AIM： To investigate those associations using data of the population-based Study of Health in Pomerania. METHODS： A study population of 3 749 residents aged 20-79 years without previously diagnosed thyroid disease wa...AIM： To investigate those associations using data of the population-based Study of Health in Pomerania. METHODS： A study population of 3 749 residents aged 20-79 years without previously diagnosed thyroid disease was available for analyses. Serum TSH was used to assess thyroid function. Cholelithiasis was defined by either a prior history of cholecystectomy or the presence of gallstones on ultrasound. Logistic regression was performed to analyze independent associations between thyroid function and cholelithiasis. RESULTS： There were 385 persons （10.3%） with low （〈0.3 mIU/L）, 3 321 persons （88.6%） with normal and 43 persons （1.2%） with high serum TSH levels （〉3 mIU/L）. The proportion of cholelithiasis among males and females was 14.4% and 25.3%, respectively. Among males, there was an independent relation between high serum TSH and cholelithiasis （OR 3.77; 95%-CI 1.06-13.41; P〈0.05）. Also among males, there was a tendency towards an elevated risk of cholelithiasis in persons with low serum TSH （OR 1.40; 95%-CI 0.96-2.02; P= 0.07）. In the female population, no such relation was identified. CONCLUSION： There is an association between thyroid and gallstone disease with a gender-specific relation between hypothyroidism and cholelithiasis.展开更多
BACKGROUND: Prognostic value of cortisol and thyroid function tests(TFTs) has previously been evaluated in medical ICUs. We aimed to evaluate prognostic efficacy of cortisol and TFTs in critically ill poisoned patient...BACKGROUND: Prognostic value of cortisol and thyroid function tests(TFTs) has previously been evaluated in medical ICUs. We aimed to evaluate prognostic efficacy of cortisol and TFTs in critically ill poisoned patients admitted to toxicology intensive care unit(ICU).METHODS: In a prospective study of consecutively enrolled subjects admitted to the toxicology ICU, lab analyses included TFTs(total T3 and T4 as well as TSH) and cortisol levels drawn between 8 am–10 am during period of the first 24 hours post-ingestion/exposure. Simplified Acute Physiology Score Ⅱ(SAPS Ⅱ) and Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ) were recorded. All scores were compared to detect the best prognostic factor. Type of poisoning was also included.RESULTS: In 200 patients evaluated, 129 were male and mean age was 31 years. In general, SAPS Ⅱ, T4, and cortisol could prognosticate death. After regression analysis, only cortisol had such efficacy(P=0.04; OR=1.06; 95%CI=1.05–1.08; cut-off=42 μg/d L; sensitivity=70%; specificity=82%). Between aluminium phosphide(ALP)-and non ALP-poisoned patients, level of consciousness, mean arterial pressure, and cortisol level could prognosticate death in ALP poisoning(all Ps<0.001 in both uni and multivariate analyses). Median(interquartile range; IQR) GCS was 7(6, 10) and 15(8, 15) in non-ALP and ALP-poisoned patients(P<0.003). SAPS Ⅱ and APACHE Ⅱ could not prognosticate death at all.CONCLUSION: Cortisol best prognosticated outcomes for subjects admitted to the toxicology ICU. Its level is higher in ALP-poisoned patients probably due to the higher stress while they remain conscious till the final stages of toxicity and are aware of deterioration of their clinical condition or may be due to their significantly lower blood pressures.展开更多
Thirty-two Wistar rats were divided randomly into four groups of eight with six females and two males in each group. The rats were exposed to high fluoride drinking water （45 mg F-L^-1 from 100 mg NaF L-1）, low diet...Thirty-two Wistar rats were divided randomly into four groups of eight with six females and two males in each group. The rats were exposed to high fluoride drinking water （45 mg F-L^-1 from 100 mg NaF L-1）, low dietary iodine （0.0855 mg kg-1）, or both together in order to assess the effects of these three regimens on the thyroid function of the offspring rats. After the animal model was established, the offspring rats were bred and 10-, 20-, 30-, 60-, and 90-d-old rats were used for the experiment. The treatments for the offspring rats were the same as those of their parents. In comparison with control rats, the relative thyroid glands were changed by three regimens, but the mean values of thyroid weight in the experimental groups saw no marked difference. Serum TT3 levels were increased in all stages in the low iodine （LI） group. In the high fluoride （HiF） group, increase in TT3 levels was observed except in 20-d-old rats. Decrease in TT3 at 20- and 90-d and increase in TT3 at 30- and 60-d were found in HiF＋LI group. Serum TT4 levels first saw an increase, and then dropped in the LI and HiF＋LI group. However, an increase in TT4 was found in the HiF group. The levels of TSH in serum rocketed at d 20, and then dropped in the next stages in experimental groups. The results suggested that thyroid disorder could be induced by high flroride in drinking water, low iodine diet, or both of them. Exposure time to fluoride or low iodine diet was one of the important factors that fluoride can induce the development of thyroid dyfunction.展开更多
With regard to brain acetylcholinesterase and acetylcholine and serum triiodothyronine(T_3) and thyroxine(T_4)profiles,a biphasic response pattern was elicited in Channa punctatus chroni- cally exposed to nonlethal do...With regard to brain acetylcholinesterase and acetylcholine and serum triiodothyronine(T_3) and thyroxine(T_4)profiles,a biphasic response pattern was elicited in Channa punctatus chroni- cally exposed to nonlethal doses of locally used pesticides,namely,Metacid-50 and Carbaryl. Data revealed that these xenobiotics caused significant inhibition of brain acetylcholinesterase activity and a decrease in thyroxine level accompanied by a concurrent increase in acetylcholine accumulation and T_3 level.It is surmised that Metacid-50 and Carbaryl influence both neural and hormonal functions.1989 Academic Press.Inc.展开更多
Objective： The purpose of the study wass to explore the correlation between thyroid function and nodular goiter accompanied with gallstone. Methods： We collected 120 cases about nodular goiter accompanied with galls...Objective： The purpose of the study wass to explore the correlation between thyroid function and nodular goiter accompanied with gallstone. Methods： We collected 120 cases about nodular goiter accompanied with gallstone and 128 cases about nodular goiter and establish 50 healthy control groups. Detected t level of hyrotropic hormone （TSH）, total triio- dothyronine （TT3）, total thyroxine in the peripheral venous blood of these cases in the three groups by using electrochemilu- minescenca immunoassay, measure level of total cholesterol （TC）, high-density tipoprotein cholesterol（HDL-C）, low-density lipoprotein cholesterol （LDL-C） and total bile acid （TBA） levels by using enzymic method, and observed the changes of thyroid function and blood lipid among the three groups. Results： The serum TT3 level in nodular goiter accompanied with gallstone group and the nodular goiter group was significantly lower than that in control group （P 〈 0.01）, and TSH level in the nodular goiter accompanied with gallstone group is significantly higher than that in control group （P 〈 0.01）, There were no statistical significance about difference of TT4 level among the three groups （P 〉 0.05）. Accordingly, TC and LDL-C level in nodular goiter accompanied with gallstone group was significantly higher than that in nodular goiter and control group （P 〈 0.01）, while TBA level in nodular goiter accompanied with gallstone group was significantly lower than that in simple nodular goiter group and control group （P 〈 0.01）. There was no statistical significance about difference of TC and LDL-C level between simple nodular goiter group and control group （P 〉 0.05）. The HDL-C level in nodular goiter accompanied with gallstone group and control group was higher than that in simple nodular goiter group （P 〈 0.01）. Conclusion： The originating etiologic factor of nodular goiter accompanied with gallstone may be related to that the decreased TT3 induced sub-clinical hypothyroidism.展开更多
Accelerating cell growth is one of the functions of thyroid hormone. In the absence or lack of this hormone, hematopoietic disorder may occur. Dynamic observation of thyroid function in aplastic anemia (AA) state has ...Accelerating cell growth is one of the functions of thyroid hormone. In the absence or lack of this hormone, hematopoietic disorder may occur. Dynamic observation of thyroid function in aplastic anemia (AA) state has not been reported yet.展开更多
