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Sustained maternal human immunodeficiency virus viral load suppression and cascade of human immunodeficiency virus testing among exposed infants in Rwanda 被引量:1
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作者 Hafidha Mhando Bakari Jackson Sebeza +6 位作者 Haji Mbwana Ally Hassan Fredrick Fussi Habib Omari Ramadhani Peter Memiah Djemima Umutesi Basile Ikuzo Gallican Rwibasira 《World Journal of Virology》 2025年第2期67-78,共12页
BACKGROUND To prevent mother to child transmission(MTCT)of human immunodeficiency virus(HIV),sustained maternal viral load suppression(VLS)and early HIV testing among HIV exposed infants(HEI)is critical.AIM To investi... BACKGROUND To prevent mother to child transmission(MTCT)of human immunodeficiency virus(HIV),sustained maternal viral load suppression(VLS)and early HIV testing among HIV exposed infants(HEI)is critical.AIM To investigate maternal viral load results and infant HIV testing uptake at 6-weeks,and 9-months and 18-months in Rwanda.METHODS Between 2015 and 2022,VLS(<200 copies/mL)was measured among pregnant women living with HIV(WLHIV)from 38-healthcare facilities.Viral loads(VL)were measured at 6-months,12-months and 24-months,respectively.For maternal VL,the unit of analysis was visit-pair,and the pairs were created to define those with VL<200 copies/mL at two consecutive visits as having sustained VLS,persistent viremia(VL≥200 copies/mL at two consecutive visits),viral rebound(VL<200 copies/mL at prior visit only)and newly suppressed(VL<200 copies/mL at subsequent visit only).HEI were considered to have persistent HIV testing if they had all three HIV tests.Poisson regression models with generalized estimating equations were used to estimate the adjusted incidence rate ratio(aIRR)and 95%CI for factors associated with sustained VLS and persistent HIV testing.RESULTS A total of 1145 mother-infant pairs were analyzed.Infant HIV testing uptake at 6-weeks,9-months and 18-months was 1145(100.0%),1089(95.1%),1006(87.9%)respectively.Nine hundred ninety-nine HEI(87.3%)tested for HIV persistently.At 18-months,the incidence of HIV among HEI was 8(0.7%).Of 1145 mothers,1076(94.0%)had≥2 VL results making a total of 2010 visit-pairs(142-single;934-double visit-pairs).The incidence rate of sustained VLS,persistent viremia,viral rebound and new suppression were 91.0%,1.3%,3.6%and 4.0%respectively.Maternal disclosure of HIV status(aIRR=1.08,95%CI:1.02-1.14)was associated with increased likelihood of sustained VLS.Having peer support(aIRR=1.0595%CI:1.01-1.10)was associated with persistent HIV testing among HEI.CONCLUSION Sustained VLS is high among pregnant WLHIV in Rwanda.The low incidence of HIV among HEI may be attributed to high VLS levels.Targeted interventions,including enhanced HIV disclosure and peer support,are crucial for improving sustained VLS and increasing infant HIV testing uptake to reduce MTCT. 展开更多
关键词 Sustained viral load suppression Mother to child human immunodeficiency virus transmission Women living with human immunodeficiency virus Human immunodeficiency virus exposed infants Human immunodeficiency virus testing Rwanda
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Development of rock creep test system considering dynamic-static and ultralow-frequency cyclic loading
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作者 Yinping Li Zhikai Dong +7 位作者 Xilin Shi Haoran Li Cuiyao Zhuo Yuanxi Liu Xiangsheng Chen Si Huang Weigang Zhao Yaodong Qi 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第11期6900-6914,共15页
This paper presents an ultralow-frequency cyclic loading creep test system for rock salt.The system comprises five subsystems:a cyclic load generation system,a triaxial pressure chamber,a pressure and deformation moni... This paper presents an ultralow-frequency cyclic loading creep test system for rock salt.The system comprises five subsystems:a cyclic load generation system,a triaxial pressure chamber,a pressure and deformation monitoring system,a signal acquisition and load control integrated system,and an automatic oil replenishment and discharge system.This test system overcomes the limitations of traditional electrohydraulic servo creep testing machines and gravity loading creep testing machines when conducting low-frequency cyclic load creep tests.This allows for long-term(1-2 years)creep tests under extremely-low-frequency cyclic loading conditions,which simulate the actual operating conditions of salt cavern gas storage.The cyclic load generation system converted constant-weight loads into a continuously variable hydraulic oil pressure and amplified the oil pressure using a pressure intensifier,which provided a stable load source for the test system.Using this test system,creep tests were performed under low-frequency cyclic loading with periods of 1 d and 7 d.The results showed that the test system performed well,as evidenced by the validation of the loading capacity,loading stability,and temperature control stability.Comparing the creep deformation of rock salt samples with the cyclic periods of 1 d and 7 d,it was observed that,within this cyclic period range,the creep deformation of the sample increased with higher loading frequencies,provided that the cyclic loading waveform and stress remained constant. 展开更多
关键词 Creep test system Cyclic load Ultralow-frequency Rock salt Rock mechanics
