Three-dimensional(3D)shape registration is a challenging problem,especially for shapes under non-rigid transformations.In this paper,a 3D non-rigid shape registration method is proposed,called balanced functional maps...Three-dimensional(3D)shape registration is a challenging problem,especially for shapes under non-rigid transformations.In this paper,a 3D non-rigid shape registration method is proposed,called balanced functional maps(BFM).The BFM algorithm generalizes the point-based correspondence to functions.By choosing the Laplace-Beltrami eigenfunctions as the function basis,the transformations between shapes can be represented by the functional map(FM)matrix.In addition,many constraints on shape registration,such as the feature descriptor,keypoint,and salient region correspondence,can be formulated linearly using the matrix.By bi-directionally searching for the nearest neighbors of points’indicator functions in the function space,the point-based correspondence can be derived from FMs.We conducted several experiments on the Topology and Orchestration Specification for Cloud Applications(TOSCA)dataset and the Shape Completion and Animation of People(SCAPE)dataset.Experimental results show that the proposed BFM algorithm is effective and has superior performance than the state-of-the-art methods on both datasets.展开更多
Mutual information has currently been one of the most intensivelyresearched measures. It has been proven to be accurate and effective registrationmeasure. Despite the general promising results, mutual information some...Mutual information has currently been one of the most intensivelyresearched measures. It has been proven to be accurate and effective registrationmeasure. Despite the general promising results, mutual information sometimes mightlead to misregistration because of neglecting spatial information and treating intensityvariations with undue sensitivity. In this paper, an extension of mutual informationframework was proposed in which higher-order spatial information regarding imagestructures was incorporated into the registration processing of PET and MR. Thesecond-order estimate of mutual information algorithm was applied to the registrationof seven patients. Evaluation from Vanderbilt University and our visual inspectionshowed that sub-voxel accuracy and robust results were achieved in all cases withsecond-order mutual information as the similarity measure and with Powell's multi-dimensional direction set method as optimization strategy.展开更多
Three-dimensional(3D)urban structures play a critical role in informing climate mitigation strategies aimed at the built environment and facilitating sustainable urban development.Regrettably,there exists a significan...Three-dimensional(3D)urban structures play a critical role in informing climate mitigation strategies aimed at the built environment and facilitating sustainable urban development.Regrettably,there exists a significant gap in detailed and consistent data on 3D building space structures with global coverage due to the challenges inherent in the data collection and model calibration processes.In this study,we constructed a global urban structure(GUS-3D)dataset,including building volume,height,and footprint information,at a 500 m spatial resolution using extensive satellite observation products and numerous reference building samples.Our analysis indicated that the total volume of buildings worldwide in2015 exceeded 1×10^(12)m^(3).Over the 1985 to 2015 period,we observed a slight increase in the magnitude of 3D building volume growth(i.e.,it increased from 166.02 km3 during the 1985–2000 period to 175.08km3 during the 2000–2015 period),while the expansion magnitudes of the two-dimensional(2D)building footprint(22.51×10^(3) vs 13.29×10^(3)km^(2))and urban extent(157×10^(3) vs 133.8×10^(3)km^(2))notably decreased.This trend highlights the significant increase in intensive vertical utilization of urban land.Furthermore,we identified significant heterogeneity in building space provision and inequality across cities worldwide.This inequality is particularly pronounced in many populous Asian cities,which has been overlooked in previous studies on economic inequality.The GUS-3D dataset shows great potential to deepen our understanding of the urban environment and creates new horizons for numerous 3D urban studies.展开更多
To address the problem of multi-missile cooperative interception against maneuvering targets at a prespecified impact time and desired Line-of-Sight(LOS)angles in ThreeDimensional(3D)space,this paper proposes a 3D lea...To address the problem of multi-missile cooperative interception against maneuvering targets at a prespecified impact time and desired Line-of-Sight(LOS)angles in ThreeDimensional(3D)space,this paper proposes a 3D leader-following cooperative interception guidance law.First,in the LOS direction of the leader,an impact time-controlled guidance law is derived based on the fixed-time stability theory,which enables the leader to complete the interception task at a prespecified impact time.Next,in the LOS direction of the followers,by introducing a time consensus tracking error function,a fixed-time consensus tracking guidance law is investigated to guarantee the consensus tracking convergence of the time-to-go.Then,in the direction normal to the LOS,by combining the designed global integral sliding mode surface and the second-order Sliding Mode Control(SMC)theory,an innovative 3D LOS-angle-constrained interception guidance law is developed,which eliminates the reaching phase in the traditional sliding mode guidance laws and effectively saves energy consumption.Moreover,it effectively suppresses the chattering phenomenon while avoiding the singularity issue,and compensates for unknown interference caused by target maneuvering online,making it convenient for practical engineering applications.Finally,theoretical proof analysis and multiple sets of numerical simulation results verify the effectiveness,superiority,and robustness of the investigated guidance law.展开更多
Liposarcoma is one of the most common soft tissue sarcomas,however,its occurrence rate is still rare compared to other cancers.Due to its rarity,in vitro experiments are an essential approach to elucidate liposarcoma ...Liposarcoma is one of the most common soft tissue sarcomas,however,its occurrence rate is still rare compared to other cancers.Due to its rarity,in vitro experiments are an essential approach to elucidate liposarcoma pathobiology.Conventional cell culture-based research(2D cell culture)is still playing a pivotal role,while several shortcomings have been recently under discussion.In vivo,mouse models are usually adopted for pre-clinical analyses with expectations to overcome the issues of 2D cell culture.However,they do not fully recapitulate human dedifferentiated liposarcoma(DDLPS)characteristics.Therefore,three-dimensional(3D)culture systems have been the recent research focus in the cell biology field with the expectation to overcome at the same time the disadvantages of 2D cell culture and in vivo animal models and fill in the gap between them.Given the liposarcoma rarity,we believe that 3D cell culture techniques,including 3D cell cultures/co-cultures,and Patient-Derived tumor Organoids(PDOs),represent a promising approach to facilitate liposarcoma investigation and elucidate its molecular mechanisms and effective therapy development.In this review,we first provide a general overview of 3D cell cultures compared to 2D cell cultures.We then focus on one of the recent 3D cell culture applications,Patient-Derived Organoids(PDOs),summarizing and discussing several PDO methodologies.Finally,we discuss the current and future applications of PDOs to sarcoma,particularly in the field of liposarcoma.展开更多