[Objectives]To explore the efficacy of Xiaojin Capsules combined with Selenium Yeast Capsules in the treatment of Hashimoto's thyroiditis(HT)with abnormal thyroid function.[Methods]A total of 180 HT patients who w...[Objectives]To explore the efficacy of Xiaojin Capsules combined with Selenium Yeast Capsules in the treatment of Hashimoto's thyroiditis(HT)with abnormal thyroid function.[Methods]A total of 180 HT patients who were treated in the First Affiliated Hospital of Henan University and Henan Provincial People's Hospital from December 2020 to December 2021 were selected as the research subjects and randomly divided into the observation group(n=120)and the control group(n=60)in at a tratio of 2∶1 ratio according to their visiting time.The observation group was treated with Xiaojin Capsules(oral,5 capsules each time,twice a day for 12 weeks)and Selenium Yeast Capsules(oral,1 capsule each time,twice a day for 12 weeks).The control group was treated with only Selenium Yeast Capsules(oral,1 capsule each time,twice a day for 12 weeks).[Results]The difference in the levels of thyroid peroxidase antibody(TPO-Ab),thyroglobulin antibody(TGAb),serum free triiodothyronine(FT_(3)),serum free thyroxine(FT_(4)),and thyroid stimulating hormone(TSH)between the observation group and control group was statistically significant(P<0.05).The diameters of thyroid between the observation group and the control group before,during and after treatment were significantly different(P<0.05).The total effective rate of the observation group was 82.5%(99/120),which was significantly higher than 56.67%(34/60)in the control group,and the difference was statistically significant(P<0.05).The cure rate(22.50%)in the observation group was significantly higher than the control group(3.33%),and the difference was statistically significant(P<0.01).The ineffective rate of the observation group was 17.50%,which was significantly lower than that of the control group(40.00%),and the difference was statistically significant(P<0.01).The markedly effective rate of the observation group was 40.83%,which was significantly higher than that of the control group(31.67%),and the difference was statistically significant(P<0.05).The effective rate in the observation group was 191%,and the effective rate in the control group was 21.67%,and the difference was not statistically significant(P>0.05).[Conclusions]Xiaojin Capsules combined with Selenium Yeast Capsules in the treatment of HT can eliminate or alleviate the clinical symptoms and signs,significantly reduce the levels of TPO-Ab and TGAb in serum,restore thyroid function,improve thyroid shape and structure in the treatment of HT,and the clinical effect is satisfactory.展开更多
Objective:To investigate the relationship of iodine nutritional status with thyroid function in pregnant women in Baotou,and provide a scientific basis for the guide of reasonable iodine supplementation.Methods:By use...Objective:To investigate the relationship of iodine nutritional status with thyroid function in pregnant women in Baotou,and provide a scientific basis for the guide of reasonable iodine supplementation.Methods:By use of As-Ce catalysis spectrophotometry,the urinary iodine concentration was determined in 90 women during different periods of pregnancy admitted to Baogang Hospital of Inner Mongolia from January 2017 to December 2017.The determination of thyroid function and the autoantibody level was carried out by electro-chemiluminescence immunoassay(ECLIA).Results:In the early trimester of pregnancy,pregnant women with iodine deficiency,iodine sufficiency and iodine excess accounted for 36.67%,40.00%and 23.33%respectively;in the middle trimester of pregnancy,they accounted for 66.67%,26.67%and 6.66%respectively;they made up 40.00%,40.00%and 20.00%respectively in the late trimester of pregnancy.The rate of iodine deficiency in women in the middle trimester of pregnancy was significantly higher than that in women in the early and the late trimesters of pregnancy respectively,and the difference was statistically significant(p<0.05).The rate of iodine deficiency in pregnant women was positively correlated to the positivity of thyroid peroxidase antibody.Moreover,it had no relationship with the positivity of thyroglobulin antibody.No matter in the pregnant women with iodine deficiency or with iodine excess,the abnormality rate of thyroid function and autoantibodies was significantly higher than that in the pregnant women with iodine sufficiency.The difference was statistically significant(p<0.05).Conclusions:The iodine deficiency in the women in the middle trimester of pregnancy is more severe than that in the women in the early and the late trimesters of pregnancy.Iodine deficiency during pregnancy is positively correlated with the positivity of thyroid peroxidase antibody.Pregnant women with iodine deficiency and iodine excess show a higher abnormality rate of thyroid function and autoantibodies.It is recommended to advocate health education on iodine nutrition to pregnant women,and conduct the dynamic monitoring of urinary iodine concentration and the screening of thyroid function and autoantibodies during pregnancy.展开更多
Objective: thyroid gland is not new to everyone. People first think of "big neck disease". Thyroid gland is an important endocrine gland in human body. It can secrete thyroid hormone to control the body'...Objective: thyroid gland is not new to everyone. People first think of "big neck disease". Thyroid gland is an important endocrine gland in human body. It can secrete thyroid hormone to control the body's energy consumption rate. It also has a direct impact on the secretion of other hormones and can effectively regulate the body's system function. The thyroid gland is also an important organ for producing calcitonin, which can keep the body's calcium balance. Once the thyroid function is abnormal, such as hypothyroidism, the synthesis of related hormones will be reduced, and the metabolism of other organisms will also be limited. It also includes some other diseases, such as macroneck disease, which will bring serious impact on human health. Therefore, the principle of "prevention first, prevention combined with treatment" should be adopted for these diseases. Clinical diagnosis is the key to diagnosis and treatment of thyroid diseases. This paper explores the five measurements of thyroid function. Methods: a total of 50 patients were selected from the department for health examination in the hospital as the control group, and 100 patients with thyroid dysfunction were selected from the department for research, 50 patients with hyperthyroidism and 50 patients with hypothyroidism. Among them, hyperthyroidism is classified as A and hypothyroidism as B. The thyroid function examination and diagnostic coincidence rate of control group and observation group A and B are investigated and analyzed. The examination is divided into five contents, including T3 (triiodothyronine), T4 (thyroxine), FT4 (free thyroxine), FT3 (free triiodothyronine) and TSH (thyroid stimulating hormone). The generated data are recorded and investigated. Results: the results of this study were evaluated. The data showed that the thyroid hormone in the control group was significantly higher than that in the observation group A, and the thyroid hormone in the other four observation groups A was significantly higher. The thyroid hormone of observation group B was higher than that of control group, and the other four items of control group were significantly higher, the difference of data results was statistically significant (P < 0.05). This study focuses on clinical diagnosis, and the diagnostic rate was evaluated. The data showed that the diagnostic rates of hyperthyroidism and hypothyroidism in both groups reached more than 90%, and there was no significant difference between the data results (P>0.05). Conclusion: practice has proved that the five tests of thyroid function have good diagnostic advantages for the clinical diagnosis of thyroid function, which not only improves the clinical diagnosis rate, but also has very important significance for the diagnosis and treatment of clinical conditions.展开更多
Thyroid dysfunction is frequent in pregnant women and is often associated with an increased risk of adverse maternal and fetal outcome. In the present work, thyroid function of pregnant women from Benin republic was s...Thyroid dysfunction is frequent in pregnant women and is often associated with an increased risk of adverse maternal and fetal outcome. In the present work, thyroid function of pregnant women from Benin republic was studied. Two hundred forty (240) pregnant women, without thyroid disease history, have been included in the study. A blood sample was drawn for measurement of TSH, free T3 and free T4 serum levels. From the first to the third trimester, plasma levels of free T3 and free T4 decreased when plasma levels of TSH increased. Using recommendations of the 2011 American Thyroid Association (ATA) guidelines, thyroid dysfunction was observed in 24.17% of subjects. Hypothyroidism was present in 22.50% of subjects with 19.17% of subclinical hypothyroidism, 0.83% of overt hypothyroidism and 2.50% of hypothyroxinemia and hyperthyroidism was observed in 1.67% of subjects. An increase from 15.52% to 28.07% was observed in the frequency of hypothyroidism from the first to the third trimester of pregnancy. When an upper cut-off value of 4 mU/L was used for TSH, as recommended in the 2017 ATA guidelines, prevalence of thyroid disorders was 14.58% with 12.91% of hypothyroidism but no hypothyroidism was observed in women in the first trimester of pregnancy. A rise in hypothyroidism frequency was observed when pregnant women age increased. Hypothyroidism was very common in pregnant women in Benin. To allow accurate assessment of thyroid status in pregnant women in Benin, pregnancy specific range for plasma level of TSH and thyroid hormones should be established.展开更多