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CFD-based Determination of Load Cell Capacity for Submarine HPMM Model Tests
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作者 Aliasghar Moghaddas Hossein nourozi +1 位作者 Morteza Ebrahimi Alireza Naderi 《哈尔滨工程大学学报(英文版)》 2025年第5期1064-1074,共11页
Captive model tests are one of the most common methods to calculate the maneuvering hydrodynamic coefficients and characteristics of surface and underwater vehicles.Considerable attention must be paid to selecting and... Captive model tests are one of the most common methods to calculate the maneuvering hydrodynamic coefficients and characteristics of surface and underwater vehicles.Considerable attention must be paid to selecting and designing the most suitable laboratory equipment for towing tanks.A computational fluid dynamics(CFD)-based method is implemented to determine the loads acting on the towing facility of the submarine model.A reversed topology is also used to ensure the appropriateness of the load cells in the developed method.In this study,the numerical simulations were evaluated using the experimental results of the SUBOFF benchmark submarine model of the Defence Advanced Research Projects Agency.The maximum and minimum loads acting on the 2.5-meter submarine model were measured by determining the body’s lightest and heaviest maneuvering test scenarios.In addition to having sufficient endurance against high loads,the precision in measuring the light load was also investigated.The horizontal planar motion mechanism(HPMM)facilities in the National Iranian Marine Laboratory were developed by locating the load cells inside the submarine model.The results were presented as a case study.A numerical-based method was developed to obtain the appropriate load measurement facilities.Load cells of HPMM test basins can be selected by following the two-way procedure presented in this study. 展开更多
关键词 Captive model tests Hydrodynamic coefficients SUBMARINE Computational fluid dynamics Horizontal planar motion mechanism load cell capacity
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Field testing of stiffened deep cement mixing piles under lateral cyclic loading 被引量:10
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作者 Werasak Raongjant Meng Jing 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2013年第2期261-265,共5页
Construction of seaside and underground wall bracing often uses stiffened deep cement mixed columns (SDCM). This research investigates methods used to improve the level of bearing capacity of these SDCM when subject... Construction of seaside and underground wall bracing often uses stiffened deep cement mixed columns (SDCM). This research investigates methods used to improve the level of bearing capacity of these SDCM when subjected to cyclic lateral loading via various types of stiffer cores. Eight piles, two deep cement mixed piles and six stiffened deep cement mixing piles with three different types of cores, H shape cross section prestressed concrete, steel pipe, and H-beam steel, were embedded though soft clay into medium-hard clay on site in Thailand. Cyclic horizontal loading was gradually applied until pile failure and the hysteresis loops of lateral load vs. lateral deformation were recorded. The lateral carrying capacities of the SDCM piles with an H-beam steel core increased by 3-4 times that of the DCM piles. This field research clearly shows that using H-beam steel as a stiffer core for SDCM piles is the best method to improve its lateral carrying capacity, ductility and energy dissipation capacity. 展开更多
关键词 stiffened deep cement mixing pile lateral capacity cyclic lateral loading energy dissipation capacity field testing
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Gust load alleviation wind tunnel tests of a large-aspect-ratio flexible wing with piezoelectric control 被引量:6
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作者 Bi Ying Xie Changchuan +1 位作者 An Chao Yang Chao 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2017年第1期292-309,共18页
An active control technique utilizing piezoelectric actuators to alleviate gust-response loads of a large-aspect-ratio flexible wing is investigated. Piezoelectric materials have been extensively used for active vibra... An active control technique utilizing piezoelectric actuators to alleviate gust-response loads of a large-aspect-ratio flexible wing is investigated. Piezoelectric materials have been extensively used for active vibration control of engineering structures. In this paper, piezoelectric materials further attempt to suppress the vibration of the aeroelastic wing caused by gust. The motion equation of the flexible wing with piezoelectric patches is obtained by Hamilton's principle with the modal approach, and then numerical gust responses are analyzed, based on which a gust load alleviation(GLA) control system is proposed. The gust load alleviation system employs classic propor tional-integral-derivative(PID) controllers which treat piezoelectric patches as control actuators and acceleration as the feedback signal. By a numerical method, the control mechanism that piezoelectric actuators can be used to alleviate gust-response loads is also analyzed qualitatively. Furthermore, through low-speed wind tunnel tests, the effectiveness of the gust load alleviation active control technology is validated. The test results agree well with the numerical results. Test results show that at a certain frequency range, the control scheme can effectively alleviate the z and x wingtip accelerations and the root bending moment of the wing to a certain extent. The control system gives satisfying gust load alleviation efficacy with the reduction rate being generally over 20%. 展开更多
