Against the backdrop of continuous social development and growing public health demands,the efficiency and scientific nature of the emergency care system are of paramount importance.This paper focuses on researching t...Against the backdrop of continuous social development and growing public health demands,the efficiency and scientific nature of the emergency care system are of paramount importance.This paper focuses on researching the construction of an emergency care system based on the concept of“linkage”,delving into its theoretical foundations,exploring innovative construction models,and analyzing practical cases.The study indicates that an emergency care system under the“linkage”concept can effectively integrate resources and enhance efficiency,providing new insights for improving the construction of the emergency care system.It aims to promote the development of the emergency care system towards a more scientific,efficient,and collaborative direction.展开更多
This research studies the process of 3D reconstruction and dynamic concision based on 2D medical digital images using virtual reality modelling language (VRML) and JavaScript language, with a focus on how to realize t...This research studies the process of 3D reconstruction and dynamic concision based on 2D medical digital images using virtual reality modelling language (VRML) and JavaScript language, with a focus on how to realize the dynamic concision of 3D medical model with script node and sensor node in VRML. The 3D reconstruction and concision of body internal organs can be built with such high quality that they are better than those obtained from the traditional methods. With the function of dynamic concision, the VRML browser can offer better windows for man-computer interaction in real-time environment than ever before. 3D reconstruction and dynamic concision with VRML can be used to meet the requirement for the medical observation of 3D reconstruction and have a promising prospect in the fields of medical imaging.展开更多
Summary: A three-dimensional (3D) graphic model of a single-chain Fv (scFv) which was derived from an anti-human placental acidic isoferritin (PAF) monoclonal antibody (MAb) was construct- ed by a homologous protein...Summary: A three-dimensional (3D) graphic model of a single-chain Fv (scFv) which was derived from an anti-human placental acidic isoferritin (PAF) monoclonal antibody (MAb) was construct- ed by a homologous protein-predicting computer algorithm on Silicon graphic computer station. The structure, surface static electricity and hydrophobicity of scFv were investigated. Computer graphic modelling indicated that all regions of scFv including the linker, variable regions of the heavy (VH) and light (VL) chains were suitable. The VH region and the VL region were involved in composing the 'hydrophobic pocket'. The linker was drifted away VH and VL regions. The complementarity determining regions (CDRs) of VH and VL regions surrounded the 'hydrophobic pocket'. This study provides a theory basis for improving antibody affinity, investigating antibody structure and analyzing the functions of VH and VL regions in antibody activity.展开更多
The three-dimensional(3D)model is of great significance to analyze the performance of nonwovens.However,the existing modelling methods could not reconstruct the 3D structure of nonwovens at low cost.A new method based...The three-dimensional(3D)model is of great significance to analyze the performance of nonwovens.However,the existing modelling methods could not reconstruct the 3D structure of nonwovens at low cost.A new method based on deep learning was proposed to reconstruct 3D models of nonwovens from multi-focus images.A convolutional neural network was trained to extract clear fibers from sequence images.Image processing algorithms were used to obtain the radius,the central axis,and depth information of fibers from the extraction results.Based on this information,3D models were built in 3D space.Furthermore,self-developed algorithms optimized the central axis and depth of fibers,which made fibers more realistic and continuous.The method with lower cost could reconstruct 3D models of nonwovens conveniently.展开更多
A method of constructing three-dimensional process model for the punching cartridge cases is presented based on DEFORM simulation analysis. Using DEFORM software,the finite element simulation models for the punching a...A method of constructing three-dimensional process model for the punching cartridge cases is presented based on DEFORM simulation analysis. Using DEFORM software,the finite element simulation models for the punching and forming process of cartridge cases are established,and the corresponding simulation result model of each intermediate procedure is obtained by continuously performing the forming process simulation. The simulation model cannot annotate size and process information due to poor interface between DEFORM software and CAD software. Thus,a 3D annotation module is developed with secondary development technology of UG NX software. Consequently,the final process model with dimension and process information is obtained. Then,with the current 3D process management system,the 3D punching and forming process design of cartridge cases can be completed further. An example is also provided to illustrate that the relative error between the simulation process model and the physical model is less than 2%,which proves the validity and reliability of the proposed method in this study.展开更多
Currently,there are a limited number of dynamic models available for braided composite plates with large overall motions,despite the incorporation of three-dimensional(3D)braided composites into rotating blade compone...Currently,there are a limited number of dynamic models available for braided composite plates with large overall motions,despite the incorporation of three-dimensional(3D)braided composites into rotating blade components.In this paper,a dynamic model of 3D 4-directional braided composite thin plates considering braiding directions is established.Based on Kirchhoff's plate assumptions,the displacement variables of the plate are expressed.By incorporating the braiding directions into the constitutive equation of the braided composites,the dynamic model of the plate considering braiding directions is obtained.The effects of the speeds,braiding directions,and braided angles on the responses of the plate with fixed-axis rotation and translational motion,respectively,are investigated.This paper presents a dynamic theory for calculating the deformation of 3D braided composite structures undergoing both translational and rotational motions.It also provides a simulation method for investigating the dynamic behavior of non-isotropic material plates in various applications.展开更多
