The Jinping Underground Laboratory is the deepest and largest underground laboratory in the world,with a maximum buried depth of approximately 2400 m.The objective is to study the brittle-ductile transition of marble ...The Jinping Underground Laboratory is the deepest and largest underground laboratory in the world,with a maximum buried depth of approximately 2400 m.The objective is to study the brittle-ductile transition of marble through a combination of experimental research and constitutive modeling.Triaxial compression and triaxial cyclic loading tests are initially conducted to explore the accumulation of pre-peak plastic strain and the deterioration of stiffness of the marble.Then,a specific constitutive model is developed to accurately reflect the pre-peak plastic hardening and post-peak strain softening behaviors based on the deformation and failure mechanism of the marble.The incremental constitutive relationship of the proposed model is subsequently derived in detail,and the model parameters are calibrated using data obtained from the test results.Finally,the effectiveness of the proposed model is assessed by comparing its results with the experimental results of the marble.The findings show that the proposed model accurately predicts the behavior of the marble,and its results are in good agreement with the test data.展开更多
China has achieved a major engineering milestone in the construction of the Beishan Underground Research Laboratory(URL)for geological disposal of high-level radioactive waste(HLW).On December 26,2025,the project team...China has achieved a major engineering milestone in the construction of the Beishan Underground Research Laboratory(URL)for geological disposal of high-level radioactive waste(HLW).On December 26,2025,the project team successfully completed the excavation of the world's first deep,continuous small-radius,steep spiral ramp by a tunnel boring machine(TBM)named Beishan No.1,which marked the completion of the underground main structure of Beishan URL.展开更多
Objective This study reports the first imported case of Lassa fever(LF)in China.Laboratory detection and molecular epidemiological analysis of the Lassa virus(LASV)from this case offer valuable insights for the preven...Objective This study reports the first imported case of Lassa fever(LF)in China.Laboratory detection and molecular epidemiological analysis of the Lassa virus(LASV)from this case offer valuable insights for the prevention and control of LF.Methods Samples of cerebrospinal fluid(CSF),blood,urine,saliva,and environmental materials were collected from the patient and their close contacts for LASV nucleotide detection.Whole-genome sequencing was performed on positive samples to analyze the genetic characteristics of the virus.Results LASV was detected in the patient’s CSF,blood,and urine,while all samples from close contacts and the environment tested negative.The virus belongs to the lineage IV strain and shares the highest homology with strains from Sierra Leone.The variability in the glycoprotein complex(GPC)among different strains ranged from 3.9%to 15.1%,higher than previously reported for the seven known lineages.Amino acid mutation analysis revealed multiple mutations within the GPC immunogenic epitopes,increasing strain diversity and potentially impacting immune response.Conclusion The case was confirmed through nucleotide detection,with no evidence of secondary transmission or viral spread.The LASV strain identified belongs to lineage IV,with broader GPC variability than previously reported.Mutations in the immune-related sites of GPC may affect immune responses,necessitating heightened vigilance regarding the virus.展开更多
With the rapid development of virtual reality(VR)and augmented reality(AR)technologies,their application potential in the field of education has become increasingly significant.For a long time,fire safety education in...With the rapid development of virtual reality(VR)and augmented reality(AR)technologies,their application potential in the field of education has become increasingly significant.For a long time,fire safety education in university laboratories has faced numerous challenges,and traditional teaching methods have been insufficiently effective,with high-risk scenarios difficult to realistically recreate.Especially in special scenarios involving hazardous chemicals,conventional training methods struggle to enable learners to achieve deep understanding and behavioral formation.This study systematically integrates immersive technology theory with safety education needs,providing a replicable technical solution for safety education in high-risk environments.Its modular design approach has reference value for expansion into other professional fields,offering practical evidence for innovation in safety education models in the digital age.展开更多
State Key Laboratory of Baiyun Obo Rare Earth Resource Researches and Comprehensive Utilization was approved by the Ministry of Science and Technology to be one of the national key laboratories in November 2022.
