E-commerce has transformed Caoxian into a hub of traditional Chinese attire.STEPPING inside Caoxian’s Youai Cloud Warehouse,a livestreaming base dedicated to hanfu(traditional clothing),it feels less like a clothing ...E-commerce has transformed Caoxian into a hub of traditional Chinese attire.STEPPING inside Caoxian’s Youai Cloud Warehouse,a livestreaming base dedicated to hanfu(traditional clothing),it feels less like a clothing warehouse and more like a time capsule.Thousands of intricately embroidered garments line the racks-from elegant horse-face skirts to modernised editions of traditional Chinese clothing.展开更多
When one steps inside Caoxian’s Youai Cloud Warehouse,a livestreaming base dedicated to hanfu,it feels less like a clothing warehouse and more like a time capsule.Thousands of intricately embroidered garments line th...When one steps inside Caoxian’s Youai Cloud Warehouse,a livestreaming base dedicated to hanfu,it feels less like a clothing warehouse and more like a time capsule.Thousands of intricately embroidered garments line the racks-from elegant horse-face skirts to modernised editions of traditional Chinese clothing.展开更多
As the global textile market continues to expand, demand for sewing threads-a critical auxiliary material-is rising. In recent years, automotive interiors, smart outdoor equipment, and medical and ecofriendly products...As the global textile market continues to expand, demand for sewing threads-a critical auxiliary material-is rising. In recent years, automotive interiors, smart outdoor equipment, and medical and ecofriendly products have emerged as new growth engines for the textile industry. This has propelled specialized niche markets for sewing threads designed for these applications, revealing significant and undeniable potential.展开更多
Samples of metal threads were prepared, underwent artificial aging, and cleaned using laser applications to define the efficiency of cleaning that gives the best results without affecting the components of the thread,...Samples of metal threads were prepared, underwent artificial aging, and cleaned using laser applications to define the efficiency of cleaning that gives the best results without affecting the components of the thread, including metal, fibers, or dyes. The present study aimed to investigate and evaluate laser cleaning of the corroded metal embroidery, revealing the chemical composition of the corrosion and prop and evaluating the effects of laser cleaning on the surface of the metal threads. It utilized SEM and LM to provide morphological information about the surface and the cleaning effect. Moreover, SEM-EDX was used to define the elemental composition, and XRD was employed to offer information on the metal. The restoration of cultural heritage depends on defining the devastating changes to the man-made pieces. It compares pre-and post-restoration conditions of the object (e.g. painting, photography, and material analysis), controlling the conditions that are almost irrevocable. An Interval Digital Macro-photography is employed to control the corrosion PS tests for a long period of museum exhibition [1].展开更多
Thin buccal bone has a risk of thread exposure, and placement of a graft is the mainline of treatment for thread exposure. However, this process takes time as the patient is expected to wait for healing to occur befor...Thin buccal bone has a risk of thread exposure, and placement of a graft is the mainline of treatment for thread exposure. However, this process takes time as the patient is expected to wait for healing to occur before the implant can be placed. To overcome the waiting period, this study views a different method. This study examines the use of guided bone regeneration on the day of implant placement on buccal bone where thread exposure occurs. This process has the advantage of avoiding the patient to go through multiple operations till receiving the final prosthetic treatment, also saving time and money for both the patient and the practitioner.展开更多
