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Research on Testing System for Three-dimensional Distribution of Luminous Intensity of LED 被引量:1
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作者 FENG Jin-yuan LIN Xue-qin FU Zhi-xin DENG Jian-qiang 《Semiconductor Photonics and Technology》 CAS 2009年第2期97-100,116,共5页
In terms of asymmetrical three-dimensional distribution(ID) of luminous intensity(LI) of light-emitting-diode(LED),a testing system was conducted in this study. Design and principle of the testing system were introduc... In terms of asymmetrical three-dimensional distribution(ID) of luminous intensity(LI) of light-emitting-diode(LED),a testing system was conducted in this study. Design and principle of the testing system were introduced. 31 photometers were placed on a concentric circle,and all of them were used to gather LI data of LED at the same time. The data acquisition card(DAC) was used to gather multichannel data and controlled motor. Experimental results indicated that the testing system had achieved the goal of testing three-dimensional distribution of LI. And each parameter could meet the requirements of industrial production and measurement. 展开更多
关键词 light-emitting-diode three-dimensional distribution luminous intensity data acquisition card PHOTOMETER
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Damage location prediction of cement-sandstone combinations under axial force:Three-dimensional structure reconstruction and stress distribution simulation based onμ-CT
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作者 Zhong Li Zhiming Yin +3 位作者 Xingquan Zhang Tao Gu Fubin Xin Zhiqiang Huang 《Natural Gas Industry B》 2025年第4期405-415,共11页
Effective isolation between the cement sheath and the sandstone is crucial for the development and production of oil and gas wells in sandstone formations.In this study,a cement-sandstone composite(CSC)was prepared,an... Effective isolation between the cement sheath and the sandstone is crucial for the development and production of oil and gas wells in sandstone formations.In this study,a cement-sandstone composite(CSC)was prepared,and based onμ-CT three-dimensional reconstruction imaging and finite element analysis(FEA)techniques,the stress distribution and potential failure mechanism at the cement-sandstone bonding interface under axial loading were analyzed.The key findings are as follows:(1)stress concentrations are highly likely to form at the gap between the cement and sandstone interface and around interfacial voids,with Von Mises stress reaching critical levels of 18.0-20.0 MPa at these locations,significantly exceeding the stress magnitudes in well-bonded regions;(2)the phenomenon of local stress concentration driven by interfacial defects can be identified as the main basis for predicting damage location in interfacial debonding and continuous shear under axial load;(3)ensuring tight cementation at the cement-sandstone interface and minimizing interfacial voids are paramount for preventing stress-induced failure;(4)the critical Von Mises stress value of 20 MPa at the interface defect can be used as a benchmark for material selection and designed to ensure long-term integrity in oil and gas well applications subjected to similar axial loads.These findings contribute to a more accurate understanding of the failure mechanism of the cement-sandstone interface and to the precise design of material properties,thereby ensuring the long-term integrity of oil and gas well applications subjected to similar axial loads. 展开更多
关键词 Cement-sandstone combination μ-CT Stress distribution simulation Damage location prediction
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Representation of three-dimensional mass distribution of the Earth's interior by biorthogonal series and its use for studying internal structure of the planet
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作者 Mykhailo Fys Mariana Yurkiv +1 位作者 Andrii Brydun Andrii Sohor 《Geodesy and Geodynamics》 EI CSCD 2024年第3期264-275,共12页
This paper utilizes the mathematical concept of approximation within an ellipsoid from a single viewpoint to present the spatial mass distribution function of the Earth's interior and its internal potential.The pr... This paper utilizes the mathematical concept of approximation within an ellipsoid from a single viewpoint to present the spatial mass distribution function of the Earth's interior and its internal potential.The primary focus lies in constructing the volume distribution of masses in the planet's interior, with the expansion coefficients being linear combinations of the Stokes constants. Several possible approaches are suggested for determining accurately these coefficients employing three-dimensional(biorthogonal)polynomials. By expressing the mass distribution function of the Earth's interior and its internal potential as a series, an algorithm is introduced for the calculation of gravitational energy. It allows us to estimate fluctuations in gravitational energy. The implementation of this algorithm offers the means of establishing the extent to which the Earth deviates from a state of hydrostatic equilibrium as a celestial body.Due to the aforementioned method, calculations have been conducted to validate its effectiveness and reliability. This example is given as an illustration of a given method for studying the internal structure of planets. 展开更多