Background: The thyroid status is evaluated by two clinical diagnostic tests which are thyroid ultrasonography and thyroid function tests. The objective of this research is to critically analyze the age and gender bas...Background: The thyroid status is evaluated by two clinical diagnostic tests which are thyroid ultrasonography and thyroid function tests. The objective of this research is to critically analyze the age and gender based variations of thyroid volume and thyroid hormone levels in the hospital based euthyroid subjects. Methodology: A total of 221 euthyroid subjects aged 1 - 86 years were selected to observe the normal thyroid size by ultrasonography at Department of Radiology and the thyroid function test values (FT3, FT4 and TSH) of 2413 euthyroid subjects aged (Results: The best fitted equations with significant correlation coefficients and p Conclusion: The thyroid size first increases and then decreases whereas the thyroxin level first decreases and then increases with aging. Left lobe volume is almost same for both genders and right lobe volume is higher in males. The thyroid size in menarche and menopause periods of females is larger than that of males. Such age- and gender-specific changes recommend the new refer-ence ranges for the normal thyroid functions.展开更多
Background: Pregnancy is associated with the change in thyroid function. Thyroid function is also affected by goitrogenic substances in some plant foods, like cassava. Aim: This study aims to assess thyroid function s...Background: Pregnancy is associated with the change in thyroid function. Thyroid function is also affected by goitrogenic substances in some plant foods, like cassava. Aim: This study aims to assess thyroid function status and its association to consumption of foods containing goitrogenic substances. Methods: A cross sectional study was done on a total of 65 pregnant women attending Sawla Health Center, South Ethiopia. Serum samples were collected and analyzed for TSH, total T4 and total T3 by using ELISA kit. Data on consumption of foods containing were obtained from food frequency questionnaire. Results: The median TSH of the first, second and third trimesters, respectively are 2.57, 1.86 and 2.42 mIU/L, which are within the reference interval (0.30-6.20 mIU/L) of the test kit. The median total T4 values (9.8, 10.0 and 10.3 μg/dl in the first, second and third trimesters, respectively) were also within the reference interval (4.8-11.6 μg/dl) of the test kits. The median total T3 in the first (2.60 ng/ml) and third (2.35 ng/ml) trimesters were elevated, but it was within the reference interval (0.69-2.02 ng/ml) in the second trimester (1.92 ng/ml). Though statistically non-significant median TSH was increased in women grouped as cassava consumers and M. stenopetala consumers while median total T4 values were decreased in these groups. Conclusion: The study subjects have normal thyroid function as the median values of TSH and total T4 were within the reference interval of the test kit. Frequent consumption of cassava and Moringa stenopetala may affect thyroid function.展开更多
Nigella sativa L. (Black seed), is a traditional herbal medicine that has been used for many purposes. The present study was designed to investigate the effects of hydro-alcoholic extract of nigella sativa L. (NS) on ...Nigella sativa L. (Black seed), is a traditional herbal medicine that has been used for many purposes. The present study was designed to investigate the effects of hydro-alcoholic extract of nigella sativa L. (NS) on performance of Forced Swimming Test (FST), blood biochemical parameters related to fatigue and thyroid functions. Therefore, Blood Urea Nitrogen (BUN), Creatine Kinase (CK), Lactic Dehydrogenase (LDH), and Total Protein (TP), triiodothyronine T3, thyroxin T4 and TSH tests were investigated. Thirty five male adult mice were randomly divided into five groups: three NS-fed groups, one fluoxetine treated group and one control group. Three NS experimental groups received hydro-alcoholic extract of NS at doses of 50, 100 and 200 mg/kg orally for two weeks. Immobility time decreased in all NS groups compared with control group. Administration of NS significantly increased the concentration of T3 and T4 of the treatment groups. On the contrary, the amount of BUN, CK, LDH, TP and TSH decreased. In conclusion, black seed extract at the experimented doses showed anti-depressant, anti-fatigue and hyperthyroid effects.展开更多
Background and Objectives:This study investigated the iodine status of pregnant women at an average altitude of approximately 2000 meters in Qujing,China.The relationship between iodine and thyroid function in differe...Background and Objectives:This study investigated the iodine status of pregnant women at an average altitude of approximately 2000 meters in Qujing,China.The relationship between iodine and thyroid function in different trimesters as well as adverse pregnancy and fetal outcomes were also investigated.Methods and Study Design:A total of 1,025 pregnant women who were admitted to Qujing Affiliated Hospital of Kunming Medical Univer sity from January 2019 to August 2021 were included.Urinary iodine concentration(UIC)was detected by color imetric method,and serum thyroid function was detected by chemiluminescence.Among them,537 pregnant women were followed up to analyze the association of iodine with adverse pregnancy and fetal outcomes.Re sults:The median UIC was 127μg/L.Serum triiodothyronine,thyroxine,free triiodothyronine,and free thyrox ine were negatively associated with urinary iodine concentration in the first and second trimesters of pregnancy.The proportion of pregnant women testing positive for thyroid peroxidase antibody(TPO-Ab)and the prevalence of thyroid autoimmunity(TAI)increased significantly in more-than-adequate iodine and excess iodine groups.Logistic regression analysis showed maternal iodine was not associated with adverse pregnancy and fetal out comes.Conclusions:Mild iodine deficiency is common among pregnant women in plateau areas of China.The relationship between iodine and thyroid function is significant in the first and second trimesters of pregnancy,es pecially in those with moderate to severe iodine deficiency.Abnormal iodine level in pregnant women was not significantly associated with adverse pregnancy and fetal outcomes in areas with predominantly mild iodine defi ciency.展开更多
With the ban of commercial Penta-BDEs, Octa-BDEs, and Deca-BDEs, many manufacturers have been transition to the production of novel brominated flame retardants (NBFRs), organophosphate ester flame retardants (OPFRs), ...With the ban of commercial Penta-BDEs, Octa-BDEs, and Deca-BDEs, many manufacturers have been transition to the production of novel brominated flame retardants (NBFRs), organophosphate ester flame retardants (OPFRs), and other alternatives. In this study, we recruited 165 employees with typical occupational exposure from a flame retardants (FRs) production plant in Laizhou Bay, which is the main FRs production area in China, to analyze the internal exposure characteristics of FRs and their potential impacts on thyroid function during the historical production and replacement process. The results showed that the detection frequencies of only triphenyl phosphate (TPHP), BDE-138 and BDE-197 (82.4 %, 61.2 % and 60.6 %, respectively) exceeded 60 % among the 34 compounds of interest, while the median concentrations of BDE-138 and BDE-197 were much higher than TPHP (medians of 103.6, 60.6 and 20.5 ng/g lw, respectively). In addition, the concentrations of these compounds in exposed group are higher than those in the control group (P < 0.05). The correlations among FRs indicated they mainly originated from the production and the debromination process. Overall, these results reflect the changes in the product structure. Free triiodothyronine (fT3) was moderately positively correlated with BDE-138, BDE-197, and TPHP (P < 0.05), and regression analysis further identified BDE-138 as a significant factor influencing fT3 levels. Despite TPHP having a rapid metabolism and short half-life, it was still widely detected in this study, indicating that future research should not only focus on the health risks of BDEs or their degradation products but also consider the health risks associated with TPHP and their mixed exposure, especially given the increasing production of OPFRs as substitutes.展开更多
OBJECTIVE:To observe the effects of Buzhong Yiqi granule(补中益气颗粒)on thyroid function and ovarian function in rats with experimental autoimmune thyroiditis(EAT).METHODS:EAT model was replicate by using the method ...OBJECTIVE:To observe the effects of Buzhong Yiqi granule(补中益气颗粒)on thyroid function and ovarian function in rats with experimental autoimmune thyroiditis(EAT).METHODS:EAT model was replicate by using the method of mixing and injecting porcine thyroglobulin with Freund's adjuvant and high iodine.Rats were randomly divided into normal control(NC)group,EAT model(EAT)group,selenium yeast(PC)group,low dose Buzhong Yiqi(BZYQ-L)group,medium dose Buzhong Yiqi(BZYQ-M)group and high dose Buzhong Yiqi(BZYQ-H)group.After two months of drug intervention according to dosage,enzyme-linked immunosorbent assay(ELISA)was used to measure the levels of free triiodothyronine(FT3),free thyroxine(FT4),thyroid-stimulating hormone(TSH),antithyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TGAb)in peripheral blood of rats.The pathological changes of rat thyroid tissues were observed under light microscope with HE staining;ELISA was used to determine estradiol(E2),follicle-stimulating hormone(FSH),luteinizing hormone(LH),testosterone(T),antimüllerian hormone(AMH),and the pathological changes of rat ovarian tissues were observed under light microscope with hematoxylin and eosin staining.RESULTS:Compared with the NC group,BZYQ granule improved the thyroid and ovarian tissue morphology,and the levels of TPOAb,TGAb and TSH in the model group rats significantly increased(P<0.05),the thyroid tissue was severely destroyed,the levels of E2,FSH,LH,T,AMH significantly increased(P<0.05),and the ovary exhibited polycystic changes;Compared with the model group,TSH level in the BZYQ-L group rats decreased(P<0.05),FSH,T,AMH levels decreased(P<0.05),in the BZYQ-M group TPOAb,TSH levels decreased(P<0.05),FSH,LH,T,AMH levels significantly decreased(P<0.05),BZYQ-H group TPOAb,TGAb,TSH levels significantly decreased(P<0.05),FSH,LH,T,AMH levels significantly decreased(P<0.05),with the greatest improvement and significantly better than selenium yeast group(P<0.05).CONCLUSIONS:BZYQ granule could regulate the thyroid function of EAT rats,reduce thyroid antibody titers,then act on the ovarian function,regulate hormone disorders,and alleviate the pathological damage of rat's ovarian tissues.The effect of high dose Buzhong Yiqi granule is the best.展开更多