Objective:To address the prediction of hemorrhagic transformation(HT)after rt-PA thrombolysis in acute cerebral infarction(ACI)patients,a predictive model integrating data engineering,algorithm optimization,and modula...Objective:To address the prediction of hemorrhagic transformation(HT)after rt-PA thrombolysis in acute cerebral infarction(ACI)patients,a predictive model integrating data engineering,algorithm optimization,and modularity was constructed.This model resolves the technical limitation of traditional clinical statistical models that overemphasize analysis while neglecting deployment readiness,thereby providing a reusable technical solution for the implementation of medical risk prediction systems.Methods:A standardized dataset was built using data from 300 ACI patients who underwent rt-PA thrombolysis.Automated data cleaning,outlier correction,and feature engineering optimization(recursive feature elimination+variance inflation factor test)were applied to select core features.An L2-regularized logistic regression algorithm was employed to construct the prediction model,which was visualized via a nomogram.Multi-dimensional performance validation was conducted through cross-validation and probability calibration techniques.Results:The incidence of HT was20.0%.Multivariate analysis identified NIHSS score(OR=1.626),blood glucose(OR=1.662),platelet count(OR=0.975),age(OR=1.091),and history of diabetes(OR=0.343)as core predictors(P<0.05).Engineering validation demonstrated excellent discrimination(AUC=0.800,95%CI:0.752-0.856).After optimization with Platt scaling,the calibration curve was highly consistent with the actual probability,with a Brier score of0.092.The prediction time per sample was<50 ms,and the convergence efficiency of model training was improved by 30%.Conclusion:This model integrates core technologies including data preprocessing,feature optimization,and algorithm improvement,exhibiting low-latency,high stability,and deployability.It provides a standardized technical framework for transforming medical prediction models from statistical conclusions into engineered products.展开更多
To comprehensively utilize the valuable geological map,exploration profile,borehole,and geochemical logging data and the knowledge on the formation of the Jinshan Ag-Au deposit for forecasting the exploration targets ...To comprehensively utilize the valuable geological map,exploration profile,borehole,and geochemical logging data and the knowledge on the formation of the Jinshan Ag-Au deposit for forecasting the exploration targets of concealed ore bodies,three-dimensional Mineral Prospectivity Modeling(MPM)of the deposit has been conducted using the weights-of-evidence(WofE)method.Conditional independence between evidence layers was tested,and the outline results using the prediction-volume(P-V)and Student's t-statistic methods for delineating favorable mineralization areas from continuous posterior probability map were critically compared.Four exploration targets delineated ultimately by the Student's t-statistic method for the discovery of minable ore bodies in each of the target areas were discussed in detail.The main conclusions include:(1)three-dimensional modeling of a deposit using multi-source reconnaissance data is useful for MPM in interpreting their relationships with known ore bodies;(2)WofE modeling can be used as a straightforward tool for integrating deposit model and reconnaissance data in MPM;(3)the Student's t-statistic method is more applicable in binarizing the continuous prospectivity map for exploration targeting than the PV approach;and(4)two target areas within high potential to find undiscovered ore bodies were diagnosed to guide future near-mine exploration activities of the Jinshan deposit.展开更多
Combining the characteristics of the course“Comprehensive Training of E-Commerce Live Streaming,”this paper embeds the CDIO(Conceive-Design-Implement-Operate)method into the live streaming training process,carries o...Combining the characteristics of the course“Comprehensive Training of E-Commerce Live Streaming,”this paper embeds the CDIO(Conceive-Design-Implement-Operate)method into the live streaming training process,carries out the virtual scene“e-commerce live streaming”course design and project-based teaching reform that integrates teaching training with learning effects,and establishes a set of cross-professional student live streaming training procedures guided by the CDIO engineering method.The training results show that the CDIO practical teaching model supported by data feedback plays an important role and significance in improving students’learning effects,and also provides some new experiences for integrating engineering thinking into the construction of new liberal arts.展开更多
Satellite Component Layout Optimization(SCLO) is crucial in satellite system design.This paper proposes a novel Satellite Three-Dimensional Component Assignment and Layout Optimization(3D-SCALO) problem tailored to en...Satellite Component Layout Optimization(SCLO) is crucial in satellite system design.This paper proposes a novel Satellite Three-Dimensional Component Assignment and Layout Optimization(3D-SCALO) problem tailored to engineering requirements, aiming to optimize satellite heat dissipation while considering constraints on static stability, 3D geometric relationships between components, and special component positions. The 3D-SCALO problem is a challenging bilevel combinatorial optimization task, involving the optimization of discrete component assignment variables in the outer layer and continuous component position variables in the inner layer,with both influencing each other. To address this issue, first, a Mixed Integer Programming(MIP) model is proposed, which reformulates the original bilevel problem into a single-level optimization problem, enabling the exploration of a more comprehensive optimization space while avoiding iterative nested optimization. Then, to model the 3D geometric relationships between components within the MIP framework, a linearized 3D Phi-function method is proposed, which handles non-overlapping and safety distance constraints between cuboid components in an explicit and effective way. Subsequently, the Finite-Rectangle Method(FRM) is proposed to manage 3D geometric constraints for complex-shaped components by approximating them with a finite set of cuboids, extending the applicability of the geometric modeling approach. Finally, the feasibility and effectiveness of the proposed MIP model are demonstrated through two numerical examples"and a real-world engineering case, which confirms its suitability for complex-shaped components and real engineering applications.展开更多