The development of minimally invasive surgery has transformed the management of gastrointestinal cancer.Notably,three-dimensional visualization systems have increased surgical precision.This editorial discusses a rece...The development of minimally invasive surgery has transformed the management of gastrointestinal cancer.Notably,three-dimensional visualization systems have increased surgical precision.This editorial discusses a recent study by Shen and Zhang,which compared the clinical applications of naked-eye threedimensional laparoscopic systems vs traditional optical systems in radical surgery for gastric and colorectal cancer.Both systems appeared to yield comparable surgical and oncological outcomes in terms of safety parameters,operating times,and quality of lymph node dissection.However,the spectacle-free system’s technical and logistical limitations hindered its effects on the surgical team’s overall competency.This editorial examines the authors’findings within the broader context of the evolution of oncologic laparoscopy,discusses the relevance of the results in light of the current literature,and proposes future research directions focused on multicenter validation,comprehensive ergonomic analysis,and technological advancements aimed at enhancing intraoperative collaboration.As technology continues to evolve,clinical implementation of new methods must be supported by robust scientific evidence and standardized criteria,to ensure tangible improvements in efficiency,safety,and oncologic outcomes.展开更多
This study summarizes the examination data of registration labels for ordinary cosmetics in Beijing from May 2021 to April 2024.It analyzes and categorizes the issues identified during label evaluations,explores the u...This study summarizes the examination data of registration labels for ordinary cosmetics in Beijing from May 2021 to April 2024.It analyzes and categorizes the issues identified during label evaluations,explores the underlying causes,and proposes regulatory countermeasures and recommendations for registrants,regulatory authorities,and social organizations.The objective is to offer practical insights and regulatory guidance to support the enhancement of cosmetic registration and regulatory standards.展开更多
Objective To put forward some suggestions for improving the registration and regulation,the efficiency of evaluation,and approval of biosimilar in China so as to promote the development of biopharmaceutical industry a...Objective To put forward some suggestions for improving the registration and regulation,the efficiency of evaluation,and approval of biosimilar in China so as to promote the development of biopharmaceutical industry and increase the accessibility of therapeutic drugs in China.Methods Literature related to the registration and regulation,evaluation and approval of biosimilars were sorted out to analyze the differences in China and the USA.Results and Conclusion Based on the analysis of the current situation of registration and regulation of biosimilars between China and the USA,it is suggested to improve the registration and regulation of biosimilars in China from the following four aspects:Establishing a biosimilar regulatory department,expanding the professional evaluation personnel,scientifically simplifying the registration and approval procedures,and constantly refining the types of communication meetings.展开更多
Objective To provide a theoretical basis for the adjustment of the registration classification of China’s biological products,and to establish a continuously improved registration classification system.Methods Based ...Objective To provide a theoretical basis for the adjustment of the registration classification of China’s biological products,and to establish a continuously improved registration classification system.Methods Based on literature research,the specific classification methods,classification principles and considerations of biological registration in China,the United States and the European Union were studied to form a complete comparative analysis.Results and Conclusion It is recommended that the division between therapeutic and preventive use should be removed from the registration classification of biologics.The therapeutic,preventive and diagnostic use of the product should be limited as part of the product specification,and the registration should be classified according to the development of biotechnology,innovation,modification and bio-similar drugs.In addition,the supervision of registration of advanced therapeutic products should be different from that of traditional biologics.展开更多
The three-dimensional particle electrode system exhibits significant potential for application in the treatment of wastewater.Nonetheless,the advancement of effective granular electrodes characterized by elevated cata...The three-dimensional particle electrode system exhibits significant potential for application in the treatment of wastewater.Nonetheless,the advancement of effective granular electrodes characterized by elevated catalytic activity and minimal energy consumption continues to pose a significant challenge.In this research,Fluorine-doped copper-carbon(F/Cu-GAC)particle electrodes were effectively synthesized through an impregnationcalcination technique,utilizing granular activated carbon as the carrier and fluorinedoped modified copper oxides as the catalytic agents.The particle electrodes were subsequently utilized to promote the degradation of 2,4,6-trichlorophenol(2,4,6-TCP)in a threedimensional electrocatalytic reactor(3DER).The F/Cu-GAC particle electrodes were polarized under the action of electric field,which promoted the heterogeneous Fenton-like reaction in which H2O2 generated by two-electron oxygen reduction reaction(2e-ORR)of O_(2) was catalytically decomposed to·OH.The 3DER equipped with F/Cu-GAC particle electrodes showed 100%removal of 2,4,6-TCP and 79.24%removal of TOC with a specific energy consumption(EC)of approximately 0.019 kWh/g·COD after 2 h of operation.The F/Cu-GAC particle electrodes exhibited an overpotential of 0.38 V and an electrochemically active surface area(ECSA)of 715 cm^(2),as determined through linear sweep voltammetry(LSV)and cyclic voltammetry(CV)assessments.These findings suggest a high level of electrocatalytic performance.Furthermore,the catalytic mechanism of the 3DER equipped with F/Cu-GAC particle electrodes was elucidated through the application of X-ray photoelectron spectroscopy(XPS),electron spin resonance(ESR),and active species capture experiments.This investigation offers a novel approach for the effective degradation of 2,4,6-TCP.展开更多
Background:Modern acupuncture anesthesia is a combination of Chinese and Western medicine that integrates the theories of acupuncture with anesthesia.However,some clinical studies of acupuncture anesthesia lack specif...Background:Modern acupuncture anesthesia is a combination of Chinese and Western medicine that integrates the theories of acupuncture with anesthesia.However,some clinical studies of acupuncture anesthesia lack specific descriptions of randomization,allocation concealment,and blinding processes,with subsequent systematic reviews indicating a risk of bias.Objective:Clinical trial registration is essential for the enhancement of the quality of clinical trials.This study aims to summarize the status of clinical trial registrations for acupuncture anesthesia listed on the World Health Organization International Clinical Trials Registry Platform(ICTRP).Search strategy:We searched the ICTRP for clinical trials related to acupuncture anesthesia registered between January 1,2001 and May 31,2023.Additionally,related publications were retrieved from PubMed,Cochrane Library,Embase,China National Knowledge Infrastructure,China Science and Technology Journal Database,and Wanfang Data.Registrations and publications were analyzed for consistency in trial design characteristics.Inclusion criteria:Clinical trials that utilized one of several acupuncture-related therapies in combination with pharmacological anesthesia during the perioperative period were eligible for this review.Data extraction and analysis:Data extracted from articles included type of surgical procedure,perioperative symptoms,study methodology,type of intervention,trial recruitment information,and publication information related to clinical enrollment.Results:A total of 166 trials related to acupuncture anesthesia from 21 countries were included in the analysis.The commonly reported symptoms in the included studies were postoperative nausea and vomiting(19.9%)and postoperative pain(13.3%).The concordance between the publications and the trial protocols in the clinical registry records was poor,with only 31.7%of the studies being fully compatible.Inconsistency rates were high for sample size(39.0%,16/41),blinding(36.6%,15/41),and secondary outcome indicators(24.4%,10/41).Conclusion:The volume of acupuncture anesthesia clinical trials registered in international trial registries over the last 20 years is low,with insufficient disclosure of results.Postoperative nausea and vomiting as well as postoperative pain,are the most investigated for acupuncture intervention.展开更多
