With respect to oceanic fluid dynamics,certain models have appeared,e.g.,an extended time-dependent(3+1)-dimensional shallow water wave equation in an ocean or a river,which we investigate in this paper.Using symbolic...With respect to oceanic fluid dynamics,certain models have appeared,e.g.,an extended time-dependent(3+1)-dimensional shallow water wave equation in an ocean or a river,which we investigate in this paper.Using symbolic computation,we find out,on one hand,a set of bilinear auto-Backlund transformations,which could connect certain solutions of that equation with other solutions of that equation itself,and on the other hand,a set of similarity reductions,which could go from that equation to a known ordinary differential equation.The results in this paper depend on all the oceanic variable coefficients in that equation.展开更多
Our study introduces scITDG,a tool designed for the analysis of time-dependent gene expression in single-cell transcriptomic sequencing data,effectively filling a gap in current analytical resources.A key advantage of...Our study introduces scITDG,a tool designed for the analysis of time-dependent gene expression in single-cell transcriptomic sequencing data,effectively filling a gap in current analytical resources.A key advantage of scITDG is its ability to identify dynamic gene expression patterns across multiple time points at single-cell resolution,which is pivotal for deciphering com-plex biological processes such as aging and tissue regeneration.The tool is compatible with widely used single-cell analysis platforms such as Seurat and Scanpy.By integrating natural cubic splines regression with bootstrapping resampling,scITDG enhances the functionality of these platforms and broadens their applicability.In this study,based on scITDG,we revealed intricate gene expression modules in mice aging and axolotl limb regeneration,providing valuable insights into cellular function and response mechanisms.The versatility of scITDG makes it applicable to a wide range of biological contexts,including development,circadian rhythms,disease progression,and therapeutic responses.展开更多
The field of diffusion micro structural magnetic resonance(MR)aims to probe timedependent diffusion,i.e.,an ensemble-averaged mean-squared displacement that is not linear in time.This time-dependence contains rich inf...The field of diffusion micro structural magnetic resonance(MR)aims to probe timedependent diffusion,i.e.,an ensemble-averaged mean-squared displacement that is not linear in time.This time-dependence contains rich information about the surrounding microenvironment.MR methods to measure time-dependent diffusion quantitatively,however,require either non-standard pulse sequences,such as oscillating gradients,or make non-physical assumptions,such as infinitely narrow gradient pulses.Here,we argue that standard spin echo and stimulated echo MR sequences can be used to probe directly.In particular,we propose a framework in which the log-signal ratio obtained from a pair of measurements with different inter-pulse spacingΔis proportional to the MSD between these twoΔvalues along the gradient direction x:-.The framework is quantitative for short,finite-duration gradient pulses and under the Gaussian phase approximation(GPA).To validate the framework,we consider onedimensional diffusion between impermeable,parallel planes,as well as periodicallyspaced,permeable planes.Excellent agreement is obtained between the estimation and the ground truth in the regime where the GPA is expected to hold.Importantly,the GPA can be made to hold for any underlying microstructure,making the proposed framework widely applicable.展开更多
Catastrophic failure in engineering structures of island reefs would occur when the tertiary creep initiates in coral reef limestone with a transition from short-to long-term load.Due to the complexity of biological s...Catastrophic failure in engineering structures of island reefs would occur when the tertiary creep initiates in coral reef limestone with a transition from short-to long-term load.Due to the complexity of biological structures,the underlying micro-behaviors involving time-dependent deformation are poorly understood.For this,an abnormal phenomenon was observed where the axial and lateral creep deformations were mutually independent by a series of triaxial tests under constant stress and strain rate conditions.The significantly large lateral creep deformation implies that the creep process cannot be described in continuum mechanics regime.Herein,it is hypothesized that sliding mechanism of crystal cleavages dominates the lateral creep deformation in coral reef limestone.Then,approaches of polarizing microscope(PM)and scanning electronic microscope(SEM)are utilized to validate the hypothesis.It shows that the sliding behavior of crystal cleavages combats with conventional creep micro-mechanisms at certain condition.The former is sensitive to time and strain rate,and is merely activated in the creep regime.展开更多
Heat transfers at the interface of adjacent saturated soil primarily through the soil particles and the water in the voids.The presence of water induces the contraction of heat flow lines at the interface,leading to t...Heat transfers at the interface of adjacent saturated soil primarily through the soil particles and the water in the voids.The presence of water induces the contraction of heat flow lines at the interface,leading to the emergence of the thermal contact resistance effect.In this paper,four thermal contact models were developed to predict the thermal contact resistance at the interface of multilayered saturated soils.Based on the theory of thermal-hydro-mechanical coupling,semi-analytical solutions of thermal consolidation subjected to time-dependent heating and loading were obtained by employing Laplace transform and its inverse transformation.Thermal consolidation characteristics of multilayered saturated soils under four different thermal contact models were discussed,and the effects of thermal resistance coefficient,partition thermal contact coefficient,and temperature amplitude on the thermal consolidation process were investigated.The outcomes indicate that the general thermal contact model results in the most pronounced thermal gradient at the interface,which can be degenerated to the other three thermal contact models.The perfect thermal contact model overestimates the deformation of the saturated soil during the thermal consolidation.Moreover,the effect of temperature on consolidation properties decreases gradually with increasing interfacial contact thermal resistance.展开更多