关键词 Mass distribution function Potential Stokes constants Biorthogonal polynomials
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A"messenger zone hypothesis"based on the visual three-dimensional spatial distribution of motoneurons innervating deep limb muscles
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作者 Chen Huang Shen Wang +3 位作者 Jin Deng Xinyi Gu Shuhang Guo Xiaofeng Yin 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1559-1567,共9页
Coordinated contraction of skeletal muscles relies on selective connections between the muscles and multiple classes of the spinal motoneuro ns.Howeve r,current research on the spatial location of the spinal motoneuro... Coordinated contraction of skeletal muscles relies on selective connections between the muscles and multiple classes of the spinal motoneuro ns.Howeve r,current research on the spatial location of the spinal motoneurons innervating differe nt muscles is limited.In this study,we investigated the spatial distribution and relative position of different motoneurons that control the deep muscles of the mouse hindlimbs,which were innervated by the obturator nerve,femoral nerve,inferior gluteal nerve,deep pe roneal nerve,and tibial nerve.Locations were visualized by combining a multiplex retrograde tracking technique compatible with three-dimensional imaging of solvent-cleared o rgans(3DISCO)and 3-D imaging technology based on lightsheet fluorescence microscopy(LSFM).Additionally,we propose the hypothesis that"messenger zones"exist as interlaced areas between the motoneuron pools that dominate the synergistic or antagonist muscle groups.We hypothesize that these interlaced neurons may participate in muscle coordination as messenger neurons.Analysis revealed the precise mutual positional relationships among the many motoneurons that innervate different deep muscles of the mouse.Not only do these findings update and supplement our knowledge regarding the overall spatial layout of spinal motoneurons that control mouse limb muscles,but they also provide insights into the mechanisms through which muscle activity is coordinated and the architecture of motor circuits. 展开更多
关键词 3-D imaging MOTONEURONS multiple retrograde tracing muscle coordination skeletal muscle spatial distribution optical tissue clearing
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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles 被引量:1
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作者 Yanting Liu Wei Huang +8 位作者 Jiayi Wen Xin Xiong Ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili Yang 《Neural Regeneration Research》 SCIE CAS 2025年第4期1124-1134,共11页
The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal degeneration.However,it remains largely unclear how PINK1 and Parkin a... The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal degeneration.However,it remains largely unclear how PINK1 and Parkin are expressed in mammalian brains.This has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small animals.Understanding this issue is critical for elucidating the in vivo roles of PINK1 and Parkin.Recently,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate brain.In the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate brain.We found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey brains.PINK1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable distribution.Immunofluorescent double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial stress.These findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage. 展开更多
关键词 NEURODEGENERATION PARKIN Parkinson’s disease PINK1 subcellular distribution
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Direct Radiative Effects of Dust Aerosols over Northwest China Revealed by Satellite-Derived Aerosol Three-Dimensional Distribution
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作者 Rui JIA Yuzhi LIU +7 位作者 Yan LI Jun LI Xiaolin HU Ronglu GAO Yunfei TIAN Yanling SUN Nannan MU Minfen ZHAO 《Journal of Meteorological Research》 SCIE CSCD 2022年第5期767-778,共12页
