BACKGROUND Patients with gastric cancer often experience slow postoperative recovery and psychological stress,necessitating enhanced nursing care to improve their prognosis.AIM To analyze the impact of a timing-theory...BACKGROUND Patients with gastric cancer often experience slow postoperative recovery and psychological stress,necessitating enhanced nursing care to improve their prognosis.AIM To analyze the impact of a timing-theory-guided three-stage integrated nursing intervention(TSIN)on the postoperative recovery of patients undergoing gastric cancer surgery.METHODS Total 84 patients that underwent gastric cancer surgeries between June 2022 and June 2024 were selected and divided into a control group and an observation group based on perioperative nursing methods.The control group(n=42)received routine nursing care,whereas the observation group(n=42)received a timing-theory-guided TSIN.The psychological adjustment capabilities,psychological stress,cancer-related fatigue levels,postoperative recovery,and quality of life of the two groups were compared.RESULTS Compared to the control group,the observation group took lesser time to get out of bed,achieve gastrointestinal motility,have the first mealtime,along with a shorter hospital stay(P<0.05).Before nursing,there were no significant differences between groups’parameters or scores(P>0.05).After nursing,the scores for psychological stress and cancer-related fatigue decreased.In contrast,the scores for psychological adjustment capabilities and quality of life increased,with more significant improvements observed in the observation group,showing significant differences within and between the groups(P<0.05).CONCLUSION Timing theory-guided TSIN can improve the psychological adjustment capabilities of patients undergoing gastric cancer surgery,reduce psychological stress and cancer-related fatigue,accelerate postoperative recovery,and improve the quality of life.展开更多
Objective:This study explores the effectiveness of a three-stage blended teaching model in the Medical Microbiology course for Clinical Medicine students within the context of smart education.Methods:Clinical Medicine...Objective:This study explores the effectiveness of a three-stage blended teaching model in the Medical Microbiology course for Clinical Medicine students within the context of smart education.Methods:Clinical Medicine students from the 2021 and 2022 classes were studied,comparing the traditional and three-stage blended teaching models.Academic performance and survey feedback were analyzed.Results:The research group’s academic performance,including daily,final exam,and average scores,was significantly higher than the control group(P<0.05).Over 95%of students approved of the new teaching model,noting improvements in competencies.Conclusion:The three-stage blended teaching model effectively boosted student engagement,interaction,academic performance,and overall skills,showing potential for broader application in medical education.展开更多
The Vienna rectifier is a widely adopted solution for high-power rectification due to its efficiency and straightforward design.However,its performance can degrade under unbalanced three phase voltage conditions,leadi...The Vienna rectifier is a widely adopted solution for high-power rectification due to its efficiency and straightforward design.However,its performance can degrade under unbalanced three phase voltage conditions,leading to current zero-crossing distortion and compromised dynamic response.This paper investigates the causes of these distortions,identifying a phase shift between the input current and the grid voltage as a primary factor,and proposes an effective distortion phase identification strategy.Furthermore,the dynamic performance is enhanced through improved current reference calculations and a refined power feedforward strategy.This approach optimizes the system's response to load changes and maintains output voltage stability under unbalanced conditions.Simulation results validate the effectiveness of the proposed methods in reducing current distortion and improving overall performance.展开更多
In this study,Computational Fluid Dynamics(CFD)together with a component transport model are exploited to investigate the influence of dimensionless parameters,involving the height of the rectifier grid and the instal...In this study,Computational Fluid Dynamics(CFD)together with a component transport model are exploited to investigate the influence of dimensionless parameters,involving the height of the rectifier grid and the installation height of the first catalyst layer,on the flow field and the overall denitration efficiency of a cement kiln’s SCR(Selective catalytic reduction)denitrification reactor.It is shown that accurate numerical results can be obtained by fitting the particle size distribution function to the actual cement kiln fly ash and implementing a non-uniform particle inlet boundary condition.The relative error between denitration efficiency derived from experimental data,numerical simulation,and real-time system pressure drop ranges from 4%to 9%.Optimization of the SCR reactor is achieved when the rectifier grid thickness ratio k/H≥0.030,the rectifier grid height ratio h/H=0.04,and the spacing between the rectifier grid and the first catalyst layer l/H=0.10.Under these conditions,airflow distribution and particle dispersion upstream of the catalyst result in increased denitration efficiencies of 3.21%,3.43%,and 3.27%,respectively,compared to the least favorable operating conditions.展开更多