The Zagros Basin in southwestern Iran is a significant source of coal,with numerous coal mines operating in the region.Ensuring the stability of coal mines is crucial for safe and efficient mining operations.This stud...The Zagros Basin in southwestern Iran is a significant source of coal,with numerous coal mines operating in the region.Ensuring the stability of coal mines is crucial for safe and efficient mining operations.This study investigates the time-varying response of rocks and roof resistance in coal mines in the Zagros Mountains using a novel approach that combines numerical simulation,relaxation testing,and rock displacement studies.The results show that rocks exhibit significant time-dependent behavior,with changes in rock mechanical properties over time.A comprehensive viscoelastic-plastic model is devel-oped to accurately describe the time-varying strain-softening response of rocks and simulate laboratory tests.The model integrates the Burgers and strain-softening models,simulating stress relaxation curves and rock displacement over time.The study reveals that the rock mass displays significant nonlinear behavior,with changes in rock mechanical properties over time.The findings of this study highlight the importance of considering the time-varying response of rocks and roof resistance in coal mine stability analysis.The results provide valuable insights into the time-dependent behavior of rock mass in coal mines in Iran,which can inform mining practices and mitigate potential hazards.Results in this study can contribute to developing strategies for improving roof stability and reducing the likelihood of roof collapses.展开更多
We present a fully time-dependent quantum wave packet evolution method for investigating molecular dynamics in intense laser fields.This approach enables the simultaneous treatment of interactions among multiple elect...We present a fully time-dependent quantum wave packet evolution method for investigating molecular dynamics in intense laser fields.This approach enables the simultaneous treatment of interactions among multiple electronic states while simultaneously tracking their time-dependent electronic,vibrational,and rotational dynamics.As an illustrative example,we consider neutral H_(2)molecules and simulate the laser-induced excitation dynamics of electronic and rotational states in strong laser fields,quantitatively distinguishing the respective contributions of electronic dipole transitions(within the classical-field approximation)and non-resonant Raman processes to the overall molecular dynamics.Furthermore,we precisely evaluate the relative contributions of direct tunneling ionization from the ground state and ionization following electronic excitation in the strong-field ionization of H_(2).The developed methodology shows strong potential for performing high-precision theoretical simulations of electronic-vibrational-rotational state excitations,ionization,and dissociation dynamics in molecules and their ions under intense laser fields.展开更多
Increasingly,attention is being directed towards time-dependent diffusion magnetic resonance imaging(TDDMRI),a method that reveals time-related changes in the diffusional behavior of water molecules in biological tiss...Increasingly,attention is being directed towards time-dependent diffusion magnetic resonance imaging(TDDMRI),a method that reveals time-related changes in the diffusional behavior of water molecules in biological tissues,thereby enabling us to probe related microstructure events.With ongoing improvements in hardware and advanced pulse sequences,significant progress has been made in applying TDDMRI to clinical research.The development of accurate mathematical models and computational methods has bolstered theoretical support for TDDMRI and elevated our understanding of molecular diffusion.In this review,we introduce the concept and basic physics of TDDMRI,and then focus on the measurement strategies and modeling approaches in short-and long-diffusion-time domains.Finally,we discuss the challenges in this field,including the requirement for efficient scanning and data processing technologies,the development of more precise models depicting time-dependent molecular diffusion,and critical clinical applications.展开更多
Geomorphological features are commonly used to identify potential landslides.Nevertheless,overemphasis on these features could lead to misjudgment.This research proposes a process-oriented approach for potential lands...Geomorphological features are commonly used to identify potential landslides.Nevertheless,overemphasis on these features could lead to misjudgment.This research proposes a process-oriented approach for potential landslide identification that considers time-dependent behaviors.The method integrates comprehensive remote sensing and geological analysis to qualitatively assess slope stability,and employs numerical analysis to quantitatively calculate aging stability.Specifically,a time-dependent stability calculation method for anticlinal slopes is developed and implemented in discrete element software,incorporating time-dependent mechanical and strength reduction calculations.By considering the time-dependent evolution of slopes,this method highlights the importance of both geomorphological features and time-dependent behaviors in landslide identification.This method has been applied to the Jiarishan slope(JRS)on the Qinghai-Tibet Plateau as a case study.The results show that the JRS,despite having landslide geomorphology,is a stable slope,highlighting the risk of misjudgment when relying solely on geomorphological features.This work provides insights into the geomorphological characterization and evolution history of the JRS and offers valuable guidance for studying slopes with similar landslide geomorphology.Furthermore,the process-oriented method incorporating timedependent evolution provides a means to evaluate potential landslides,reducing misjudgment due to excessive reliance on geomorphological features.展开更多
To investigate the long-term stability of deep rocks,a three-dimensional(3D)time-dependent model that accounts for excavation-induced damage and complex stress state is developed.This model comprises three main compon...To investigate the long-term stability of deep rocks,a three-dimensional(3D)time-dependent model that accounts for excavation-induced damage and complex stress state is developed.This model comprises three main components:a 3D viscoplastic isotropic constitutive relation that considers excavation damage and complex stress state,a quantitative relationship between critical irreversible deformation and complex stress state,and evolution characteristics of strength parameters.The proposed model is implemented in a self-developed numerical code,i.e.CASRock.The reliability of the model is validated through experiments.It is indicated that the time-dependent fracturing potential index(xTFPI)at a given time during the attenuation creep stage shows a negative correlation with the extent of excavationinduced damage.The time-dependent fracturing process of rock demonstrates a distinct interval effect of the intermediate principal stress,thereby highlighting the 3D stress-dependent characteristic of the model.Finally,the influence of excavation-induced damage and intermediate principal stress on the time-dependent fracturing characteristics of the surrounding rocks around the tunnel is discussed.展开更多
