网络流媒体播放,正成为Hi-Fi主流音源。越来越多爱乐者不再执着于传统CD或繁琐的本地存储,转而寻求更高效、更轻松的聆听方式。HiFi ROSE RS451正是这样一台应运而生的新一代网络流媒体播放器。它集流媒体、解码、耳放及前级等功能于一...网络流媒体播放,正成为Hi-Fi主流音源。越来越多爱乐者不再执着于传统CD或繁琐的本地存储,转而寻求更高效、更轻松的聆听方式。HiFi ROSE RS451正是这样一台应运而生的新一代网络流媒体播放器。它集流媒体、解码、耳放及前级等功能于一身,以高度集成打破场景边界,为发烧友与耳机玩家打通客厅与桌面,实现全场景高保真体验——让音乐爱好者拥有更多被音乐浸润的时刻。展开更多
BACKGROUND Crohn’s disease(CD)is a chronic inflammatory bowel disease with unknown etiology.Inflammatory chemical mediators synthesized from arachidonic acid,an n-6 polyunsaturated fatty acid(PUFA),have been shown to...BACKGROUND Crohn’s disease(CD)is a chronic inflammatory bowel disease with unknown etiology.Inflammatory chemical mediators synthesized from arachidonic acid,an n-6 polyunsaturated fatty acid(PUFA),have been shown to activate CD.Additionally,n-3 PUFAs are metabolized by the same enzyme as n-6 PUFAs and known to inhibit the arachidonic acid cascade.Our previous study noted that the presence of erythrocyte membrane fatty acids is a characteristic finding in Japanese CD patients.It was thus speculated that FADS2 gene polymorphisms,which induce PUFA metabolizing enzymes,are involved in the pathogenesis of CD,though no such relationship was found.AIM To investigate the relationship of FADS2 polymorphisms with serum and erythrocyte membrane fatty acid composition ratios,and disease activity.METHODS Using previously reported findings regarding FADS2 genetic polymorphisms,the records of 52 CD patients undergoing treatment at Jikei University Kashiwa Hospital were analyzed.Mutations noted were divided into three groups;wild-type(GG),heterozygous mutants(GA),and homozygous(AA),with the activities of delta-6 and delta-5 desaturases compared using redefined d6d index(rd.d6di)and d5d index(d5di).Additionally,comparisons of serum and erythrocyte membranes for fatty acid composition,and also gene polymorphisms and CD activity index(CDAI)were performed.RESULTS The presence of the rs174538 mutation in FADS2 resulted in reduction of only rd.d6di in the erythrocyte membrane(P<0.01).In contrast,that mutation was found to be associated with d5di induced by FADS1 in serum(P=0.019)as well as the erythrocyte membrane(P<0.0001),and also with reduction in the fatty acid composition of arachidonic acid in both serum(P<0.0001)and the erythrocyte membrane(P<0.01).Regarding disease activity,a positive correlation of CDAI score with rd.d6di in both serum(P<0.05)and the erythrocyte membrane(P<0.05)was found only in the rs174538 wild-type group.In contrast,there was no correction between CDAI and d5di in either serum or erythrocyte membrane samples.CONCLUSION The rs174538 mutation alters the fatty acid profile through strong linkage to the FADS1 gene.In wild-type individuals,rd.d6di was positively correlated with CDAI,suggesting predictive utility of disease severity.展开更多
为满足煤矿掘进设备在复杂井下环境中对高可靠性、实时性和多节点组网通信的需求,设计了一种基于RS-485总线与控制器局域网络(Controller Area Network,CAN)融合的掘进设备本地通信系统。通过构建“高速骨干、低速接入”分层架构,重点...为满足煤矿掘进设备在复杂井下环境中对高可靠性、实时性和多节点组网通信的需求,设计了一种基于RS-485总线与控制器局域网络(Controller Area Network,CAN)融合的掘进设备本地通信系统。通过构建“高速骨干、低速接入”分层架构,重点研究了基于CAN总线高可靠性的短帧传输技术、基于异构网关优先级调度的实时通信技术以及基于分层拓扑的多节点组网扩展技术。实际应用结果表明,该系统能够有效提升掘进设备通信系统的可靠性和实时性,同时具备良好的节点扩展能力。展开更多
文摘网络流媒体播放,正成为Hi-Fi主流音源。越来越多爱乐者不再执着于传统CD或繁琐的本地存储,转而寻求更高效、更轻松的聆听方式。HiFi ROSE RS451正是这样一台应运而生的新一代网络流媒体播放器。它集流媒体、解码、耳放及前级等功能于一身,以高度集成打破场景边界,为发烧友与耳机玩家打通客厅与桌面,实现全场景高保真体验——让音乐爱好者拥有更多被音乐浸润的时刻。
文摘BACKGROUND Crohn’s disease(CD)is a chronic inflammatory bowel disease with unknown etiology.Inflammatory chemical mediators synthesized from arachidonic acid,an n-6 polyunsaturated fatty acid(PUFA),have been shown to activate CD.Additionally,n-3 PUFAs are metabolized by the same enzyme as n-6 PUFAs and known to inhibit the arachidonic acid cascade.Our previous study noted that the presence of erythrocyte membrane fatty acids is a characteristic finding in Japanese CD patients.It was thus speculated that FADS2 gene polymorphisms,which induce PUFA metabolizing enzymes,are involved in the pathogenesis of CD,though no such relationship was found.AIM To investigate the relationship of FADS2 polymorphisms with serum and erythrocyte membrane fatty acid composition ratios,and disease activity.METHODS Using previously reported findings regarding FADS2 genetic polymorphisms,the records of 52 CD patients undergoing treatment at Jikei University Kashiwa Hospital were analyzed.Mutations noted were divided into three groups;wild-type(GG),heterozygous mutants(GA),and homozygous(AA),with the activities of delta-6 and delta-5 desaturases compared using redefined d6d index(rd.d6di)and d5d index(d5di).Additionally,comparisons of serum and erythrocyte membranes for fatty acid composition,and also gene polymorphisms and CD activity index(CDAI)were performed.RESULTS The presence of the rs174538 mutation in FADS2 resulted in reduction of only rd.d6di in the erythrocyte membrane(P<0.01).In contrast,that mutation was found to be associated with d5di induced by FADS1 in serum(P=0.019)as well as the erythrocyte membrane(P<0.0001),and also with reduction in the fatty acid composition of arachidonic acid in both serum(P<0.0001)and the erythrocyte membrane(P<0.01).Regarding disease activity,a positive correlation of CDAI score with rd.d6di in both serum(P<0.05)and the erythrocyte membrane(P<0.05)was found only in the rs174538 wild-type group.In contrast,there was no correction between CDAI and d5di in either serum or erythrocyte membrane samples.CONCLUSION The rs174538 mutation alters the fatty acid profile through strong linkage to the FADS1 gene.In wild-type individuals,rd.d6di was positively correlated with CDAI,suggesting predictive utility of disease severity.
文摘为满足煤矿掘进设备在复杂井下环境中对高可靠性、实时性和多节点组网通信的需求,设计了一种基于RS-485总线与控制器局域网络(Controller Area Network,CAN)融合的掘进设备本地通信系统。通过构建“高速骨干、低速接入”分层架构,重点研究了基于CAN总线高可靠性的短帧传输技术、基于异构网关优先级调度的实时通信技术以及基于分层拓扑的多节点组网扩展技术。实际应用结果表明,该系统能够有效提升掘进设备通信系统的可靠性和实时性,同时具备良好的节点扩展能力。