[Objectives]To study the reference value of thyroid function in healthy women of childbearing age during different pregnancies(early,middle and late pregnancy)in Jingzhou City.[Methods]362 healthy women of childbearin...[Objectives]To study the reference value of thyroid function in healthy women of childbearing age during different pregnancies(early,middle and late pregnancy)in Jingzhou City.[Methods]362 healthy women of childbearing age during different pregnancies(early,middle and late pregnancy)were selected as the study group,and 360 non-pregnant women were selected as the control group.Serum thyroid hormone levels in the two groups were detected,and the reference value was expressed as the median(M)and 95%confidence interval(CI).On this basis,the chart of changing trend of thyroid hormone in the early,middle and late pregnancy were plotted.[Results]Compared with the control group,FT3,TT4,TT3,FT4and TSH in the early,middle and late pregnancy were significantly different in the study group(P<0.05).In the study group,there were significant differences in the early,middle and late pregnancy(P<0.05).[Conclusions]This trend chart has certain reference value in the screening,diagnosis and treatment of thyroid diseases in healthy women of childbearing age during different pregnancies(early,middle and late pregnancy)in Jingzhou City of Hubei Province.展开更多
Background:Recent studies have found that thyroid function may be associated with the occurrence and development of advanced liver fibrosis in patients with metabolic dysfunction-associated fatty liver disease(MAFLD)....Background:Recent studies have found that thyroid function may be associated with the occurrence and development of advanced liver fibrosis in patients with metabolic dysfunction-associated fatty liver disease(MAFLD).However,the majority of such research has consisted of cross-sectional studies.This retrospective cohort study aimed to investigate the effect of low-normal thyroid function on advanced liver fibrosis in MAFLD patients over a 5-year period.Methods:This retrospective cohort study enrolled 825 outpatients and inpatients with MAFLD who attended the Third Affiliated Hospital of Sun Yat-sen University(Guangzhou,China)between January 2011 and December 2018.Based on plasma thyroid hormone and thyroid-stimulating hormone levels,these patients were divided into two groups,namely a low-normal thyroid function group and a strict-normal thyroid function group.The fibrosis-4 score was used to assess advanced liver fibrosis.A chi-square test was conducted to compare the occurrence of advanced fibrosis between the groups.Results:Among the 825 MAFLD patients,117 and 708 were defined as having low-normal thyroid function and strict-normal thyroid function,respectively.Follow-up data were available for 767 patients(93.0%)during a 5-year period.Eight(7.5%)MAFLD patients with low-normal thyroid function and 26(3.9%)with strict-normal thyroid function developed advanced liver fibrosis and the cumulative incidence was not significantly different(P=0.163).Stratification analysis showed that the lean MAFLD patients(body mass index≤23kg/m^(2))with low-normal thyroid function had a higher risk of advanced liver fibrosis than the lean MAFLD patients with strict-normal thyroid function(P<0.05).Conclusion:Low-normal thyroid function is associated with advanced liver fibrosis among lean MAFLD patients.展开更多
To explore the predictive value of thyroid function in severe aplastic anemia(SAA)patients treated with immunosuppressive therapy(IST),149 SAA patients in our center were enrolled between February 2015 and June 2020 i...To explore the predictive value of thyroid function in severe aplastic anemia(SAA)patients treated with immunosuppressive therapy(IST),149 SAA patients in our center were enrolled between February 2015 and June 2020 in this study.We assessed the thyroid function of 134 patients without primary thyroid diseases,and discovered that 89 patients were accompanied by abnormal thyroid hormone,especially low triiodothyronine(T3).Patients with higher pretreatment-free T3(FT3)levels(>5 pmol/L)demonstrated superior response rates at 3 and 6 months after IST compared to those with lower FT3 levels(54.5%vs 35.4%,P=.020;67.3%vs 46.9%,P=.020).Multivariate analysis indicated that shorter disease duration(≤56 days)and response at 6 months were independent favorable factors of overall survival(relative risk[RR]=2.66,95%confidence interval[CI]=1.03–6.90,P=.040;RR=30.10,95%CI=4.02–225.66,P=.001).The 6-year failure-free survival(FFS)was 53.8%(95%CI=40.9%–65.1%).Multivariate analysis revealed that patients with a response at 6 months,shorter duration(≤56 days)and receiving rabbit antithymocyte globulin(ATG)had better FFS outcomes than those without a response at 6 months,with a longer duration and receiving porcine ATG(RR=22.6,95%CI=7.9–64.9,P<.001;RR=2.4,95%CI=1.3–4.5,P=.006;RR=2.5,95%CI=1.1–5.8,P=.030).In conclusion,FT3 levels reflect the severity of SAA,and patients with higher FT3 levels(>5 pmol/L)had superior response rates than those with lower ones.展开更多
Background： Maternal thyroid dysfunction is common during pregnancy, and physiological changes during pregnancy can lead to the overdiagnosis of hyperthyroidism and misdiagnosis of hypothyroidism with nongestation-sp...Background： Maternal thyroid dysfunction is common during pregnancy, and physiological changes during pregnancy can lead to the overdiagnosis of hyperthyroidism and misdiagnosis of hypothyroidism with nongestation-specific reference intervals. Our aim was to compare sequential with nonsequential methods for the evaluation of thyroid function in pregnant women. Methods： We tested pregnant women who underwent their trimester prenatal screening at our hospital from February 2011 to September 2012 for serum thyroid stimulating hormone （TSH） and free thyroxine （FT4） using the Abbott and Roche kits. There were 447 and 200 patients enrolled in the nonsequential and sequential groups, respectively. The central 95% range between the 2.5th and the 97.5th percentiles was used as the reference interval for the thyroid function parameter. Results： The nonsequential group exhibited a significantly larger degree of dispersion in the TSH reference interval during the 2nd and 3rd trimesters as measured using both the Abbott and Roche kits （all P 〈 0.05）. The TSH reference intervals were significantly larger in the nonsequential group than in the sequential group during the 3rd trimester as measured with both the Abbott （4.95 vs. 3.77 mU/L, P 〈 0.001） and Roche kits （6.62 vs. 5.01 mU/L, P〈 0.004）. The nonsequential group had a significantly larger FT4 reference interval as measured with the Abbott kit during all trimesters （ 12.64 vs. 5.82 pmol/L; 7,96 vs. 4.77 pmol/L; 8.10 vs. 4.77 pmol/L, respectively, all P 〈 0.05）, whereas a significantly larger FT4 reference interval was only observed during the 2nd trimester with the Roche kit （7.76 vs. 5.52 pmol/L, P = 0.002）. Conclusions： It was more reasonable to establish reference intervals for the evaluation of maternal thyroid function using the sequential method during each trimester of pregnancy. Moreover, the exclusion of pregnancy-related complications should be considered in the inclusion criteria for thyroid function tests.展开更多
基金Supported by the German Federal Ministry for Education and Research, No. 01ZZ96030, from the Ministry for Education, Research and Cultural Affairs and the Ministry for Social Affairs of the State Mecklenburg-West Pomerania
文摘AIM： To investigate those associations using data of the population-based Study of Health in Pomerania. METHODS： A study population of 3 749 residents aged 20-79 years without previously diagnosed thyroid disease was available for analyses. Serum TSH was used to assess thyroid function. Cholelithiasis was defined by either a prior history of cholecystectomy or the presence of gallstones on ultrasound. Logistic regression was performed to analyze independent associations between thyroid function and cholelithiasis. RESULTS： There were 385 persons （10.3%） with low （〈0.3 mIU/L）, 3 321 persons （88.6%） with normal and 43 persons （1.2%） with high serum TSH levels （〉3 mIU/L）. The proportion of cholelithiasis among males and females was 14.4% and 25.3%, respectively. Among males, there was an independent relation between high serum TSH and cholelithiasis （OR 3.77; 95%-CI 1.06-13.41; P〈0.05）. Also among males, there was a tendency towards an elevated risk of cholelithiasis in persons with low serum TSH （OR 1.40; 95%-CI 0.96-2.02; P= 0.07）. In the female population, no such relation was identified. CONCLUSION： There is an association between thyroid and gallstone disease with a gender-specific relation between hypothyroidism and cholelithiasis.
