标本送江苏省疾病控制中心检测,并进行病毒分离。结果2004-2005年全市各县区病毒性脑膜炎病例呈现散发状态;2006年1~7月份共查出病例数为968例,从6月份起出现疫情上升,1县2区出现爆发,7月份达高峰,爆发病例为473例,占全市总病例数的48.86%;主要累及15岁以下儿童,占94.44%;男性多于女性,男女比为2.65:1;主要临床表现为发热、头痛、呕吐、脑膜刺激征阳性、脑脊液有核细胞增多。饭前洗手与多吃瓜果为保护因素,说明该病与不良卫生习惯有关系。23份脑脊液经PCR检测,16份ECHO_(30)肠道病毒阳性。结论2006年夏季江苏省连云港市病毒性脑膜炎出现一次爆发并波及1县2区,致病病原体为埃可30型肠道病毒(Echovirus 30,ECHO_(30))肠道病毒,不良卫生习惯可能是导致该病发生流行的危险因素。 展开更多
关键词 echo30 脑膜炎 爆发 流行病学调查
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PC-based artif icial neural network inversion for airborne time-domain electromagnetic data 被引量:8
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作者 朱凯光 马铭遥 +4 位作者 车宏伟 杨二伟 嵇艳鞠 于生宝 林君 《Applied Geophysics》 SCIE CSCD 2012年第1期1-8,114,共9页
Traditionally, airborne time-domain electromagnetic (ATEM) data are inverted to derive the earth model by iteration. However, the data are often highly correlated among channels and consequently cause ill-posed and ... Traditionally, airborne time-domain electromagnetic (ATEM) data are inverted to derive the earth model by iteration. However, the data are often highly correlated among channels and consequently cause ill-posed and over-determined problems in the inversion. The correlation complicates the mapping relation between the ATEM data and the earth parameters and thus increases the inversion complexity. To obviate this, we adopt principal component analysis to transform ATEM data into orthogonal principal components (PCs) to reduce the correlations and the data dimensionality and simultaneously suppress the unrelated noise. In this paper, we use an artificial neural network (ANN) to approach the PCs mapping relation with the earth model parameters, avoiding the calculation of Jacobian derivatives. The PC-based ANN algorithm is applied to synthetic data for layered models compared with data-based ANN for airborne time-domain electromagnetic inversion. The results demonstrate the PC-based ANN advantages of simpler network structure, less training steps, and better inversion results over data-based ANN, especially for contaminated data. Furthermore, the PC-based ANN algorithm effectiveness is examined by the inversion of the pseudo 2D model and comparison with data-based ANN and Zhody's methods. The results indicate that PC-based ANN inversion can achieve a better agreement with the true model and also proved that PC-based ANN is feasible to invert large ATEM datasets. 展开更多
关键词 Principal component analysis artificial neural network airborne time-domain electromagnetics INVERSION CONDUCTIVITY