关键词 Active control Aeroelastic wing Gust load alleviation Gust response Piezoelectric actuators Wind tunnel test
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Model tests on XCC-piled embankment under dynamic train load of high-speed railways 被引量:8
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作者 Niu Tingting Liu Hanlong +1 位作者 Ding Xuanming Zheng Changjie 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2018年第3期581-594,共14页
Piled embankments,which offer many advantages,are increasingly popular in construction of high-speed railways in China.Although the performance of piled embankment under static loading is well-known,the behavior under... Piled embankments,which offer many advantages,are increasingly popular in construction of high-speed railways in China.Although the performance of piled embankment under static loading is well-known,the behavior under the dynamic train load of a high-speed railway is not yet understood.In light of this,a heavily instrumented piled embankment model was set up,and a model test was carried out,in which a servo-hydraulic actuator outputting M-shaped waves was adopted to simulate the process of a running train.Earth pressure,settlement,strain in the geogrid and pile and excess pore water pressure were measured.The results show that the soil arching height under the dynamic train load of a high-speed railway is shorter than under static loading.The growth trend for accumulated settlement slowed down after long-term vibration although there was still a tendency for it to increase.Accumulated geogrid strain has an increasing tendency after long-term vibration.The closer the embankment edge,the greater the geogrid strain over the subsoil.Strains in the pile were smaller under dynamic train loads,and their distribution was different from that under static loading.At the same elevation,excess pore water pressure under the track slab was greater than that under the embankment shoulder. 展开更多
关键词 piled embankment model test dynamic train load of high-speed railways XCC-pile M-shaped wave
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Brazilian disc test study on tensile strength-weakening effect of high pre-loaded red sandstone under dynamic disturbance 被引量:23
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作者 GONG Feng-qiang WU Wu-xing ZHANG Le 《Journal of Central South University》 SCIE EI CAS CSCD 2020年第10期2899-2913,共15页
Tensile failure(spalling or slabbing)often occurs on the sidewall of deep tunnel,which is closely related to the coupled stress state of deep rock mass under high pre-static load and dynamic disturbance.To reveal the ... Tensile failure(spalling or slabbing)often occurs on the sidewall of deep tunnel,which is closely related to the coupled stress state of deep rock mass under high pre-static load and dynamic disturbance.To reveal the mechanism of rock tensile failure caused by this coupled stress mode,the Brazilian disc tests were carried on red sandstone under high pre-static load induced by dynamic disturbance.Based on the pure static tensile fracture load of red sandstone specimen,two static load levels(80%and 90%of the pure static tensile fracture load)were selected as the initial high pre-static loading state,and then the dynamic disturbance load was applied until the rock specimen was destroyed.The dynamic disturbance loading mode adopted a sinusoidal wave(sine-wave)load,and the loading wave amplitude was 20%and 10%of the pure static tensile fracture load,respectively.The dynamic disturbance frequencies were set to 1,10,20,30,40,and 50 Hz.The results show that the tensile failure strength and peak displacement of red sandstone specimens under coupled load actions are lower than those under pure static tensile load,and both parameters decrease significantly with the increase of dynamic disturbance frequency.With the increase of dynamic disturbance frequency,the decrease range of tensile strength of red sandstone increased from 3.3%to 9.4%when the pre-static load level is 80%.While when the pre-static load level is 90%,the decrease range will increase from 7.4%to 11.6%.This weakening effect of tensile strength shows that the deep surrounding rock is more likely to fail under the coupled load actions of pre-static load and dynamic disturbance.In this tensile failure mechanism of the deep surrounding rock,the stress environment of deep sidewall rock determines that the failure mode of rock is a tensile failure,the pre-static load level dominates the tensile failure strength of surrounding rock,and dynamic disturbance promotes the strength-weakening effect and affects the weakening range. 展开更多
关键词 SPALLING deep surrounding rock strength-weakening effect pre-static load dynamic disturbance tensile failure Brazilian disc test
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Testing and modeling of cyclically loaded rock anchors 被引量:5
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作者 Joar Tistel Gustav Grimstad Gudmund Eiksund 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2017年第6期1010-1030,共21页