Northwest China is recognized as a main source and a major transport channel of dust aerosols in East Asia.With a fragile ecological environment,this region is quite sensitive to global climate change.Based on the sat... Northwest China is recognized as a main source and a major transport channel of dust aerosols in East Asia.With a fragile ecological environment,this region is quite sensitive to global climate change.Based on the satellite-derived aerosol three-dimensional distribution,the direct radiative effects of dust aerosols over Northwest China are evaluated.Aerosols over Northwest China are mainly distributed in the Tarim Basin,Junggar Basin,Gobi Desert,and Loess Plateau.The aerosol extinction coefficients are greater than 0.36 km-1 over the Tarim Basin and 0.16 km^(-1) over the Gobi Desert and Loess Plateau,decreasing with height.Aerosols over Northwest China are mainly composed of pure dust and polluted dust.These dust aerosols can modify the horizontal temperature gradient,vertical thermodynamic structure,and diurnal temperature range by absorbing and scattering shortwave radiation and emitting longwave radiation.For the column atmosphere,the radiative effect of dust aerosols shows heating effect of approximately 0.3 K day^(-1) during the daytime and cooling effect of approximately-0.4 K day^(-1) at night.In the vertical direction,dust aerosols can heat up the lower atmosphere(0.5–1.5 K day^(-1))and cool down the upper atmosphere(about-1.0 K day^(-1))during the daytime,while they cool down the lower atmosphere(-3 to-1.5 K day^(-1))and heat up the upper atmosphere(1–1.5 K day^(-1))at night.There are also significant lateral and vertical variations in the dust radiative effects corresponding to their spatial distributions.This study provides some scientific basis for reducing uncertainty in the investigation of aerosol radiative effects and provides observation evidence for simulation studies. 展开更多
关键词 aerosol three-dimensional distribution direct radiative effect Northwest China
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Revealing the intrinsic connection between residual strain distribution and dissolution mode in Mg-Sc-Y-Ag anode for Mg-air battery 被引量:2
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作者 Wei-li Cheng Xu-bang Hao +4 位作者 Jin-hui Wang Hui Yu Li-fei Wang Ze-qin Cui Cheng Chang 《Journal of Magnesium and Alloys》 2025年第3期1020-1033,共14页
The dominated contradiction in optimizing the performance of magnesium-air battery anode lies in the difficulty of achieving a good balance between activation and passivation during discharge process.To further reconci... The dominated contradiction in optimizing the performance of magnesium-air battery anode lies in the difficulty of achieving a good balance between activation and passivation during discharge process.To further reconcile this contradiction,two Mg-0.1Sc-0.1Y-0.1Ag anodes with different residual strain distribution through extrusion with/without annealing are fabricated.The results indicate that annealing can significantly lessen the“pseudo-anode”regions,thereby changing the dissolution mode of the matrix and achieving an effective dissolution during discharge.Additionally,p-type semiconductor characteristic of discharge productfilm could suppress the self-corrosion reaction without reducing the polarization of anode.The magnesium-air battery utilizing annealed Mg-0.1Sc-0.1Y-0.1Ag as anode achieves a synergistic improvement in specific capacity(1388.89 mA h g^(-1))and energy density(1960.42 mW h g^(-1)).This anode modification method accelerates the advancement of high efficiency and long lifespan magnesium-air batteries,offering renewable and cost-effective energy solutions for electronics and emergency equipment. 展开更多
关键词 Mg-air batteries ANODE Residual strain distribution Dissolution mode Discharge mechanism
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Three-dimensional line-of-sight-angle-constrained leader-following cooperative interception guidance law with prespecified impact time 被引量:1
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作者 Hao YOU Xinlong CHANG Jiufen ZHAO 《Chinese Journal of Aeronautics》 2025年第1期491-506,共16页
To address the problem of multi-missile cooperative interception against maneuvering targets at a prespecified impact time and desired Line-of-Sight(LOS)angles in ThreeDimensional(3D)space,this paper proposes a 3D lea... To address the problem of multi-missile cooperative interception against maneuvering targets at a prespecified impact time and desired Line-of-Sight(LOS)angles in ThreeDimensional(3D)space,this paper proposes a 3D leader-following cooperative interception guidance law.First,in the LOS direction of the leader,an impact time-controlled guidance law is derived based on the fixed-time stability theory,which enables the leader to complete the interception task at a prespecified impact time.Next,in the LOS direction of the followers,by introducing a time consensus tracking error function,a fixed-time consensus tracking guidance law is investigated to guarantee the consensus tracking convergence of the time-to-go.Then,in the direction normal to the LOS,by combining the designed global integral sliding mode surface and the second-order Sliding Mode Control(SMC)theory,an innovative 3D LOS-angle-constrained interception guidance law is developed,which eliminates the reaching phase in the traditional sliding mode guidance laws and effectively saves energy consumption.Moreover,it effectively suppresses the chattering phenomenon while avoiding the singularity issue,and compensates for unknown interference caused by target maneuvering online,making it convenient for practical engineering applications.Finally,theoretical proof analysis and multiple sets of numerical simulation results verify the effectiveness,superiority,and robustness of the investigated guidance law. 展开更多
