The islets of Langerhans orchestrate body responses to nutritional,neural,and hormonal stimuli,thus intricately maintaining blood glucose homeostasis and shaping the metabolic landscape[1].This specialized micro-organ...The islets of Langerhans orchestrate body responses to nutritional,neural,and hormonal stimuli,thus intricately maintaining blood glucose homeostasis and shaping the metabolic landscape[1].This specialized micro-organ is primarily composed ofα,β,δ,and PP cells,with the insulin-producingβcells being the dominant cell type[2].Abnormalities inβcell proliferation,mass,and function have been observed in various metabolic disorders[2,3].Thus,maintaining an optimalβcell proliferation capacity is essential not only for islet development and metabolic regulation but also for functional recovery and regeneration of the dysfunctionalβcells and islets[2].展开更多
基金supported by the following grants:the National Natural Science Foundation of China(32101015 and 82270670)Fundamental Research Funds for the Central Universities(2021QNA7009)+1 种基金Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2021R01012)Leading Innovation and Entrepreneur Team of Hangzhou(TD2020006).
文摘The islets of Langerhans orchestrate body responses to nutritional,neural,and hormonal stimuli,thus intricately maintaining blood glucose homeostasis and shaping the metabolic landscape[1].This specialized micro-organ is primarily composed ofα,β,δ,and PP cells,with the insulin-producingβcells being the dominant cell type[2].Abnormalities inβcell proliferation,mass,and function have been observed in various metabolic disorders[2,3].Thus,maintaining an optimalβcell proliferation capacity is essential not only for islet development and metabolic regulation but also for functional recovery and regeneration of the dysfunctionalβcells and islets[2].