A brittle creep and time-dependent fracturing process model of rock is established by incorporating the stress corrosion model into discrete element method to analyze the creep behavior and microcrack evolution in bri...A brittle creep and time-dependent fracturing process model of rock is established by incorporating the stress corrosion model into discrete element method to analyze the creep behavior and microcrack evolution in brittle rocks at a micro-scale level.Experimental validation of the model is performed,followed by numerical simu-lations to investigate the creep properties and microcrack evolution in rocks under single-stage loading,multi-stage loading,and confining pressure,at various constant stress levels.The results demonstrate that as the stress level increases in single-stage creep simulations,the time-to-failure progressively decreases.The growth of microcracks during uniaxial creep occurs in three stages,with tensile microcracks being predominant and the spatial distribution of microcracks becoming more dispersed at higher stress levels.In multi-stage loadingunloading simulations,microcracks continue to form during the unloading stage,indicating cumulative damage resulting from increased axial stress.Additionally,the creep behaviour of rocks under confining pressure is not solely determined by the magnitude of the confining pressure,but is also influenced by the magnitude of the axial stress.The findings contribute to a better understanding of rock deformation and failure processes under different loading conditions,and they can be valuable for applications in rock mechanics and rock engineering.展开更多
We investigate the impact of pairwise and group interactions on the spread of epidemics through an activity-driven model based on time-dependent networks.The effects of pairwise/group interaction proportion and pairwi...We investigate the impact of pairwise and group interactions on the spread of epidemics through an activity-driven model based on time-dependent networks.The effects of pairwise/group interaction proportion and pairwise/group interaction intensity are explored by extensive simulation and theoretical analysis.It is demonstrated that altering the group interaction proportion can either hinder or enhance the spread of epidemics,depending on the relative social intensity of group and pairwise interactions.As the group interaction proportion decreases,the impact of reducing group social intensity diminishes.The ratio of group and pairwise social intensity can affect the effect of group interaction proportion on the scale of infection.A weak heterogeneous activity distribution can raise the epidemic threshold,and reduce the scale of infection.These results benefit the design of epidemic control strategy.展开更多
It remains a big challenge to develop solid-state stimuli-responsive materials for time-dependent information encryption and inkless erasable printing with long retention times.Herein,a 2D Cu_(2)I_(2)-based MOF with p...It remains a big challenge to develop solid-state stimuli-responsive materials for time-dependent information encryption and inkless erasable printing with long retention times.Herein,a 2D Cu_(2)I_(2)-based MOF with photoresponsive spiropyran(SP)groups orderly installed on its skeleton is developed.The structural isomerization from SP to colored merocyanine(MC)form can be triggered by removing the CH_(3)CN vips.Besides,the degree of structural isomerization and the retention time can be adjusted by controlling the amount of CH_(3)CN vips,exhibiting dynamic photochromic behavior with multicolor states and tunable retention time.Based on these advantages,time-dependent information encryption is successfully achieved.Furthermore,the long retention time(>72 h)of the MC form under daylight conditions in the CH_(3)CN-removed Cu_(2)I_(2)-based MOF and good repeatability make it promising in various applications,such as temporary calendars,price-cards,billboards,and reusable identity cards.This work provides a novel design strategy to fabricate multi-functional MOF-based smart materials for challenging applications of time-dependent information encryption and inkless erasable printing.展开更多
Dynamic assembly on time scale is common in biological systems but rare for artificial materials,especially for smart luminescent materials.Programming molecular assembly in a spatio-temporal manner and resulting in w...Dynamic assembly on time scale is common in biological systems but rare for artificial materials,especially for smart luminescent materials.Programming molecular assembly in a spatio-temporal manner and resulting in white-light-including multicolor fluorescence with time-dynamic features remains challenging.Herein,controlling molecular assembly on time scale is achieved by integrating a pH-responsive motif to a transient alkaline solution which is fabricated by activators(NaOH)and deactivators(esters),leading to automatic assembly on time scale and time-dependent multicolor fluorescence changing from blue to white and yellow.The kinetics of the assembly process is dependent on the ester hydrolysis process,which can be controlled by varying ester concentrations,temperature,initial pH,stirring rate and ester structures.This dynamic fluorescent system can be further developed for intelligent fluorescent materials such as fluorescent ink,three-dimension(3D)codes and even four-dimension(4D)codes,exhibiting a promising potential for information encryption.展开更多
This paper develops a generalized scalar auxiliary variable(SAV)method for the time-dependent Ginzburg-Landau equations.The backward Euler method is used for discretizing the temporal derivative of the time-dependent ...This paper develops a generalized scalar auxiliary variable(SAV)method for the time-dependent Ginzburg-Landau equations.The backward Euler method is used for discretizing the temporal derivative of the time-dependent Ginzburg-Landau equations.In this method,the system is decoupled and linearized to avoid solving the non-linear equation at each step.The theoretical analysis proves that the generalized SAV method can preserve the maximum bound principle and energy stability,and this is confirmed by the numerical result,and also shows that the numerical algorithm is stable.展开更多
Accurately estimating the State of Health(SOH)and Remaining Useful Life(RUL)of lithium-ion batteries(LIBs)is crucial for the continuous and stable operation of battery management systems.However,due to the complex int...Accurately estimating the State of Health(SOH)and Remaining Useful Life(RUL)of lithium-ion batteries(LIBs)is crucial for the continuous and stable operation of battery management systems.However,due to the complex internal chemical systems of LIBs and the nonlinear degradation of their performance,direct measurement of SOH and RUL is challenging.To address these issues,the Twin Support Vector Machine(TWSVM)method is proposed to predict SOH and RUL.Initially,the constant current charging time of the lithium battery is extracted as a health indicator(HI),decomposed using Variational Modal Decomposition(VMD),and feature correlations are computed using Importance of Random Forest Features(RF)to maximize the extraction of critical factors influencing battery performance degradation.Furthermore,to enhance the global search capability of the Convolution Optimization Algorithm(COA),improvements are made using Good Point Set theory and the Differential Evolution method.The Improved Convolution Optimization Algorithm(ICOA)is employed to optimize TWSVM parameters for constructing SOH and RUL prediction models.Finally,the proposed models are validated using NASA and CALCE lithium-ion battery datasets.Experimental results demonstrate that the proposed models achieve an RMSE not exceeding 0.007 and an MAPE not exceeding 0.0082 for SOH and RUL prediction,with a relative error in RUL prediction within the range of[-1.8%,2%].Compared to other models,the proposed model not only exhibits superior fitting capability but also demonstrates robust performance.展开更多