Parvalbumin-positive(PV^(+))interneuron dysfunction is believed to be linked to autism spectrum disorder(ASD),a neurodevelopmental disorder characterized by social deficits and stereotypical behaviors.However,the mech...Parvalbumin-positive(PV^(+))interneuron dysfunction is believed to be linked to autism spectrum disorder(ASD),a neurodevelopmental disorder characterized by social deficits and stereotypical behaviors.However,the mechanisms behind PV^(+)interneuron dysfunction remain largely unclear.Here,we found that a deficiency of Biorientation Defective 1(Bod1)in PV^(+)interneurons led to an ASD-like phenotype in Pvalb-Cre;Bod1f/f mice.Mechanistically,we observed that Bod1 deficiency induced hypoactivity of PV^(+)interneurons and hyperactivity of calcium/calmodulin-dependent protein kinaseⅡalpha(CaMKⅡα)neurons in the medial prefrontal cortex,as determined by whole-cell patch-clamp recording.Additionally,Bod1 deficiency decreased the power of highgamma oscillation,assessed by in vivo multi-channel electrophysiological recording.Furthermore,we found that Bod1 deficiency enhanced the inwardly rectifying K^(+)current,leading to an increase in the resting membrane potential of PV^(+)interneurons.Importantly,the gain-of-function of Bod1 improved social deficits and stereotypical behaviors in Pvalb-Cre;Bod1f/f mice.These findings provide mechanistic insights into the PV^(+)interneuron dysfunction and suggest new strategies for developing PV^(+)interneuron-targeted therapies for ASD.展开更多
Based on a typical prototype of a soil slope in engineering practice, a numerical model of a three-stage soil slope supported by the anchor frame structure was established by means of FLAC3D code. The dynamic response...Based on a typical prototype of a soil slope in engineering practice, a numerical model of a three-stage soil slope supported by the anchor frame structure was established by means of FLAC3D code. The dynamic responses of three-stage soil slope and frame structure were studied by performing a series of bidirectional Wenchuan motions in terms of the failure mode of three-stage structure, the acceleration of soil slope, the displacement of frame structure, and the anchor stress of frame structure. The response accelerations in both horizontal and vertical directions are the most largely amplified at the slope top of each stage subjected to different shaking cases. The platforms among the stages reduce the amplification effect of response acceleration. The residual displacement of frame structure increases significantly as the intensity of shaking case increases. The frame structure at each stage presents a combined displacement mode consisting of a translation and a rotation around the vertex. The anchor stress of frame structure is mainly increased by the first intense pulse of Wenchuan seismic wave, and it is sensitive to the intensity of shaking case. The anchor stress of frame structure at the first stage is the most considerably enlarged by earthquake loading.展开更多
Based on three-stage data envelopment analysis(DEA) model estimates of resource utilization efficiency of coal,we selected 29 provinces from China's 2012 input-output data and used the bootstrap DEA model to corre...Based on three-stage data envelopment analysis(DEA) model estimates of resource utilization efficiency of coal,we selected 29 provinces from China's 2012 input-output data and used the bootstrap DEA model to correct the bias.The results show that the mean overall technical efficiency,pure technical efficiency,and scale efficiency was 0.833,0.998,and 0.711 in 2012,respectively.Moreover,the comprehensive technical efficiency score indicates that the scale is invalid.Area utilization efficiencies for the eastern,central,and western regions were 0.917,0.731,and 0.629,respectively.The results prove that there are significant differences in the distribution of coal resources utilization efficiency across regions.展开更多
Two-oriented agriculture was a complex organism coupling production,economics,society and ecology.Its development process was affected by various factors such as producers,nature,society,etc.In order to overcome measu...Two-oriented agriculture was a complex organism coupling production,economics,society and ecology.Its development process was affected by various factors such as producers,nature,society,etc.In order to overcome measurement error of traditional data envelopment analysis caused by ignoring random,three-stage DEA model was studied to remove environmental factors and random effects.On the foundation of this model was two-oriented agriculture comprehensive production efficiency of 14 cities were estimated in Hunan Province in 2008,and brown forth corresponding policy proposals to promote agricultural development.展开更多
From the perspective of agricultural insurance agency,this paper focuses on the study of operational efficiency of agricultural insurance agency,and analyzes the operational efficiency of agricultural insurance agency...From the perspective of agricultural insurance agency,this paper focuses on the study of operational efficiency of agricultural insurance agency,and analyzes the operational efficiency of agricultural insurance agency and its influencing factors,in order to improve the operational efficiency of agricultural insurance agency,better supply agricultural insurance and achieve the policy effect of agricultural insurance.The results of this paper are as follows:( i) Either comprehensive operational efficiency or scale efficiency of Chinese-funded agency is higher than that of foreign-funded agency,but its pure technical efficiency is lower than that of foreign-funded agency,indicating that the managerial decision ability of Chinese-funded agency is weaker than that of foreign-funded agency,and needs to be improved;( ii) The operational efficiency of professional agricultural insurance agency is higher than that of comprehensive agricultural insurance agency,and the agricultural insurance agency is greatly affected by environmental factors;( iii) The operating time of agricultural insurance agency is proportional to its operational efficiency;( iv) The quality of employees is positively correlated with the capital and cost input difference,but negatively correlated with the difference in the number of employees. Therefore,it is necessary to pay attention to the improvement of employees' working efficiency while laying emphasis on employees' quality.展开更多