Robot-assisted surgery has become an indispensable component in modern neurosurgical procedures.However,existing registration methods for neurosurgical robots often rely on high-end hardware and involve prolonged or u...Robot-assisted surgery has become an indispensable component in modern neurosurgical procedures.However,existing registration methods for neurosurgical robots often rely on high-end hardware and involve prolonged or unstable registration times,limiting their applicability in dynamic and time-sensitive intraoperative settings.This paper proposes a novel fully automatic monocular-based registration and real-time tracking method.First,dedicated fiducials are designed,and an automatic preoperative and intraoperative detection method for these fiducials is introduced.Second,a geometric representation of the fiducials is constructed based on a 2D KD-Tree.Through a two-stage optimization process,the depth of 2D fiducials is estimated,and 2D-3D correspondences are established to achieve monocular registration.This approach enables fully automatic intraoperative registration using only a single optical camera.Finally,a six-degree-of-freedom visual servo control strategy inspired by the mass-spring-damper system is proposed.By integrating artificial potential field and admittance control,the strategy ensures real-time responsiveness and stable tracking.Experimental results demonstrate that the proposed method achieves a registration time of 0.23 s per instance with an average error of 0.58 mm.Additionally,the motion performance of the control strategy has been validated.Preliminary experiments verify the effectiveness of MonoTracker in dynamic tracking scenarios.This method holds promise for enhancing the adaptability of neurosurgical robots and offers significant clinical application potential.展开更多
The geolocation of ground targets by airborne image sensors is an important task for unmanned aerial vehicles or surveillance aircraft.This paper proposes an Iterative Geolocation based on Cross-view Image Registratio...The geolocation of ground targets by airborne image sensors is an important task for unmanned aerial vehicles or surveillance aircraft.This paper proposes an Iterative Geolocation based on Cross-view Image Registration(IGCIR)that can provide real-time target location results with high precision.The proposed method has two key features.First,a cross-view image registration process is introduced,including a projective transformation and a two-stage multi-sensor registration.This process utilizes both gradient information and phase information of cross-view images.This allows the registration process to reach a good balance between matching precision and computational efficiency.By matching the airborne camera view to the preloaded digital map,the geolocation accuracy can reach the accuracy level of the digital map for any ground target appearing in the airborne camera view.Second,the proposed method uses the registration results to perform an iteration process,which compensates for the bias of the strap-down initial navigation module online.Although it is challenging to provide cross-view registration results with high frequency,such an iteration process allows the method to generate real-time,highly accurate location results.The effectiveness of the proposed IGCIR method is verified by a series of flying-test experiments.The results show that the location accuracy of the method can reach 4.18 m(at 10 km standoff distance).展开更多
In this study,CiteSpace software is used to carry out visual analysis on the three-dimensional research literature on urban recreation space from the perspective of compact city theory in the past 20 years,exploring t...In this study,CiteSpace software is used to carry out visual analysis on the three-dimensional research literature on urban recreation space from the perspective of compact city theory in the past 20 years,exploring the scientific development trend and research hotspots in this field.The results show that the number of published documents shows a fluctuating upward trend,and the significant growth rate reflects the role of policy orientation in promoting the concept of compact city.The co-occurrence analysis of keywords reveals the research hotspots of“compact city”,“recreation space”and“urban park”,while the emergence of new keywords such as“vertical city”and“spatial justice”indicates the new trend of recent research.The cluster analysis and timeline map further show the evolution of research themes,with“compact city”being the largest cluster and having rich connections with other themes such as“urban design”and“urban park”.展开更多
This paper aims to develop a nonrigid registration method of preoperative and intraoperative thoracoabdominal CT images in computer-assisted interventional surgeries for accurate tumor localization and tissue visualiz...This paper aims to develop a nonrigid registration method of preoperative and intraoperative thoracoabdominal CT images in computer-assisted interventional surgeries for accurate tumor localization and tissue visualization enhancement.However,fine structure registration of complex thoracoabdominal organs and large deformation registration caused by respiratory motion is challenging.To deal with this problem,we propose a 3D multi-scale attention VoxelMorph(MAVoxelMorph)registration network.To alleviate the large deformation problem,a multi-scale axial attention mechanism is utilized by using a residual dilated pyramid pooling for multi-scale feature extraction,and position-aware axial attention for long-distance dependencies between pixels capture.To further improve the large deformation and fine structure registration results,a multi-scale context channel attention mechanism is employed utilizing content information via adjacent encoding layers.Our method was evaluated on four public lung datasets(DIR-Lab dataset,Creatis dataset,Learn2Reg dataset,OASIS dataset)and a local dataset.Results proved that the proposed method achieved better registration performance than current state-of-the-art methods,especially in handling the registration of large deformations and fine structures.It also proved to be fast in 3D image registration,using about 1.5 s,and faster than most methods.Qualitative and quantitative assessments proved that the proposed MA-VoxelMorph has the potential to realize precise and fast tumor localization in clinical interventional surgeries.展开更多