关键词 three-dimensional cooperative interception Leader-following missiles Prespecified impact time LOS-angle-constrained Fixed-time stability Global integral sliding mode
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Cement-mortar lining failure and metal release caused by electrochemical corrosion of ductile iron pipes in drinking water distribution systems 被引量:1
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作者 Hao Guo Rui Wang +5 位作者 Menghan Jiang Yimei Tian Yapeng Jin Weigao Zhao Chenwan Wang Jianhua Yin 《Journal of Environmental Sciences》 2025年第6期488-502,共15页
The electrochemical corrosion of ductile pipes(DPs)in drinking water distribution systems(DWDS)has a crucial impact on cement-mortar lining(CML)failure and metal release,potentially leading to drinking water quality d... The electrochemical corrosion of ductile pipes(DPs)in drinking water distribution systems(DWDS)has a crucial impact on cement-mortar lining(CML)failure and metal release,potentially leading to drinking water quality deterioration and posing a risk to public health.An in-situ scanning vibrating electrode technique(SVET)with micron-scale resolution,microscopic scale detection and water quality analysis were used to investigate the corrosion behavior and metal release from DPs throughout the whole CML failure process.Metal pollutants release occurred at three different stages of CML failure process,and there are potential risks of water quality deterioration exceeding the maximum allowable levels set by national standards in the partial failure stage and lining peeling stage.Furthermore,the effects of water chemistry(Cl^(−),SO_(4)^(2−),NO_(3)−,and Ca^(2+))on corrosion scale growth and iron release activity,were investigated during the CML partial failure stage.Results showed that the CML failure process in DPs was accelerated by the autocatalysis of localized corrosion.Cl^(−)was found to damage the uncorroded metal surface,while SO_(4)^(2−)mainly dissolved the corrosion scale surface,increasing iron release.Both the oxidation of NO_(3)−and selective sedimentation of Ca2+were found to enhance the stability of corrosion scales and inhibit iron release. 展开更多
关键词 Water distribution system Cement mortar lining Corrosion Metal release SVET
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Data driven prediction of fragment velocity distribution under explosive loading conditions 被引量:4
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作者 Donghwan Noh Piemaan Fazily +4 位作者 Songwon Seo Jaekun Lee Seungjae Seo Hoon Huh Jeong Whan Yoon 《Defence Technology(防务技术)》 2025年第1期109-119,共11页
This study presents a machine learning-based method for predicting fragment velocity distribution in warhead fragmentation under explosive loading condition.The fragment resultant velocities are correlated with key de... This study presents a machine learning-based method for predicting fragment velocity distribution in warhead fragmentation under explosive loading condition.The fragment resultant velocities are correlated with key design parameters including casing dimensions and detonation positions.The paper details the finite element analysis for fragmentation,the characterizations of the dynamic hardening and fracture models,the generation of comprehensive datasets,and the training of the ANN model.The results show the influence of casing dimensions on fragment velocity distributions,with the tendencies indicating increased resultant velocity with reduced thickness,increased length and diameter.The model's predictive capability is demonstrated through the accurate predictions for both training and testing datasets,showing its potential for the real-time prediction of fragmentation performance. 展开更多
关键词 Data driven prediction Dynamic fracture model Dynamic hardening model FRAGMENTATION Fragment velocity distribution High strain rate Machine learning
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Investigation of spatiotemporal distribution and formation mechanisms of ozone pollution in eastern Chinese cities applying convolutional neural network 被引量:1
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作者 Qiaoli Wang Dongping Sheng +7 位作者 Chengzhi Wu Xiaojie Ou Shengdong Yao Jingkai Zhao Feili Li Wei Li Jianmeng Chen 《Journal of Environmental Sciences》 2025年第2期126-138,共13页