Rockbursts, which mainly affect mining roadways, are dynamic disasters arising from the surrounding rock under high stress. Understanding the interaction between supports and the surrounding rock is necessary for effe...Rockbursts, which mainly affect mining roadways, are dynamic disasters arising from the surrounding rock under high stress. Understanding the interaction between supports and the surrounding rock is necessary for effective rockburst control. In this study, the squeezing behavior of the surrounding rock is analyzed in rockburst roadways, and a mechanical model of rockbursts is established considering the dynamic support stress, thus deriving formulas and providing characteristic curves for describing the interaction between the support and surrounding rock. Design principles and parameters of supports for rockburst control are proposed. The results show that only when the geostress magnitude exceeds a critical value can it drive the formation of rockburst conditions. The main factors influencing the convergence response and rockburst occurrence around roadways are geostress, rock brittleness, uniaxial compressive strength, and roadway excavation size. Roadway support devices can play a role in controlling rockburst by suppressing the squeezing evolution of the surrounding rock towards instability points of rockburst. Further, the higher the strength and the longer the impact stroke of support devices with constant resistance, the more easily multiple balance points can be formed with the surrounding rock to control rockburst occurrence. Supports with long impact stroke allow adaptation to varying geostress levels around the roadway, aiding in rockburst control. The results offer a quantitative method for designing support systems for rockburst-prone roadways. The design criterion of supports is determined by the intersection between the convergence curve of the surrounding rock and the squeezing deformation curve of the support devices.展开更多
The time-dependent resilience of an in-service aging structure provides quantitative measure of the structural ability to prepare for,adapt to,withstand and recover from disruptive events.Resilience models have been p...The time-dependent resilience of an in-service aging structure provides quantitative measure of the structural ability to prepare for,adapt to,withstand and recover from disruptive events.Resilience models have been proposed in the literature to evaluate the resilience of aging structures subjected to discrete load processes,which are,however,not applicable to handle resilience problems considering continuous load processes.In this paper,a new method is developed to evaluate the time-dependent resilience of aging structures subjected to a continuous load process.The proposed method serves as the complement of the existing resilience models addressing discrete load processes,and takes into account the aging effects of the structural resistance/capacity and the nonstationarity in loads as a result of climate change.A structure suffers from a damage state upon the occurrence of an upcrossing of the load effect with respect to the resistance/capacity,leading to the reduction of the performance function,followed by a recovery process that restores the performance.The proposed method enables the time-dependent resilience to be evaluated via a closed form solution.It is also revealed that,the proposed resilience model takes an extended form of the existing formula for upcrossing-based time-dependent reliability,thus establishing a unified framework for the two quantities.The applicability of the proposed method is demonstrated through examining the time-dependent resilience of a residential building subjected to wind load.The effects of key factors on resilience,including the nonstationarity and correlation structure of the load process,as well as the resistance/capacity deterioration scenario,are investigated through an example.In particular,the structural resilience would be overestimated if ignoring the potential impacts of climate change,which is a relatively non-conservative evaluation.展开更多
Structural regulation of Pd-based electrocatalytic hydrodechlorination(EHDC)catalyst for constructing high-efficient cathode materials with low noble metal content and high atom utilization is crucial but still challe...Structural regulation of Pd-based electrocatalytic hydrodechlorination(EHDC)catalyst for constructing high-efficient cathode materials with low noble metal content and high atom utilization is crucial but still challenging.Herein,a support electron inductive effect of Pd-Mn/Ni foam catalyst was proposed via in-situ Mn doping to optimize the electronic structure of the Ni foam(NF),which can inductive regulation of Pd for improving the EHDC performance.The mass activity and current efficiency of Pd-Mn/NF catalyst are 2.91 and 1.34 times superior to that of Pd/NF with 2,4-dichlorophenol as model compound,respectively.The Mn-doped interlayer optimized the electronic structure of Pd by bringing the d-state closer to the Fermi level than Pd on the NF surface,which optimizied the binding of EHDC intermediates.Additionally,the Mn-doped interlayer acted as a promoter for generating H∗and accelerating the EHDC reaction.This work presents a simple and effective regulation strategy for constructing high-efficient cathode catalyst for the EHDC of chlorinated organic compounds.展开更多
Open networks and heterogeneous services in the Internet of Vehicles(IoV)can lead to security and privacy challenges.One key requirement for such systems is the preservation of user privacy,ensuring a seamless experie...Open networks and heterogeneous services in the Internet of Vehicles(IoV)can lead to security and privacy challenges.One key requirement for such systems is the preservation of user privacy,ensuring a seamless experience in driving,navigation,and communication.These privacy needs are influenced by various factors,such as data collected at different intervals,trip durations,and user interactions.To address this,the paper proposes a Support Vector Machine(SVM)model designed to process large amounts of aggregated data and recommend privacy preserving measures.The model analyzes data based on user demands and interactions with service providers or neighboring infrastructure.It aims to minimize privacy risks while ensuring service continuity and sustainability.The SVMmodel helps validate the system’s reliability by creating a hyperplane that distinguishes between maximum and minimum privacy recommendations.The results demonstrate the effectiveness of the proposed SVM model in enhancing both privacy and service performance.展开更多
基金financially supported by the Scientific Research Foundation of North China University of Technology(Grant Nos.11005136024XN147-87 and 110051360024XN151-86).