To provide reference for the prevention and control of diseases,pests,and weeds on Zanthoxylum bungeanum Maxim.and the research and development of new pesticide registrations,this paper analyzes the quantity,variety s...To provide reference for the prevention and control of diseases,pests,and weeds on Zanthoxylum bungeanum Maxim.and the research and development of new pesticide registrations,this paper analyzes the quantity,variety structure,dosage forms,and toxicity of pesticides registered on Z.bungeanum in China.The analysis reveals a relatively low quantity of pesticide registrations on Z.bungeanum,with no herbicide registrations;suspension concentrates dominate the dosage forms,and pesticide toxicity is classified as low-toxicity or micro-toxicity;registered pesticides target only rust,anthracnose,scale insects,aphids,and spider mites,while plant growth regulators solely involve growth regulation and shoot control.Given the current status of limited and incomplete pesticide registrations targeting major diseases,pests,and weeds on Z.bungeanum,severe product homogenization,and unknown maximum residue limits,it is recommended to intensify efforts in pesticide registration on Z.bungeanum,actively research and apply green control technologies,strengthen technical training guidance and pesticide supervision enforcement,to promote the healthy development of the industry.展开更多
BACKGROUND Ganglioneuroma is a rare,well-differentiated,slow-growing benign tumor of the peripheral nerves,with surgical resection being the only curative treatment.Surgical resection of ganglioneuromas encasing major...BACKGROUND Ganglioneuroma is a rare,well-differentiated,slow-growing benign tumor of the peripheral nerves,with surgical resection being the only curative treatment.Surgical resection of ganglioneuromas encasing major blood vessels remains a substantial clinical challenge.Traditionally,these cases often require open abdominal surgery or combined organ resections,and in some instances,the tumors are considered unresectable.Currently,no reports have described the resection of such tumors via laparoscopy.CASE SUMMARY A 35-year-old woman was admitted to our hospital after the incidental discovery of a retroperitoneal space-occupying lesion.Imaging revealed a mass with the celiac axis and superior mesenteric artery passing through it.A neurogenic tumor was suspected,with ganglioneuroma being the most likely diagnosis.Following comprehensive preoperative preparation,the retroperitoneal tumor was resected using a three-dimensional laparoscopy combined with an organ suspension technique.The surgical approach involved incising the tumor along the vascular axis and conducting meticulous,vascular-preserving tumor excision.The operation lasted approximately 458 minutes,with an estimated blood loss of 50 mL.The patient was discharged on the 8th postoperative day.A transient liver injury occurred after surgery but improved rapidly.After 11 months of postoperative follow-up,no complications or tumor recurrence were observed.CONCLUSION This case illustrates the feasibility of minimally invasive laparoscopic resection for retroperitoneal ganglioneuromas encasing major blood vessels.展开更多
Thermal metamaterial represents a groundbreaking approach to control heat conduction,and,as a crucial component,thermal invisibility is of utmost importance for heat management.Despite the flourishing development of t...Thermal metamaterial represents a groundbreaking approach to control heat conduction,and,as a crucial component,thermal invisibility is of utmost importance for heat management.Despite the flourishing development of thermal invisibility schemes,they still face two limitations in practical applications.First,objects are typically completely enclosed in traditional cloaks,making them difficult to use and unsuitable for objects with heat sources.Second,although some theoretical proposals have been put forth to change the thermal conductivity of materials to achieve dynamic invisibility,their designs are complex and rigid,making them unsuitable for large-scale use in real threedimensional(3D)spaces.Here,we propose a concept of a thermal dome to achieve 3D invisibility.Our scheme includes an open functional area,greatly enhancing its usability and applicability.It features a reconfigurable structure,constructed with simple isotropic natural materials,making it suitable for dynamic requirements.The performance of our reconfigurable thermal dome has been confirmed through simulations and experiments,consistent with the theory.The introduction of this concept can greatly advance the development of thermal invisibility technology from theory to engineering and provide inspiration for other physical domains,such as direct current electric fields and magnetic fields.展开更多
The three-dimensional spectral analysis method was applied to airglow data from September 2023 to August 2024 derivedfrom an OH airglow imager located at the Hejing station (42.79°N, 83.73°E) to study the pr...The three-dimensional spectral analysis method was applied to airglow data from September 2023 to August 2024 derivedfrom an OH airglow imager located at the Hejing station (42.79°N, 83.73°E) to study the propagation characteristics of gravity waves(GWs) over Northwest China. We found that obvious seasonal variations occur in the propagation of GWs. In spring, GWs mainlypropagate in the northeast direction. In summer and autumn, GWs mainly propagate in the north direction. However, GWs mainlypropagate in the south direction in winter. The direction of GW propagation in the zonal direction is controlled by the wind-filteringeffect, whereas the north–south meridional direction is mainly determined by the location of the wave source. We found that the averageenergy spectrum exhibits a 10%–20% higher intensity in summer and winter compared with spring and autumn. For the first time, wereport the seasonal variation characteristics of GWs over the inland areas of Northwest China, which is of great significance forunderstanding the regional distribution characteristics of GWs.展开更多
Internal multiples are commonly present in seismic data due to variations in velocity or density of subsurface media.They can reduce the signal-to-noise ratio of seismic data and degrade the quality of the image.With ...Internal multiples are commonly present in seismic data due to variations in velocity or density of subsurface media.They can reduce the signal-to-noise ratio of seismic data and degrade the quality of the image.With the development of seismic exploration into deep and ultradeep events,especially those from complex targets in the western region of China,the internal multiple eliminations become increasingly challenging.Currently,three-dimensional(3D)seismic data are primarily used for oil and gas target recognition and drilling.Effectively eliminating internal multiples in 3D seismic data of complex structures and mitigating their adverse effects is crucial for enhancing the success rate of drilling.In this study,we propose an internal multiple prediction algorithm for 3D seismic data in complex structures using the Marchenko autofocusing theory.This method can predict the accurate internal multiples of time difference without an accurate velocity model and the implementation process mainly consists of several steps.Firstly,simulating direct waves with a 3D macroscopic velocity model.Secondly,using direct waves and 3D full seismic acquisition records to obtain the upgoing and down-going Green's functions between the virtual source point and surface.Thirdly,constructing internal multiples of the relevant layers by upgoing and downgoing Green's functions.Finally,utilizing the adaptive matching subtraction method to remove predicted internal multiples from the original data to obtain seismic records without multiples.Compared with the two-dimensional(2D)Marchenko algo-rithm,the performance of the 3D Marchenko algorithm for internal multiple prediction has been significantly enhanced,resulting in higher computational accuracy.Numerical simulation test results indicate that our proposed method can effectively eliminate internal multiples in 3D seismic data,thereby exhibiting important theoretical and industrial application value.展开更多
基金the China Scholarship Council under Grant No.201406070059.