One of the technologies that have attracted the most attention recently across a variety of applications is the Internet of Things (IoT). The Internet of Things (IoT) is the combination of sensor, embedded computing, ...One of the technologies that have attracted the most attention recently across a variety of applications is the Internet of Things (IoT). The Internet of Things (IoT) is the combination of sensor, embedded computing, and communication technologies. The goal of the Internet of Things is to provide seamless services to anything, everywhere, at any time. The internet of things (IoT) technologies plays a vital role everywhere after the internet and information and communication technology, ushering in the fourth disruptive technology revolution (ICT). For real-time processing, communication, and monitoring, the smart items are linked together through wired or wireless connections. Implementing the IoT system presents security and privacy challenges since IoT devices are incompatible with current security standards based on tradition. This paper discusses IoT security strands, mitigation strategies, and privacy issues. This study’s major objective is to get more knowledge about security threats, mitigation techniques, and privacy concerns in IoT devices. The authors also mentioned a few cutting-edge technologies that can address general security problems. This study’s major objectives are to find research gaps in IoT security and match solution paradigms. The advent and rapid growth of the Internet of Things (IoT), which offers innumerable benefits, facilities, and applications including smart grids, smart homes, smart cities, and intelligent transportation systems (ITS), have an impact on everyone’s life. However, the deployment and use of sensing devices exposes IoT-based systems and applications to many security flaws and attacks. Furthermore, the lack of standardization brought on by the diversity of devices and technologies makes integrating security in the IoT a severe problem. The purpose of this review paper is to highlight the numerous security threats, challenges, and attacks that IoT-enabled applications face.展开更多
The expressions of the radius and the surface tension of surface of tension Rs and γs in terms of the pressure distribution for nanoscale liquid threads are of great importance for molecular dynamics （MD） simulatio...The expressions of the radius and the surface tension of surface of tension Rs and γs in terms of the pressure distribution for nanoscale liquid threads are of great importance for molecular dynamics （MD） simulations of the interfacial phenomena of nanoscale fluids; these two basic expressions are derived in this paper. Although these expressions were derived first in the literature[Kim B G, Lee J S, Han M H, and Park S, 2006 Nanoscale and Microscale Thermophysical Engineering, 10, 283] and used widely thereafter, the derivation is wrong both in logical structure and physical thought. In view of the importance of these basic expressions, the logic and physical mistakes appearing in that derivation are pointed out.展开更多
This paper presents, without altering the AADL meta-model, a formal description of static and behavioral aspects of the AADL thread component. This active and concurrent applicative component of AADL poses many challe...This paper presents, without altering the AADL meta-model, a formal description of static and behavioral aspects of the AADL thread component. This active and concurrent applicative component of AADL poses many challenges to its formalization and analysis including instantaneous and/or delayed communications, concurrent tasks and time-dependent features, and the need to analyze correctness. This formalization, based on real-time object-oriented theories, allows not only a precise description of the semantics of threads composition with respect to their timing requirements but also makes possible the formal verification of behavioral properties.展开更多
Great economic benefit will be made if a kind of low-cost gas-tight thread can be developed on the basis of API round thread with a relatively lowest cost to replace the existing premium thread.In this paper,a kind of...Great economic benefit will be made if a kind of low-cost gas-tight thread can be developed on the basis of API round thread with a relatively lowest cost to replace the existing premium thread.In this paper,a kind of gas-tight threads was designed and manufactured based on the round threads according to the API Spec 5B standard.An elastic sealing ring was added in the middle of the collar,and gas tightness was realized by virtue of the interference matching between the elastic sealing ring and the casing thread.Then,its ultimate bearing capacity was analyzed by using the finite element analysis software MSC.Marc/Mentat.Finally,ISO 13679Bseries andCseries tests,and tension tests under internal gas pressure in the bending setting were carried out onØ73.02×5.51 mm J55 gas-tight threads according to the ISO 13679 standard.It is shown that the gas sealing performance of this gas-tight thread is good,and the results of ultimate internal pressure cycling and the thermal cycling test on sealing pipe ends meet the requirements of ISO 13679.Besides,its internal pressure strength,tensile strength and collapse strength are much higher than those required by GB/T 20657 standard.It is concluded that this type of gas-tight threads can be used in the development of low-pressure gas wells in the Ordos Basin.It has the potential to cut down the casing cost greatly and it can be used as the reference for the design of new gas-tight threads.展开更多