文摘With respect to oceanic fluid dynamics,certain models have appeared,e.g.,an extended time-dependent(3+1)-dimensional shallow water wave equation in an ocean or a river,which we investigate in this paper.Using symbolic computation,we find out,on one hand,a set of bilinear auto-Backlund transformations,which could connect certain solutions of that equation with other solutions of that equation itself,and on the other hand,a set of similarity reductions,which could go from that equation to a known ordinary differential equation.The results in this paper depend on all the oceanic variable coefficients in that equation.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDC0200000)the National Natural Science Foundation of China(82322025,82488301,82125011,82271600,82361148131)+15 种基金the National Key Research and Development Pro-gram of China(2022YFA1103700,2020YFA0804000)the Stra-tegic Priority Research Program of the Chinese Academy of Sci-ences(XDA0460403)the National Natural Science Foundation of China(92168201,82330044,32341001,32121001,82192863,82361148130,8231101626)Non-Communicable Chronic Diseases-National Science and Technology Major Project(2024ZD0530400)Youth Innovation Promotion Association of CAS(2022083)Young Elite Scientists Sponsorship Program by CAST(2021QNRC001)International Partnership Program of Chinese Academy of Sciences(073GJHZ2023019FN)he Program of the Beijing Natural Science Foundation(JQ24044,Z240018,F251011,Z230011)Shenzhen Medi-cal Research Fund(C2406001)CAS Project for Young Scientists in Basic Research(YSBR-076,YSBR-012)the Informatization Plan of Chinese Academy of Sciences(CAS-WX2022SDC-XK14)New Cor-nerstone Science Foundation through the XPLORER PRIZE(2021-1045)Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes(JYY2023-13)CAS Youth Interdisciplinary Team,Key Laboratory of Alzheimer's Disease of Zhejiang Province(ZJAD-2024001)Initiative Scientific Research Program,Institute of Zoology,CAS(2023IOZ0102,2023IOZ0202,2024IOZ0103)Beijing Anzhen Hospital High Level Research Funding(2024AZB3002).
文摘Our study introduces scITDG,a tool designed for the analysis of time-dependent gene expression in single-cell transcriptomic sequencing data,effectively filling a gap in current analytical resources.A key advantage of scITDG is its ability to identify dynamic gene expression patterns across multiple time points at single-cell resolution,which is pivotal for deciphering com-plex biological processes such as aging and tissue regeneration.The tool is compatible with widely used single-cell analysis platforms such as Seurat and Scanpy.By integrating natural cubic splines regression with bootstrapping resampling,scITDG enhances the functionality of these platforms and broadens their applicability.In this study,based on scITDG,we revealed intricate gene expression modules in mice aging and axolotl limb regeneration,providing valuable insights into cellular function and response mechanisms.The versatility of scITDG makes it applicable to a wide range of biological contexts,including development,circadian rhythms,disease progression,and therapeutic responses.
基金supported by the intramural research program(IRP)of the Eunice Kennedy Shriver National Institute of Child Health and Human Development。
文摘The field of diffusion micro structural magnetic resonance(MR)aims to probe timedependent diffusion,i.e.,an ensemble-averaged mean-squared displacement that is not linear in time.This time-dependence contains rich information about the surrounding microenvironment.MR methods to measure time-dependent diffusion quantitatively,however,require either non-standard pulse sequences,such as oscillating gradients,or make non-physical assumptions,such as infinitely narrow gradient pulses.Here,we argue that standard spin echo and stimulated echo MR sequences can be used to probe directly.In particular,we propose a framework in which the log-signal ratio obtained from a pair of measurements with different inter-pulse spacingΔis proportional to the MSD between these twoΔvalues along the gradient direction x:-.The framework is quantitative for short,finite-duration gradient pulses and under the Gaussian phase approximation(GPA).To validate the framework,we consider onedimensional diffusion between impermeable,parallel planes,as well as periodicallyspaced,permeable planes.Excellent agreement is obtained between the estimation and the ground truth in the regime where the GPA is expected to hold.Importantly,the GPA can be made to hold for any underlying microstructure,making the proposed framework widely applicable.
基金supported by the National Natural Science Foundation of China(Grant Nos.41877267,41877260)the Priority Research Program of the Chinese Academy of Science(Grant No.XDA13010201).
文摘Catastrophic failure in engineering structures of island reefs would occur when the tertiary creep initiates in coral reef limestone with a transition from short-to long-term load.Due to the complexity of biological structures,the underlying micro-behaviors involving time-dependent deformation are poorly understood.For this,an abnormal phenomenon was observed where the axial and lateral creep deformations were mutually independent by a series of triaxial tests under constant stress and strain rate conditions.The significantly large lateral creep deformation implies that the creep process cannot be described in continuum mechanics regime.Herein,it is hypothesized that sliding mechanism of crystal cleavages dominates the lateral creep deformation in coral reef limestone.Then,approaches of polarizing microscope(PM)and scanning electronic microscope(SEM)are utilized to validate the hypothesis.It shows that the sliding behavior of crystal cleavages combats with conventional creep micro-mechanisms at certain condition.The former is sensitive to time and strain rate,and is merely activated in the creep regime.
基金Projects(U24B20113,42477162) supported by the National Natural Science Foundation of ChinaProject(2025C02228) supported by the Primary Research and Development Plan of Zhejiang Province,China。
文摘Heat transfers at the interface of adjacent saturated soil primarily through the soil particles and the water in the voids.The presence of water induces the contraction of heat flow lines at the interface,leading to the emergence of the thermal contact resistance effect.In this paper,four thermal contact models were developed to predict the thermal contact resistance at the interface of multilayered saturated soils.Based on the theory of thermal-hydro-mechanical coupling,semi-analytical solutions of thermal consolidation subjected to time-dependent heating and loading were obtained by employing Laplace transform and its inverse transformation.Thermal consolidation characteristics of multilayered saturated soils under four different thermal contact models were discussed,and the effects of thermal resistance coefficient,partition thermal contact coefficient,and temperature amplitude on the thermal consolidation process were investigated.The outcomes indicate that the general thermal contact model results in the most pronounced thermal gradient at the interface,which can be degenerated to the other three thermal contact models.The perfect thermal contact model overestimates the deformation of the saturated soil during the thermal consolidation.Moreover,the effect of temperature on consolidation properties decreases gradually with increasing interfacial contact thermal resistance.