文摘Three-dimensional(3D)shape registration is a challenging problem,especially for shapes under non-rigid transformations.In this paper,a 3D non-rigid shape registration method is proposed,called balanced functional maps(BFM).The BFM algorithm generalizes the point-based correspondence to functions.By choosing the Laplace-Beltrami eigenfunctions as the function basis,the transformations between shapes can be represented by the functional map(FM)matrix.In addition,many constraints on shape registration,such as the feature descriptor,keypoint,and salient region correspondence,can be formulated linearly using the matrix.By bi-directionally searching for the nearest neighbors of points’indicator functions in the function space,the point-based correspondence can be derived from FMs.We conducted several experiments on the Topology and Orchestration Specification for Cloud Applications(TOSCA)dataset and the Shape Completion and Animation of People(SCAPE)dataset.Experimental results show that the proposed BFM algorithm is effective and has superior performance than the state-of-the-art methods on both datasets.
基金The images and the standard transformation were provided as part of the project,"Retrospective Im-age Registration Evaluation"(National Institutes of Health,1 R01 CA89323),the principal investigator,J.Michael Fitzpatrick,Vanderbilt Universi
文摘Mutual information has currently been one of the most intensivelyresearched measures. It has been proven to be accurate and effective registrationmeasure. Despite the general promising results, mutual information sometimes mightlead to misregistration because of neglecting spatial information and treating intensityvariations with undue sensitivity. In this paper, an extension of mutual informationframework was proposed in which higher-order spatial information regarding imagestructures was incorporated into the registration processing of PET and MR. Thesecond-order estimate of mutual information algorithm was applied to the registrationof seven patients. Evaluation from Vanderbilt University and our visual inspectionshowed that sub-voxel accuracy and robust results were achieved in all cases withsecond-order mutual information as the similarity measure and with Powell's multi-dimensional direction set method as optimization strategy.
基金supported by the National Science Fund for Distinguished Young Scholars(42225107)the National Natural Science Foundation of China(42001326,42371414,42171409,and 42271419)+1 种基金the Natural Science Foundation of Guangdong Province of China(2022A1515012207)the Basic and Applied Basic Research Project of Guangzhou Science and Technology Planning(202201011539)。
文摘Three-dimensional(3D)urban structures play a critical role in informing climate mitigation strategies aimed at the built environment and facilitating sustainable urban development.Regrettably,there exists a significant gap in detailed and consistent data on 3D building space structures with global coverage due to the challenges inherent in the data collection and model calibration processes.In this study,we constructed a global urban structure(GUS-3D)dataset,including building volume,height,and footprint information,at a 500 m spatial resolution using extensive satellite observation products and numerous reference building samples.Our analysis indicated that the total volume of buildings worldwide in2015 exceeded 1×10^(12)m^(3).Over the 1985 to 2015 period,we observed a slight increase in the magnitude of 3D building volume growth(i.e.,it increased from 166.02 km3 during the 1985–2000 period to 175.08km3 during the 2000–2015 period),while the expansion magnitudes of the two-dimensional(2D)building footprint(22.51×10^(3) vs 13.29×10^(3)km^(2))and urban extent(157×10^(3) vs 133.8×10^(3)km^(2))notably decreased.This trend highlights the significant increase in intensive vertical utilization of urban land.Furthermore,we identified significant heterogeneity in building space provision and inequality across cities worldwide.This inequality is particularly pronounced in many populous Asian cities,which has been overlooked in previous studies on economic inequality.The GUS-3D dataset shows great potential to deepen our understanding of the urban environment and creates new horizons for numerous 3D urban studies.
文摘To address the problem of multi-missile cooperative interception against maneuvering targets at a prespecified impact time and desired Line-of-Sight(LOS)angles in ThreeDimensional(3D)space,this paper proposes a 3D leader-following cooperative interception guidance law.First,in the LOS direction of the leader,an impact time-controlled guidance law is derived based on the fixed-time stability theory,which enables the leader to complete the interception task at a prespecified impact time.Next,in the LOS direction of the followers,by introducing a time consensus tracking error function,a fixed-time consensus tracking guidance law is investigated to guarantee the consensus tracking convergence of the time-to-go.Then,in the direction normal to the LOS,by combining the designed global integral sliding mode surface and the second-order Sliding Mode Control(SMC)theory,an innovative 3D LOS-angle-constrained interception guidance law is developed,which eliminates the reaching phase in the traditional sliding mode guidance laws and effectively saves energy consumption.Moreover,it effectively suppresses the chattering phenomenon while avoiding the singularity issue,and compensates for unknown interference caused by target maneuvering online,making it convenient for practical engineering applications.Finally,theoretical proof analysis and multiple sets of numerical simulation results verify the effectiveness,superiority,and robustness of the investigated guidance law.
文摘Liposarcoma is one of the most common soft tissue sarcomas,however,its occurrence rate is still rare compared to other cancers.Due to its rarity,in vitro experiments are an essential approach to elucidate liposarcoma pathobiology.Conventional cell culture-based research(2D cell culture)is still playing a pivotal role,while several shortcomings have been recently under discussion.In vivo,mouse models are usually adopted for pre-clinical analyses with expectations to overcome the issues of 2D cell culture.However,they do not fully recapitulate human dedifferentiated liposarcoma(DDLPS)characteristics.Therefore,three-dimensional(3D)culture systems have been the recent research focus in the cell biology field with the expectation to overcome at the same time the disadvantages of 2D cell culture and in vivo animal models and fill in the gap between them.Given the liposarcoma rarity,we believe that 3D cell culture techniques,including 3D cell cultures/co-cultures,and Patient-Derived tumor Organoids(PDOs),represent a promising approach to facilitate liposarcoma investigation and elucidate its molecular mechanisms and effective therapy development.In this review,we first provide a general overview of 3D cell cultures compared to 2D cell cultures.We then focus on one of the recent 3D cell culture applications,Patient-Derived Organoids(PDOs),summarizing and discussing several PDO methodologies.Finally,we discuss the current and future applications of PDOs to sarcoma,particularly in the field of liposarcoma.