In the highlands of Qiaoqi Tibetan Township in Ya'an City,Sichuan Province,Nengkaman's journey began not with a thread,but with a camera.Starting in 2014,the now 40-year-old Tibetan woman documented the daily ...In the highlands of Qiaoqi Tibetan Township in Ya'an City,Sichuan Province,Nengkaman's journey began not with a thread,but with a camera.Starting in 2014,the now 40-year-old Tibetan woman documented the daily life and culture of her homeland,only to notice through her lens that the traditional crafts of yak wool weaving and Qiaoqi waistband making-once essential skills for local women-were quietly disappearing.展开更多
As we age,our skin loses elasticity and wrinkles form.To prevent this,most people try to improve skin wrinkles by performing procedures such as fillers,and absorbable lifting threads.Another way to solve this structur...As we age,our skin loses elasticity and wrinkles form.To prevent this,most people try to improve skin wrinkles by performing procedures such as fillers,and absorbable lifting threads.Another way to solve this structural problem is to use an elastic thread.Although elastic sutures made of polymer materials(such as silicone)are widely used,data regarding their properties and potential effectiveness are lacking.This study aimed to investigate the effects of inserting non-absorbable elastic threads,with different manufacturing requirements and methods,on the skin and subcutaneous tissue.In this study,non-absorbable elastic threads ELATENS and Elasticum using different manufacturing methods were compared.Each thread was transplanted into the subcutaneous layer of the back of a rat to induce wrinkles.After inducing wrinkles in the skin of rat,the degree of skin maintenance by each thread and the thickness of the capsule formed around the suture were measured.Through ex-vivo experiments on each thread,the fixation force in the tissue was confirmed.In a comparison of inflammatory response and collagen formation through histological analysis,it was confirmed that there was no significant difference from the equivalent comparative product.In conclusion,the degree of encapsulation between tissues and collagen fiber formation for improving skin wrinkles was superior in elastic threads compared to non-elastic threads.It is believed that this provides certain elasticity to the skin layer and can induce cell influx to improve wrinkles.展开更多
Alzheimer’s disease is a multi-amyloidosis disease characterized by amyloid-βdeposits in brain blood vessels,microaneurysms,and senile plaques.How amyloid-βdeposition affects axon pathology has not been examined ex...Alzheimer’s disease is a multi-amyloidosis disease characterized by amyloid-βdeposits in brain blood vessels,microaneurysms,and senile plaques.How amyloid-βdeposition affects axon pathology has not been examined extensively.We used immunohistochemistry and immunofluorescence staining to analyze the forebrain tissue slices of Alzheimer’s disease patients.Widespread axonal amyloidosis with distinctive axonal enlargement was observed in patients with Alzheimer’s disease.On average,amyloid-β-positive axon diameters in Alzheimer’s disease brains were 1.72 times those of control brain axons.Furthermore,axonal amyloidosis was associated with microtubule-associated protein 2 reduction,tau phosphorylation,lysosome destabilization,and several blood-related markers,such as apolipoprotein E,alpha-hemoglobin,glycosylated hemoglobin type A1C,and hemin.Lysosome destabilization in Alzheimer’s disease was also clearly identified in the neuronal soma,where it was associated with the co-expression of amyloid-β,Cathepsin D,alpha-hemoglobin,actin alpha 2,and collagen type IV.This suggests that exogenous hemorrhagic protein intake influences neural lysosome stability.Additionally,the data showed that amyloid-β-containing lysosomes were 2.23 times larger than control lysosomes.Furthermore,under rare conditions,axonal breakages were observed,which likely resulted in Wallerian degeneration.In summary,axonal enlargement associated with amyloidosis,micro-bleeding,and lysosome destabilization is a major defect in patients with Alzheimer’s disease.This finding suggests that,in addition to the well-documented neural soma and synaptic damage,axonal damage is a key component of neuronal defects in Alzheimer’s disease.展开更多