The Norwegian Public Roads Administration(NPRA) is planning for an upgrade of the E39 highway route at the westcoast of Norway. Fixed links shall replace ferries at seven fjord crossings. Wide spans and large depths a... The Norwegian Public Roads Administration(NPRA) is planning for an upgrade of the E39 highway route at the westcoast of Norway. Fixed links shall replace ferries at seven fjord crossings. Wide spans and large depths at the crossings combined with challenging subsea topography and environmental loads call for an extension of existing practice. A variety of bridge concepts are evaluated in the feasibility study. The structures will experience significant loads from deadweight, traffic and environment. Anchoring of these forces is thus one of the challenges met in the project. Large-size subsea rock anchors are considered a viable alternative. These can be used for anchoring of floating structures but also with the purpose of increasing capacity of fixed structures. This paper presents first a thorough study of factors affecting rock anchor bond capacity. Laboratory testing of rock anchors subjected to cyclic loading is thereafter presented. Finally, the paper presents a model predicting the capacity of a rock anchor segment, in terms of a ribbed bar, subjected to a cyclic load history. The research assumes a failure mode occurring in the interface between the rock anchor and the surrounding grout. The constitutive behavior of the bonding interface is investigated for anchors subjected to cyclic one-way tensile loads. The model utilizes the static bond capacity curve as a basis, defining the ultimate bond sbuand the slip s1 at τ. A limited number of input parameters are required to apply the model. The model defines the bond-slip behavior with the belonging rock anchor capacity depending on the cyclic load level(τcy/τ), the cyclic load ratio(R= τcy/τcy), and the number of load cycles(N). The constitutive model is intended to model short anchor lengths representing an incremental length of a complete rock anchor. 展开更多
关键词 Rock anchor Rock bolt Bond-slip model Cyclic loading Empirical model Laboratory testing Bond degradation
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Model test to investigate failure mechanism and loading characteristics of shallow-bias tunnels with small clear distance 被引量:11
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作者 雷明锋 林大涌 +3 位作者 杨伟超 施成华 彭立敏 黄娟 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第12期3312-3321,共10页
Based on the similarity theory,a tunnel excavation simulation testing system under typical unsymmetrical loading conditions was established.Using this system,the failure mechanism of surrounding rock of shallow-bias t... Based on the similarity theory,a tunnel excavation simulation testing system under typical unsymmetrical loading conditions was established.Using this system,the failure mechanism of surrounding rock of shallow-bias tunnels with small clear distance was analyzed along with the load characteristics.The results show that:1) The failure process of surrounding rock of shallow-bias tunnels with small clear distance consists of structural and stratum deformation induced by tunnel excavation; Microfracture surfaces are formed in the tunnel surrounding rock and extend deep into the rock mass in a larger density; Tensile cracking occurs in shallow position on the deep-buried side,with shear slip in deep rock mass.In the meantime,rapid deformation and slip take place on the shallow-buried side until the surrounding rocks totally collapse.The production and development of micro-fracture surfaces in the tunnel surrounding rock and tensile cracking in the shallow position on the deep-buried side represent the key stages of failure.2) The final failure mode is featured by an inverted conical fracture with tunnel arch as its top and the slope at tunnel entrance slope as its bottom.The range of failure on the deep-buried side is significantly larger than that on the shallow-buried side.Such difference becomes more prominent with the increasing bias angle.What distinguishes it from the "linear fracture surface" model is that the model proposed has a larger fracture angle on the two sides.Moreover,the bottom of the fracture is located at the springing line of tunnel arch.3) The total vertical load increases with bias angle.Compared with the existing methods,the unsymmetrical loading effect in measurement is more prominent.At last,countermeasures are proposed according to the analysis results: during engineering process,1) The surrounding rock mass on the deep-buried side should be reinforced apart from the tunnel surrounding rock for shallow-buried tunnels with small clear distance; moreover,the scope of consolidation should go beyond the midline of tunnel(along the direction of the top of slope) by 4 excavation spans of single tunnel.2) It is necessary to modify the load value of shallow-bias tunnels with small clear distance. 展开更多
关键词 shallow-bias tunnels with small spacing failure mechanism loading characteristics model test
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Load Reduction Test Method of Similarity Theory and BP Neural Networks of Large Cranes 被引量:4
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作者 YANG Ruigang DUAN Zhibin +2 位作者 LU Yi WANG Lei XU Gening 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2016年第1期145-151,共7页