文摘BACKGROUND: Prognostic value of cortisol and thyroid function tests(TFTs) has previously been evaluated in medical ICUs. We aimed to evaluate prognostic efficacy of cortisol and TFTs in critically ill poisoned patients admitted to toxicology intensive care unit(ICU).METHODS: In a prospective study of consecutively enrolled subjects admitted to the toxicology ICU, lab analyses included TFTs(total T3 and T4 as well as TSH) and cortisol levels drawn between 8 am–10 am during period of the first 24 hours post-ingestion/exposure. Simplified Acute Physiology Score Ⅱ(SAPS Ⅱ) and Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ) were recorded. All scores were compared to detect the best prognostic factor. Type of poisoning was also included.RESULTS: In 200 patients evaluated, 129 were male and mean age was 31 years. In general, SAPS Ⅱ, T4, and cortisol could prognosticate death. After regression analysis, only cortisol had such efficacy(P=0.04; OR=1.06; 95%CI=1.05–1.08; cut-off=42 μg/d L; sensitivity=70%; specificity=82%). Between aluminium phosphide(ALP)-and non ALP-poisoned patients, level of consciousness, mean arterial pressure, and cortisol level could prognosticate death in ALP poisoning(all Ps<0.001 in both uni and multivariate analyses). Median(interquartile range; IQR) GCS was 7(6, 10) and 15(8, 15) in non-ALP and ALP-poisoned patients(P<0.003). SAPS Ⅱ and APACHE Ⅱ could not prognosticate death at all.CONCLUSION: Cortisol best prognosticated outcomes for subjects admitted to the toxicology ICU. Its level is higher in ALP-poisoned patients probably due to the higher stress while they remain conscious till the final stages of toxicity and are aware of deterioration of their clinical condition or may be due to their significantly lower blood pressures.
基金sponsored by the National Natural Science Foundation of China (30170681)the Foundation of Henan Institute of Science and Technology, China(6007)
文摘Thirty-two Wistar rats were divided randomly into four groups of eight with six females and two males in each group. The rats were exposed to high fluoride drinking water （45 mg F-L^-1 from 100 mg NaF L-1）, low dietary iodine （0.0855 mg kg-1）, or both together in order to assess the effects of these three regimens on the thyroid function of the offspring rats. After the animal model was established, the offspring rats were bred and 10-, 20-, 30-, 60-, and 90-d-old rats were used for the experiment. The treatments for the offspring rats were the same as those of their parents. In comparison with control rats, the relative thyroid glands were changed by three regimens, but the mean values of thyroid weight in the experimental groups saw no marked difference. Serum TT3 levels were increased in all stages in the low iodine （LI） group. In the high fluoride （HiF） group, increase in TT3 levels was observed except in 20-d-old rats. Decrease in TT3 at 20- and 90-d and increase in TT3 at 30- and 60-d were found in HiF＋LI group. Serum TT4 levels first saw an increase, and then dropped in the LI and HiF＋LI group. However, an increase in TT4 was found in the HiF group. The levels of TSH in serum rocketed at d 20, and then dropped in the next stages in experimental groups. The results suggested that thyroid disorder could be induced by high flroride in drinking water, low iodine diet, or both of them. Exposure time to fluoride or low iodine diet was one of the important factors that fluoride can induce the development of thyroid dyfunction.
文摘With regard to brain acetylcholinesterase and acetylcholine and serum triiodothyronine(T_3) and thyroxine(T_4)profiles,a biphasic response pattern was elicited in Channa punctatus chroni- cally exposed to nonlethal doses of locally used pesticides,namely,Metacid-50 and Carbaryl. Data revealed that these xenobiotics caused significant inhibition of brain acetylcholinesterase activity and a decrease in thyroxine level accompanied by a concurrent increase in acetylcholine accumulation and T_3 level.It is surmised that Metacid-50 and Carbaryl influence both neural and hormonal functions.1989 Academic Press.Inc.
文摘Objective： The purpose of the study wass to explore the correlation between thyroid function and nodular goiter accompanied with gallstone. Methods： We collected 120 cases about nodular goiter accompanied with gallstone and 128 cases about nodular goiter and establish 50 healthy control groups. Detected t level of hyrotropic hormone （TSH）, total triio- dothyronine （TT3）, total thyroxine in the peripheral venous blood of these cases in the three groups by using electrochemilu- minescenca immunoassay, measure level of total cholesterol （TC）, high-density tipoprotein cholesterol（HDL-C）, low-density lipoprotein cholesterol （LDL-C） and total bile acid （TBA） levels by using enzymic method, and observed the changes of thyroid function and blood lipid among the three groups. Results： The serum TT3 level in nodular goiter accompanied with gallstone group and the nodular goiter group was significantly lower than that in control group （P 〈 0.01）, and TSH level in the nodular goiter accompanied with gallstone group is significantly higher than that in control group （P 〈 0.01）, There were no statistical significance about difference of TT4 level among the three groups （P 〉 0.05）. Accordingly, TC and LDL-C level in nodular goiter accompanied with gallstone group was significantly higher than that in nodular goiter and control group （P 〈 0.01）, while TBA level in nodular goiter accompanied with gallstone group was significantly lower than that in simple nodular goiter group and control group （P 〈 0.01）. There was no statistical significance about difference of TC and LDL-C level between simple nodular goiter group and control group （P 〉 0.05）. The HDL-C level in nodular goiter accompanied with gallstone group and control group was higher than that in simple nodular goiter group （P 〈 0.01）. Conclusion： The originating etiologic factor of nodular goiter accompanied with gallstone may be related to that the decreased TT3 induced sub-clinical hypothyroidism.
文摘Accelerating cell growth is one of the functions of thyroid hormone. In the absence or lack of this hormone, hematopoietic disorder may occur. Dynamic observation of thyroid function in aplastic anemia (AA) state has not been reported yet.
