BACKGROUND Dyslipidemia and type 2 diabetes mellitus(T2DM)are chronic conditions with substantial public health implications.Effective management of lipid metabolism in patients with T2DM is critical.However,there has...BACKGROUND Dyslipidemia and type 2 diabetes mellitus(T2DM)are chronic conditions with substantial public health implications.Effective management of lipid metabolism in patients with T2DM is critical.However,there has been insufficient attention given to the relationship between thyroid hormone sensitivity and dyslipidemia in the T2DM population,particularly concerning non-high-density lipoprotein cholesterol(non-HDL-C).AIM To clarify the association between thyroid hormone sensitivity and dyslipidemia in patients with T2DM.METHODS In this cross-sectional study,thyroid hormone sensitivity indices,the thyroid feedback quantile-based index(TFQI),the thyroid-stimulating hormone index(TSHI),the thyrotrophic T4 resistance index(TT4RI),and the free triiodothyronine(FT3)/free thyroxine(FT4)ratio were calculated.Logistic regression analysis was performed to determine the associations between those composite indices and non-HDL-C levels.Random forest variable importance and Shapley Additive Explanations(SHAP)summary plots were used to identify the strength and direction of the association between hyper-non-HDL-C and its major predictor.RESULTS Among the 994 participants,389(39.13%)had high non-HDL-C levels.Logistic regression analysis revealed that the risk of hyper-non-HDL-C was positively correlated with the TFQI(OR:1.584;95%CI:1.088-2.304;P=0.016),TSHI(OR:1.238;95%CI:1.034-1.482;P=0.02),and TT4RI(OR:1.075;95%CI:1.006-1.149;P=0.032)but was not significantly correlated with the FT3/FT4 ratio.The relationships between composite indices of the thyroid system and non-HDL-C levels differed according to sex.An increased risk of hyper-non-HDL-C was associated with elevated TSHI levels in men(OR:1.331;95%CI:1.003-1.766;P=0.048)but elevated TFQI levels in women(OR:2.337;95%CI:1.4-3.901;P=0.001).Among the analyzed variables,the average SHAP values were highest for TSHI,followed by TT4RI.CONCLUSION Impaired sensitivity to thyroid hormones was associated with high non-HDL-C levels in patients with T2DM.展开更多
Objective: to study the effect of individualized nursing on patients with thyroid cancer after operation. Methods: the time from the beginning to the end of the study was June 2019 to June 2020. The research object wa...Objective: to study the effect of individualized nursing on patients with thyroid cancer after operation. Methods: the time from the beginning to the end of the study was June 2019 to June 2020. The research object was patients with thyroid cancer in our hospital. The number of cases was 60. Patients were divided into groups according to their clinical nursing methods. Patients received individualized care after surgery as the analysis group, and patients received routine care after surgery as the comparison group. The incidence of postoperative complications and postoperative recovery indicators were compared between the two groups. Results: the incidence of postoperative complications and postoperative recovery index of the analysis group were better than those of the control group, P < 0.05. Conclusion: individualized nursing can effectively promote the recovery of patients with thyroid cancer.展开更多
目的:比较各大洲、不同人类发展指数(human development index,HDI)国家2022年甲状腺癌流行现状,了解中国与高HDI国家和东亚地区甲状腺癌发病和死亡差异,为中国甲状腺癌诊断策略的制定提供依据。方法:从GLOBOCAN 2022数据库下载并整理...目的:比较各大洲、不同人类发展指数(human development index,HDI)国家2022年甲状腺癌流行现状,了解中国与高HDI国家和东亚地区甲状腺癌发病和死亡差异,为中国甲状腺癌诊断策略的制定提供依据。方法:从GLOBOCAN 2022数据库下载并整理甲状腺癌发病和死亡数据,使用Spearman秩相关系数分析HDI与标化发病率(standardized incidence rate,SIR)、标化死亡率(standardized mortality rate,SMR)、死亡发病比(mortality to incidence ratio,M/I)之间的关联。结果:2022年全球各大洲甲状腺癌SIR以非洲、欧洲、拉丁美洲和加勒比地区、大洋洲、亚洲和北美洲的顺序递增,SMR以北美洲、欧洲、亚洲、大洋洲、拉丁美洲和加勒比地区和非洲的顺序递增。甲状腺癌SIR(r=0.693,P<0.001)与HDI呈正相关,而SMR(r=-0.264,P<0.001)和M/I(r=-0.711,P<0.001)与HDI呈负相关。中国甲状腺癌SIR高于东亚地区,SMR与东亚地区相等。中国甲状腺癌SIR高于高HDI国家,SMR低于高HDI国家。结论:甲状腺癌过度诊断问题在中国等人类高发展指数国家较为严重,中国应及时调整甲状腺癌诊断和筛查策略,避免医疗资源浪费。展开更多
基金Supported by the Xuanwu Hospital Capital Medical University Science Program for Fostering Young Scholars,No.YC20220113the Pilot Project for Public,No.Beijing Medical Research 2021-8.
文摘BACKGROUND Dyslipidemia and type 2 diabetes mellitus(T2DM)are chronic conditions with substantial public health implications.Effective management of lipid metabolism in patients with T2DM is critical.However,there has been insufficient attention given to the relationship between thyroid hormone sensitivity and dyslipidemia in the T2DM population,particularly concerning non-high-density lipoprotein cholesterol(non-HDL-C).AIM To clarify the association between thyroid hormone sensitivity and dyslipidemia in patients with T2DM.METHODS In this cross-sectional study,thyroid hormone sensitivity indices,the thyroid feedback quantile-based index(TFQI),the thyroid-stimulating hormone index(TSHI),the thyrotrophic T4 resistance index(TT4RI),and the free triiodothyronine(FT3)/free thyroxine(FT4)ratio were calculated.Logistic regression analysis was performed to determine the associations between those composite indices and non-HDL-C levels.Random forest variable importance and Shapley Additive Explanations(SHAP)summary plots were used to identify the strength and direction of the association between hyper-non-HDL-C and its major predictor.RESULTS Among the 994 participants,389(39.13%)had high non-HDL-C levels.Logistic regression analysis revealed that the risk of hyper-non-HDL-C was positively correlated with the TFQI(OR:1.584;95%CI:1.088-2.304;P=0.016),TSHI(OR:1.238;95%CI:1.034-1.482;P=0.02),and TT4RI(OR:1.075;95%CI:1.006-1.149;P=0.032)but was not significantly correlated with the FT3/FT4 ratio.The relationships between composite indices of the thyroid system and non-HDL-C levels differed according to sex.An increased risk of hyper-non-HDL-C was associated with elevated TSHI levels in men(OR:1.331;95%CI:1.003-1.766;P=0.048)but elevated TFQI levels in women(OR:2.337;95%CI:1.4-3.901;P=0.001).Among the analyzed variables,the average SHAP values were highest for TSHI,followed by TT4RI.CONCLUSION Impaired sensitivity to thyroid hormones was associated with high non-HDL-C levels in patients with T2DM.
文摘Objective: to study the effect of individualized nursing on patients with thyroid cancer after operation. Methods: the time from the beginning to the end of the study was June 2019 to June 2020. The research object was patients with thyroid cancer in our hospital. The number of cases was 60. Patients were divided into groups according to their clinical nursing methods. Patients received individualized care after surgery as the analysis group, and patients received routine care after surgery as the comparison group. The incidence of postoperative complications and postoperative recovery indicators were compared between the two groups. Results: the incidence of postoperative complications and postoperative recovery index of the analysis group were better than those of the control group, P < 0.05. Conclusion: individualized nursing can effectively promote the recovery of patients with thyroid cancer.
