Sir2(silent information regulator 2)结构域蛋白作为沉默信息调节因子Sirtuins家族的一员,存在于从细菌到人类的各种生物体中。在真核生物中,Sir2结构域蛋白是烟酰胺腺嘌呤二核苷酸(NAD+)依赖性脱乙酰酶,作为蛋白质去乙酰化酶或ADP核...Sir2(silent information regulator 2)结构域蛋白作为沉默信息调节因子Sirtuins家族的一员,存在于从细菌到人类的各种生物体中。在真核生物中,Sir2结构域蛋白是烟酰胺腺嘌呤二核苷酸(NAD+)依赖性脱乙酰酶,作为蛋白质去乙酰化酶或ADP核糖基转移酶发挥作用,参与调节转录抑制、基因重组、DNA修复和细胞周期过程。最近研究发现,在原核生物中,含有Sir2结构域的蛋白广泛分布于多种微生物免疫系统中,并作为NAD水解酶即NADase,在细菌被噬菌体感染时,能够快速水解细菌体内的NAD+,从而引起被感染的细菌的死亡。研究表明,Thoeris、SPARSA、Sir2-HerA、DSR2和Kongming等防御系统均通过Sir2结构域依赖的NAD水解酶发挥作用。该综述主要介绍了这五种抗噬菌体防御系统,并讨论了Sir2结构域在噬菌体防御中发挥的重要作用,为深入了解原核生物Sir2 NADase介导的抗噬菌体机制提供了理论支撑。展开更多
A six-variable geometrical nonlinear shear deformation laminatedtheory is presented by which normal stress and strain distributioncan be calculated. by considering some affective factors that wereneglected under the f...A six-variable geometrical nonlinear shear deformation laminatedtheory is presented by which normal stress and strain distributioncan be calculated. by considering some affective factors that wereneglected under the finite deformation condition, an improved vonKarman geometrical non- linear deformation-strain relation is usedfor large deformation analysis. After analyzing the bending problemof laminated plates, and comparing it with 3-D elasticity solutionsand J.N.Reddy five-vari- able simple higher-order shear deformationlaminated theory, we can conclude that a satisfactory cal- culationprecision has been achieved, which shows that is especially suitablefor the calculation in the condition of large deformation and thelaminated thick plate analysis.展开更多
文摘Sir2(silent information regulator 2)结构域蛋白作为沉默信息调节因子Sirtuins家族的一员,存在于从细菌到人类的各种生物体中。在真核生物中,Sir2结构域蛋白是烟酰胺腺嘌呤二核苷酸(NAD+)依赖性脱乙酰酶,作为蛋白质去乙酰化酶或ADP核糖基转移酶发挥作用,参与调节转录抑制、基因重组、DNA修复和细胞周期过程。最近研究发现,在原核生物中,含有Sir2结构域的蛋白广泛分布于多种微生物免疫系统中,并作为NAD水解酶即NADase,在细菌被噬菌体感染时,能够快速水解细菌体内的NAD+,从而引起被感染的细菌的死亡。研究表明,Thoeris、SPARSA、Sir2-HerA、DSR2和Kongming等防御系统均通过Sir2结构域依赖的NAD水解酶发挥作用。该综述主要介绍了这五种抗噬菌体防御系统,并讨论了Sir2结构域在噬菌体防御中发挥的重要作用,为深入了解原核生物Sir2 NADase介导的抗噬菌体机制提供了理论支撑。
文摘A six-variable geometrical nonlinear shear deformation laminatedtheory is presented by which normal stress and strain distributioncan be calculated. by considering some affective factors that wereneglected under the finite deformation condition, an improved vonKarman geometrical non- linear deformation-strain relation is usedfor large deformation analysis. After analyzing the bending problemof laminated plates, and comparing it with 3-D elasticity solutionsand J.N.Reddy five-vari- able simple higher-order shear deformationlaminated theory, we can conclude that a satisfactory cal- culationprecision has been achieved, which shows that is especially suitablefor the calculation in the condition of large deformation and thelaminated thick plate analysis.