ZHANG Yongmei is turning thethreads of her life around and isweaving success from an all toocommon sob-story.Laid off ten yearsago,Zhang Yongmei is now a well-known name in certain circles ofBeijing,both for the work ...ZHANG Yongmei is turning thethreads of her life around and isweaving success from an all toocommon sob-story.Laid off ten yearsago,Zhang Yongmei is now a well-known name in certain circles ofBeijing,both for the work she does andthe help she brings to those who haveshared a similar fate.Her secret weapon?—pet fashion for the export market andplenty of perseverance.As manager展开更多
MAYBE I should be grateful to my mother. When I was very young, she taught me how to knit socks. Using a kind of white nylon thread and a needle made from a kind of hairpin, a durable sock could be made. Before long I...MAYBE I should be grateful to my mother. When I was very young, she taught me how to knit socks. Using a kind of white nylon thread and a needle made from a kind of hairpin, a durable sock could be made. Before long I had mastered the skill, then knit a pair of socks for each of my family members. However, my mother seemed to be a collector of socks and didn’t allow me to stop knitting them until I came to hate this task. Luckily, my mother changed her interest. One day while she展开更多
A young artist reinvents an old sartorial skill from rural ethnic communities into globally recognized high fashion.LACKING a unified writing system,the ancestors of the Miao people,an ethnic group primarily living in...A young artist reinvents an old sartorial skill from rural ethnic communities into globally recognized high fashion.LACKING a unified writing system,the ancestors of the Miao people,an ethnic group primarily living in mountainous areas in central and southwestern China,encoded their history in the exquisite design of traditional clothing,especially embroidery.They express reverence for nature and appreciation of life with needles and threads.展开更多
BACKGROUND A total of 100 patients diagnosed with mixed hemorrhoids from October 2022 to September 2023 in our hospital were randomly divided into groups by dice rolling and compared with the efficacy of different tre...BACKGROUND A total of 100 patients diagnosed with mixed hemorrhoids from October 2022 to September 2023 in our hospital were randomly divided into groups by dice rolling and compared with the efficacy of different treatment options.AIM To analyze the clinical effect and prognosis of mixed hemorrhoids treated with polidocanol injection combined with automatic elastic thread ligation operation(RPH).METHODS A total of 100 patients with mixed hemorrhoids who visited our hospital from October 2022 to September 2023 were selected and randomly divided into the control group(n=50)and the treatment group(n=50)by rolling the dice.The procedure for prolapse and hemorrhoids(PPH)was adopted in the control group,while polidocanol foam injection+RPH was adopted in the treatment group.The therapeutic effects,operation time,wound healing time,hospital stay,pain situation(24 hours post-operative pain score,first defecation pain score),quality of life(QOL),incidence of complications(post-operative hemorrhage,edema,infection),incidence of anal stenosis 3 months post-operatively and recurrence rate 1 year post-operatively of the two groups were compared.RESULTS Compared with the control group,the total effective rate of treatment group was higher,and the difference was significant(P<0.05).The operation time/wound healing time/hospital stay in the treatment group were shorter than those in the control group(P<0.05).The pain scores at 24 hours after operation/first defecation pain score of the treatment group was significantly lower than those in the control group(P<0.05).After surgery,the QOL scores of the two groups decreased,with the treatment group having higher scores than that of the control group(P<0.05).Compared with the control group,the incidence of postoperative complications in the treatment group was lower,and the difference was significant(P<0.05);However,there was no significant difference in the incidence of postoperative bleeding between the two groups(P>0.05);There was no significant difference in the incidence of anal stenosis 3 months after operation and the recurrence rate 1 year after operation between the two groups(P>0.05).CONCLUSION For patients with mixed hemorrhoids,the therapeutic effect achieved by using polidocanol injection combined with RPH was better.The wounds of the patients healed faster,the postoperative pain was milder,QOL improved,and the incidence of complications was lower,and the short-term and long-term prognosis was good.展开更多