This paper focuses on concrete technical management in construction engineering.It explains the core elements,including production mix ratio,analyzes problems of traditional models,presents innovative management model...This paper focuses on concrete technical management in construction engineering.It explains the core elements,including production mix ratio,analyzes problems of traditional models,presents innovative management models like BIM+GIS and their applications,and covers aspects such as job competence standards and prefabricated modular construction regulations,emphasizing the significance and development direction of innovative models.展开更多
Background:Traditional imaging approaches to keratoconus(KCN)have thus far failed to produce a standardized approach for diagnosis.While many diagnostic modalities and metrics exist,none have proven robust enough to b...Background:Traditional imaging approaches to keratoconus(KCN)have thus far failed to produce a standardized approach for diagnosis.While many diagnostic modalities and metrics exist,none have proven robust enough to be considered a gold standard.This study aims to introduce novel metrics to differentiate between KCN and healthy corneas using three-dimensional(3D)measurements of surface area and volume.Methods:This retrospective observational study examined KCN patients along with healthy control patients between the ages of 20 and 79 years old at the University of Maryland,Baltimore.The selected patients underwent a nine-line raster scan anterior segment optical coherence tomography(AS-OCT).ImageJ was used to determine the central 6 mm of each image and each corneal image was then divided into six 1 mm segments.Free-D software was then used to render the nine different images into a 3D model to calculate corneal surface area and volume.A two-tailed Mann-Whitney test was used to assess statistical significance when comparing these subsets.Results:Thirty-three eyes with KCN,along with 33 healthy control,were enrolled.There were statistically significant differences between the healthy and KCN groups in the metric of anterior corneal surface area(13.927 vs.13.991 mm^(2),P=0.046),posterior corneal surface area(14.045 vs.14.173 mm^(2),P<0.001),and volume(8.430 vs.7.773 mm3,P<0.001)within the central 6 mm.Conclusions:3D corneal models derived from AS-OCT can be used to measure anterior corneal surface area,posterior corneal surface area,and corneal volume.All three parameters are statistically different between corneas with KCN and healthy corneas.Further study and application of these parameters may yield new methodologies for the detection of KCN.展开更多
The management of large-scale architectural engineering projects(e.g.,airports,hospitals)is plagued by information silos,cost overruns,and scheduling delays.While building information modeling(BIM)has improved 3D desi...The management of large-scale architectural engineering projects(e.g.,airports,hospitals)is plagued by information silos,cost overruns,and scheduling delays.While building information modeling(BIM)has improved 3D design coordination,its static nature limits its utility in real-time construction management and operational phases.This paper proposes a novel synergistic framework that integrates the static,deep data of BIM with the dynamic,real-time capabilities of digital twin(DT)technology.The framework establishes a closed-loop data flow from design(BIM)to construction(IoT,drones,BIM 360)to operation(DT platform).We detail the technological stack required,including IoT sensors,cloud computing,and AI-driven analytics.The application of this framework is illustrated through a simulated case study of a mega-terminal airport construction project,demonstrating potential reductions in rework by 15%,improvement in labor productivity by 10%,and enhanced predictive maintenance capabilities.This research contributes to the field of construction engineering by providing a practical model for achieving full lifecycle digitalization and intelligent project management.展开更多
New energy-storage systems play a pivotal role in the development of the new power system for advancing the energy transition in China.In the“14th Five-Year Plan”for the New Energy-Storage Development,it is proposed...New energy-storage systems play a pivotal role in the development of the new power system for advancing the energy transition in China.In the“14th Five-Year Plan”for the New Energy-Storage Development,it is proposed to expand investment and construction models by promoting the deployment of energy-storage facilities through the ways of self-construction,leasing,and purchasing,and to encourage the development of the shared energy-storage.However,the current scarcity in the model of the shared energy-storage invest-ment and construction substantially restricts its development,particularly due to unclear mechanisms for cost and benefit allocation,which also discourages potential investors.To address the issue,this paper proposes investment and construction models for shared energy-storage that aligns with the present stage of energy storage development.In specific,three main models are introduced:(1)Cen-tralized Self-built Shared Energy-Storage model(CSSES),(2)Third-party Investment Shared Energy-Storage model(TISES),and(3)Distributed Self-built Shared Energy Storage(DSSES)model.The cost–benefit analysis is conducted for each model.The results indicate that the CSSES model achieves the highest internal rate of return(11.5%)and the shortest payback period,while the DSSES model per-forms acceptable with an IRR of 9.4%.In contrast,the TISES model shows the lowest IRR(6.7%)and requires higher electricity price for being feasible.Furthermore,the study employs the entropy weight method and the analytic hierarchy process(AHP)for indicator eval-uation,and integrates the technique for order preference by the similarity to an ideal solution(TOPSIS)for scheme optimization.The results show that both the CSSES model and the DSSES model achieve the highest proximity scores.Under environmental regulations,these models demonstrate superior economic benefits by optimizing energy storage utilization,reducing user costs,and enhancing overall profitability.展开更多
This research focuses on using BIM modeling optimization to control construction-period risks in the pre-construction stage of industrial factory buildings.It analyzes common risk factors and limitations of traditiona...This research focuses on using BIM modeling optimization to control construction-period risks in the pre-construction stage of industrial factory buildings.It analyzes common risk factors and limitations of traditional approaches.BIM-based methods like collision detection,4D simulation,multi-dimensional data integration,etc.,can effectively mitigate risks.Stakeholder collaboration,digital twin testing,and lean BIM integration is also crucial.Case studies show BIM can reduce risks by 32-41%,with a three phase roadmap provided.展开更多