文摘The Zagros Basin in southwestern Iran is a significant source of coal,with numerous coal mines operating in the region.Ensuring the stability of coal mines is crucial for safe and efficient mining operations.This study investigates the time-varying response of rocks and roof resistance in coal mines in the Zagros Mountains using a novel approach that combines numerical simulation,relaxation testing,and rock displacement studies.The results show that rocks exhibit significant time-dependent behavior,with changes in rock mechanical properties over time.A comprehensive viscoelastic-plastic model is devel-oped to accurately describe the time-varying strain-softening response of rocks and simulate laboratory tests.The model integrates the Burgers and strain-softening models,simulating stress relaxation curves and rock displacement over time.The study reveals that the rock mass displays significant nonlinear behavior,with changes in rock mechanical properties over time.The findings of this study highlight the importance of considering the time-varying response of rocks and roof resistance in coal mine stability analysis.The results provide valuable insights into the time-dependent behavior of rock mass in coal mines in Iran,which can inform mining practices and mitigate potential hazards.Results in this study can contribute to developing strategies for improving roof stability and reducing the likelihood of roof collapses.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFA1602502)the National Natural Science Foundation of China(Grant No.12450404)。
文摘We present a fully time-dependent quantum wave packet evolution method for investigating molecular dynamics in intense laser fields.This approach enables the simultaneous treatment of interactions among multiple electronic states while simultaneously tracking their time-dependent electronic,vibrational,and rotational dynamics.As an illustrative example,we consider neutral H_(2)molecules and simulate the laser-induced excitation dynamics of electronic and rotational states in strong laser fields,quantitatively distinguishing the respective contributions of electronic dipole transitions(within the classical-field approximation)and non-resonant Raman processes to the overall molecular dynamics.Furthermore,we precisely evaluate the relative contributions of direct tunneling ionization from the ground state and ionization following electronic excitation in the strong-field ionization of H_(2).The developed methodology shows strong potential for performing high-precision theoretical simulations of electronic-vibrational-rotational state excitations,ionization,and dissociation dynamics in molecules and their ions under intense laser fields.
基金supported by the Ministry of Science and Technology of the People’s Republic of China(No.2021ZD0200202)the National Natural Science Foundation of China(No.82122032)the Science and Technology Department of Zhejiang Province(Nos.202006140 and 2022C03057).
文摘Increasingly,attention is being directed towards time-dependent diffusion magnetic resonance imaging(TDDMRI),a method that reveals time-related changes in the diffusional behavior of water molecules in biological tissues,thereby enabling us to probe related microstructure events.With ongoing improvements in hardware and advanced pulse sequences,significant progress has been made in applying TDDMRI to clinical research.The development of accurate mathematical models and computational methods has bolstered theoretical support for TDDMRI and elevated our understanding of molecular diffusion.In this review,we introduce the concept and basic physics of TDDMRI,and then focus on the measurement strategies and modeling approaches in short-and long-diffusion-time domains.Finally,we discuss the challenges in this field,including the requirement for efficient scanning and data processing technologies,the development of more precise models depicting time-dependent molecular diffusion,and critical clinical applications.
基金supported by the National Natural Science Foundation of China(Grant Nos.41972284 and 42090054)This work was also supported by the State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Independent Research Project(Grant No.SKLGP2020Z005).
文摘Geomorphological features are commonly used to identify potential landslides.Nevertheless,overemphasis on these features could lead to misjudgment.This research proposes a process-oriented approach for potential landslide identification that considers time-dependent behaviors.The method integrates comprehensive remote sensing and geological analysis to qualitatively assess slope stability,and employs numerical analysis to quantitatively calculate aging stability.Specifically,a time-dependent stability calculation method for anticlinal slopes is developed and implemented in discrete element software,incorporating time-dependent mechanical and strength reduction calculations.By considering the time-dependent evolution of slopes,this method highlights the importance of both geomorphological features and time-dependent behaviors in landslide identification.This method has been applied to the Jiarishan slope(JRS)on the Qinghai-Tibet Plateau as a case study.The results show that the JRS,despite having landslide geomorphology,is a stable slope,highlighting the risk of misjudgment when relying solely on geomorphological features.This work provides insights into the geomorphological characterization and evolution history of the JRS and offers valuable guidance for studying slopes with similar landslide geomorphology.Furthermore,the process-oriented method incorporating timedependent evolution provides a means to evaluate potential landslides,reducing misjudgment due to excessive reliance on geomorphological features.
基金supported by the National Natural Science Foundation of China(Grant No.52125903)the China Postdoctoral Science Foundation(Grant No.2023M730367)the Fundamental Research Funds for Central Public Welfare Research Institutes of China(Grant No.CKSF2023323/YT).
文摘To investigate the long-term stability of deep rocks,a three-dimensional(3D)time-dependent model that accounts for excavation-induced damage and complex stress state is developed.This model comprises three main components:a 3D viscoplastic isotropic constitutive relation that considers excavation damage and complex stress state,a quantitative relationship between critical irreversible deformation and complex stress state,and evolution characteristics of strength parameters.The proposed model is implemented in a self-developed numerical code,i.e.CASRock.The reliability of the model is validated through experiments.It is indicated that the time-dependent fracturing potential index(xTFPI)at a given time during the attenuation creep stage shows a negative correlation with the extent of excavationinduced damage.The time-dependent fracturing process of rock demonstrates a distinct interval effect of the intermediate principal stress,thereby highlighting the 3D stress-dependent characteristic of the model.Finally,the influence of excavation-induced damage and intermediate principal stress on the time-dependent fracturing characteristics of the surrounding rocks around the tunnel is discussed.
基金supported by the National Natural Science Foundation of China(grant numbers 42172312,52211540395)support from the Institut Universitaire de France(IUF).