多核处理器越来越普及,如何通过软件技术最大提升CPU每个核心的使用率,成为热点问题。引入多核并行编程模型Threading Building Blocks,并与raw threads、Open MP进行各方面详细比较,分析了其优劣。并研究了TBB结合MPI在SMP集群系统上...多核处理器越来越普及,如何通过软件技术最大提升CPU每个核心的使用率,成为热点问题。引入多核并行编程模型Threading Building Blocks,并与raw threads、Open MP进行各方面详细比较,分析了其优劣。并研究了TBB结合MPI在SMP集群系统上实现高效的混合并行计算应用的方法。最终发现TBB在多核编程方面有显著的优势。TTB和MPI的结合,又为多核处理器结点集群提供了并行层次化结构,大大优化集群的性能。展开更多
The direct growth of InGaAs high-electron-mobility transistors(HEMTs)on silicon facilitates their low-cost production on large-scale wafers.On a U-shaped patterned Si(001)substrate,we have achieved a high-quality In_(...The direct growth of InGaAs high-electron-mobility transistors(HEMTs)on silicon facilitates their low-cost production on large-scale wafers.On a U-shaped patterned Si(001)substrate,we have achieved a high-quality In_(0.36)Ga_(0.64)As film with a threading dislocation density of∼7×10^(6)cm^(−2).The fabricated HEMT devices exhibit outstanding electrical characteristics,including a high Hall mobility of 4732 cm^(2)/V·s and an effective mobility of 3305 cm^(2)/V・s at room temperature.Through precise gate-recess processing and surface passivation,both depletion-mode and enhancement-mode devices were realized with transconductances reaching 500mS/mm for a channel length of 100 nm.These results indicate their significant potential for the development of next-generation high-speed Ⅲ-Ⅴ electronic devices on silicon platforms that are compatible with CMOS technology.展开更多
文摘E-commerce has transformed Caoxian into a hub of traditional Chinese attire.STEPPING inside Caoxian’s Youai Cloud Warehouse,a livestreaming base dedicated to hanfu(traditional clothing),it feels less like a clothing warehouse and more like a time capsule.Thousands of intricately embroidered garments line the racks-from elegant horse-face skirts to modernised editions of traditional Chinese clothing.
文摘When one steps inside Caoxian’s Youai Cloud Warehouse,a livestreaming base dedicated to hanfu,it feels less like a clothing warehouse and more like a time capsule.Thousands of intricately embroidered garments line the racks-from elegant horse-face skirts to modernised editions of traditional Chinese clothing.
文摘As the global textile market continues to expand, demand for sewing threads-a critical auxiliary material-is rising. In recent years, automotive interiors, smart outdoor equipment, and medical and ecofriendly products have emerged as new growth engines for the textile industry. This has propelled specialized niche markets for sewing threads designed for these applications, revealing significant and undeniable potential.
文摘Samples of metal threads were prepared, underwent artificial aging, and cleaned using laser applications to define the efficiency of cleaning that gives the best results without affecting the components of the thread, including metal, fibers, or dyes. The present study aimed to investigate and evaluate laser cleaning of the corroded metal embroidery, revealing the chemical composition of the corrosion and prop and evaluating the effects of laser cleaning on the surface of the metal threads. It utilized SEM and LM to provide morphological information about the surface and the cleaning effect. Moreover, SEM-EDX was used to define the elemental composition, and XRD was employed to offer information on the metal. The restoration of cultural heritage depends on defining the devastating changes to the man-made pieces. It compares pre-and post-restoration conditions of the object (e.g. painting, photography, and material analysis), controlling the conditions that are almost irrevocable. An Interval Digital Macro-photography is employed to control the corrosion PS tests for a long period of museum exhibition [1].
文摘Thin buccal bone has a risk of thread exposure, and placement of a graft is the mainline of treatment for thread exposure. However, this process takes time as the patient is expected to wait for healing to occur before the implant can be placed. To overcome the waiting period, this study views a different method. This study examines the use of guided bone regeneration on the day of implant placement on buccal bone where thread exposure occurs. This process has the advantage of avoiding the patient to go through multiple operations till receiving the final prosthetic treatment, also saving time and money for both the patient and the practitioner.