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福建省2011年病毒性脑炎暴发病原Echo30分子流行病学分析 被引量:22
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作者 杨秀惠 严延生 +6 位作者 翁育伟 何爱华 张红榕 陈炜 许江阳 林其财 周勇 《中国人兽共患病学报》 CAS CSCD 北大核心 2012年第3期265-269,共5页
目的了解福建省2011年病毒性脑炎暴发的病原特点及福建省近10年Echo30分子流行病学特征。方法应用细胞培养法获得病毒株,微量血清中和试验或RT-PCR序列分析鉴定Echo30血清型,提取病毒RNA核酸,逆转录为cD-NA,分段扩增VP1基因序列全长,测... 目的了解福建省2011年病毒性脑炎暴发的病原特点及福建省近10年Echo30分子流行病学特征。方法应用细胞培养法获得病毒株,微量血清中和试验或RT-PCR序列分析鉴定Echo30血清型,提取病毒RNA核酸,逆转录为cD-NA,分段扩增VP1基因序列全长,测定并分析扩增产物的序列。结果 2011年4月1日-6月2日,从福建省4个县(市)区病毒性脑炎病例标本中分离的病毒经鉴定均为Echo30;VP1基因序列分析显示,泉州市安溪和德化两地流行株高度同源(核苷酸与氨基酸序列同源性分别为99.0%和99.6%),同福安和厦门流行株(核苷酸与氨基酸序列同源性分别为98.5%和100%)核苷酸差异约9%,3个位点氨基酸出现了变异。近10年福建省Echo30分子流行病学分析显示,2011年泉州流行株并非由2005年当地流行株进化而来,而与2008年河南省分离株(HQ625646-Henan/04/2008)同源性最高;近10年福建省Echo30存在多基因型、多谱系的同时传播,并在2006年发现了两株第III新基因型病毒。结论造成2011年福建省病毒性脑炎暴发的病原为Echo30,且至少存在两条不同传播链病毒同时流行。Echo30福建株呈多基因型、多谱系分布流行特点。 展开更多
关键词 病毒性脑炎 echo30 VP1基因 分子流行病学
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一起ECHO 30病毒引发游泳队脑炎爆发调查 被引量:2
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作者 曾士典 章显权 +1 位作者 贾俐挺 谢海滨 《疾病监测》 CAS 2007年第3期170-171,共2页
目的分析ECHO30病毒性脑炎在冬季体校游泳队爆发的特征。方法应用流行病学描述方法,对体校学生进行筛查;采集典型病例脑脊液(CSF)、血液样本和泳池水样进行实验室检测。结果病例均为体校游泳队学生,共发病37例,罹患率25.18%,性别间罹患... 目的分析ECHO30病毒性脑炎在冬季体校游泳队爆发的特征。方法应用流行病学描述方法,对体校学生进行筛查;采集典型病例脑脊液(CSF)、血液样本和泳池水样进行实验室检测。结果病例均为体校游泳队学生,共发病37例,罹患率25.18%,性别间罹患率差异无统计学意义(x2=0.03,P>0.50),流行9d;游泳池水污染严重,6份CSF样本肠道病毒核糖核酸阳性,2份分离到ECHO30肠道病毒。结论游泳池循环净水和消毒设备应正常运转,日常监督监测应加强。 展开更多
关键词 echo 30 病毒性脑炎 爆发
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ECHO 19引起龙岩市儿童病毒性脑炎的流行病学调查 被引量:11
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作者 陈前进 俞新莲 +5 位作者 张月花 杨秀惠 严延生 黄开华 吴水新 邓小如 《海峡预防医学杂志》 CAS 2005年第4期14-16,共3页
[目的]探讨龙岩市2004年儿童病毒性脑炎流行的病因、流行规律及特征.[方法]对142例病毒性脑炎病例进行流行病学调查,对其中30例的脑脊液标本进行病毒分离和型别鉴定.[结果]142例患者分布在我市的6个县(市、区),其中新罗区占(66.2%),另... [目的]探讨龙岩市2004年儿童病毒性脑炎流行的病因、流行规律及特征.[方法]对142例病毒性脑炎病例进行流行病学调查,对其中30例的脑脊液标本进行病毒分离和型别鉴定.[结果]142例患者分布在我市的6个县(市、区),其中新罗区占(66.2%),另有广东省大埔县2例;年龄以5~12岁为多;男性68.3%,女性31.7%;5~6月为发病高峰.临床主要表现为突然发病、发热(92.4%)、头痛(83.1%)、呕吐(68.6%)等;脑电图以轻中度异常为主;67.8%血常规正常;脑脊液常规87.5%颅内压力增高,56.8%细胞数增加.疗程10天左右.从30份脑脊液中检出16株ECHO 19病毒.[结论]流行病学调查及实验室病原检测确认,龙岩市儿童病毒性脑炎病原为ECHO 19. 展开更多
关键词 病毒性脑炎 echo19 儿童 流行病学调查 脑脊液
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应用ECHO模型评价药物治疗管理服务在儿童支气管哮喘治疗中的效果 被引量:2
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作者 连玉菲 邱学佳 +2 位作者 杨玉鹏 刘洪涛 董占军 《医药导报》 CAS 北大核心 2024年第10期1672-1679,共8页