基金Supported by Scientific Research Project for Maternal and Child Care Fund of China Population Welfare Foundation(FY202001213921)。
文摘[Objectives]To explore the efficacy of Xiaojin Capsules combined with Selenium Yeast Capsules in the treatment of Hashimoto's thyroiditis(HT)with abnormal thyroid function.[Methods]A total of 180 HT patients who were treated in the First Affiliated Hospital of Henan University and Henan Provincial People's Hospital from December 2020 to December 2021 were selected as the research subjects and randomly divided into the observation group(n=120)and the control group(n=60)in at a tratio of 2∶1 ratio according to their visiting time.The observation group was treated with Xiaojin Capsules(oral,5 capsules each time,twice a day for 12 weeks)and Selenium Yeast Capsules(oral,1 capsule each time,twice a day for 12 weeks).The control group was treated with only Selenium Yeast Capsules(oral,1 capsule each time,twice a day for 12 weeks).[Results]The difference in the levels of thyroid peroxidase antibody(TPO-Ab),thyroglobulin antibody(TGAb),serum free triiodothyronine(FT_(3)),serum free thyroxine(FT_(4)),and thyroid stimulating hormone(TSH)between the observation group and control group was statistically significant(P<0.05).The diameters of thyroid between the observation group and the control group before,during and after treatment were significantly different(P<0.05).The total effective rate of the observation group was 82.5%(99/120),which was significantly higher than 56.67%(34/60)in the control group,and the difference was statistically significant(P<0.05).The cure rate(22.50%)in the observation group was significantly higher than the control group(3.33%),and the difference was statistically significant(P<0.01).The ineffective rate of the observation group was 17.50%,which was significantly lower than that of the control group(40.00%),and the difference was statistically significant(P<0.01).The markedly effective rate of the observation group was 40.83%,which was significantly higher than that of the control group(31.67%),and the difference was statistically significant(P<0.05).The effective rate in the observation group was 191%,and the effective rate in the control group was 21.67%,and the difference was not statistically significant(P>0.05).[Conclusions]Xiaojin Capsules combined with Selenium Yeast Capsules in the treatment of HT can eliminate or alleviate the clinical symptoms and signs,significantly reduce the levels of TPO-Ab and TGAb in serum,restore thyroid function,improve thyroid shape and structure in the treatment of HT,and the clinical effect is satisfactory.
文摘Objective:To investigate the relationship of iodine nutritional status with thyroid function in pregnant women in Baotou,and provide a scientific basis for the guide of reasonable iodine supplementation.Methods:By use of As-Ce catalysis spectrophotometry,the urinary iodine concentration was determined in 90 women during different periods of pregnancy admitted to Baogang Hospital of Inner Mongolia from January 2017 to December 2017.The determination of thyroid function and the autoantibody level was carried out by electro-chemiluminescence immunoassay(ECLIA).Results:In the early trimester of pregnancy,pregnant women with iodine deficiency,iodine sufficiency and iodine excess accounted for 36.67%,40.00%and 23.33%respectively;in the middle trimester of pregnancy,they accounted for 66.67%,26.67%and 6.66%respectively;they made up 40.00%,40.00%and 20.00%respectively in the late trimester of pregnancy.The rate of iodine deficiency in women in the middle trimester of pregnancy was significantly higher than that in women in the early and the late trimesters of pregnancy respectively,and the difference was statistically significant(p<0.05).The rate of iodine deficiency in pregnant women was positively correlated to the positivity of thyroid peroxidase antibody.Moreover,it had no relationship with the positivity of thyroglobulin antibody.No matter in the pregnant women with iodine deficiency or with iodine excess,the abnormality rate of thyroid function and autoantibodies was significantly higher than that in the pregnant women with iodine sufficiency.The difference was statistically significant(p<0.05).Conclusions:The iodine deficiency in the women in the middle trimester of pregnancy is more severe than that in the women in the early and the late trimesters of pregnancy.Iodine deficiency during pregnancy is positively correlated with the positivity of thyroid peroxidase antibody.Pregnant women with iodine deficiency and iodine excess show a higher abnormality rate of thyroid function and autoantibodies.It is recommended to advocate health education on iodine nutrition to pregnant women,and conduct the dynamic monitoring of urinary iodine concentration and the screening of thyroid function and autoantibodies during pregnancy.
文摘Objective: thyroid gland is not new to everyone. People first think of "big neck disease". Thyroid gland is an important endocrine gland in human body. It can secrete thyroid hormone to control the body's energy consumption rate. It also has a direct impact on the secretion of other hormones and can effectively regulate the body's system function. The thyroid gland is also an important organ for producing calcitonin, which can keep the body's calcium balance. Once the thyroid function is abnormal, such as hypothyroidism, the synthesis of related hormones will be reduced, and the metabolism of other organisms will also be limited. It also includes some other diseases, such as macroneck disease, which will bring serious impact on human health. Therefore, the principle of "prevention first, prevention combined with treatment" should be adopted for these diseases. Clinical diagnosis is the key to diagnosis and treatment of thyroid diseases. This paper explores the five measurements of thyroid function. Methods: a total of 50 patients were selected from the department for health examination in the hospital as the control group, and 100 patients with thyroid dysfunction were selected from the department for research, 50 patients with hyperthyroidism and 50 patients with hypothyroidism. Among them, hyperthyroidism is classified as A and hypothyroidism as B. The thyroid function examination and diagnostic coincidence rate of control group and observation group A and B are investigated and analyzed. The examination is divided into five contents, including T3 (triiodothyronine), T4 (thyroxine), FT4 (free thyroxine), FT3 (free triiodothyronine) and TSH (thyroid stimulating hormone). The generated data are recorded and investigated. Results: the results of this study were evaluated. The data showed that the thyroid hormone in the control group was significantly higher than that in the observation group A, and the thyroid hormone in the other four observation groups A was significantly higher. The thyroid hormone of observation group B was higher than that of control group, and the other four items of control group were significantly higher, the difference of data results was statistically significant (P < 0.05). This study focuses on clinical diagnosis, and the diagnostic rate was evaluated. The data showed that the diagnostic rates of hyperthyroidism and hypothyroidism in both groups reached more than 90%, and there was no significant difference between the data results (P>0.05). Conclusion: practice has proved that the five tests of thyroid function have good diagnostic advantages for the clinical diagnosis of thyroid function, which not only improves the clinical diagnosis rate, but also has very important significance for the diagnosis and treatment of clinical conditions.
文摘Thyroid dysfunction is frequent in pregnant women and is often associated with an increased risk of adverse maternal and fetal outcome. In the present work, thyroid function of pregnant women from Benin republic was studied. Two hundred forty (240) pregnant women, without thyroid disease history, have been included in the study. A blood sample was drawn for measurement of TSH, free T3 and free T4 serum levels. From the first to the third trimester, plasma levels of free T3 and free T4 decreased when plasma levels of TSH increased. Using recommendations of the 2011 American Thyroid Association (ATA) guidelines, thyroid dysfunction was observed in 24.17% of subjects. Hypothyroidism was present in 22.50% of subjects with 19.17% of subclinical hypothyroidism, 0.83% of overt hypothyroidism and 2.50% of hypothyroxinemia and hyperthyroidism was observed in 1.67% of subjects. An increase from 15.52% to 28.07% was observed in the frequency of hypothyroidism from the first to the third trimester of pregnancy. When an upper cut-off value of 4 mU/L was used for TSH, as recommended in the 2017 ATA guidelines, prevalence of thyroid disorders was 14.58% with 12.91% of hypothyroidism but no hypothyroidism was observed in women in the first trimester of pregnancy. A rise in hypothyroidism frequency was observed when pregnant women age increased. Hypothyroidism was very common in pregnant women in Benin. To allow accurate assessment of thyroid status in pregnant women in Benin, pregnancy specific range for plasma level of TSH and thyroid hormones should be established.