The use of an electrical network as close as possible to its limits can lead to its instability in the event of a high amplitude disturbance. The damping of system oscillations can be achieved by conventional means of...The use of an electrical network as close as possible to its limits can lead to its instability in the event of a high amplitude disturbance. The damping of system oscillations can be achieved by conventional means of voltage and speed regulation but also by FACTS (Flexible AC Transmission Systems) devices, which are increasingly used in power networks. In this work, optimal control coordination between a hybrid power flow controller and a three-level inverter was used to improve the transient stability of a transmission line. The UPFC is a combination of a serial compensator (SSSC) and a parallel compensator (STATCOM) both connected to a DC-LINK DC bus. The SSSC acts as a voltage source for the network and injects a voltage that can be adjusted in phase and amplitude in addition to the network voltage;the STATCOM acts as a current source. The approach used is tested in the Matlab Simulink environment on a single machine network. Optimal controller tuning gives a better transient stability improvement by reducing the transport angle oscillations from 248.17% to 9.85%.展开更多
In order to improve the dynamic response bandwidth of three-stage electro-hydraulic servo valve,a new method,speed-feedback control is presented in this paper.The construction and principle of three-stage electro-hydr...In order to improve the dynamic response bandwidth of three-stage electro-hydraulic servo valve,a new method,speed-feedback control is presented in this paper.The construction and principle of three-stage electro-hydraulic servo valve are explained,and the mathematical model of three-stage electro-hydraulic servo valve is built in frequency domain.Experimental and simulation results show that the bandwidth compared with proportional control is improved under speed-feedback control.Moreover,the research results play an important role in developing high performance three-stage electro-hydraulic servo valve.展开更多
Numerical simulation of enhanced fluid flow characteristics in a three-stage double-stirring extraction tank was conducted with the coupling of an Eulerian multiphase flow model and a Morsi-Alexander interphase drag f...Numerical simulation of enhanced fluid flow characteristics in a three-stage double-stirring extraction tank was conducted with the coupling of an Eulerian multiphase flow model and a Morsi-Alexander interphase drag force model. Results show that the addition of a stirring device into the settler can efficiently reduce the volume fraction of out-of-phase impurity in the outlet, and accelerate the settling separation of oil-water mixture. Such addition can also effectively break down the oil-water-wrapped liquid droplets coming from the mixer, inhibit reflux from the outlet, and improve the oil-water separation. The addition of a stirring device induces ignorable power consumption compared with that by the mixer, and can thus facilitate the commercialized promotion of this novel equipment.展开更多
Objective Rapakivi granites,characterized by rapakivi texture,Atype granite feature and an anorogenic setting,commonly occur in the Proterozoic of the Northern Hemisphere（Fig.la）.Recently,more and more Phanerozoic r...Objective Rapakivi granites,characterized by rapakivi texture,Atype granite feature and an anorogenic setting,commonly occur in the Proterozoic of the Northern Hemisphere（Fig.la）.Recently,more and more Phanerozoic rapakivi granite suites have been identified and some even occur in orogenic belts.Significantly,three-stage,Proterozoic.展开更多
This paper uses a three-stage DEA model to measure the land use efficiency of the three major urban agglomerations in the Yangtze River Delta,Beijing-Tianjin-Hebei,and the Pearl River Delta from 2007 to 2018.The follo...This paper uses a three-stage DEA model to measure the land use efficiency of the three major urban agglomerations in the Yangtze River Delta,Beijing-Tianjin-Hebei,and the Pearl River Delta from 2007 to 2018.The following conclusions are drawn through research:first,the urban land use efficiency of the three major urban agglomerations in the Yangtze River Delta,Beijing-Tianjin-Hebei,and the Pearl River Delta all showed a downward trend,with the rates of decline being 6.06%,2.86%,and 24.34%respectively.In particular,the Pearl River Delta urban agglomeration had the largest decline.Second,the overall urban land use efficiency of the Beijing-Tianjin-Hebei urban agglomeration is relatively high,and the amount of redundancy is relatively small.The rate of decline is significantly lower than the urban land use efficiency of the two major urban agglomerations in the Yangtze River Delta and the Pearl River Delta.The land use efficiency of the Yangtze River Delta and Pearl River Delta urban agglomerations is in a state of continuous decline.Third,the proportion of cities with the effectiveness of returns to scale of urban land use efficiency in the three major urban agglomerations has decreased by 10.53%,10%,and 33.34%,respectively.The Pearl River Delta has the largest decline.Fourth,the land use efficiency of the Yangtze River Delta urban agglomeration is quite different.The central-peripheral phenomenon is evident for the Beijing-Tianjin-Hebei urban agglomerations and the Pearl River Delta urban agglomerations.展开更多
Rational design and construction of oxygen reduction reaction(ORR)electrocatalysts with high activity,good stability,and low price are essential for the practical applications of renewable energy conversion devices,su...Rational design and construction of oxygen reduction reaction(ORR)electrocatalysts with high activity,good stability,and low price are essential for the practical applications of renewable energy conversion devices,such as metal-air batteries.Electronic modification through constructing metal/semiconductor Schottky heterointerface represents a powerful strategy to enhance the electrochemical performance.Herein,we demonstrate a concept of Schottky electrocatalyst composed of uniform Co nanoparticles in situ anchored on the carbon nanotubes aligned on the carbon nanosheets(denoted as Co@N-CNTs/NSs hereafter)toward ORR.Both experimental findings and theoretical simulation testify that the rectifying contact could impel the voluntary electron flow from Co to N-CNTs/NSs and create an internal electric field,thereby boosting the electron transfer rate and improving the intrinsic activity.As a consequence,the Co@N-CNTs/NSs deliver outstanding ORR activity,impressive long-term durability,excellent methanol tolerance,and good performance as the air-cathode in the Zn-air batteries.The design concept of Schottky contact may provide the innovational inspirations for the synthesis of advanced catalysts in sustainable energy conversion fields.展开更多