A three-dimensional finite element simulation was carried out to investigate the effects of tunnel construction on nearby pile foundation.The displacement controlled model (DCM) was used to simulate the tunneling-indu...A three-dimensional finite element simulation was carried out to investigate the effects of tunnel construction on nearby pile foundation.The displacement controlled model (DCM) was used to simulate the tunneling-induced volume loss effects.The numerical model was verified based on the results of a centrifuge test and a set of parametric studies was implemented based on this model.There is good agreement between the trend of the results of the centrifuge test and the present model.The results of parametric studies show that the tunnelling-induced pile internal force and deformation depend mainly on the pile?tunnel distance,the pile length to tunnel depth ratio and the volume loss.Two different zones are separated by a 45° line projected from the tunnel springline.Within the zone of influence,the pile is subjected to tensile force and large settlement;whereas outside the zone of influence,dragload and small settlement are induced.It is also established that the impact of tunnelling on a pile group is substantially smaller as compared with a single pile in the same location with the rear pile in a group,demonstrating a positive pile group effect.展开更多
The development of digital twins for geotechnical structures necessitates the real-time updates of threedimensional(3D)virtual models(e.g.numerical finite element method(FEM)model)to accurately predict time-varying ge...The development of digital twins for geotechnical structures necessitates the real-time updates of threedimensional(3D)virtual models(e.g.numerical finite element method(FEM)model)to accurately predict time-varying geotechnical responses(e.g.consolidation settlement)in a 3D spatial domain.However,traditional 3D numerical model updating approaches are computationally prohibitive and therefore difficult to update the 3D responses in real time.To address these challenges,this study proposes a novel machine learning framework called sparse dictionary learning(T-3D-SDL)for real-time updating of time-varying 3D geotechnical responses.In T-3D-SDL,a concerned dataset(e.g.time-varying 3D settlement)is approximated as a linear superposition of dictionary atoms generated from 3D random FEM analyses.Field monitoring data are then used to identify non-trivial atoms and estimate their weights within a Bayesian framework for model updating and prediction.The proposed approach enables the real-time update of temporally varying settlements with a high 3D spatial resolution and quantified uncertainty as field monitoring data evolve.The proposed approach is illustrated using an embankment construction project.The results show that the proposed approach effectively improves settlement predictions along temporal and 3D spatial dimensions,with minimal latency(e.g.within minutes),as monitoring data appear.In addition,the proposed approach requires only a reasonably small number of 3D FEM model evaluations,avoids the use of widely adopted yet often criticized surrogate models,and effectively addresses the limitations(e.g.computational inefficiency)of existing 3D model updating approaches.展开更多
The purpose of this study was to establish a method for measuring the knee valgus angle from the ana- tomical and mechanical axes on three-dimensional reconstruction imaging models, and to use this method for estimati...The purpose of this study was to establish a method for measuring the knee valgus angle from the ana- tomical and mechanical axes on three-dimensional reconstruction imaging models, and to use this method for estimating an average knee valgus angle value for northern Chinese adults. Computed tomographic angiography data in DICOM format for 128 normal femurs from 64 adult subjects were chosen for analysis. After the femur images were subjected to three-dimensional reconstruction, the deepest point in the intercondylar notch （point A）, the midpoint of the medullary cavity 20 cm above the knee-joint line （point B）, and the landmark of the femoral head rotation center （point C） were identified on each three-dimensional model. The knee valgus angle was defined as the angle enclosed by the distal femoral anatomical axis （line AB） and the femoral mechanical axis （line AC）. The average （mean＋SD） of knee valgus angle for the 128 femurs was 6.20°±1.20° （range, 3.05° to 10.64°）. Significant positive correlations were found between the knee valgus angles of the right and left sides and between the knee valgus angle and age. During total knee arthroplasty, choosing a valgus cut angle of approximately 6° may achieve a good result in reestablishing the natural mechanical alignment of the lower extremity for patients of northern Chinese ethnicity. Larger valgus cut angles should be chosen for older patients.展开更多
Three-dimensional visualization technology converts engineering design drawings and data into graphics or images, realizes virtual reality perception of simulated users in future construction scene, enhances the inter...Three-dimensional visualization technology converts engineering design drawings and data into graphics or images, realizes virtual reality perception of simulated users in future construction scene, enhances the interaction between project management and technical personnel and engineering construction achievement, and provides intuitive, flexible and strong realistic experience for project management. It can effectively improve the level of project communication, and assist the needs of project construction planning management, training, exhibition, etc. As a tool to help improve project management skills, it has good application effect and prospects.展开更多
文摘Against the backdrop of continuous social development and growing public health demands,the efficiency and scientific nature of the emergency care system are of paramount importance.This paper focuses on researching the construction of an emergency care system based on the concept of“linkage”,delving into its theoretical foundations,exploring innovative construction models,and analyzing practical cases.The study indicates that an emergency care system under the“linkage”concept can effectively integrate resources and enhance efficiency,providing new insights for improving the construction of the emergency care system.It aims to promote the development of the emergency care system towards a more scientific,efficient,and collaborative direction.