文摘One of the technologies that have attracted the most attention recently across a variety of applications is the Internet of Things (IoT). The Internet of Things (IoT) is the combination of sensor, embedded computing, and communication technologies. The goal of the Internet of Things is to provide seamless services to anything, everywhere, at any time. The internet of things (IoT) technologies plays a vital role everywhere after the internet and information and communication technology, ushering in the fourth disruptive technology revolution (ICT). For real-time processing, communication, and monitoring, the smart items are linked together through wired or wireless connections. Implementing the IoT system presents security and privacy challenges since IoT devices are incompatible with current security standards based on tradition. This paper discusses IoT security strands, mitigation strategies, and privacy issues. This study’s major objective is to get more knowledge about security threats, mitigation techniques, and privacy concerns in IoT devices. The authors also mentioned a few cutting-edge technologies that can address general security problems. This study’s major objectives are to find research gaps in IoT security and match solution paradigms. The advent and rapid growth of the Internet of Things (IoT), which offers innumerable benefits, facilities, and applications including smart grids, smart homes, smart cities, and intelligent transportation systems (ITS), have an impact on everyone’s life. However, the deployment and use of sensing devices exposes IoT-based systems and applications to many security flaws and attacks. Furthermore, the lack of standardization brought on by the diversity of devices and technologies makes integrating security in the IoT a severe problem. The purpose of this review paper is to highlight the numerous security threats, challenges, and attacks that IoT-enabled applications face.
基金RαProject supported by the National Natural Science Foundation of China(Grant No.11072242)the Research and Development Program of Science and Technology of Higher Education of Shanxi Province,China(Grant No.20121029)
文摘The expressions of the radius and the surface tension of surface of tension Rs and γs in terms of the pressure distribution for nanoscale liquid threads are of great importance for molecular dynamics （MD） simulations of the interfacial phenomena of nanoscale fluids; these two basic expressions are derived in this paper. Although these expressions were derived first in the literature[Kim B G, Lee J S, Han M H, and Park S, 2006 Nanoscale and Microscale Thermophysical Engineering, 10, 283] and used widely thereafter, the derivation is wrong both in logical structure and physical thought. In view of the importance of these basic expressions, the logic and physical mistakes appearing in that derivation are pointed out.
文摘This paper presents, without altering the AADL meta-model, a formal description of static and behavioral aspects of the AADL thread component. This active and concurrent applicative component of AADL poses many challenges to its formalization and analysis including instantaneous and/or delayed communications, concurrent tasks and time-dependent features, and the need to analyze correctness. This formalization, based on real-time object-oriented theories, allows not only a precise description of the semantics of threads composition with respect to their timing requirements but also makes possible the formal verification of behavioral properties.
文摘Great economic benefit will be made if a kind of low-cost gas-tight thread can be developed on the basis of API round thread with a relatively lowest cost to replace the existing premium thread.In this paper,a kind of gas-tight threads was designed and manufactured based on the round threads according to the API Spec 5B standard.An elastic sealing ring was added in the middle of the collar,and gas tightness was realized by virtue of the interference matching between the elastic sealing ring and the casing thread.Then,its ultimate bearing capacity was analyzed by using the finite element analysis software MSC.Marc/Mentat.Finally,ISO 13679Bseries andCseries tests,and tension tests under internal gas pressure in the bending setting were carried out onØ73.02×5.51 mm J55 gas-tight threads according to the ISO 13679 standard.It is shown that the gas sealing performance of this gas-tight thread is good,and the results of ultimate internal pressure cycling and the thermal cycling test on sealing pipe ends meet the requirements of ISO 13679.Besides,its internal pressure strength,tensile strength and collapse strength are much higher than those required by GB/T 20657 standard.It is concluded that this type of gas-tight threads can be used in the development of low-pressure gas wells in the Ordos Basin.It has the potential to cut down the casing cost greatly and it can be used as the reference for the design of new gas-tight threads.
文摘In the highlands of Qiaoqi Tibetan Township in Ya'an City,Sichuan Province,Nengkaman's journey began not with a thread,but with a camera.Starting in 2014,the now 40-year-old Tibetan woman documented the daily life and culture of her homeland,only to notice through her lens that the traditional crafts of yak wool weaving and Qiaoqi waistband making-once essential skills for local women-were quietly disappearing.