文摘The development of minimally invasive surgery has transformed the management of gastrointestinal cancer.Notably,three-dimensional visualization systems have increased surgical precision.This editorial discusses a recent study by Shen and Zhang,which compared the clinical applications of naked-eye threedimensional laparoscopic systems vs traditional optical systems in radical surgery for gastric and colorectal cancer.Both systems appeared to yield comparable surgical and oncological outcomes in terms of safety parameters,operating times,and quality of lymph node dissection.However,the spectacle-free system’s technical and logistical limitations hindered its effects on the surgical team’s overall competency.This editorial examines the authors’findings within the broader context of the evolution of oncologic laparoscopy,discusses the relevance of the results in light of the current literature,and proposes future research directions focused on multicenter validation,comprehensive ergonomic analysis,and technological advancements aimed at enhancing intraoperative collaboration.As technology continues to evolve,clinical implementation of new methods must be supported by robust scientific evidence and standardized criteria,to ensure tangible improvements in efficiency,safety,and oncologic outcomes.
文摘This study summarizes the examination data of registration labels for ordinary cosmetics in Beijing from May 2021 to April 2024.It analyzes and categorizes the issues identified during label evaluations,explores the underlying causes,and proposes regulatory countermeasures and recommendations for registrants,regulatory authorities,and social organizations.The objective is to offer practical insights and regulatory guidance to support the enhancement of cosmetic registration and regulatory standards.
文摘Objective To put forward some suggestions for improving the registration and regulation,the efficiency of evaluation,and approval of biosimilar in China so as to promote the development of biopharmaceutical industry and increase the accessibility of therapeutic drugs in China.Methods Literature related to the registration and regulation,evaluation and approval of biosimilars were sorted out to analyze the differences in China and the USA.Results and Conclusion Based on the analysis of the current situation of registration and regulation of biosimilars between China and the USA,it is suggested to improve the registration and regulation of biosimilars in China from the following four aspects:Establishing a biosimilar regulatory department,expanding the professional evaluation personnel,scientifically simplifying the registration and approval procedures,and constantly refining the types of communication meetings.
文摘Objective To provide a theoretical basis for the adjustment of the registration classification of China’s biological products,and to establish a continuously improved registration classification system.Methods Based on literature research,the specific classification methods,classification principles and considerations of biological registration in China,the United States and the European Union were studied to form a complete comparative analysis.Results and Conclusion It is recommended that the division between therapeutic and preventive use should be removed from the registration classification of biologics.The therapeutic,preventive and diagnostic use of the product should be limited as part of the product specification,and the registration should be classified according to the development of biotechnology,innovation,modification and bio-similar drugs.In addition,the supervision of registration of advanced therapeutic products should be different from that of traditional biologics.
基金supported by Guangxi Science and Technology Major Program(No.AA23073008)Hubei Key Laboratory of Water System Science for Sponge City Construction(Wuhan University)(No.2023–05)Nanning Innovation and Entrepreneur Leading Talent Project(No.2021001).
文摘The three-dimensional particle electrode system exhibits significant potential for application in the treatment of wastewater.Nonetheless,the advancement of effective granular electrodes characterized by elevated catalytic activity and minimal energy consumption continues to pose a significant challenge.In this research,Fluorine-doped copper-carbon(F/Cu-GAC)particle electrodes were effectively synthesized through an impregnationcalcination technique,utilizing granular activated carbon as the carrier and fluorinedoped modified copper oxides as the catalytic agents.The particle electrodes were subsequently utilized to promote the degradation of 2,4,6-trichlorophenol(2,4,6-TCP)in a threedimensional electrocatalytic reactor(3DER).The F/Cu-GAC particle electrodes were polarized under the action of electric field,which promoted the heterogeneous Fenton-like reaction in which H2O2 generated by two-electron oxygen reduction reaction(2e-ORR)of O_(2) was catalytically decomposed to·OH.The 3DER equipped with F/Cu-GAC particle electrodes showed 100%removal of 2,4,6-TCP and 79.24%removal of TOC with a specific energy consumption(EC)of approximately 0.019 kWh/g·COD after 2 h of operation.The F/Cu-GAC particle electrodes exhibited an overpotential of 0.38 V and an electrochemically active surface area(ECSA)of 715 cm^(2),as determined through linear sweep voltammetry(LSV)and cyclic voltammetry(CV)assessments.These findings suggest a high level of electrocatalytic performance.Furthermore,the catalytic mechanism of the 3DER equipped with F/Cu-GAC particle electrodes was elucidated through the application of X-ray photoelectron spectroscopy(XPS),electron spin resonance(ESR),and active species capture experiments.This investigation offers a novel approach for the effective degradation of 2,4,6-TCP.
基金supported by grants from Shanghai Municipal Health Commission and Shanghai Municipal Administration of TCM—Standardization of TCM in 2023“Clinical Practice Guide for Combined Acupuncture-Drug Anesthesia”(No.2023JS05)Shanghai Clinical Medical Research Center of Acupuncture and Moxibustion(No.20MC1920500)+1 种基金Shanghai master Chinese medicine practitioners academic experience research studio construction project(No.SHGZS-202212)Shanghai Key Clinical Specialties 2019 Accreditation Program(No.shslczdzk04701)。
文摘Background:Modern acupuncture anesthesia is a combination of Chinese and Western medicine that integrates the theories of acupuncture with anesthesia.However,some clinical studies of acupuncture anesthesia lack specific descriptions of randomization,allocation concealment,and blinding processes,with subsequent systematic reviews indicating a risk of bias.Objective:Clinical trial registration is essential for the enhancement of the quality of clinical trials.This study aims to summarize the status of clinical trial registrations for acupuncture anesthesia listed on the World Health Organization International Clinical Trials Registry Platform(ICTRP).Search strategy:We searched the ICTRP for clinical trials related to acupuncture anesthesia registered between January 1,2001 and May 31,2023.Additionally,related publications were retrieved from PubMed,Cochrane Library,Embase,China National Knowledge Infrastructure,China Science and Technology Journal Database,and Wanfang Data.Registrations and publications were analyzed for consistency in trial design characteristics.Inclusion criteria:Clinical trials that utilized one of several acupuncture-related therapies in combination with pharmacological anesthesia during the perioperative period were eligible for this review.Data extraction and analysis:Data extracted from articles included type of surgical procedure,perioperative symptoms,study methodology,type of intervention,trial recruitment information,and publication information related to clinical enrollment.Results:A total of 166 trials related to acupuncture anesthesia from 21 countries were included in the analysis.The commonly reported symptoms in the included studies were postoperative nausea and vomiting(19.9%)and postoperative pain(13.3%).The concordance between the publications and the trial protocols in the clinical registry records was poor,with only 31.7%of the studies being fully compatible.Inconsistency rates were high for sample size(39.0%,16/41),blinding(36.6%,15/41),and secondary outcome indicators(24.4%,10/41).Conclusion:The volume of acupuncture anesthesia clinical trials registered in international trial registries over the last 20 years is low,with insufficient disclosure of results.Postoperative nausea and vomiting as well as postoperative pain,are the most investigated for acupuncture intervention.