基金Postdoctoral Fund of China (No. 2003034518), Fund of Health Bureau of Zhejiang Province (No. 2004B042), China
文摘This research studies the process of 3D reconstruction and dynamic concision based on 2D medical digital images using virtual reality modelling language (VRML) and JavaScript language, with a focus on how to realize the dynamic concision of 3D medical model with script node and sensor node in VRML. The 3D reconstruction and concision of body internal organs can be built with such high quality that they are better than those obtained from the traditional methods. With the function of dynamic concision, the VRML browser can offer better windows for man-computer interaction in real-time environment than ever before. 3D reconstruction and dynamic concision with VRML can be used to meet the requirement for the medical observation of 3D reconstruction and have a promising prospect in the fields of medical imaging.
文摘Summary: A three-dimensional (3D) graphic model of a single-chain Fv (scFv) which was derived from an anti-human placental acidic isoferritin (PAF) monoclonal antibody (MAb) was construct- ed by a homologous protein-predicting computer algorithm on Silicon graphic computer station. The structure, surface static electricity and hydrophobicity of scFv were investigated. Computer graphic modelling indicated that all regions of scFv including the linker, variable regions of the heavy (VH) and light (VL) chains were suitable. The VH region and the VL region were involved in composing the 'hydrophobic pocket'. The linker was drifted away VH and VL regions. The complementarity determining regions (CDRs) of VH and VL regions surrounded the 'hydrophobic pocket'. This study provides a theory basis for improving antibody affinity, investigating antibody structure and analyzing the functions of VH and VL regions in antibody activity.
基金National Natural Science Foundation of China(No.61771123)。
文摘The three-dimensional(3D)model is of great significance to analyze the performance of nonwovens.However,the existing modelling methods could not reconstruct the 3D structure of nonwovens at low cost.A new method based on deep learning was proposed to reconstruct 3D models of nonwovens from multi-focus images.A convolutional neural network was trained to extract clear fibers from sequence images.Image processing algorithms were used to obtain the radius,the central axis,and depth information of fibers from the extraction results.Based on this information,3D models were built in 3D space.Furthermore,self-developed algorithms optimized the central axis and depth of fibers,which made fibers more realistic and continuous.The method with lower cost could reconstruct 3D models of nonwovens conveniently.
基金Supported by the National Defense Basic Scientific Research Project(A1020131011)
文摘A method of constructing three-dimensional process model for the punching cartridge cases is presented based on DEFORM simulation analysis. Using DEFORM software,the finite element simulation models for the punching and forming process of cartridge cases are established,and the corresponding simulation result model of each intermediate procedure is obtained by continuously performing the forming process simulation. The simulation model cannot annotate size and process information due to poor interface between DEFORM software and CAD software. Thus,a 3D annotation module is developed with secondary development technology of UG NX software. Consequently,the final process model with dimension and process information is obtained. Then,with the current 3D process management system,the 3D punching and forming process design of cartridge cases can be completed further. An example is also provided to illustrate that the relative error between the simulation process model and the physical model is less than 2%,which proves the validity and reliability of the proposed method in this study.