Static load tests are an important means of supervising and detecting a crane's lift capacity. Due to space restrictions, however, there are difficulties and potential danger when testing large bridge cranes. To solv... Static load tests are an important means of supervising and detecting a crane's lift capacity. Due to space restrictions, however, there are difficulties and potential danger when testing large bridge cranes. To solve the loading problems of large-tonnage cranes during testing, an equivalency test is proposed based on the similarity theory and BP neural networks. The maximum stress and displacement of a large bridge crane is tested in small loads, combined with the training neural network of a similar structure crane through stress and displacement data which is collected by a physics simulation progressively loaded to a static load test load within the material scope of work. The maximum stress and displacement of a crane under a static load test load can be predicted through the relationship of stress, displacement, and load. By measuring the stress and displacement of small tonnage weights, the stress and displacement of large loads can be predicted, such as the maximum load capacity, which is 1.25 times the rated capacity. Experimental study shows that the load reduction test method can reflect the lift capacity of large bridge cranes. The load shedding predictive analysis for Sanxia 1200 t bridge crane test data indicates that when the load is 1.25 times the rated lifting capacity, the predicted displacement and actual displacement error is zero. The method solves the problem that lifting capacities are difficult to obtain and testing accidents are easily possible when 1.25 times related weight loads are tested for large tonnage cranes. 展开更多
关键词 similarity theory BP neural network large bridge crane load reduction equivalent test method
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Static load test and load transfer mechanism study of squeezed branch and plate pile in collapsible loess foundation 被引量:9
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作者 GAO Xiao-juan WANG Jin-chang ZHU Xiang-rong 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2007年第7期1110-1117,共8页
As a special geological phenomenon, the character of collapsible loess foundation is collapsible when penetrated by water. This character leads to the soil losing load bearing capacity largely and may lead to foundati... As a special geological phenomenon, the character of collapsible loess foundation is collapsible when penetrated by water. This character leads to the soil losing load bearing capacity largely and may lead to foundation failure. Pile is a popular foundation used in collapsible loess. The squeezed branch and plate pile is a new type of pile developed in recent years and has not be used in a project before. In this paper three squeezed branch and plate piles are tested in collapsible loess after immersion processing. The results may be used for reference in similar construction project, and to provide theoretical references for de- signing of the squeezed branch and plate piles in engineering practice. 展开更多
关键词 Collapsible loess foundation Squeezed branch and plate pile Immersion processing Full-scale static load test
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Test and numerical investigations on static and dynamic characteristics of extra-wide concrete self-anchored suspension bridge under vehicle loads 被引量:8
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作者 ZHOU Guang-pan LI Ai-qun +1 位作者 LI Jian-hui DUAN Mao-jun 《Journal of Central South University》 SCIE EI CAS CSCD 2017年第10期2382-2395,共14页
The present work is aimed at studying the mechanic properties of the extra-wide concrete self-anchored suspension bridge under static and dynamic vehicle loads. Based on the field test using 12 heavy trucks and finite... The present work is aimed at studying the mechanic properties of the extra-wide concrete self-anchored suspension bridge under static and dynamic vehicle loads. Based on the field test using 12 heavy trucks and finite element simulations, the static deformations of different components, stress increments and distributions of the girder, as well as the vibration characteristics and damping ratio of the Hunan Road Bridge were analyzed, which is the widest self-anchored suspension bridge in China at present. The dynamic responses were calculated using the Newmark-β integration method assisted by the simulation models of bridge and vehicles, the influences on the dynamic impact coefficient(DIC) brought by the vehicle parameters, girder width, eccentricity travel and deck flatness were also researched. The spatial effect of the girder is obvious due to the extra width, which performs as the stress increments distribute unevenly along the transverse direction, and the girder deflections and stress increments of the upper plate change as a "V" and "M" shape respectively under the symmetrical vehicle loads affected by the shear lag effect, cross slope and local effect of the wheels, the maximum of stress increments are located in the junctions with the inner webs. The obvious girder torsional deformation and the apparent unevenness of the hanger forces between the two cable planes under the eccentric vehicle loads, together with the mode shapes