Objective: To investigate the effects of standardized three-stage rehabilitation combined with edaravone therapy on the neurotrophic state and oxidative stress injury in patients with cerebral infarction. Methods: A t...Objective: To investigate the effects of standardized three-stage rehabilitation combined with edaravone therapy on the neurotrophic state and oxidative stress injury in patients with cerebral infarction. Methods: A total of 90 patients with acute cerebral infarction who were treated in the hospital between May 2015 and April 2017 were divided into control group (n=45) and observation group (n=45) by random number table. Control group received edaravone therapy, and observation group received standardized three-stage rehabilitation combined with edaravone therapy. The differences in neurotrophic state and oxidative stress injury were compared between the two groups before and after treatment. Results: There was no statistically significant difference in serum levels of neurotrophic indexes and oxidative stress indexes between the two groups before treatment. After treatment, serum neurotrophic indexes BDNF and NGF levels of observation group were higher than those of control group;serum oxidation indexes AOPPs, LHP and MDA levels were lower than those of control group whereas SOD, CAT and T-AOC levels were higher than those of control group. Conclusion:Standardized three-stage rehabilitation combined with edaravone therapy can effectively optimize the neurotrophic state and inhibit the oxidative stress in patients with cerebral infarction.展开更多
This paper introduces a practical solving scheme of gradetransition trajectory optimization(GTTO) problems under typical certificate-checking–updating framework. Due to complicated kinetics of polymerization,differen...This paper introduces a practical solving scheme of gradetransition trajectory optimization(GTTO) problems under typical certificate-checking–updating framework. Due to complicated kinetics of polymerization,differential/algebraic equations(DAEs) always cause great computational burden and system non-linearity usually makes GTTO non-convex bearing multiple optima. Therefore, coupled with the three-stage decomposition model, a three-section algorithm of dynamic programming(TSDP) is proposed based on the general iteration mechanism of iterative programming(IDP) and incorporated with adaptivegrid allocation scheme and heuristic modifications. The algorithm iteratively performs dynamic programming with heuristic modifications under constant calculation loads and adaptively allocates the valued computational resources to the regions that can further improve the optimality under the guidance of local error estimates. TSDP is finally compared with IDP and interior point method(IP) to verify its efficiency of computation.展开更多
Current MSM switching fabric has poor performance under unbalanced traffic. This paper presents an alternative, novel Central-stage Buffered Three-stage Clos switching (CB-3Clos) fabric and proves that this fabric can...Current MSM switching fabric has poor performance under unbalanced traffic. This paper presents an alternative, novel Central-stage Buffered Three-stage Clos switching (CB-3Clos) fabric and proves that this fabric can emulate output queuing switch without any speedup. By analyzing the condition to satisfy the central-stage load-balance, this paper also proposes a Central-stage Load-balanced-based Distributed Scheduling algorithm (CLDS) for CB-3Clos. The results show that, compared with Concurrent Round-Robin based Dispatching (CRRD) algorithm based on MSM, CLDS algorithm has high throughput irrespective with the traffic model and better performance in mean packet delay.展开更多
As the non-periodic inspections are common in practice,a two-stage inspection model based on a three-stage failure process is proposed. The two-stage inspection means that the system is inspected with the first inspec...As the non-periodic inspections are common in practice,a two-stage inspection model based on a three-stage failure process is proposed. The two-stage inspection means that the system is inspected with the first inspection interval T_1 and the second inspection interval T_2. Because of the three color schemes commonly used in industry,three stages are divided by the system lifetime:normal, minor defective and severe defective stages. Upon the failure of the system,replacement is carried out. Maintenance is done once identifying the severe defective stage. However,when the minor defective stage is identified by the second inspection interval T_2,action of halving the subsequent inspection interval is adopted.Otherwise,no action is required. Our objective function is to optimize the inspection intervals so as to minimize the expected cost per unit time. Finally,a numerical example is presented to illustrate the effectiveness of the proposed model.展开更多
In response to the strategic call for the " Great Protection" of the Yangtze River Economic Belt and to fulfill the important historical tasks assigned by the state to the provinces and cities of the area,th...In response to the strategic call for the " Great Protection" of the Yangtze River Economic Belt and to fulfill the important historical tasks assigned by the state to the provinces and cities of the area,the Yangtze River Economic Belt is adjusting the agricultural industry structure,optimizing the input-output ratio,and ensuring stable and sustainable agricultural production. Based on the combination of the three-stage Data Envelopment Analysis( DEA) model and cluster analysis,this study examined the Yangtze River Economic Belt from 2008 to 2018 to measure its agricultural production efficiency and to analyze its temporal and spatial characteristics. Studies showed that exogenous environmental factors significantly( P < 5%) impacted agricultural production efficiency in the Yangtze River Economic Zone,and there were temporal and spatial differences. These included:(1) after excluding environmental factors,the overall agricultural production efficiency of the Yangtze River Economic Zone had improved. Sichuan Province and Jiangsu Province were at the forefront of efficiency,whereas the agricultural production efficiency of Shanghai had declined obviously.(2) The agricultural production efficiency of the Yangtze River Economic Belt varied year by year,with fluctuating development. The middle reaches of the Yangtze River had advanced agricultural production efficiency more than the upstream and downstream regions,and the agricultural production efficiency of the individual provinces did not match their economic and social development.(3) Increases in labor,land,irrigation,and other input factors increased agriculture production efficiency,and there was no correlation between fiscal investment,per capita gross domestic product( GDP) and agricultural production efficiency,while the disaster-affected area had a significantly negative impact on agricultural production efficiency.展开更多