基金Project supported by the National Natural Science Foundation of China(Nos.12372071 and 12372070)the Aeronautical Science Fund of China(No.2022Z055052001)the Foundation of China Scholarship Council(No.202306830079)。
文摘Currently,there are a limited number of dynamic models available for braided composite plates with large overall motions,despite the incorporation of three-dimensional(3D)braided composites into rotating blade components.In this paper,a dynamic model of 3D 4-directional braided composite thin plates considering braiding directions is established.Based on Kirchhoff's plate assumptions,the displacement variables of the plate are expressed.By incorporating the braiding directions into the constitutive equation of the braided composites,the dynamic model of the plate considering braiding directions is obtained.The effects of the speeds,braiding directions,and braided angles on the responses of the plate with fixed-axis rotation and translational motion,respectively,are investigated.This paper presents a dynamic theory for calculating the deformation of 3D braided composite structures undergoing both translational and rotational motions.It also provides a simulation method for investigating the dynamic behavior of non-isotropic material plates in various applications.
文摘Objective:To address the prediction of hemorrhagic transformation(HT)after rt-PA thrombolysis in acute cerebral infarction(ACI)patients,a predictive model integrating data engineering,algorithm optimization,and modularity was constructed.This model resolves the technical limitation of traditional clinical statistical models that overemphasize analysis while neglecting deployment readiness,thereby providing a reusable technical solution for the implementation of medical risk prediction systems.Methods:A standardized dataset was built using data from 300 ACI patients who underwent rt-PA thrombolysis.Automated data cleaning,outlier correction,and feature engineering optimization(recursive feature elimination+variance inflation factor test)were applied to select core features.An L2-regularized logistic regression algorithm was employed to construct the prediction model,which was visualized via a nomogram.Multi-dimensional performance validation was conducted through cross-validation and probability calibration techniques.Results:The incidence of HT was20.0%.Multivariate analysis identified NIHSS score(OR=1.626),blood glucose(OR=1.662),platelet count(OR=0.975),age(OR=1.091),and history of diabetes(OR=0.343)as core predictors(P<0.05).Engineering validation demonstrated excellent discrimination(AUC=0.800,95%CI:0.752-0.856).After optimization with Platt scaling,the calibration curve was highly consistent with the actual probability,with a Brier score of0.092.The prediction time per sample was<50 ms,and the convergence efficiency of model training was improved by 30%.Conclusion:This model integrates core technologies including data preprocessing,feature optimization,and algorithm improvement,exhibiting low-latency,high stability,and deployability.It provides a standardized technical framework for transforming medical prediction models from statistical conclusions into engineered products.
基金financially supported by the Ministry of Science and Technology of China(Nos.2022YFF0801201,2021YFC2900300)the National Natural Science Foundation of China(Nos.41872245,U1911202)the Guangdong Basic and Applied Basic Research Foundation(No.2020A1515010666)。
文摘To comprehensively utilize the valuable geological map,exploration profile,borehole,and geochemical logging data and the knowledge on the formation of the Jinshan Ag-Au deposit for forecasting the exploration targets of concealed ore bodies,three-dimensional Mineral Prospectivity Modeling(MPM)of the deposit has been conducted using the weights-of-evidence(WofE)method.Conditional independence between evidence layers was tested,and the outline results using the prediction-volume(P-V)and Student's t-statistic methods for delineating favorable mineralization areas from continuous posterior probability map were critically compared.Four exploration targets delineated ultimately by the Student's t-statistic method for the discovery of minable ore bodies in each of the target areas were discussed in detail.The main conclusions include:(1)three-dimensional modeling of a deposit using multi-source reconnaissance data is useful for MPM in interpreting their relationships with known ore bodies;(2)WofE modeling can be used as a straightforward tool for integrating deposit model and reconnaissance data in MPM;(3)the Student's t-statistic method is more applicable in binarizing the continuous prospectivity map for exploration targeting than the PV approach;and(4)two target areas within high potential to find undiscovered ore bodies were diagnosed to guide future near-mine exploration activities of the Jinshan deposit.
基金phased research achievement of the Major Project of Philosophy and Social Sciences Research in Jiangsu Universities“Research on the Intervention Mechanism of Short Video Addiction”(2024SJZD145)。
文摘Combining the characteristics of the course“Comprehensive Training of E-Commerce Live Streaming,”this paper embeds the CDIO(Conceive-Design-Implement-Operate)method into the live streaming training process,carries out the virtual scene“e-commerce live streaming”course design and project-based teaching reform that integrates teaching training with learning effects,and establishes a set of cross-professional student live streaming training procedures guided by the CDIO engineering method.The training results show that the CDIO practical teaching model supported by data feedback plays an important role and significance in improving students’learning effects,and also provides some new experiences for integrating engineering thinking into the construction of new liberal arts.
基金supported by the National Natural Science Foundation of China(No.92371206)the Postgraduate Scientific Research Innovation Project of Hunan Province,China(No.CX2023063).