文摘Background: The thyroid status is evaluated by two clinical diagnostic tests which are thyroid ultrasonography and thyroid function tests. The objective of this research is to critically analyze the age and gender based variations of thyroid volume and thyroid hormone levels in the hospital based euthyroid subjects. Methodology: A total of 221 euthyroid subjects aged 1 - 86 years were selected to observe the normal thyroid size by ultrasonography at Department of Radiology and the thyroid function test values (FT3, FT4 and TSH) of 2413 euthyroid subjects aged (Results: The best fitted equations with significant correlation coefficients and p Conclusion: The thyroid size first increases and then decreases whereas the thyroxin level first decreases and then increases with aging. Left lobe volume is almost same for both genders and right lobe volume is higher in males. The thyroid size in menarche and menopause periods of females is larger than that of males. Such age- and gender-specific changes recommend the new refer-ence ranges for the normal thyroid functions.
文摘Background: Pregnancy is associated with the change in thyroid function. Thyroid function is also affected by goitrogenic substances in some plant foods, like cassava. Aim: This study aims to assess thyroid function status and its association to consumption of foods containing goitrogenic substances. Methods: A cross sectional study was done on a total of 65 pregnant women attending Sawla Health Center, South Ethiopia. Serum samples were collected and analyzed for TSH, total T4 and total T3 by using ELISA kit. Data on consumption of foods containing were obtained from food frequency questionnaire. Results: The median TSH of the first, second and third trimesters, respectively are 2.57, 1.86 and 2.42 mIU/L, which are within the reference interval (0.30-6.20 mIU/L) of the test kit. The median total T4 values (9.8, 10.0 and 10.3 μg/dl in the first, second and third trimesters, respectively) were also within the reference interval (4.8-11.6 μg/dl) of the test kits. The median total T3 in the first (2.60 ng/ml) and third (2.35 ng/ml) trimesters were elevated, but it was within the reference interval (0.69-2.02 ng/ml) in the second trimester (1.92 ng/ml). Though statistically non-significant median TSH was increased in women grouped as cassava consumers and M. stenopetala consumers while median total T4 values were decreased in these groups. Conclusion: The study subjects have normal thyroid function as the median values of TSH and total T4 were within the reference interval of the test kit. Frequent consumption of cassava and Moringa stenopetala may affect thyroid function.
文摘Nigella sativa L. (Black seed), is a traditional herbal medicine that has been used for many purposes. The present study was designed to investigate the effects of hydro-alcoholic extract of nigella sativa L. (NS) on performance of Forced Swimming Test (FST), blood biochemical parameters related to fatigue and thyroid functions. Therefore, Blood Urea Nitrogen (BUN), Creatine Kinase (CK), Lactic Dehydrogenase (LDH), and Total Protein (TP), triiodothyronine T3, thyroxin T4 and TSH tests were investigated. Thirty five male adult mice were randomly divided into five groups: three NS-fed groups, one fluoxetine treated group and one control group. Three NS experimental groups received hydro-alcoholic extract of NS at doses of 50, 100 and 200 mg/kg orally for two weeks. Immobility time decreased in all NS groups compared with control group. Administration of NS significantly increased the concentration of T3 and T4 of the treatment groups. On the contrary, the amount of BUN, CK, LDH, TP and TSH decreased. In conclusion, black seed extract at the experimented doses showed anti-depressant, anti-fatigue and hyperthyroid effects.
基金supported by Yunnan Province Basic Re search Special Program-Kunming Medical University Joint Special Program-Superficial Program(202101AY070001-226)Yunnan Provincial Science and Technology Talents and Plat form Program(202305AD160002)Kunming Medical Uni versity"14th Five-Year Plan"Key Discipline Construction Pro jects.The funders supported the costs of this study.
文摘Background and Objectives:This study investigated the iodine status of pregnant women at an average altitude of approximately 2000 meters in Qujing,China.The relationship between iodine and thyroid function in different trimesters as well as adverse pregnancy and fetal outcomes were also investigated.Methods and Study Design:A total of 1,025 pregnant women who were admitted to Qujing Affiliated Hospital of Kunming Medical Univer sity from January 2019 to August 2021 were included.Urinary iodine concentration(UIC)was detected by color imetric method,and serum thyroid function was detected by chemiluminescence.Among them,537 pregnant women were followed up to analyze the association of iodine with adverse pregnancy and fetal outcomes.Re sults:The median UIC was 127μg/L.Serum triiodothyronine,thyroxine,free triiodothyronine,and free thyrox ine were negatively associated with urinary iodine concentration in the first and second trimesters of pregnancy.The proportion of pregnant women testing positive for thyroid peroxidase antibody(TPO-Ab)and the prevalence of thyroid autoimmunity(TAI)increased significantly in more-than-adequate iodine and excess iodine groups.Logistic regression analysis showed maternal iodine was not associated with adverse pregnancy and fetal out comes.Conclusions:Mild iodine deficiency is common among pregnant women in plateau areas of China.The relationship between iodine and thyroid function is significant in the first and second trimesters of pregnancy,es pecially in those with moderate to severe iodine deficiency.Abnormal iodine level in pregnant women was not significantly associated with adverse pregnancy and fetal outcomes in areas with predominantly mild iodine defi ciency.
基金supported by the National Natural Science Foundation of China(Grant No.22106091)the Natural Science Foundation of Shandong Province,China(Grant No.ZR2021QB126)the State Key Joint Laboratory of Environment Simulation and Pollution Control(No.18K04ESPCT).
文摘With the ban of commercial Penta-BDEs, Octa-BDEs, and Deca-BDEs, many manufacturers have been transition to the production of novel brominated flame retardants (NBFRs), organophosphate ester flame retardants (OPFRs), and other alternatives. In this study, we recruited 165 employees with typical occupational exposure from a flame retardants (FRs) production plant in Laizhou Bay, which is the main FRs production area in China, to analyze the internal exposure characteristics of FRs and their potential impacts on thyroid function during the historical production and replacement process. The results showed that the detection frequencies of only triphenyl phosphate (TPHP), BDE-138 and BDE-197 (82.4 %, 61.2 % and 60.6 %, respectively) exceeded 60 % among the 34 compounds of interest, while the median concentrations of BDE-138 and BDE-197 were much higher than TPHP (medians of 103.6, 60.6 and 20.5 ng/g lw, respectively). In addition, the concentrations of these compounds in exposed group are higher than those in the control group (P < 0.05). The correlations among FRs indicated they mainly originated from the production and the debromination process. Overall, these results reflect the changes in the product structure. Free triiodothyronine (fT3) was moderately positively correlated with BDE-138, BDE-197, and TPHP (P < 0.05), and regression analysis further identified BDE-138 as a significant factor influencing fT3 levels. Despite TPHP having a rapid metabolism and short half-life, it was still widely detected in this study, indicating that future research should not only focus on the health risks of BDEs or their degradation products but also consider the health risks associated with TPHP and their mixed exposure, especially given the increasing production of OPFRs as substitutes.