Severe ground-level ozone(O_(3))pollution over major Chinese cities has become one of the most challenging problems,which have deleterious effects on human health and the sustainability of society.This study explored ... Severe ground-level ozone(O_(3))pollution over major Chinese cities has become one of the most challenging problems,which have deleterious effects on human health and the sustainability of society.This study explored the spatiotemporal distribution characteristics of ground-level O_(3) and its precursors based on conventional pollutant and meteorological monitoring data in Zhejiang Province from 2016 to 2021.Then,a high-performance convolutional neural network(CNN)model was established by expanding the moment and the concentration variations to general factors.Finally,the response mechanism of O_(3) to the variation with crucial influencing factors is explored by controlling variables and interpolating target variables.The results indicated that the annual average MDA8-90th concentrations in Zhejiang Province are higher in the northern and lower in the southern.When the wind direction(WD)ranges from east to southwest and the wind speed(WS)ranges between 2 and 3 m/sec,higher O_(3) concentration prone to occur.At different temperatures(T),the O_(3) concentration showed a trend of first increasing and subsequently decreasing with increasing NO_(2) concentration,peaks at the NO_(2) concentration around 0.02mg/m^(3).The sensitivity of NO_(2) to O_(3) formation is not easily affected by temperature,barometric pressure and dew point temperature.Additionally,there is a minimum IRNO_(2) at each temperature when the NO_(2) concentration is 0.03 mg/m^(3),and this minimum IRNO_(2) decreases with increasing temperature.The study explores the response mechanism of O_(3) with the change of driving variables,which can provide a scientific foundation and methodological support for the targeted management of O_(3) pollution. 展开更多
关键词 OZONE Spatiotemporal distribution Convolutional neural network Ozone formation rules Incremental reactivity
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Spatial-temporal distribution and emission of urban scale air pollutants in Hefei based on Mobile-DOAS 被引量:1
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作者 Zhidong Zhang Pinhua Xie +8 位作者 Ang Li Min Qin Jin Xu Zhaokun Hu Xin Tian Feng Hu Yinsheng Lv Jiangyi Zheng Youtao Li 《Journal of Environmental Sciences》 2025年第5期238-251,共14页
As a significant city in the Yangtze River Delta regions,Hefei has experienced rapid changes in the sources of air pollution due to its high-speed economic development and urban expansion.However,there has been limite... As a significant city in the Yangtze River Delta regions,Hefei has experienced rapid changes in the sources of air pollution due to its high-speed economic development and urban expansion.However,there has been limited research in recent years on the spatial-temporal distribution and emission of its atmospheric pollutants.To address this,this study conducted mobile observations of urban roads using the Mobile-DOAS instrument from June 2021 to May 2022.The monitoring results exhibit a favourable consistent with TROPOMI satellite data and ground monitoring station data.Temporally,there were pronounced seasonal variations in air pollutants.Spatially,high concentration of HCHO and NO_(2)were closely associated with traffic congestion on roadways,while heightened SO_(2)levels were attributed to winter heating and industrial emissions.The study also revealed that with the implementation of road policies,the average vehicle speed increased by 95.4%,while the NO concentration decreased by 54.4%.In the estimation of urban NO_(x)emission flux,it was observed that in temporal terms,compared with inventory data,the emissions calculated viamobile measurements exhibitedmore distinct seasonal patterns,with the highest emission rate of 349 g/sec in winter and the lowest of 142 g/sec in summer.In spatial terms,the significant difference in emissions between the inner and outer ring roads also suggests the presence of the city’s primary NO_(x)emission sources in the area between these two rings.This study offers data support for formulating the next phase of air pollution control measures in urban areas. 展开更多
关键词 Mobile-DOAS HCHO NO_(2) SO_(2) Spatial-temporal distribution NOx emission
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Efficient and Stable Perovskite Solar Cells and Modules Enabled by Tailoring Additive Distribution According to the Film Growth Dynamics
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作者 Mengen Ma Cuiling Zhang +5 位作者 Yujiao Ma Weile Li Yao Wang Shaohang Wu Chong Liu Yaohua Mai 《Nano-Micro Letters》 SCIE EI CAS 2025年第2期387-400,共14页
Gas quenching and vacuum quenching process are widely applied to accelerate solvent volatilization to induce nucleation of perovskites in blade-coating method.In this work,we found these two pre-crystallization proces... Gas quenching and vacuum quenching process are widely applied to accelerate solvent volatilization to induce nucleation of perovskites in blade-coating method.In this work,we found these two pre-crystallization processes lead to different order of crystallization dynamics within the perovskite thin film,resulting in the differences of additive distribution.We then tailor-designed an additive molecule named 1,3-bis(4-methoxyphenyl)thiourea to obtain films with fewer defects and holes at the buried interface,and prepared perovskite solar cells with a certified efficiency of 23.75%.Furthermore,this work also demonstrates an efficiency of 20.18%for the large-area perovskite solar module(PSM)with an aperture area of 60.84 cm^(2).The PSM possesses remarkable continuous operation stability for maximum power point tracking of T_(90)>1000 h in ambient air. 展开更多