文摘Satellite Component Layout Optimization(SCLO) is crucial in satellite system design.This paper proposes a novel Satellite Three-Dimensional Component Assignment and Layout Optimization(3D-SCALO) problem tailored to engineering requirements, aiming to optimize satellite heat dissipation while considering constraints on static stability, 3D geometric relationships between components, and special component positions. The 3D-SCALO problem is a challenging bilevel combinatorial optimization task, involving the optimization of discrete component assignment variables in the outer layer and continuous component position variables in the inner layer,with both influencing each other. To address this issue, first, a Mixed Integer Programming(MIP) model is proposed, which reformulates the original bilevel problem into a single-level optimization problem, enabling the exploration of a more comprehensive optimization space while avoiding iterative nested optimization. Then, to model the 3D geometric relationships between components within the MIP framework, a linearized 3D Phi-function method is proposed, which handles non-overlapping and safety distance constraints between cuboid components in an explicit and effective way. Subsequently, the Finite-Rectangle Method(FRM) is proposed to manage 3D geometric constraints for complex-shaped components by approximating them with a finite set of cuboids, extending the applicability of the geometric modeling approach. Finally, the feasibility and effectiveness of the proposed MIP model are demonstrated through two numerical examples"and a real-world engineering case, which confirms its suitability for complex-shaped components and real engineering applications.
文摘This paper focuses on concrete technical management in construction engineering.It explains the core elements,including production mix ratio,analyzes problems of traditional models,presents innovative management models like BIM+GIS and their applications,and covers aspects such as job competence standards and prefabricated modular construction regulations,emphasizing the significance and development direction of innovative models.
文摘Background:Traditional imaging approaches to keratoconus(KCN)have thus far failed to produce a standardized approach for diagnosis.While many diagnostic modalities and metrics exist,none have proven robust enough to be considered a gold standard.This study aims to introduce novel metrics to differentiate between KCN and healthy corneas using three-dimensional(3D)measurements of surface area and volume.Methods:This retrospective observational study examined KCN patients along with healthy control patients between the ages of 20 and 79 years old at the University of Maryland,Baltimore.The selected patients underwent a nine-line raster scan anterior segment optical coherence tomography(AS-OCT).ImageJ was used to determine the central 6 mm of each image and each corneal image was then divided into six 1 mm segments.Free-D software was then used to render the nine different images into a 3D model to calculate corneal surface area and volume.A two-tailed Mann-Whitney test was used to assess statistical significance when comparing these subsets.Results:Thirty-three eyes with KCN,along with 33 healthy control,were enrolled.There were statistically significant differences between the healthy and KCN groups in the metric of anterior corneal surface area(13.927 vs.13.991 mm^(2),P=0.046),posterior corneal surface area(14.045 vs.14.173 mm^(2),P<0.001),and volume(8.430 vs.7.773 mm3,P<0.001)within the central 6 mm.Conclusions:3D corneal models derived from AS-OCT can be used to measure anterior corneal surface area,posterior corneal surface area,and corneal volume.All three parameters are statistically different between corneas with KCN and healthy corneas.Further study and application of these parameters may yield new methodologies for the detection of KCN.
文摘The management of large-scale architectural engineering projects(e.g.,airports,hospitals)is plagued by information silos,cost overruns,and scheduling delays.While building information modeling(BIM)has improved 3D design coordination,its static nature limits its utility in real-time construction management and operational phases.This paper proposes a novel synergistic framework that integrates the static,deep data of BIM with the dynamic,real-time capabilities of digital twin(DT)technology.The framework establishes a closed-loop data flow from design(BIM)to construction(IoT,drones,BIM 360)to operation(DT platform).We detail the technological stack required,including IoT sensors,cloud computing,and AI-driven analytics.The application of this framework is illustrated through a simulated case study of a mega-terminal airport construction project,demonstrating potential reductions in rework by 15%,improvement in labor productivity by 10%,and enhanced predictive maintenance capabilities.This research contributes to the field of construction engineering by providing a practical model for achieving full lifecycle digitalization and intelligent project management.
基金supported by the Humanities and Social Sciences of Ministry of Education Planning Fund of China(Grant No.21YJA790009)the National Natural Science Foundation of China(Grant No.72140001).
文摘New energy-storage systems play a pivotal role in the development of the new power system for advancing the energy transition in China.In the“14th Five-Year Plan”for the New Energy-Storage Development,it is proposed to expand investment and construction models by promoting the deployment of energy-storage facilities through the ways of self-construction,leasing,and purchasing,and to encourage the development of the shared energy-storage.However,the current scarcity in the model of the shared energy-storage invest-ment and construction substantially restricts its development,particularly due to unclear mechanisms for cost and benefit allocation,which also discourages potential investors.To address the issue,this paper proposes investment and construction models for shared energy-storage that aligns with the present stage of energy storage development.In specific,three main models are introduced:(1)Cen-tralized Self-built Shared Energy-Storage model(CSSES),(2)Third-party Investment Shared Energy-Storage model(TISES),and(3)Distributed Self-built Shared Energy Storage(DSSES)model.The cost–benefit analysis is conducted for each model.The results indicate that the CSSES model achieves the highest internal rate of return(11.5%)and the shortest payback period,while the DSSES model per-forms acceptable with an IRR of 9.4%.In contrast,the TISES model shows the lowest IRR(6.7%)and requires higher electricity price for being feasible.Furthermore,the study employs the entropy weight method and the analytic hierarchy process(AHP)for indicator eval-uation,and integrates the technique for order preference by the similarity to an ideal solution(TOPSIS)for scheme optimization.The results show that both the CSSES model and the DSSES model achieve the highest proximity scores.Under environmental regulations,these models demonstrate superior economic benefits by optimizing energy storage utilization,reducing user costs,and enhancing overall profitability.