文摘As we age,our skin loses elasticity and wrinkles form.To prevent this,most people try to improve skin wrinkles by performing procedures such as fillers,and absorbable lifting threads.Another way to solve this structural problem is to use an elastic thread.Although elastic sutures made of polymer materials(such as silicone)are widely used,data regarding their properties and potential effectiveness are lacking.This study aimed to investigate the effects of inserting non-absorbable elastic threads,with different manufacturing requirements and methods,on the skin and subcutaneous tissue.In this study,non-absorbable elastic threads ELATENS and Elasticum using different manufacturing methods were compared.Each thread was transplanted into the subcutaneous layer of the back of a rat to induce wrinkles.After inducing wrinkles in the skin of rat,the degree of skin maintenance by each thread and the thickness of the capsule formed around the suture were measured.Through ex-vivo experiments on each thread,the fixation force in the tissue was confirmed.In a comparison of inflammatory response and collagen formation through histological analysis,it was confirmed that there was no significant difference from the equivalent comparative product.In conclusion,the degree of encapsulation between tissues and collagen fiber formation for improving skin wrinkles was superior in elastic threads compared to non-elastic threads.It is believed that this provides certain elasticity to the skin layer and can induce cell influx to improve wrinkles.
基金supported by the National Natural Science Foundation of China,No.81472235(to HF)the Shanghai Jiao Tong University Medical and Engineering Project,Nos.YG2021QN53(to HF),YG2017MS71(to HF)+1 种基金the International Cooperation Project of the National Natural Science Foundation of China,No.82020108017(to DC)the Innovation Group Project of the National Natural Science Foundation of China,No.81921002(to DC).
文摘Alzheimer’s disease is a multi-amyloidosis disease characterized by amyloid-βdeposits in brain blood vessels,microaneurysms,and senile plaques.How amyloid-βdeposition affects axon pathology has not been examined extensively.We used immunohistochemistry and immunofluorescence staining to analyze the forebrain tissue slices of Alzheimer’s disease patients.Widespread axonal amyloidosis with distinctive axonal enlargement was observed in patients with Alzheimer’s disease.On average,amyloid-β-positive axon diameters in Alzheimer’s disease brains were 1.72 times those of control brain axons.Furthermore,axonal amyloidosis was associated with microtubule-associated protein 2 reduction,tau phosphorylation,lysosome destabilization,and several blood-related markers,such as apolipoprotein E,alpha-hemoglobin,glycosylated hemoglobin type A1C,and hemin.Lysosome destabilization in Alzheimer’s disease was also clearly identified in the neuronal soma,where it was associated with the co-expression of amyloid-β,Cathepsin D,alpha-hemoglobin,actin alpha 2,and collagen type IV.This suggests that exogenous hemorrhagic protein intake influences neural lysosome stability.Additionally,the data showed that amyloid-β-containing lysosomes were 2.23 times larger than control lysosomes.Furthermore,under rare conditions,axonal breakages were observed,which likely resulted in Wallerian degeneration.In summary,axonal enlargement associated with amyloidosis,micro-bleeding,and lysosome destabilization is a major defect in patients with Alzheimer’s disease.This finding suggests that,in addition to the well-documented neural soma and synaptic damage,axonal damage is a key component of neuronal defects in Alzheimer’s disease.
文摘ZHANG Yongmei is turning thethreads of her life around and isweaving success from an all toocommon sob-story.Laid off ten yearsago,Zhang Yongmei is now a well-known name in certain circles ofBeijing,both for the work she does andthe help she brings to those who haveshared a similar fate.Her secret weapon?—pet fashion for the export market andplenty of perseverance.As manager
文摘MAYBE I should be grateful to my mother. When I was very young, she taught me how to knit socks. Using a kind of white nylon thread and a needle made from a kind of hairpin, a durable sock could be made. Before long I had mastered the skill, then knit a pair of socks for each of my family members. However, my mother seemed to be a collector of socks and didn’t allow me to stop knitting them until I came to hate this task. Luckily, my mother changed her interest. One day while she
文摘A young artist reinvents an old sartorial skill from rural ethnic communities into globally recognized high fashion.LACKING a unified writing system,the ancestors of the Miao people,an ethnic group primarily living in mountainous areas in central and southwestern China,encoded their history in the exquisite design of traditional clothing,especially embroidery.They express reverence for nature and appreciation of life with needles and threads.