such as the girder transverse bending and torsion which appear relatively earlier, all reflect the weakened torsional rigidity of the extra-wide girder. The transverse displacements of towers are more obvious than the longitudinal ones. As for the influences on the DIC, the static effect of the heavier vehicles plays a major role when pass through with a higher speed and the changes of vehicle suspension stiffness generate greater impacts than the suspension damp. The values of DIC in the vehicle-running side during the eccentric travel, affected by the restricts from the static effects of the eccentric moving trucks, are significantly smaller than the vehicle-free side, the increase in the road roughness is the most sensitive one among the above influential factors. The results could provide references for the design, static and dynamic response analysis of the similar extra-wide suspension bridges. 展开更多
关键词 self-anchored suspension bridge extra-wide girder field test simulation vehicle loads increments distribution damping ratio mode shape dynamic impact coefficient
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Mechanical Properties of Deep-buried Marble Material Under Loading and Unloading Tests 被引量:2
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作者 李新平 ZHAO Hang +1 位作者 WANG Bin XIAO Taoli 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2013年第3期514-520,共7页
The mechanical properties are essentially different when rock material is subjected to loading or unloading conditions. In this study, loading and unloading tests with various confining pressures are conducted to inve... The mechanical properties are essentially different when rock material is subjected to loading or unloading conditions. In this study, loading and unloading tests with various confining pressures are conducted to investigate the mechanical properties of marble material samples taken from the deep diversion tunnels of Jinping II Hydropower Station. The stress-strain relationship, failure characteristics and strength criterion are compared and analyzed based on the experiment results. The results show: in the loading and unloading test, peak strength, lateral strain, axial strain and plastic deformation increase significantly as the confining pressure increases. Lateral strain increased significantly and obvious lateral dilatancy can be observed to the change of confining pressure; The fracture mode is mainly the single shear fracture for the triaxial compression test and post-peak test, angle between the failure surface and the ends of the rock material becomes smaller as the confining pressure increases. Hock-Brown strength criterion reflects the strength characteristics of marble material under two different unloading conditions, and has some supplementary effects to the rock material of mechanical field. 展开更多
关键词 deep-buried material loading and unloading tests mechanical properties strength criterion shear fracture
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New combination test for hepatitis C virus genotype and viral load determination using Amplicor GT HCV MONITOR test v2.0 被引量:3
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作者 Motokazu Mukaide Yasuhito Tanaka +10 位作者 Hirokazu Kakuda Kei Fujiwara Fuat Kurbanov Eturo Orito Kentaro Yoshioka Kiyotaka Fujise Shoji Harada Takazumi Kozaki Kazuo Takemura Kazumasa Hikiji Masashi Mizokami 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第4期469-475,共7页
AIM: To develop a new sensitive and inexpensive hepatitis C virus (HCV) combination test (HCV Guideline test) that enables the determination of HCV genotypes 1, 2 and 3, and simultaneous determination of HCV viral loa... AIM: To develop a new sensitive and inexpensive hepatitis C virus (HCV) combination test (HCV Guideline test) that enables the determination of HCV genotypes 1, 2 and 3, and simultaneous determination of HCV viral load using commercial Amplicor GT HOV MONITOR test v2.0 (microwell version). METHODS: The HCV Guideline test used the PCR product generated in commercial Amplicor GT HCV Monitor test v2.0 for viral load measurement using microwell plate version of Amplicor HCV Monitor and also captured on separate plates containing capture probes and competitive oligonucleotide probes specific for HCV genotypes 1, 2 and 3, The HCV genotype was subsequently determined using the biotin-labeled PCR product and five biotin-labeled HCV-specific probes. RESULTS: The sensitivity of the HCV Guideline test was 0.5 KIU/mL. Specificity of the HCV Guideline test was confirmed by direct sequencing of HCV core region and molecular evolutionary analyses based on a panel of 31 samples. The comparison of the HCV Guideline test and an in-house HCV core genotyping assay using 252 samples from chronic hepatitis C patients indicated concordant results for 97.2% of samples (59.5% genotype 1, 33.7% genotype 2, 6.0% genotype 3, and 0.8% mixed genotypes). Similarly, the HCV Guideline test showed concordance with a serological test, and the serological test failed to assign any serotype in 12.7% of the samples, indicating a better sensitivity of the HCV Guideline test. CONCLUSION: Clinically, both viral load and genotypes (1, 2 and 3) have been found to be major predictors of antiviral therapy outcome regarding chronic hepatitis C based on guidelines and they are, in normal circumstances, performed as separate stand-alone assays. The HCV Guideline test is a useful method for screening large cohorts in a routine clinical setting for determining the treatment regimen and for predicting the outcome of antiviral therapy of chronic hepatitis C. 展开更多