目的探究药物治疗管理(MTM)服务对儿童哮喘治疗的应用效果。方法选取2022年7—12月在河北省人民医院咳喘药学门诊就诊的5~11岁哮喘患儿107例,随机分成对照组(50例)和干预组(52例)。对照组患儿首诊时给予单次吸入制剂教育服务;干预组患... 目的探究药物治疗管理(MTM)服务对儿童哮喘治疗的应用效果。方法选取2022年7—12月在河北省人民医院咳喘药学门诊就诊的5~11岁哮喘患儿107例,随机分成对照组(50例)和干预组(52例)。对照组患儿首诊时给予单次吸入制剂教育服务;干预组患儿给予全程规范化MTM服务。应用经济、临床与人文结果(ECHO)模型,分别于干预前、干预3个月及干预6个月后,统计2组患儿在经济(药物成本、成本-效用比),临床(ACT评分、吸入制剂使用正确率、哮喘发作次数)和人文(EQ-5D-5L效用值、Morisky用药依从性、患者满意度)结果中的差异,评价MTM服务在哮喘患儿中的应用效果。结果干预前2组各项评分指标差异无统计学意义;干预后干预组患儿经济结果、临床结果、人文结果3方面均优于对照组,差异有统计学意义(P<0.05)。结论药师主导的MTM服务可使哮喘患儿在经济、临床、人文多维度获益,既使哮喘患儿疾病得到长期有效控制,又提升药师药学专科服务能力。 展开更多
关键词 echo模型 儿童哮喘 效果评价 吸入制剂
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肠道病毒ECHO25河南分离株基因特征分析 被引量:4
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作者 晁灵 黄学勇 +1 位作者 李幸乐 许汴利 《病毒学报》 CAS CSCD 北大核心 2010年第6期443-446,共4页
首次对ECHO25病毒进行分子生物学分析,阐明ECHO25(Entric Cytopathic Human Orphanviruses Type25)病毒河南分离株的分子生物学特征及其与世界其它分离株的基因关系。逆转录-聚合酶链反应(RT-PCR)扩增出VP1蛋白编码基因并进行序列测定,... 首次对ECHO25病毒进行分子生物学分析,阐明ECHO25(Entric Cytopathic Human Orphanviruses Type25)病毒河南分离株的分子生物学特征及其与世界其它分离株的基因关系。逆转录-聚合酶链反应(RT-PCR)扩增出VP1蛋白编码基因并进行序列测定,将所测4株ECHO25病毒的VP1序列与GenBank上已发表的ECH-O25病毒VP1区进行同源性比较及遗传进化分析发现:河南省4株ECHO25与标准株JV-4核苷酸同源性为79.2%~80.1%,氨基酸同源性为89.0%~92.4%;河南省4株ECHO25核苷酸同源性为93.0%~99.0%,氨基酸同源性为92.4%~97.5%;HN-01分离株与HN-26分离株高度同源,其核苷酸同源性达99.0%;河南省4株ECHO25同属B1基因亚型。 展开更多
关键词 echo25 基因 序列分析 系统发生树
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急性弛缓性麻痹病例中ECHO11病毒的基因特征分析 被引量:4
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作者 刘桂艳 许文波 +5 位作者 纪峰 张勇 王海岩 李岩 严冬梅 徐爱强 《病毒学报》 CAS CSCD 北大核心 2006年第1期22-30,共9页
该文首次分析了我国ECHO11病毒的分子流行病学资料。1999~2004年,ECHO11病毒是山东省急性弛缓性麻痹(AFP)病例中分离到的优势毒株,2003年从山东省482例AFP病例中共分离到11株ECHO11病毒,其中相关的10例病例分布跨越山东省大部分... 该文首次分析了我国ECHO11病毒的分子流行病学资料。1999~2004年,ECHO11病毒是山东省急性弛缓性麻痹(AFP)病例中分离到的优势毒株,2003年从山东省482例AFP病例中共分离到11株ECHO11病毒,其中相关的10例病例分布跨越山东省大部分地区,但发病日期集中在7月和12月。该研究试图通过对VP1编码基因全序列的测定和分析,为探讨ECHO11病毒与AFP之间的病因关系提供线索。分子流行病学研究提示,11株ECHO11毒株都位于同一传播链,核苷酸同源性为97.2%~100%,氨基酸同源性为99.6%~100%,其中7月和12月的分离株之间相层8~9个核苷酸,氨基酸序列一致。这说明山东省2003年7月和12月分别发生了ECHO11病毒流行,但这些毒株与AFP的病因关系尚需进一步研究。11株病毒组成了A基因型中的一个新亚型,在进化树上单独呈密切相关的一簇,与同基因型内的其它亚型的核苷酸同源性为82.2%~84.7%,氨基酸同源性为94.8%~97.6%. 展开更多
关键词 急性弛缓性麻痹病例 echo11病毒 基因特征
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Radar Echo and Lightning Characteristics Analysis on A Strong Thunderstorm Weather in Fuxin 被引量:1
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作者 马虹旭 杨仲江 +1 位作者 王伟 才奎志 《Meteorological and Environmental Research》 CAS 2010年第5期48-50,101,共4页