关键词 Gas quenching Additive distribution Buried passivation Blade coating Crystallization dynamics
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Impact of coking plant to heavy metal characteristics in groundwater of surrounding areas:Spatial distribution,source apportionment and risk assessments 被引量:1
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作者 Congqing Wang Wanjun Wang +5 位作者 ChaoWang Shixing Ren Yingjun Wu Meicheng Wen Guiying Li Taicheng An 《Journal of Environmental Sciences》 2025年第3期688-698,共11页
Coking industry is a potential source of heavy metals(HMs)pollution.However,its impacts to the groundwater of surrounding residential areas have not been well understood.This study investigated the pollution character... Coking industry is a potential source of heavy metals(HMs)pollution.However,its impacts to the groundwater of surrounding residential areas have not been well understood.This study investigated the pollution characteristics and health risks of HMs in groundwater nearby a typical coking plant.Nine HMs including Fe,Zn,Mo,As,Cu,Ni,Cr,Pb and Cd were analyzed.The average concentration of total HMswas higher in the nearby area(244.27μg/L)than that of remote area away the coking plant(89.15μg/L).The spatial distribution of pollution indices including heavy metal pollution index(HPI),Nemerow index(NI)and contamination degree(CD),all demonstrated higher values at the nearby residential areas,suggesting coking activity could significantly impact the HMs distribution characteristics.Four sources of HMs were identified by Positive Matrix Factorization(PMF)model,which indicated coal washing and coking emission were the dominant sources,accounted for 40.4%,and 31.0%,respectively.Oral ingestionwas found to be the dominant exposure pathway with higher exposure dose to children than adults.Hazard quotient(HQ)values were below 1.0,suggesting negligible non-carcinogenic health risks,while potential carcinogenic risks were from Pb and Ni with cancer risk(CR)values>10−6.Monte Carlo simulation matched well with the calculated results with HMs concentrations to be the most sensitive parameters.This study provides insights into understanding how the industrial coking activities can impact the HMs pollution characteristics in groundwater,thus facilitating the implement of HMs regulation in coking industries. 展开更多
关键词 Coking industry Heavy metal GROUNDWATER Spatial distribution Source apportionment Monte Carlo simulation
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Three-dimensional models:from cell culture to Patient-Derived Organoid and its application to future liposarcoma research
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作者 SAYUMI TAHARA SYDNEY RENTSCH +4 位作者 FERNANDA COSTAS CASAL DE FARIA PATRICIA SARCHET ROMA KARNA FEDERICA CALORE RAPHAEL E.POLLOCK 《Oncology Research》 SCIE 2025年第1期1-13,共13页
Liposarcoma is one of the most common soft tissue sarcomas,however,its occurrence rate is still rare compared to other cancers.Due to its rarity,in vitro experiments are an essential approach to elucidate liposarcoma ... Liposarcoma is one of the most common soft tissue sarcomas,however,its occurrence rate is still rare compared to other cancers.Due to its rarity,in vitro experiments are an essential approach to elucidate liposarcoma pathobiology.Conventional cell culture-based research(2D cell culture)is still playing a pivotal role,while several shortcomings have been recently under discussion.In vivo,mouse models are usually adopted for pre-clinical analyses with expectations to overcome the issues of 2D cell culture.However,they do not fully recapitulate human dedifferentiated liposarcoma(DDLPS)characteristics.Therefore,three-dimensional(3D)culture systems have been the recent research focus in the cell biology field with the expectation to overcome at the same time the disadvantages of 2D cell culture and in vivo animal models and fill in the gap between them.Given the liposarcoma rarity,we believe that 3D cell culture techniques,including 3D cell cultures/co-cultures,and Patient-Derived tumor Organoids(PDOs),represent a promising approach to facilitate liposarcoma investigation and elucidate its molecular mechanisms and effective therapy development.In this review,we first provide a general overview of 3D cell cultures compared to 2D cell cultures.We then focus on one of the recent 3D cell culture applications,Patient-Derived Organoids(PDOs),summarizing and discussing several PDO methodologies.Finally,we discuss the current and future applications of PDOs to sarcoma,particularly in the field of liposarcoma. 展开更多
关键词 Cell culture LIPOSARCOMA Patient-Derived Organoid(PDO) SPHEROID three-dimensional(3D)cell culture
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Identification and distribution patterns of the ultra-deep small-scale strike-slip faults based on convolutional neural network in Tarim Basin,NW China 被引量:1
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作者 Hao Li Jun Han +4 位作者 Cheng Huang Lian-Bo Zeng Bo Lin Ying-Tao Yao Yi-Chen Song 《Petroleum Science》 2025年第8期3152-3167,共16页