关键词 Hepatitis CVirus HCV Guideline test Viral load GENOTYPE
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Application of bi-directional static loading test to deep foundations 被引量:4
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作者 Guoliang Dai Weiming Gong 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE 2012年第3期269-275,共7页
Bi-directional static loading test adopting load cells is widely used around the world at present,with increase in diameter and length of deep foundations.In this paper,a new simple conversion method to predict the eq... Bi-directional static loading test adopting load cells is widely used around the world at present,with increase in diameter and length of deep foundations.In this paper,a new simple conversion method to predict the equivalent pile head load-settlement curve considering elastic shortening of deep foundation was put forward according to the load transfer mechanism.The proposed conversion method was applied to root caisson foundation in a bridge and to large diameter pipe piles in a sea wind power plant.Some new load cells,test procedure,and construction technology were adopted based on the applications to different deep foundations,which could enlarge the application scopes of bi-directional loading test.A new type of bi-directional loading test for pipe pile was conducted,in which the load cell was installed and loaded after the pipe pile with special connector has been set up.Unlike the conventional bi-directional loading test,the load cell can be reused and shows an evident economic benefit. 展开更多
关键词 deep foundations bi-directional static loading test root caisson foundation large diameter pipe pile
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Effects of water saturation and loading rate on direct shear tests of andesite 被引量:2
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作者 Tianshu Bao Kimihiro Hashiba Katsunori Fukui 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2022年第2期653-662,共10页
For estimating the long-term stability of underground framework,it is vital to learn the mechanical and rheological characteristics of rock in multiple water saturation conditions.However,the majority of previous stud... For estimating the long-term stability of underground framework,it is vital to learn the mechanical and rheological characteristics of rock in multiple water saturation conditions.However,the majority of previous studies explored the rheological properties of rock in air-dried and water saturated conditions,as well as the water effects on compressive and tensile strengths.In this study,andesite was subjected to direct shear tests under five water saturation conditions,which were controlled by varying the wetting and drying time.The tests were conducted at alternating displacement rates under three vertical stresses.The results reveal that the shear strength decreases exponentially as water saturation increases,and that the increase in shear strength with a tenfold increase in displacement rate is nearly constant for each of the vertical stresses.Based on the findings of the shear tests in this study and the compression and tension tests in previous studies,the influences of both water saturation and loading rate on the Hoek-Brown failure criterion for the andesite was examined.These results indicate that the brittleness index of the andesite,which is defined as the ratio of uniaxial compressive strength to tensile strength,is independent of both water saturation and loading rate and that the influences of the water saturation dependence and the loading rate dependence of the failure criterion can be converted between each other. 展开更多
关键词 Direct shear test Water saturation loading rate dependence Failure criterion
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Design and Experiment of Electronic-hydraulic Loading Test-bed Based on Tractor's Hydraulic Steering By-wire 被引量:1
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作者 Yue JIN Yang LU +3 位作者 Jiahui GONG Zhixiong LU Wenming LI Jungan WU 《Asian Agricultural Research》 2015年第12期86-89,共4页
An Electro-hydraulic loading system is designed based on a test-bed of tractor's hydraulic steering by-wire. To simulate the steering resistance driving tractor in many kinds of soils and roads,the loading force i... An Electro-hydraulic loading system is designed based on a test-bed of tractor's hydraulic steering by-wire. To simulate the steering resistance driving tractor in many kinds of soils and roads,the loading force is controlled to make proportional and continuous variable by an electro-hydraulic proportional relief valve. A steering resistance loading test-bed is built to test three kinds of steering resistance including constant,step and sine style. Tire lateral resistance is also tested under different steering conditions. The result shows that the electro-hydraulic loading system has high stability and following performance. Besides,the system's steady state error is lower than 3. 1%,and it meets the test requirement of tractor's hydraulic steering by-wire. 展开更多
关键词 TRACTOR Hydraulic steering by-wire loading system ELECTRO-HYDRAULIC proportional RELIEF valve BENCH test