文摘BACKGROUND A total of 100 patients diagnosed with mixed hemorrhoids from October 2022 to September 2023 in our hospital were randomly divided into groups by dice rolling and compared with the efficacy of different treatment options.AIM To analyze the clinical effect and prognosis of mixed hemorrhoids treated with polidocanol injection combined with automatic elastic thread ligation operation(RPH).METHODS A total of 100 patients with mixed hemorrhoids who visited our hospital from October 2022 to September 2023 were selected and randomly divided into the control group(n=50)and the treatment group(n=50)by rolling the dice.The procedure for prolapse and hemorrhoids(PPH)was adopted in the control group,while polidocanol foam injection+RPH was adopted in the treatment group.The therapeutic effects,operation time,wound healing time,hospital stay,pain situation(24 hours post-operative pain score,first defecation pain score),quality of life(QOL),incidence of complications(post-operative hemorrhage,edema,infection),incidence of anal stenosis 3 months post-operatively and recurrence rate 1 year post-operatively of the two groups were compared.RESULTS Compared with the control group,the total effective rate of treatment group was higher,and the difference was significant(P<0.05).The operation time/wound healing time/hospital stay in the treatment group were shorter than those in the control group(P<0.05).The pain scores at 24 hours after operation/first defecation pain score of the treatment group was significantly lower than those in the control group(P<0.05).After surgery,the QOL scores of the two groups decreased,with the treatment group having higher scores than that of the control group(P<0.05).Compared with the control group,the incidence of postoperative complications in the treatment group was lower,and the difference was significant(P<0.05);However,there was no significant difference in the incidence of postoperative bleeding between the two groups(P>0.05);There was no significant difference in the incidence of anal stenosis 3 months after operation and the recurrence rate 1 year after operation between the two groups(P>0.05).CONCLUSION For patients with mixed hemorrhoids,the therapeutic effect achieved by using polidocanol injection combined with RPH was better.The wounds of the patients healed faster,the postoperative pain was milder,QOL improved,and the incidence of complications was lower,and the short-term and long-term prognosis was good.
文摘多核处理器越来越普及,如何通过软件技术最大提升CPU每个核心的使用率,成为热点问题。引入多核并行编程模型Threading Building Blocks,并与raw threads、Open MP进行各方面详细比较,分析了其优劣。并研究了TBB结合MPI在SMP集群系统上实现高效的混合并行计算应用的方法。最终发现TBB在多核编程方面有显著的优势。TTB和MPI的结合,又为多核处理器结点集群提供了并行层次化结构,大大优化集群的性能。
基金supported by the National Natural Science Foundation of China (Grant Nos. 92165207 and 62225407)the Innovation Program for Quantum Science and Technology (Grant No. 2021ZD0302300)。
文摘The direct growth of InGaAs high-electron-mobility transistors(HEMTs)on silicon facilitates their low-cost production on large-scale wafers.On a U-shaped patterned Si(001)substrate,we have achieved a high-quality In_(0.36)Ga_(0.64)As film with a threading dislocation density of∼7×10^(6)cm^(−2).The fabricated HEMT devices exhibit outstanding electrical characteristics,including a high Hall mobility of 4732 cm^(2)/V·s and an effective mobility of 3305 cm^(2)/V・s at room temperature.Through precise gate-recess processing and surface passivation,both depletion-mode and enhancement-mode devices were realized with transconductances reaching 500mS/mm for a channel length of 100 nm.These results indicate their significant potential for the development of next-generation high-speed Ⅲ-Ⅴ electronic devices on silicon platforms that are compatible with CMOS technology.