文摘BACKGROUND Patients with gastric cancer often experience slow postoperative recovery and psychological stress,necessitating enhanced nursing care to improve their prognosis.AIM To analyze the impact of a timing-theory-guided three-stage integrated nursing intervention(TSIN)on the postoperative recovery of patients undergoing gastric cancer surgery.METHODS Total 84 patients that underwent gastric cancer surgeries between June 2022 and June 2024 were selected and divided into a control group and an observation group based on perioperative nursing methods.The control group(n=42)received routine nursing care,whereas the observation group(n=42)received a timing-theory-guided TSIN.The psychological adjustment capabilities,psychological stress,cancer-related fatigue levels,postoperative recovery,and quality of life of the two groups were compared.RESULTS Compared to the control group,the observation group took lesser time to get out of bed,achieve gastrointestinal motility,have the first mealtime,along with a shorter hospital stay(P<0.05).Before nursing,there were no significant differences between groups’parameters or scores(P>0.05).After nursing,the scores for psychological stress and cancer-related fatigue decreased.In contrast,the scores for psychological adjustment capabilities and quality of life increased,with more significant improvements observed in the observation group,showing significant differences within and between the groups(P<0.05).CONCLUSION Timing theory-guided TSIN can improve the psychological adjustment capabilities of patients undergoing gastric cancer surgery,reduce psychological stress and cancer-related fatigue,accelerate postoperative recovery,and improve the quality of life.
基金Henan Province Medical Education Research Project(Exploration and Reform of the“Three-Fusion”Teaching Model for Medical Microbiology Courses under the New Medical Education Context,WJLX2024199)Teaching Reform Research Project of Pingdingshan University(Exploration of a Three-Stage Hybrid Teaching Model for Basic Medical Courses in Clinical Medicine under the Context of Smart Education,2023-JY42)“Ideological and Political Education”Project for the“Medical Microbiology and Parasitology”Course at Pingdingshan University.
文摘Objective:This study explores the effectiveness of a three-stage blended teaching model in the Medical Microbiology course for Clinical Medicine students within the context of smart education.Methods:Clinical Medicine students from the 2021 and 2022 classes were studied,comparing the traditional and three-stage blended teaching models.Academic performance and survey feedback were analyzed.Results:The research group’s academic performance,including daily,final exam,and average scores,was significantly higher than the control group(P<0.05).Over 95%of students approved of the new teaching model,noting improvements in competencies.Conclusion:The three-stage blended teaching model effectively boosted student engagement,interaction,academic performance,and overall skills,showing potential for broader application in medical education.
文摘The Vienna rectifier is a widely adopted solution for high-power rectification due to its efficiency and straightforward design.However,its performance can degrade under unbalanced three phase voltage conditions,leading to current zero-crossing distortion and compromised dynamic response.This paper investigates the causes of these distortions,identifying a phase shift between the input current and the grid voltage as a primary factor,and proposes an effective distortion phase identification strategy.Furthermore,the dynamic performance is enhanced through improved current reference calculations and a refined power feedforward strategy.This approach optimizes the system's response to load changes and maintains output voltage stability under unbalanced conditions.Simulation results validate the effectiveness of the proposed methods in reducing current distortion and improving overall performance.
基金Anhui Province Key Research and Development Plan of the Ecological Environment Project(No.202104i07020016).
文摘In this study,Computational Fluid Dynamics(CFD)together with a component transport model are exploited to investigate the influence of dimensionless parameters,involving the height of the rectifier grid and the installation height of the first catalyst layer,on the flow field and the overall denitration efficiency of a cement kiln’s SCR(Selective catalytic reduction)denitrification reactor.It is shown that accurate numerical results can be obtained by fitting the particle size distribution function to the actual cement kiln fly ash and implementing a non-uniform particle inlet boundary condition.The relative error between denitration efficiency derived from experimental data,numerical simulation,and real-time system pressure drop ranges from 4%to 9%.Optimization of the SCR reactor is achieved when the rectifier grid thickness ratio k/H≥0.030,the rectifier grid height ratio h/H=0.04,and the spacing between the rectifier grid and the first catalyst layer l/H=0.10.Under these conditions,airflow distribution and particle dispersion upstream of the catalyst result in increased denitration efficiencies of 3.21%,3.43%,and 3.27%,respectively,compared to the least favorable operating conditions.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFE0108600 to Y.M.L.)the National Natural Science Foundations of China(Grant Nos.82473918 and 82104162 to X.X.L.).