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Load Transfer Test of Post-Tensioned Anchorage Zone in Ultra High Performance Concrete 被引量:2
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作者 Jee-Sang Kim Changbin Joh Yoon-Seok Choi 《Engineering(科研)》 2015年第3期115-128,共14页
Researches on ultra-high performance concrete (UHPC) have been conducted worldwide owing to its outstanding durability and strength performances. The exploitation of the mechanical properties of UHPC will render it po... Researches on ultra-high performance concrete (UHPC) have been conducted worldwide owing to its outstanding durability and strength performances. The exploitation of the mechanical properties of UHPC will render it possible to achieve economic design through substantial reduction in the cross sectional dimensions and simplification in the reinforcement arrangement. This paper investigates experimentally the load transfer in the prestressed concrete anchorage zone. To provide distinctive features of UHPC compared to ordinary concrete, the cross sectional dimensions of the member were reduced and the stress distribution, deformation and cracking pattern of the PS anchorage zone were examined experimentally according to the degree of reinforcement of the members chosen. The distributions of the bursting stress, spalling stress and longitudinal edge stress in the specimens were observed according to the various types of reinforcement. All the specimens satisfied the load-bearing capacity criterion specified by the European ETAG-013 guidelines and their stress distributions were similar to those in the PS anchorages of post-tensioned members applying ordinary concrete. The cracks propagated longitudinally with lengths up to twice the cross sectional dimensions and their width was smaller than when applying ordinary concrete owing to the bridging effect of the steel fibers in UHPC. Accordingly, the exploitation of the high strength of UHPC enabled us to secure the resistance of the anchorage with no need for particular reinforcing devices. 展开更多
关键词 UHPC PS ANCHORAGE Zone load Transfer test BURSTING FORCE SPLITTING FORCE
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A method for predicting critical load evaluating adhesion of coatings in scratch testing 被引量:1
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作者 陈溪芳 严密 +1 位作者 杨德人 HIROSEYukio 《Journal of Zhejiang University Science》 CSCD 2003年第6期709-713,共5页
In this paper based on the experiment principle of evaluating adhesion property by scratch testing, the peeling mechanism of thin films is discussed by applying contact theory and surface physics theory. A mathematica... In this paper based on the experiment principle of evaluating adhesion property by scratch testing, the peeling mechanism of thin films is discussed by applying contact theory and surface physics theory. A mathematical model predicting the critical load is proposed for calculating critical load as determined byscratch testing. The factors for correctly evaluating adhesion of coatings according to the experimental data arediscussed. 展开更多
关键词 COATING ADHESION Scratch testing Critical load prediction
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An innovative test method for mechanical properties of sandstone under instantaneous unloading confining pressure 被引量:1
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作者 Xuesheng Liu Shenglong Yang +3 位作者 Yunliang Tan Jun Wang Xuebin Li Yu Zhang 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第12期1677-1692,共16页
With the increase of underground engineering construction depth,the phenomenon of surrounding rock sudden failure caused by supporting structure failure occurs frequently.The conventional unloading con-fining pressure... With the increase of underground engineering construction depth,the phenomenon of surrounding rock sudden failure caused by supporting structure failure occurs frequently.The conventional unloading con-fining pressure(CUCP)test cannot simulate the plastic yielding and instantaneous unloading process of supporting structure to rock.Thus,a high stress loading-instantaneous unloading confining pressure(HSL-IUCP)test method was proposed and applied by considering bolt’s fracture under stress.The wall thickness of confining pressure plates and the material of bolts were changed to realize different confin-ing pressure loading stiffness(CPLS)and lateral maximum allowable deformation(LMAD).The superio-rity of HSL-ICPU method is verified compared with CUCP.The rock failure mechanism caused by sudden failure of supporting structure is obtained.The results show that when CPLS increases from 1.35 to 2.33 GN/m,rock’s peak strength and elastic modulus increase by 25.18%and 23.70%,respectively.The fracture characteristics change from tensile failure to tensile-shear mixed failure.When LMAD decreases from 0.40 to 0.16 mm,rock’s residual strength,peak strain,and residual strain decrease by 91.80%,16.94%,and 21.92%,respectively,and post-peak drop modulus increases by 140.47%.The test results obtained by this method are closer to rock’s real mechanical response characteristics compared with CUCP. 展开更多
关键词 High stress Instantaneous unloading confining pressure test method Confining pressure loading stiffness Lateral maximum allowable deformation Rock properties
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