The isolated fracture-vug systems controlled by small-scale strike-slip faults within ultra-deep carbonate rocks of the Tarim Basin exhibit significant exploration potential.The study employs a novel training set inco... The isolated fracture-vug systems controlled by small-scale strike-slip faults within ultra-deep carbonate rocks of the Tarim Basin exhibit significant exploration potential.The study employs a novel training set incorporating innovative fault labels to train a U-Net-structured CNN model,enabling effective identification of small-scale strike-slip faults through seismic data interpretation.Based on the CNN faults,we analyze the distribution patterns of small-scale strike-slip faults.The small-scale strike-slip faults can be categorized into NNW-trending and NE-trending groups with strike lengths ranging 200–5000 m.The development intensity of small-scale strike-slip faults in the Lower Yingshan Member notably exceeds that in the Upper Member.The Lower and Upper Yingshan members are two distinct mechanical layers with contrasting brittleness characteristics,separated by a low-brittleness layer.The superior brittleness of the Lower Yingshan Member enhances the development intensity of small-scale strike-slip faults compared to the upper member,while the low-brittleness layer exerts restrictive effects on vertical fault propagation.Fracture-vug systems formed by interactions of two or more small-scale strike-slip faults demonstrate larger sizes than those controlled by individual faults.All fracture-vug system sizes show positive correlations with the vertical extents of associated small-scale strike-slip faults,particularly intersection and approaching fracture-vug systems exhibit accelerated size increases proportional to the vertical extents. 展开更多
关键词 Small-scale strike-slip faults Convolutional neural network Fault label Isolated fracture-vug system distribution patterns
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Distribution network gray-start and emergency recovery strategy with pumped storage unit under a typhoon 被引量:1
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作者 Zhenguo Wang Hui Hou +4 位作者 Chao Liu Shaohua Wang Zhengtian Li Xiangning Lin Te Li 《Global Energy Interconnection》 2025年第1期121-133,共13页
Typhoons can cause large-area blackouts or partial outages of distribution networks.We define a partial outage state in the distribution network as a gray state and propose a gray-start strategy and two-stage distribu... Typhoons can cause large-area blackouts or partial outages of distribution networks.We define a partial outage state in the distribution network as a gray state and propose a gray-start strategy and two-stage distribution network emergency recovery framework.A phase-space reconstruction and stacked integrated model for predicting wind and photovoltaic generation during typhoon disasters is proposed in the first stage.This provides guidance for second-stage post-disaster emergency recovery scheduling.The emergency recovery scheduling model is established in the second stage,and this model is supported by a thermal power-generating unit,mobile emergency generators,and distributed generators.Distributed generation includes wind power generation,photovoltaics,fuel cells,etc.Simultaneously,we con-sider the gray-start based on the pumped storage unit to be an important first step in the emergency recovery strategy.This model is val-idated on the improved IEEE 33 node system,which utilizes data from the 2022 super typhoon“Muifa”in Zhoushan,Zhejiang,China.Simulations indicate the superiority of a gray start with a pumped storage unit and the proposed emergency recovery strategy. 展开更多
关键词 Wind and photovoltaic generation prediction Pumped storage unit Gray-start distribution network Emergency recovery strategy
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Plasmid-mediated transfer of antibiotic resistance genes and biofilm formation in a simulated drinking water distribution system under chlorine pressure 被引量:1
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作者 Yexing Wang Yingyu Zhang +2 位作者 Xiuneng Zhu Yulin Tang Yongji Zhang 《Journal of Environmental Sciences》 2025年第6期376-388,共13页
The effects of disinfectants and plasmid-based antibiotic resistance genes(ARGs)on the growth of microorganisms and the plasmid-mediated transfer of ARGs in the water and biofilm of the drinkingwater distribution syst... The effects of disinfectants and plasmid-based antibiotic resistance genes(ARGs)on the growth of microorganisms and the plasmid-mediated transfer of ARGs in the water and biofilm of the drinkingwater distribution system under simulated conditionswere explored.The heterotrophic plate count of the water in reactors with 0.1 mg/L NaClO and NH_(2)Cl was higher than in the control groups.Therewas no similar phenomenon in biofilm.In thewater of reactors containing NaClO,the aphA and bla geneswere lower than in the antibiotic resistant bacteria group,while both genes were higher in the water of reactors with