文摘This research focuses on using BIM modeling optimization to control construction-period risks in the pre-construction stage of industrial factory buildings.It analyzes common risk factors and limitations of traditional approaches.BIM-based methods like collision detection,4D simulation,multi-dimensional data integration,etc.,can effectively mitigate risks.Stakeholder collaboration,digital twin testing,and lean BIM integration is also crucial.Case studies show BIM can reduce risks by 32-41%,with a three phase roadmap provided.
文摘A three-dimensional finite element simulation was carried out to investigate the effects of tunnel construction on nearby pile foundation.The displacement controlled model (DCM) was used to simulate the tunneling-induced volume loss effects.The numerical model was verified based on the results of a centrifuge test and a set of parametric studies was implemented based on this model.There is good agreement between the trend of the results of the centrifuge test and the present model.The results of parametric studies show that the tunnelling-induced pile internal force and deformation depend mainly on the pile?tunnel distance,the pile length to tunnel depth ratio and the volume loss.Two different zones are separated by a 45° line projected from the tunnel springline.Within the zone of influence,the pile is subjected to tensile force and large settlement;whereas outside the zone of influence,dragload and small settlement are induced.It is also established that the impact of tunnelling on a pile group is substantially smaller as compared with a single pile in the same location with the rear pile in a group,demonstrating a positive pile group effect.
基金supported by a grant from the Research Grant Council of Hong Kong Special Administrative Region(Project No.11207724).
文摘The development of digital twins for geotechnical structures necessitates the real-time updates of threedimensional(3D)virtual models(e.g.numerical finite element method(FEM)model)to accurately predict time-varying geotechnical responses(e.g.consolidation settlement)in a 3D spatial domain.However,traditional 3D numerical model updating approaches are computationally prohibitive and therefore difficult to update the 3D responses in real time.To address these challenges,this study proposes a novel machine learning framework called sparse dictionary learning(T-3D-SDL)for real-time updating of time-varying 3D geotechnical responses.In T-3D-SDL,a concerned dataset(e.g.time-varying 3D settlement)is approximated as a linear superposition of dictionary atoms generated from 3D random FEM analyses.Field monitoring data are then used to identify non-trivial atoms and estimate their weights within a Bayesian framework for model updating and prediction.The proposed approach enables the real-time update of temporally varying settlements with a high 3D spatial resolution and quantified uncertainty as field monitoring data evolve.The proposed approach is illustrated using an embankment construction project.The results show that the proposed approach effectively improves settlement predictions along temporal and 3D spatial dimensions,with minimal latency(e.g.within minutes),as monitoring data appear.In addition,the proposed approach requires only a reasonably small number of 3D FEM model evaluations,avoids the use of widely adopted yet often criticized surrogate models,and effectively addresses the limitations(e.g.computational inefficiency)of existing 3D model updating approaches.
基金supported by the Norman Bethune B Program of Jilin University(No.2012216)the Science and Technology Development Program of Jilin Province(No.20100750),China
文摘The purpose of this study was to establish a method for measuring the knee valgus angle from the ana- tomical and mechanical axes on three-dimensional reconstruction imaging models, and to use this method for estimating an average knee valgus angle value for northern Chinese adults. Computed tomographic angiography data in DICOM format for 128 normal femurs from 64 adult subjects were chosen for analysis. After the femur images were subjected to three-dimensional reconstruction, the deepest point in the intercondylar notch （point A）, the midpoint of the medullary cavity 20 cm above the knee-joint line （point B）, and the landmark of the femoral head rotation center （point C） were identified on each three-dimensional model. The knee valgus angle was defined as the angle enclosed by the distal femoral anatomical axis （line AB） and the femoral mechanical axis （line AC）. The average （mean＋SD） of knee valgus angle for the 128 femurs was 6.20°±1.20° （range, 3.05° to 10.64°）. Significant positive correlations were found between the knee valgus angles of the right and left sides and between the knee valgus angle and age. During total knee arthroplasty, choosing a valgus cut angle of approximately 6° may achieve a good result in reestablishing the natural mechanical alignment of the lower extremity for patients of northern Chinese ethnicity. Larger valgus cut angles should be chosen for older patients.
文摘Three-dimensional visualization technology converts engineering design drawings and data into graphics or images, realizes virtual reality perception of simulated users in future construction scene, enhances the interaction between project management and technical personnel and engineering construction achievement, and provides intuitive, flexible and strong realistic experience for project management. It can effectively improve the level of project communication, and assist the needs of project construction planning management, training, exhibition, etc. As a tool to help improve project management skills, it has good application effect and prospects.