文摘Parvalbumin-positive(PV^(+))interneuron dysfunction is believed to be linked to autism spectrum disorder(ASD),a neurodevelopmental disorder characterized by social deficits and stereotypical behaviors.However,the mechanisms behind PV^(+)interneuron dysfunction remain largely unclear.Here,we found that a deficiency of Biorientation Defective 1(Bod1)in PV^(+)interneurons led to an ASD-like phenotype in Pvalb-Cre;Bod1f/f mice.Mechanistically,we observed that Bod1 deficiency induced hypoactivity of PV^(+)interneurons and hyperactivity of calcium/calmodulin-dependent protein kinaseⅡalpha(CaMKⅡα)neurons in the medial prefrontal cortex,as determined by whole-cell patch-clamp recording.Additionally,Bod1 deficiency decreased the power of highgamma oscillation,assessed by in vivo multi-channel electrophysiological recording.Furthermore,we found that Bod1 deficiency enhanced the inwardly rectifying K^(+)current,leading to an increase in the resting membrane potential of PV^(+)interneurons.Importantly,the gain-of-function of Bod1 improved social deficits and stereotypical behaviors in Pvalb-Cre;Bod1f/f mice.These findings provide mechanistic insights into the PV^(+)interneuron dysfunction and suggest new strategies for developing PV^(+)interneuron-targeted therapies for ASD.
基金Projects(51878667,51678571)supported by the National Natural Science Foundation of ChinaProject(2018zzts657)supported by the Central South University Postgraduates’Innovation,ChinaProject(2018JJ2517)supported by the Hunan Provincial Natural Science Foundation of China。
文摘Based on a typical prototype of a soil slope in engineering practice, a numerical model of a three-stage soil slope supported by the anchor frame structure was established by means of FLAC3D code. The dynamic responses of three-stage soil slope and frame structure were studied by performing a series of bidirectional Wenchuan motions in terms of the failure mode of three-stage structure, the acceleration of soil slope, the displacement of frame structure, and the anchor stress of frame structure. The response accelerations in both horizontal and vertical directions are the most largely amplified at the slope top of each stage subjected to different shaking cases. The platforms among the stages reduce the amplification effect of response acceleration. The residual displacement of frame structure increases significantly as the intensity of shaking case increases. The frame structure at each stage presents a combined displacement mode consisting of a translation and a rotation around the vertex. The anchor stress of frame structure is mainly increased by the first intense pulse of Wenchuan seismic wave, and it is sensitive to the intensity of shaking case. The anchor stress of frame structure at the first stage is the most considerably enlarged by earthquake loading.
基金the National Social Science Foundation of China(No.11BGL028)Higher Education Research Fund for the Doctoral Program of China(No.20110095110003)
文摘Based on three-stage data envelopment analysis(DEA) model estimates of resource utilization efficiency of coal,we selected 29 provinces from China's 2012 input-output data and used the bootstrap DEA model to correct the bias.The results show that the mean overall technical efficiency,pure technical efficiency,and scale efficiency was 0.833,0.998,and 0.711 in 2012,respectively.Moreover,the comprehensive technical efficiency score indicates that the scale is invalid.Area utilization efficiencies for the eastern,central,and western regions were 0.917,0.731,and 0.629,respectively.The results prove that there are significant differences in the distribution of coal resources utilization efficiency across regions.
文摘Two-oriented agriculture was a complex organism coupling production,economics,society and ecology.Its development process was affected by various factors such as producers,nature,society,etc.In order to overcome measurement error of traditional data envelopment analysis caused by ignoring random,three-stage DEA model was studied to remove environmental factors and random effects.On the foundation of this model was two-oriented agriculture comprehensive production efficiency of 14 cities were estimated in Hunan Province in 2008,and brown forth corresponding policy proposals to promote agricultural development.
文摘From the perspective of agricultural insurance agency,this paper focuses on the study of operational efficiency of agricultural insurance agency,and analyzes the operational efficiency of agricultural insurance agency and its influencing factors,in order to improve the operational efficiency of agricultural insurance agency,better supply agricultural insurance and achieve the policy effect of agricultural insurance.The results of this paper are as follows:( i) Either comprehensive operational efficiency or scale efficiency of Chinese-funded agency is higher than that of foreign-funded agency,but its pure technical efficiency is lower than that of foreign-funded agency,indicating that the managerial decision ability of Chinese-funded agency is weaker than that of foreign-funded agency,and needs to be improved;( ii) The operational efficiency of professional agricultural insurance agency is higher than that of comprehensive agricultural insurance agency,and the agricultural insurance agency is greatly affected by environmental factors;( iii) The operating time of agricultural insurance agency is proportional to its operational efficiency;( iv) The quality of employees is positively correlated with the capital and cost input difference,but negatively correlated with the difference in the number of employees. Therefore,it is necessary to pay attention to the improvement of employees' working efficiency while laying emphasis on employees' quality.