基金National Natural Science Foundation of China:Action Mechanism of Buzhong Yiqi Decoction in Treating Hashimoto's Thyroiditis based on transforming growth factor β/Smad Signaling Pathway and the Balance between Treg and Th17 Cells(No.81973855)。
文摘OBJECTIVE:To observe the effects of Buzhong Yiqi granule(补中益气颗粒)on thyroid function and ovarian function in rats with experimental autoimmune thyroiditis(EAT).METHODS:EAT model was replicate by using the method of mixing and injecting porcine thyroglobulin with Freund's adjuvant and high iodine.Rats were randomly divided into normal control(NC)group,EAT model(EAT)group,selenium yeast(PC)group,low dose Buzhong Yiqi(BZYQ-L)group,medium dose Buzhong Yiqi(BZYQ-M)group and high dose Buzhong Yiqi(BZYQ-H)group.After two months of drug intervention according to dosage,enzyme-linked immunosorbent assay(ELISA)was used to measure the levels of free triiodothyronine(FT3),free thyroxine(FT4),thyroid-stimulating hormone(TSH),antithyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TGAb)in peripheral blood of rats.The pathological changes of rat thyroid tissues were observed under light microscope with HE staining;ELISA was used to determine estradiol(E2),follicle-stimulating hormone(FSH),luteinizing hormone(LH),testosterone(T),antimüllerian hormone(AMH),and the pathological changes of rat ovarian tissues were observed under light microscope with hematoxylin and eosin staining.RESULTS:Compared with the NC group,BZYQ granule improved the thyroid and ovarian tissue morphology,and the levels of TPOAb,TGAb and TSH in the model group rats significantly increased(P<0.05),the thyroid tissue was severely destroyed,the levels of E2,FSH,LH,T,AMH significantly increased(P<0.05),and the ovary exhibited polycystic changes;Compared with the model group,TSH level in the BZYQ-L group rats decreased(P<0.05),FSH,T,AMH levels decreased(P<0.05),in the BZYQ-M group TPOAb,TSH levels decreased(P<0.05),FSH,LH,T,AMH levels significantly decreased(P<0.05),BZYQ-H group TPOAb,TGAb,TSH levels significantly decreased(P<0.05),FSH,LH,T,AMH levels significantly decreased(P<0.05),with the greatest improvement and significantly better than selenium yeast group(P<0.05).CONCLUSIONS:BZYQ granule could regulate the thyroid function of EAT rats,reduce thyroid antibody titers,then act on the ovarian function,regulate hormone disorders,and alleviate the pathological damage of rat's ovarian tissues.The effect of high dose Buzhong Yiqi granule is the best.
文摘[Objectives]To study the reference value of thyroid function in healthy women of childbearing age during different pregnancies(early,middle and late pregnancy)in Jingzhou City.[Methods]362 healthy women of childbearing age during different pregnancies(early,middle and late pregnancy)were selected as the study group,and 360 non-pregnant women were selected as the control group.Serum thyroid hormone levels in the two groups were detected,and the reference value was expressed as the median(M)and 95%confidence interval(CI).On this basis,the chart of changing trend of thyroid hormone in the early,middle and late pregnancy were plotted.[Results]Compared with the control group,FT3,TT4,TT3,FT4and TSH in the early,middle and late pregnancy were significantly different in the study group(P<0.05).In the study group,there were significant differences in the early,middle and late pregnancy(P<0.05).[Conclusions]This trend chart has certain reference value in the screening,diagnosis and treatment of thyroid diseases in healthy women of childbearing age during different pregnancies(early,middle and late pregnancy)in Jingzhou City of Hubei Province.
基金supported by Guangzhou Science and Technology Bureau.Guangzhou Science and Technology Bureau Project:Basic and clinical research of traditional Chinese medicine berberine in the treatment of non-alcoholic fatty liver disease by promoting intestinal GLP-1 secretion[No.201903010099].
文摘Background:Recent studies have found that thyroid function may be associated with the occurrence and development of advanced liver fibrosis in patients with metabolic dysfunction-associated fatty liver disease(MAFLD).However,the majority of such research has consisted of cross-sectional studies.This retrospective cohort study aimed to investigate the effect of low-normal thyroid function on advanced liver fibrosis in MAFLD patients over a 5-year period.Methods:This retrospective cohort study enrolled 825 outpatients and inpatients with MAFLD who attended the Third Affiliated Hospital of Sun Yat-sen University(Guangzhou,China)between January 2011 and December 2018.Based on plasma thyroid hormone and thyroid-stimulating hormone levels,these patients were divided into two groups,namely a low-normal thyroid function group and a strict-normal thyroid function group.The fibrosis-4 score was used to assess advanced liver fibrosis.A chi-square test was conducted to compare the occurrence of advanced fibrosis between the groups.Results:Among the 825 MAFLD patients,117 and 708 were defined as having low-normal thyroid function and strict-normal thyroid function,respectively.Follow-up data were available for 767 patients(93.0%)during a 5-year period.Eight(7.5%)MAFLD patients with low-normal thyroid function and 26(3.9%)with strict-normal thyroid function developed advanced liver fibrosis and the cumulative incidence was not significantly different(P=0.163).Stratification analysis showed that the lean MAFLD patients(body mass index≤23kg/m^(2))with low-normal thyroid function had a higher risk of advanced liver fibrosis than the lean MAFLD patients with strict-normal thyroid function(P<0.05).Conclusion:Low-normal thyroid function is associated with advanced liver fibrosis among lean MAFLD patients.
基金supported by grants from the Haihe Laboratory of Cell Ecosystem Innovation Fund(No.HH22KYZX0041)the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2021-RW320-011)the Fundamental Research Funds for Central Universities(No.3332021057).
文摘To explore the predictive value of thyroid function in severe aplastic anemia(SAA)patients treated with immunosuppressive therapy(IST),149 SAA patients in our center were enrolled between February 2015 and June 2020 in this study.We assessed the thyroid function of 134 patients without primary thyroid diseases,and discovered that 89 patients were accompanied by abnormal thyroid hormone,especially low triiodothyronine(T3).Patients with higher pretreatment-free T3(FT3)levels(>5 pmol/L)demonstrated superior response rates at 3 and 6 months after IST compared to those with lower FT3 levels(54.5%vs 35.4%,P=.020;67.3%vs 46.9%,P=.020).Multivariate analysis indicated that shorter disease duration(≤56 days)and response at 6 months were independent favorable factors of overall survival(relative risk[RR]=2.66,95%confidence interval[CI]=1.03–6.90,P=.040;RR=30.10,95%CI=4.02–225.66,P=.001).The 6-year failure-free survival(FFS)was 53.8%(95%CI=40.9%–65.1%).Multivariate analysis revealed that patients with a response at 6 months,shorter duration(≤56 days)and receiving rabbit antithymocyte globulin(ATG)had better FFS outcomes than those without a response at 6 months,with a longer duration and receiving porcine ATG(RR=22.6,95%CI=7.9–64.9,P<.001;RR=2.4,95%CI=1.3–4.5,P=.006;RR=2.5,95%CI=1.1–5.8,P=.030).In conclusion,FT3 levels reflect the severity of SAA,and patients with higher FT3 levels(>5 pmol/L)had superior response rates than those with lower ones.
基金This work was supported by grants from the National Natural Science Foundation of China （No. 81471516） and Shanghai Municipal Science and Technology Commission Medical Guide Project （No. 134119a1102）.
文摘Background： Maternal thyroid dysfunction is common during pregnancy, and physiological changes during pregnancy can lead to the overdiagnosis of hyperthyroidism and misdiagnosis of hypothyroidism with nongestation-specific reference intervals. Our aim was to compare sequential with nonsequential methods for the evaluation of thyroid function in pregnant women. Methods： We tested pregnant women who underwent their trimester prenatal screening at our hospital from February 2011 to September 2012 for serum thyroid stimulating hormone （TSH） and free thyroxine （FT4） using the Abbott and Roche kits. There were 447 and 200 patients enrolled in the nonsequential and sequential groups, respectively. The central 95% range between the 2.5th and the 97.5th percentiles was used as the reference interval for the thyroid function parameter. Results： The nonsequential group exhibited a significantly larger degree of dispersion in the TSH reference interval during the 2nd and 3rd trimesters as measured using both the Abbott and Roche kits （all P 〈 0.05）. The TSH reference intervals were significantly larger in the nonsequential group than in the sequential group during the 3rd trimester as measured with both the Abbott （4.95 vs. 3.77 mU/L, P 〈 0.001） and Roche kits （6.62 vs. 5.01 mU/L, P〈 0.004）. The nonsequential group had a significantly larger FT4 reference interval as measured with the Abbott kit during all trimesters （ 12.64 vs. 5.82 pmol/L; 7,96 vs. 4.77 pmol/L; 8.10 vs. 4.77 pmol/L, respectively, all P 〈 0.05）, whereas a significantly larger FT4 reference interval was only observed during the 2nd trimester with the Roche kit （7.76 vs. 5.52 pmol/L, P = 0.002）. Conclusions： It was more reasonable to establish reference intervals for the evaluation of maternal thyroid function using the sequential method during each trimester of pregnancy. Moreover, the exclusion of pregnancy-related complications should be considered in the inclusion criteria for thyroid function tests.