基金Supported by National Natural Science Foundation of China(Grant No.92148206).
文摘Robot-assisted surgery has become an indispensable component in modern neurosurgical procedures.However,existing registration methods for neurosurgical robots often rely on high-end hardware and involve prolonged or unstable registration times,limiting their applicability in dynamic and time-sensitive intraoperative settings.This paper proposes a novel fully automatic monocular-based registration and real-time tracking method.First,dedicated fiducials are designed,and an automatic preoperative and intraoperative detection method for these fiducials is introduced.Second,a geometric representation of the fiducials is constructed based on a 2D KD-Tree.Through a two-stage optimization process,the depth of 2D fiducials is estimated,and 2D-3D correspondences are established to achieve monocular registration.This approach enables fully automatic intraoperative registration using only a single optical camera.Finally,a six-degree-of-freedom visual servo control strategy inspired by the mass-spring-damper system is proposed.By integrating artificial potential field and admittance control,the strategy ensures real-time responsiveness and stable tracking.Experimental results demonstrate that the proposed method achieves a registration time of 0.23 s per instance with an average error of 0.58 mm.Additionally,the motion performance of the control strategy has been validated.Preliminary experiments verify the effectiveness of MonoTracker in dynamic tracking scenarios.This method holds promise for enhancing the adaptability of neurosurgical robots and offers significant clinical application potential.
基金supported by the National Level Project of China(No.52-L0D01-0613-20/22)。
文摘The geolocation of ground targets by airborne image sensors is an important task for unmanned aerial vehicles or surveillance aircraft.This paper proposes an Iterative Geolocation based on Cross-view Image Registration(IGCIR)that can provide real-time target location results with high precision.The proposed method has two key features.First,a cross-view image registration process is introduced,including a projective transformation and a two-stage multi-sensor registration.This process utilizes both gradient information and phase information of cross-view images.This allows the registration process to reach a good balance between matching precision and computational efficiency.By matching the airborne camera view to the preloaded digital map,the geolocation accuracy can reach the accuracy level of the digital map for any ground target appearing in the airborne camera view.Second,the proposed method uses the registration results to perform an iteration process,which compensates for the bias of the strap-down initial navigation module online.Although it is challenging to provide cross-view registration results with high frequency,such an iteration process allows the method to generate real-time,highly accurate location results.The effectiveness of the proposed IGCIR method is verified by a series of flying-test experiments.The results show that the location accuracy of the method can reach 4.18 m(at 10 km standoff distance).
基金Sponsored by the Project of Sichuan Landscape and Recreation Research Center(JGYQ2020037).
文摘In this study,CiteSpace software is used to carry out visual analysis on the three-dimensional research literature on urban recreation space from the perspective of compact city theory in the past 20 years,exploring the scientific development trend and research hotspots in this field.The results show that the number of published documents shows a fluctuating upward trend,and the significant growth rate reflects the role of policy orientation in promoting the concept of compact city.The co-occurrence analysis of keywords reveals the research hotspots of“compact city”,“recreation space”and“urban park”,while the emergence of new keywords such as“vertical city”and“spatial justice”indicates the new trend of recent research.The cluster analysis and timeline map further show the evolution of research themes,with“compact city”being the largest cluster and having rich connections with other themes such as“urban design”and“urban park”.
基金supported in part by the National Natural Science Foundation of China[62301374]Hubei Provincial Natural Science Foundation of China[2022CFB804]+2 种基金Hubei Provincial Education Research Project[B2022057]the Youths Science Foundation of Wuhan Institute of Technology[K202240]the 15th Graduate Education Innovation Fund of Wuhan Institute of Technology[CX2023295].
文摘This paper aims to develop a nonrigid registration method of preoperative and intraoperative thoracoabdominal CT images in computer-assisted interventional surgeries for accurate tumor localization and tissue visualization enhancement.However,fine structure registration of complex thoracoabdominal organs and large deformation registration caused by respiratory motion is challenging.To deal with this problem,we propose a 3D multi-scale attention VoxelMorph(MAVoxelMorph)registration network.To alleviate the large deformation problem,a multi-scale axial attention mechanism is utilized by using a residual dilated pyramid pooling for multi-scale feature extraction,and position-aware axial attention for long-distance dependencies between pixels capture.To further improve the large deformation and fine structure registration results,a multi-scale context channel attention mechanism is employed utilizing content information via adjacent encoding layers.Our method was evaluated on four public lung datasets(DIR-Lab dataset,Creatis dataset,Learn2Reg dataset,OASIS dataset)and a local dataset.Results proved that the proposed method achieved better registration performance than current state-of-the-art methods,especially in handling the registration of large deformations and fine structures.It also proved to be fast in 3D image registration,using about 1.5 s,and faster than most methods.Qualitative and quantitative assessments proved that the proposed MA-VoxelMorph has the potential to realize precise and fast tumor localization in clinical interventional surgeries.
基金Supported by Sichuan Province Zanthoxylum bungeanum Maxim.Innovation Team Project"Green Control of Diseases and Weeds on Zanthoxylum bungeanum Maxim."Institute-Local Cooperation Project"Demonstration of Chemical Fertilizer and Pesticide Reduction Techniques in Hongya County(2024-2026)".