文摘The use of an electrical network as close as possible to its limits can lead to its instability in the event of a high amplitude disturbance. The damping of system oscillations can be achieved by conventional means of voltage and speed regulation but also by FACTS (Flexible AC Transmission Systems) devices, which are increasingly used in power networks. In this work, optimal control coordination between a hybrid power flow controller and a three-level inverter was used to improve the transient stability of a transmission line. The UPFC is a combination of a serial compensator (SSSC) and a parallel compensator (STATCOM) both connected to a DC-LINK DC bus. The SSSC acts as a voltage source for the network and injects a voltage that can be adjusted in phase and amplitude in addition to the network voltage;the STATCOM acts as a current source. The approach used is tested in the Matlab Simulink environment on a single machine network. Optimal controller tuning gives a better transient stability improvement by reducing the transport angle oscillations from 248.17% to 9.85%.
基金Ministry of Science and Technology of China(No.2006BAF01B12-03)
文摘In order to improve the dynamic response bandwidth of three-stage electro-hydraulic servo valve,a new method,speed-feedback control is presented in this paper.The construction and principle of three-stage electro-hydraulic servo valve are explained,and the mathematical model of three-stage electro-hydraulic servo valve is built in frequency domain.Experimental and simulation results show that the bandwidth compared with proportional control is improved under speed-feedback control.Moreover,the research results play an important role in developing high performance three-stage electro-hydraulic servo valve.
基金financially supported by the National 863 Plan(2010AA03A405and 2012AA062303)+4 种基金the National 973 Plan(2012CBA01205)the National Natural Science Foundation of China(U120227451204040)the National Science and Technology Support Program(2012BAE01B02)the Fundamental Research Funds for the Central Universities(N130702001 and N130607001)
文摘Numerical simulation of enhanced fluid flow characteristics in a three-stage double-stirring extraction tank was conducted with the coupling of an Eulerian multiphase flow model and a Morsi-Alexander interphase drag force model. Results show that the addition of a stirring device into the settler can efficiently reduce the volume fraction of out-of-phase impurity in the outlet, and accelerate the settling separation of oil-water mixture. Such addition can also effectively break down the oil-water-wrapped liquid droplets coming from the mixer, inhibit reflux from the outlet, and improve the oil-water separation. The addition of a stirring device induces ignorable power consumption compared with that by the mixer, and can thus facilitate the commercialized promotion of this novel equipment.
基金supported by the National Natural Science Foundation of China(grants No.41172062, 40872054 and 40372043)the China Geological Survey(grant No.1212010811033)
文摘Objective Rapakivi granites,characterized by rapakivi texture,Atype granite feature and an anorogenic setting,commonly occur in the Proterozoic of the Northern Hemisphere（Fig.la）.Recently,more and more Phanerozoic rapakivi granite suites have been identified and some even occur in orogenic belts.Significantly,three-stage,Proterozoic.
文摘This paper uses a three-stage DEA model to measure the land use efficiency of the three major urban agglomerations in the Yangtze River Delta,Beijing-Tianjin-Hebei,and the Pearl River Delta from 2007 to 2018.The following conclusions are drawn through research:first,the urban land use efficiency of the three major urban agglomerations in the Yangtze River Delta,Beijing-Tianjin-Hebei,and the Pearl River Delta all showed a downward trend,with the rates of decline being 6.06%,2.86%,and 24.34%respectively.In particular,the Pearl River Delta urban agglomeration had the largest decline.Second,the overall urban land use efficiency of the Beijing-Tianjin-Hebei urban agglomeration is relatively high,and the amount of redundancy is relatively small.The rate of decline is significantly lower than the urban land use efficiency of the two major urban agglomerations in the Yangtze River Delta and the Pearl River Delta.The land use efficiency of the Yangtze River Delta and Pearl River Delta urban agglomerations is in a state of continuous decline.Third,the proportion of cities with the effectiveness of returns to scale of urban land use efficiency in the three major urban agglomerations has decreased by 10.53%,10%,and 33.34%,respectively.The Pearl River Delta has the largest decline.Fourth,the land use efficiency of the Yangtze River Delta urban agglomeration is quite different.The central-peripheral phenomenon is evident for the Beijing-Tianjin-Hebei urban agglomerations and the Pearl River Delta urban agglomerations.
基金This study was financially supported by the National Natural Science Foundation of China(Grant/Award Number:22232004,22272179,21972068,and 22072067).
文摘Rational design and construction of oxygen reduction reaction(ORR)electrocatalysts with high activity,good stability,and low price are essential for the practical applications of renewable energy conversion devices,such as metal-air batteries.Electronic modification through constructing metal/semiconductor Schottky heterointerface represents a powerful strategy to enhance the electrochemical performance.Herein,we demonstrate a concept of Schottky electrocatalyst composed of uniform Co nanoparticles in situ anchored on the carbon nanotubes aligned on the carbon nanosheets(denoted as Co@N-CNTs/NSs hereafter)toward ORR.Both experimental findings and theoretical simulation testify that the rectifying contact could impel the voluntary electron flow from Co to N-CNTs/NSs and create an internal electric field,thereby boosting the electron transfer rate and improving the intrinsic activity.As a consequence,the Co@N-CNTs/NSs deliver outstanding ORR activity,impressive long-term durability,excellent methanol tolerance,and good performance as the air-cathode in the Zn-air batteries.The design concept of Schottky contact may provide the innovational inspirations for the synthesis of advanced catalysts in sustainable energy conversion fields.