NH_(2)Cl than in the control group.Chloramine may promote the transfer of ARGs in the water phase.Both genes in the biofilm of the reactors containing chlorine were lower than the control group.Correlation analysis between ARGs and water quality parameters revealed that the copy numbers of the aphA gene were significantly positively correlated with the copy numbers of the bla gene in water and significantly negatively correlated in biofilm(p<0.05).The results of the sequencing assay showed that bacteria in the biofilm,in the presence of disinfectant,were primarily Gram-negative.1.0 mg/L chlorine decreased the diversity of the community in the biofilm.The relative abundance of some bacteria that may undergo transfer increased in the biofilm of the reactor containing 0.1 mg/L chlorine. 展开更多
关键词 DISINFECTANT Antibiotic resistance genes(ARGs) Heterotrophic plate count(HPC) Drinking water distribution system Biofilm
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Optimal Planning of Multiple PV-DG in Radial Distribution Systems Using Loss Sensitivity Analysis and Genetic Algorithm
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作者 A. Elkholy 《Journal of Power and Energy Engineering》 2025年第2期1-22,共22页
This paper introduces an optimized planning approach for integrating photovoltaic as distributed generation (PV-DG) into the radial distribution power systems, utilizing exhaustive load flow (ELF), loss sensitivity fa... This paper introduces an optimized planning approach for integrating photovoltaic as distributed generation (PV-DG) into the radial distribution power systems, utilizing exhaustive load flow (ELF), loss sensitivity factor (LSF), genetic algorithms (GA) methods, and numerical method based on LSF. The methodology aims to determine the optimal allocation and sizing of multiple PV-DG to minimize power loss through time series power flow analysis. An approach utilizing continuous sensitivity analysis is developed and inherently leverages power flow and loss equations to compute LSF of all buses in the system towards employing a dynamic PV-DG model for more accurate results. The algorithm uses a numerical grid search method to optimize PV-DG placement in a power distribution system, focusing on minimizing system losses. It combines iterative analysis, sensitivity assessment, and comprehensive visualization to identify and present the optimal PV-DG configurations. The present-ed algorithms are verified through co-simulation framework combining MATLAB and OpenDSS to carry out analysis for 12-bus radial distribution test system. The proposed numerical method is compared with other algorithms, such as ELF, LSF methods, and Genetic Algorithms (GA). Results show that the proposed numerical method performs well in comparison with LSF and ELF solutions. 展开更多
关键词 Photovoltaic Systems distributed Generation Multiple Allocation and Sizing Power Losses Radial distribution System Genetic Algorithm
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Reactive Power Optimization Model of Active Distribution Network with New Energy and Electric Vehicles 被引量:1
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作者 Chenxu Wang Jing Bian Rui Yuan 《Energy Engineering》 2025年第3期985-1003,共19页
Considering the uncertainty of grid connection of electric vehicle charging stations and the uncertainty of new energy and residential electricity load,a spatio-temporal decoupling strategy of dynamic reactive power o... Considering the uncertainty of grid connection of electric vehicle charging stations and the uncertainty of new energy and residential electricity load,a spatio-temporal decoupling strategy of dynamic reactive power optimization based on clustering-local relaxation-correction is proposed.Firstly,the k-medoids clustering algorithm is used to divide the reduced power scene into periods.Then,the discrete variables and continuous variables are optimized in the same period of time.Finally,the number of input groups of parallel capacitor banks(CB)in multiple periods is fixed,and then the secondary static reactive power optimization correction is carried out by using the continuous reactive power output device based on the static reactive power compensation device(SVC),the new energy grid-connected inverter,and the electric vehicle charging station.According to the characteristics of the model,a hybrid optimization algorithm with a cross-feedback mechanism is used to solve different types of variables,and an improved artificial hummingbird algorithm based on tent chaotic mapping and adaptive mutation is proposed to improve the solution efficiency.The simulation results show that the proposed decoupling strategy can obtain satisfactory optimization resultswhile strictly guaranteeing the dynamic constraints of discrete variables,and the hybrid algorithm can effectively solve the mixed integer nonlinear optimization problem. 展开更多
关键词 Active distribution network new energy electric vehicles dynamic reactive power optimization kmedoids clustering hybrid optimization algorithm
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