文摘A brittle creep and time-dependent fracturing process model of rock is established by incorporating the stress corrosion model into discrete element method to analyze the creep behavior and microcrack evolution in brittle rocks at a micro-scale level.Experimental validation of the model is performed,followed by numerical simu-lations to investigate the creep properties and microcrack evolution in rocks under single-stage loading,multi-stage loading,and confining pressure,at various constant stress levels.The results demonstrate that as the stress level increases in single-stage creep simulations,the time-to-failure progressively decreases.The growth of microcracks during uniaxial creep occurs in three stages,with tensile microcracks being predominant and the spatial distribution of microcracks becoming more dispersed at higher stress levels.In multi-stage loadingunloading simulations,microcracks continue to form during the unloading stage,indicating cumulative damage resulting from increased axial stress.Additionally,the creep behaviour of rocks under confining pressure is not solely determined by the magnitude of the confining pressure,but is also influenced by the magnitude of the axial stress.The findings contribute to a better understanding of rock deformation and failure processes under different loading conditions,and they can be valuable for applications in rock mechanics and rock engineering.
基金This work was supported by the National Natural Science Foundation of China(Grant No.12072340)the China Postdoctoral Science Foundation(Grant No.2022M720727)the Jiangsu Funding Program for Excellent Postdoctoral Talent(Grant No.2022ZB130).
文摘We investigate the impact of pairwise and group interactions on the spread of epidemics through an activity-driven model based on time-dependent networks.The effects of pairwise/group interaction proportion and pairwise/group interaction intensity are explored by extensive simulation and theoretical analysis.It is demonstrated that altering the group interaction proportion can either hinder or enhance the spread of epidemics,depending on the relative social intensity of group and pairwise interactions.As the group interaction proportion decreases,the impact of reducing group social intensity diminishes.The ratio of group and pairwise social intensity can affect the effect of group interaction proportion on the scale of infection.A weak heterogeneous activity distribution can raise the epidemic threshold,and reduce the scale of infection.These results benefit the design of epidemic control strategy.
基金supported by the National Natural Science Foundation of China(Nos.21825106,92061201,22105175)Postdoctoral Research Grant in Henan Province(No.202102001)。
文摘It remains a big challenge to develop solid-state stimuli-responsive materials for time-dependent information encryption and inkless erasable printing with long retention times.Herein,a 2D Cu_(2)I_(2)-based MOF with photoresponsive spiropyran(SP)groups orderly installed on its skeleton is developed.The structural isomerization from SP to colored merocyanine(MC)form can be triggered by removing the CH_(3)CN vips.Besides,the degree of structural isomerization and the retention time can be adjusted by controlling the amount of CH_(3)CN vips,exhibiting dynamic photochromic behavior with multicolor states and tunable retention time.Based on these advantages,time-dependent information encryption is successfully achieved.Furthermore,the long retention time(>72 h)of the MC form under daylight conditions in the CH_(3)CN-removed Cu_(2)I_(2)-based MOF and good repeatability make it promising in various applications,such as temporary calendars,price-cards,billboards,and reusable identity cards.This work provides a novel design strategy to fabricate multi-functional MOF-based smart materials for challenging applications of time-dependent information encryption and inkless erasable printing.
基金supported by the National Natural Science Foundation of China(Nos.22220102004,22025503)Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX03)+4 种基金the Innovation Program of Shanghai Municipal Education Commission(No.2023ZKZD40)the Fundamental Research Funds for the Central Universitiesthe Programme of Introducing Talents of Discipline to Universities(No.B16017)Science and Technology Commission of Shanghai Municipality(No.21JC1401700)the Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study(No.SN-ZJU-SIAS-006)。
文摘Dynamic assembly on time scale is common in biological systems but rare for artificial materials,especially for smart luminescent materials.Programming molecular assembly in a spatio-temporal manner and resulting in white-light-including multicolor fluorescence with time-dynamic features remains challenging.Herein,controlling molecular assembly on time scale is achieved by integrating a pH-responsive motif to a transient alkaline solution which is fabricated by activators(NaOH)and deactivators(esters),leading to automatic assembly on time scale and time-dependent multicolor fluorescence changing from blue to white and yellow.The kinetics of the assembly process is dependent on the ester hydrolysis process,which can be controlled by varying ester concentrations,temperature,initial pH,stirring rate and ester structures.This dynamic fluorescent system can be further developed for intelligent fluorescent materials such as fluorescent ink,three-dimension(3D)codes and even four-dimension(4D)codes,exhibiting a promising potential for information encryption.
基金supported by the National Natural Science Foundation of China(12126318,12126302).
文摘This paper develops a generalized scalar auxiliary variable(SAV)method for the time-dependent Ginzburg-Landau equations.The backward Euler method is used for discretizing the temporal derivative of the time-dependent Ginzburg-Landau equations.In this method,the system is decoupled and linearized to avoid solving the non-linear equation at each step.The theoretical analysis proves that the generalized SAV method can preserve the maximum bound principle and energy stability,and this is confirmed by the numerical result,and also shows that the numerical algorithm is stable.
基金funded by the Pyramid Talent Training Project of Beijing University of Civil Engineering and Architecture under Grant GJZJ20220802。
文摘Accurately estimating the State of Health(SOH)and Remaining Useful Life(RUL)of lithium-ion batteries(LIBs)is crucial for the continuous and stable operation of battery management systems.However,due to the complex internal chemical systems of LIBs and the nonlinear degradation of their performance,direct measurement of SOH and RUL is challenging.To address these issues,the Twin Support Vector Machine(TWSVM)method is proposed to predict SOH and RUL.Initially,the constant current charging time of the lithium battery is extracted as a health indicator(HI),decomposed using Variational Modal Decomposition(VMD),and feature correlations are computed using Importance of Random Forest Features(RF)to maximize the extraction of critical factors influencing battery performance degradation.Furthermore,to enhance the global search capability of the Convolution Optimization Algorithm(COA),improvements are made using Good Point Set theory and the Differential Evolution method.The Improved Convolution Optimization Algorithm(ICOA)is employed to optimize TWSVM parameters for constructing SOH and RUL prediction models.Finally,the proposed models are validated using NASA and CALCE lithium-ion battery datasets.Experimental results demonstrate that the proposed models achieve an RMSE not exceeding 0.007 and an MAPE not exceeding 0.0082 for SOH and RUL prediction,with a relative error in RUL prediction within the range of[-1.8%,2%].Compared to other models,the proposed model not only exhibits superior fitting capability but also demonstrates robust performance.