文摘Objective: To investigate the effects of standardized three-stage rehabilitation combined with edaravone therapy on the neurotrophic state and oxidative stress injury in patients with cerebral infarction. Methods: A total of 90 patients with acute cerebral infarction who were treated in the hospital between May 2015 and April 2017 were divided into control group (n=45) and observation group (n=45) by random number table. Control group received edaravone therapy, and observation group received standardized three-stage rehabilitation combined with edaravone therapy. The differences in neurotrophic state and oxidative stress injury were compared between the two groups before and after treatment. Results: There was no statistically significant difference in serum levels of neurotrophic indexes and oxidative stress indexes between the two groups before treatment. After treatment, serum neurotrophic indexes BDNF and NGF levels of observation group were higher than those of control group;serum oxidation indexes AOPPs, LHP and MDA levels were lower than those of control group whereas SOD, CAT and T-AOC levels were higher than those of control group. Conclusion:Standardized three-stage rehabilitation combined with edaravone therapy can effectively optimize the neurotrophic state and inhibit the oxidative stress in patients with cerebral infarction.
基金Supported by the National Basic Research Program of China(2012CB720500)the National High Technology Research and Development Program of China(2013AA040702)
文摘This paper introduces a practical solving scheme of gradetransition trajectory optimization(GTTO) problems under typical certificate-checking–updating framework. Due to complicated kinetics of polymerization,differential/algebraic equations(DAEs) always cause great computational burden and system non-linearity usually makes GTTO non-convex bearing multiple optima. Therefore, coupled with the three-stage decomposition model, a three-section algorithm of dynamic programming(TSDP) is proposed based on the general iteration mechanism of iterative programming(IDP) and incorporated with adaptivegrid allocation scheme and heuristic modifications. The algorithm iteratively performs dynamic programming with heuristic modifications under constant calculation loads and adaptively allocates the valued computational resources to the regions that can further improve the optimality under the guidance of local error estimates. TSDP is finally compared with IDP and interior point method(IP) to verify its efficiency of computation.
基金Funded by the National Basic Research Program of China (No.2007CB307102)National High Tech Research and Development Program of China (No.2005AA121210)National Natural Science Foundation of China (No. 60572042)
文摘Current MSM switching fabric has poor performance under unbalanced traffic. This paper presents an alternative, novel Central-stage Buffered Three-stage Clos switching (CB-3Clos) fabric and proves that this fabric can emulate output queuing switch without any speedup. By analyzing the condition to satisfy the central-stage load-balance, this paper also proposes a Central-stage Load-balanced-based Distributed Scheduling algorithm (CLDS) for CB-3Clos. The results show that, compared with Concurrent Round-Robin based Dispatching (CRRD) algorithm based on MSM, CLDS algorithm has high throughput irrespective with the traffic model and better performance in mean packet delay.
文摘As the non-periodic inspections are common in practice,a two-stage inspection model based on a three-stage failure process is proposed. The two-stage inspection means that the system is inspected with the first inspection interval T_1 and the second inspection interval T_2. Because of the three color schemes commonly used in industry,three stages are divided by the system lifetime:normal, minor defective and severe defective stages. Upon the failure of the system,replacement is carried out. Maintenance is done once identifying the severe defective stage. However,when the minor defective stage is identified by the second inspection interval T_2,action of halving the subsequent inspection interval is adopted.Otherwise,no action is required. Our objective function is to optimize the inspection intervals so as to minimize the expected cost per unit time. Finally,a numerical example is presented to illustrate the effectiveness of the proposed model.
基金Supported by the Strategic Leading Science and Technology Project (Class A)of Chinese Academy of Sciences (XDA23020101)the National Natural Science Foundation of China (41801129)。
文摘In response to the strategic call for the " Great Protection" of the Yangtze River Economic Belt and to fulfill the important historical tasks assigned by the state to the provinces and cities of the area,the Yangtze River Economic Belt is adjusting the agricultural industry structure,optimizing the input-output ratio,and ensuring stable and sustainable agricultural production. Based on the combination of the three-stage Data Envelopment Analysis( DEA) model and cluster analysis,this study examined the Yangtze River Economic Belt from 2008 to 2018 to measure its agricultural production efficiency and to analyze its temporal and spatial characteristics. Studies showed that exogenous environmental factors significantly( P < 5%) impacted agricultural production efficiency in the Yangtze River Economic Zone,and there were temporal and spatial differences. These included:(1) after excluding environmental factors,the overall agricultural production efficiency of the Yangtze River Economic Zone had improved. Sichuan Province and Jiangsu Province were at the forefront of efficiency,whereas the agricultural production efficiency of Shanghai had declined obviously.(2) The agricultural production efficiency of the Yangtze River Economic Belt varied year by year,with fluctuating development. The middle reaches of the Yangtze River had advanced agricultural production efficiency more than the upstream and downstream regions,and the agricultural production efficiency of the individual provinces did not match their economic and social development.(3) Increases in labor,land,irrigation,and other input factors increased agriculture production efficiency,and there was no correlation between fiscal investment,per capita gross domestic product( GDP) and agricultural production efficiency,while the disaster-affected area had a significantly negative impact on agricultural production efficiency.