文摘To provide reference for the prevention and control of diseases,pests,and weeds on Zanthoxylum bungeanum Maxim.and the research and development of new pesticide registrations,this paper analyzes the quantity,variety structure,dosage forms,and toxicity of pesticides registered on Z.bungeanum in China.The analysis reveals a relatively low quantity of pesticide registrations on Z.bungeanum,with no herbicide registrations;suspension concentrates dominate the dosage forms,and pesticide toxicity is classified as low-toxicity or micro-toxicity;registered pesticides target only rust,anthracnose,scale insects,aphids,and spider mites,while plant growth regulators solely involve growth regulation and shoot control.Given the current status of limited and incomplete pesticide registrations targeting major diseases,pests,and weeds on Z.bungeanum,severe product homogenization,and unknown maximum residue limits,it is recommended to intensify efforts in pesticide registration on Z.bungeanum,actively research and apply green control technologies,strengthen technical training guidance and pesticide supervision enforcement,to promote the healthy development of the industry.
基金Supported by the Zhejiang Medical Science and Technology Project,No.2022KY1325 and No.2023KY381Public Welfare Project of Jinhua Science and Technology Plan,No.2023-4-084Major Project of Jinhua Science and Technology Plan,No.2023-3-066.
文摘BACKGROUND Ganglioneuroma is a rare,well-differentiated,slow-growing benign tumor of the peripheral nerves,with surgical resection being the only curative treatment.Surgical resection of ganglioneuromas encasing major blood vessels remains a substantial clinical challenge.Traditionally,these cases often require open abdominal surgery or combined organ resections,and in some instances,the tumors are considered unresectable.Currently,no reports have described the resection of such tumors via laparoscopy.CASE SUMMARY A 35-year-old woman was admitted to our hospital after the incidental discovery of a retroperitoneal space-occupying lesion.Imaging revealed a mass with the celiac axis and superior mesenteric artery passing through it.A neurogenic tumor was suspected,with ganglioneuroma being the most likely diagnosis.Following comprehensive preoperative preparation,the retroperitoneal tumor was resected using a three-dimensional laparoscopy combined with an organ suspension technique.The surgical approach involved incising the tumor along the vascular axis and conducting meticulous,vascular-preserving tumor excision.The operation lasted approximately 458 minutes,with an estimated blood loss of 50 mL.The patient was discharged on the 8th postoperative day.A transient liver injury occurred after surgery but improved rapidly.After 11 months of postoperative follow-up,no complications or tumor recurrence were observed.CONCLUSION This case illustrates the feasibility of minimally invasive laparoscopic resection for retroperitoneal ganglioneuromas encasing major blood vessels.
基金supported by the National Natural Science Foundation of China to Jiping Huang(12035004 and 12320101004)the Innovation Program of the Shanghai Municipal Education Commission to Jiping Huang(2023ZKZD06)+2 种基金the National Natural Science Foundation of China to Ying Li(92163123 and 52250191)the Zhejiang Provincial Natural Science Foundation of China to Ying Li(LZ24A050002)the National Natural Science Foundation of China to Liujun Xu(12375040,12088101,and U2330401).
文摘Thermal metamaterial represents a groundbreaking approach to control heat conduction,and,as a crucial component,thermal invisibility is of utmost importance for heat management.Despite the flourishing development of thermal invisibility schemes,they still face two limitations in practical applications.First,objects are typically completely enclosed in traditional cloaks,making them difficult to use and unsuitable for objects with heat sources.Second,although some theoretical proposals have been put forth to change the thermal conductivity of materials to achieve dynamic invisibility,their designs are complex and rigid,making them unsuitable for large-scale use in real threedimensional(3D)spaces.Here,we propose a concept of a thermal dome to achieve 3D invisibility.Our scheme includes an open functional area,greatly enhancing its usability and applicability.It features a reconfigurable structure,constructed with simple isotropic natural materials,making it suitable for dynamic requirements.The performance of our reconfigurable thermal dome has been confirmed through simulations and experiments,consistent with the theory.The introduction of this concept can greatly advance the development of thermal invisibility technology from theory to engineering and provide inspiration for other physical domains,such as direct current electric fields and magnetic fields.
基金supported by the National Science Foundation of China(Grant Nos.42374205 and 41974179)the Specialized Research Fund of the National Space Science Center,Chinese Academy of Sciences(Grant No.E4PD3010)supported by the Specialized Research Fund for State Key Laboratories.
文摘The three-dimensional spectral analysis method was applied to airglow data from September 2023 to August 2024 derivedfrom an OH airglow imager located at the Hejing station (42.79°N, 83.73°E) to study the propagation characteristics of gravity waves(GWs) over Northwest China. We found that obvious seasonal variations occur in the propagation of GWs. In spring, GWs mainlypropagate in the northeast direction. In summer and autumn, GWs mainly propagate in the north direction. However, GWs mainlypropagate in the south direction in winter. The direction of GW propagation in the zonal direction is controlled by the wind-filteringeffect, whereas the north–south meridional direction is mainly determined by the location of the wave source. We found that the averageenergy spectrum exhibits a 10%–20% higher intensity in summer and winter compared with spring and autumn. For the first time, wereport the seasonal variation characteristics of GWs over the inland areas of Northwest China, which is of great significance forunderstanding the regional distribution characteristics of GWs.
文摘Internal multiples are commonly present in seismic data due to variations in velocity or density of subsurface media.They can reduce the signal-to-noise ratio of seismic data and degrade the quality of the image.With the development of seismic exploration into deep and ultradeep events,especially those from complex targets in the western region of China,the internal multiple eliminations become increasingly challenging.Currently,three-dimensional(3D)seismic data are primarily used for oil and gas target recognition and drilling.Effectively eliminating internal multiples in 3D seismic data of complex structures and mitigating their adverse effects is crucial for enhancing the success rate of drilling.In this study,we propose an internal multiple prediction algorithm for 3D seismic data in complex structures using the Marchenko autofocusing theory.This method can predict the accurate internal multiples of time difference without an accurate velocity model and the implementation process mainly consists of several steps.Firstly,simulating direct waves with a 3D macroscopic velocity model.Secondly,using direct waves and 3D full seismic acquisition records to obtain the upgoing and down-going Green's functions between the virtual source point and surface.Thirdly,constructing internal multiples of the relevant layers by upgoing and downgoing Green's functions.Finally,utilizing the adaptive matching subtraction method to remove predicted internal multiples from the original data to obtain seismic records without multiples.Compared with the two-dimensional(2D)Marchenko algo-rithm,the performance of the 3D Marchenko algorithm for internal multiple prediction has been significantly enhanced,resulting in higher computational accuracy.Numerical simulation test results indicate that our proposed method can effectively eliminate internal multiples in 3D seismic data,thereby exhibiting important theoretical and industrial application value.