Based on the radar data and lightning position indicator data of strong thunderstorm weather which happened in Fuxin on July 8,2007,the relationship between the lightning activity and the radar echo was analyzed.The r... Based on the radar data and lightning position indicator data of strong thunderstorm weather which happened in Fuxin on July 8,2007,the relationship between the lightning activity and the radar echo was analyzed.The results showed that Fuxin area located in the cross position of T-shaped trough and was affected by the cold air which continuously glided down.The corresponding warm front on the ground advanced southward and arrived here.It was the weather background of this thunderstorm weather.The position variation of lightning occurrence was closely related to the strong echo movement of squall line,and the velocity echo clearly reflected and predicted the movement tendency of the radar echo. 展开更多
关键词 Strong thunderstorm weather Radar echo LIGHTNING Fuxin China
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Comparison of the time-domain electromagnetic field from an infinitesimal point charge and dipole source 被引量:3
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作者 周楠楠 薛国强 王贺元 《Applied Geophysics》 SCIE CSCD 2013年第3期349-356,359,共9页
An electromagnetic field is generated through the accelerating movement of two equal but opposite charges of a single dipole. An electromagnetic field can also be generated by a time-varying infinitesimal point charge... An electromagnetic field is generated through the accelerating movement of two equal but opposite charges of a single dipole. An electromagnetic field can also be generated by a time-varying infinitesimal point charge. In this study, a comparison between the electromagnetic fields of an infinitesimal point charge and a dipole has been presented. First, the time-domain potential function of a point source in a 3D conductive medium is derived. Then the electric and magnetic fields in a 3D homogeneous lossless space are derived via the relation between the potential and field. The field differences between the infinitesimal point charge and the dipole in the step-off time, far-source, and near-source zones are analyzed, and the accuracy of the solutions from these sources is investigated. It is also shown that the field of the infinitesimal point charge in the near-source zone is different from that of the dipole, whereas the far-source zone fields of these two sources are identical. The comparison of real and simulated data shows that the infinitesimal point charge represents the real source better than the divole source. 展开更多
关键词 Infinitesimal point charge dipole source time-domain electromagnetic response near-source zone.