基金funded by the National Natural Science Foundation of China (No. 52304133)the National Key R&D Program of China (No. 2022YFC3004605)the Department of Science and Technology of Liaoning Province (No. 2023-BS-083)。
文摘Rockbursts, which mainly affect mining roadways, are dynamic disasters arising from the surrounding rock under high stress. Understanding the interaction between supports and the surrounding rock is necessary for effective rockburst control. In this study, the squeezing behavior of the surrounding rock is analyzed in rockburst roadways, and a mechanical model of rockbursts is established considering the dynamic support stress, thus deriving formulas and providing characteristic curves for describing the interaction between the support and surrounding rock. Design principles and parameters of supports for rockburst control are proposed. The results show that only when the geostress magnitude exceeds a critical value can it drive the formation of rockburst conditions. The main factors influencing the convergence response and rockburst occurrence around roadways are geostress, rock brittleness, uniaxial compressive strength, and roadway excavation size. Roadway support devices can play a role in controlling rockburst by suppressing the squeezing evolution of the surrounding rock towards instability points of rockburst. Further, the higher the strength and the longer the impact stroke of support devices with constant resistance, the more easily multiple balance points can be formed with the surrounding rock to control rockburst occurrence. Supports with long impact stroke allow adaptation to varying geostress levels around the roadway, aiding in rockburst control. The results offer a quantitative method for designing support systems for rockburst-prone roadways. The design criterion of supports is determined by the intersection between the convergence curve of the surrounding rock and the squeezing deformation curve of the support devices.
基金supported by the Australian Government through the Australian Research Council’s Discovery Early Career Researcher Award(DE240100207).
文摘The time-dependent resilience of an in-service aging structure provides quantitative measure of the structural ability to prepare for,adapt to,withstand and recover from disruptive events.Resilience models have been proposed in the literature to evaluate the resilience of aging structures subjected to discrete load processes,which are,however,not applicable to handle resilience problems considering continuous load processes.In this paper,a new method is developed to evaluate the time-dependent resilience of aging structures subjected to a continuous load process.The proposed method serves as the complement of the existing resilience models addressing discrete load processes,and takes into account the aging effects of the structural resistance/capacity and the nonstationarity in loads as a result of climate change.A structure suffers from a damage state upon the occurrence of an upcrossing of the load effect with respect to the resistance/capacity,leading to the reduction of the performance function,followed by a recovery process that restores the performance.The proposed method enables the time-dependent resilience to be evaluated via a closed form solution.It is also revealed that,the proposed resilience model takes an extended form of the existing formula for upcrossing-based time-dependent reliability,thus establishing a unified framework for the two quantities.The applicability of the proposed method is demonstrated through examining the time-dependent resilience of a residential building subjected to wind load.The effects of key factors on resilience,including the nonstationarity and correlation structure of the load process,as well as the resistance/capacity deterioration scenario,are investigated through an example.In particular,the structural resilience would be overestimated if ignoring the potential impacts of climate change,which is a relatively non-conservative evaluation.
基金supported by the National Natural Science Foundation of China(Nos.22178388 and 22108306)Taishan Scholars Program of Shandong Province(No.tsqn201909065)Chongqing Science and Technology Bureau(No.cstc2019jscx-gksb X0032).
文摘Structural regulation of Pd-based electrocatalytic hydrodechlorination(EHDC)catalyst for constructing high-efficient cathode materials with low noble metal content and high atom utilization is crucial but still challenging.Herein,a support electron inductive effect of Pd-Mn/Ni foam catalyst was proposed via in-situ Mn doping to optimize the electronic structure of the Ni foam(NF),which can inductive regulation of Pd for improving the EHDC performance.The mass activity and current efficiency of Pd-Mn/NF catalyst are 2.91 and 1.34 times superior to that of Pd/NF with 2,4-dichlorophenol as model compound,respectively.The Mn-doped interlayer optimized the electronic structure of Pd by bringing the d-state closer to the Fermi level than Pd on the NF surface,which optimizied the binding of EHDC intermediates.Additionally,the Mn-doped interlayer acted as a promoter for generating H∗and accelerating the EHDC reaction.This work presents a simple and effective regulation strategy for constructing high-efficient cathode catalyst for the EHDC of chlorinated organic compounds.
基金supported by the Deanship of Graduate Studies and Scientific Research at University of Bisha for funding this research through the promising program under grant number(UB-Promising-33-1445).
文摘Open networks and heterogeneous services in the Internet of Vehicles(IoV)can lead to security and privacy challenges.One key requirement for such systems is the preservation of user privacy,ensuring a seamless experience in driving,navigation,and communication.These privacy needs are influenced by various factors,such as data collected at different intervals,trip durations,and user interactions.To address this,the paper proposes a Support Vector Machine(SVM)model designed to process large amounts of aggregated data and recommend privacy preserving measures.The model analyzes data based on user demands and interactions with service providers or neighboring infrastructure.It aims to minimize privacy risks while ensuring service continuity and sustainability.The SVMmodel helps validate the system’s reliability by creating a hyperplane that distinguishes between maximum and minimum privacy recommendations.The results demonstrate the effectiveness of the proposed SVM model in enhancing both privacy and service performance.