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2011~2014年中国福建龙岩市Echo 30型病毒分子流行病学特征分析 被引量:2
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作者 陈前进 曹春远 +6 位作者 张彦锋 杨秀惠 吴水新 何云 廖亦红 何春荣 罗招福 《病毒学报》 CAS CSCD 北大核心 2016年第6期727-732,共6页
了解中国福建省龙岩市2011-2014年病毒性脑炎散发病例中Echo 30分子流行病学特征。收集病毒性脑炎或中枢神经系统感染脑脊液标本,细胞培养分离病毒,RT-PCR扩增VP1基因序列全长以鉴定Echo 30血清型及遗传特征分析。2011-2014年共从608例... 了解中国福建省龙岩市2011-2014年病毒性脑炎散发病例中Echo 30分子流行病学特征。收集病毒性脑炎或中枢神经系统感染脑脊液标本,细胞培养分离病毒,RT-PCR扩增VP1基因序列全长以鉴定Echo 30血清型及遗传特征分析。2011-2014年共从608例监测病例中分离到168株肠道病毒,其中60株为Echo 30;60例Echo 30相关病例分析显示,Echo 30流行高峰为6-8月;波及年龄范围广,以小于10岁高发(65%);临床症状以发热、头痛和呕吐为主,脑脊液清,细胞和蛋白含量检测多增加。VP1区分析显示,2011-2014年龙岩流行株均属于h基因型,但有两个传播链共同循环;与2011年导致福建省病毒性脑炎暴发毒株高度同源,但2014年龙岩株均在VP1蛋白I 120V出现新氨基酸变异。福建省2011年暴发流行株仍流行于龙岩市,且两个传播链病毒仍共同循环,但2014年病毒株出现了新的变异,持续监测将有利于早期发现病毒变异积累和评估疾病流行的风险。 展开更多
关键词 echo 30型病毒 病毒性脑炎 VP1 分子流行病学
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一起Echo 30型病毒性脑膜炎暴发疫情发生危险因素的病例对照研究 被引量:3
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作者 马焰 姚建香 +2 位作者 李蒋清 谢棋 崔亮亮 《医学动物防制》 2014年第10期1101-1103,共3页
目的分析一起Echo 30型病毒性脑膜炎暴发疫情传播的危险因素,为预防措施的制定提供科学依据。方法采用1∶2匹配病例对照研究方法,采集个人卫生行为与习惯、饮水方式、可能的暴露史等信息,对危险因素的探索采用条件Logistic回归进行单因... 目的分析一起Echo 30型病毒性脑膜炎暴发疫情传播的危险因素,为预防措施的制定提供科学依据。方法采用1∶2匹配病例对照研究方法,采集个人卫生行为与习惯、饮水方式、可能的暴露史等信息,对危险因素的探索采用条件Logistic回归进行单因素及多因素分析。结果病例103例,罹患率4.6%(103/2 255),流行病学曲线为持续同源暴露。饮用直饮水机温开水(OR=18.3,95%CI为2.0-169.5)和饮用生水(OR=15.5,95%CI为1.7-141.8)是主要危险因素,在校上下楼梯时经常扶楼梯扶手(OR=5.1,95%CI为1.25-21.0)、与2例及以上病例密切接触(OR=5.2,95%CI为1.4-20.0)是危险因素;饭前经常洗手(OR=0.3,95%CI为0.1-0.99)、洗手时经常使用洗手液(香皂或肥皂)(OR=0.1,95%CI为0.03-0.5)是保护性因素。结论饮水污染是该起疫情暴发的首要危险因素。卫生行为习惯与疫情流行也密切相关。 展开更多
关键词 echo 30型病毒 暴发 危险因素 病例对照研究
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Numerical modeling of the 2D time-domain transient electromagnetic secondary field of the line source of the current excitation 被引量:4
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作者 刘云 王绪本 王贇 《Applied Geophysics》 SCIE CSCD 2013年第2期134-144,235,共12页
To effectively minimize the electromagnetic field response in the total field solution, we propose a numerical modeling method for the two-dimensional (2D) time- domain transient electromagnetic secondary field of t... To effectively minimize the electromagnetic field response in the total field solution, we propose a numerical modeling method for the two-dimensional (2D) time- domain transient electromagnetic secondary field of the line source based on the DuFort- Frankel finite-difference method. In the proposed method, we included the treatment of the earth-air boundary conductivity, calculated the normalized partial derivative of the induced electromotive force (Emf), and determined the forward time step. By extending upward the earth-air interface to the air grid nodes and the zero-value boundary conditions, not only we have a method that is more efficient but also simpler than the total field solution. We computed and analyzed the homogeneous half-space model and the fiat layered model with high precision--the maximum relative error is less than 0.01% between our method and the analytical method--and the solution speed is roughly three times faster than the total-field solution. Lastly, we used the model of a thin body embedded in a homogeneous half-space at different delay times to depict the downward and upward spreading characteristics of the induced eddy current, and the physical interaction processes between the electromagnetic field and the underground low-resistivity body. 展开更多
关键词 time-domain transient electromagnetics secondary field DuFort-Frankel finite-difference method numerical modeling.
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