State Key Laboratory of Baiyun Obo Rare Earth Resource Researches and Comprehensive Utilization was approved by the Ministry of Science and Technology to be one of the national key laboratories in November 2022.The la...State Key Laboratory of Baiyun Obo Rare Earth Resource Researches and Comprehensive Utilization was approved by the Ministry of Science and Technology to be one of the national key laboratories in November 2022.The laboratory was reconstructed based on former State Key Laboratory of Baiyun Obo Rare Earth Resources Researches and Comprehensive Utilization.展开更多
State Key Laboratory of Baiyun Obo Rare Earth Resource Researches and Comprehensive Utilization was approved by the Ministry of Science and Technology to be one of the national key laboratories in November 2022.The la...State Key Laboratory of Baiyun Obo Rare Earth Resource Researches and Comprehensive Utilization was approved by the Ministry of Science and Technology to be one of the national key laboratories in November 2022.The laboratory was reconstructed based on former State Key Laboratory of Baiyun Obo Rare Earth Resources Researches and Comprehensive Utilization.展开更多
Drawing upon self-determination theory,this study examines the effects of vicarious abusive supervision on third-party’s self-efficacy and task performance within organizational contexts.Data were collected via surve...Drawing upon self-determination theory,this study examines the effects of vicarious abusive supervision on third-party’s self-efficacy and task performance within organizational contexts.Data were collected via surveys from 337 employees across diverse organizations.The results indicate that vicarious abusive supervision significantly undermines both self-efficacy and task performance among employees who are indirectly exposed to such behavior but not directly targeted.Furthermore,self-efficacy serves as a mediator between vicarious abusive supervision and task performance;however,this mediating effect is attenuated for employees with a high promotion focus.These findings provide valuable theoretical and practical insights,particularly in the domain of organizational behavior,by emphasizing the critical role of promotion focus in mitigating the negative effects of vicarious abusive supervision.This research contributes to the organizational behavior literature by shifting the focus from the traditional supervisor-subordinate dynamic to a third-party perspective,thereby enriching our understanding of how vicarious abusive supervision impacts employees within organizational settings.The study underscores the importance of self-efficacy and promotion focus as key factors in unethical leadership contexts.展开更多
As the Philippines celebrated the 2nd Asia Laboratory Animal Day(ALAD)last November 29,2025,the Philippine Association for Laboratory Animal Sciences(PALAS)reflected on a year marked by growth,collaboration,and renewe...As the Philippines celebrated the 2nd Asia Laboratory Animal Day(ALAD)last November 29,2025,the Philippine Association for Laboratory Animal Sciences(PALAS)reflected on a year marked by growth,collaboration,and renewed commitment to ethical and scientific excellence in animal-based research.Throughout 2025,PALAS has continued to strengthen the laboratory animal science community by advancing education,capacity building,policy advocacy,and regional cooperation.These efforts underscore PALAS’vital role in shaping a culture of responsible animal research aligned with international standards.展开更多
Rational laboratory layout design and scientific management systems are key to improving overall laboratory efficiency and safety,providing a solid foundation and guarantee for the smooth progress of scientific resear...Rational laboratory layout design and scientific management systems are key to improving overall laboratory efficiency and safety,providing a solid foundation and guarantee for the smooth progress of scientific research.This article addresses a series of issues such as low testing efficiency caused by unreasonable laboratory layouts,incomplete or outdated equipment configurations affecting testing accuracy,and safety hazards arising from the lack of effective laboratory management systems.It conducts an in-depth exploration of the design and planning strategies for physicochemical laboratories.By proposing specific designs and guidelines for the location selection,functional zoning,and layout requirements of physicochemical laboratories,the aim is to optimize laboratory space utilization,enhance testing efficiency,and ensure the advancement of equipment configurations and the accuracy of testing precision.Simultaneously,it emphasizes the establishment of an effective laboratory management system to prevent and control safety hazards,safeguarding the lives of laboratory personnel and ensuring stable laboratory operations.展开更多
This study describes the design and performance of a laboratory-based tender X-ray spectrometer for X-ray absorption spectroscopy.The system enables effective absorption spectra to be measured within the 2.0-9.0 keV r...This study describes the design and performance of a laboratory-based tender X-ray spectrometer for X-ray absorption spectroscopy.The system enables effective absorption spectra to be measured within the 2.0-9.0 keV range using Rowland circle geometry;it covers the K edge of 3d transition metals,the L edge of lanthanides,and the M edge of actinides.The spectrometer is configured with a Rowland circle with a diameter of 500 mm and integrates a 250 W liquid metal jet X-ray source,spherical bent crystal analyzer,and energy-resolving silicon drift detector.The X-ray source is installed outside the vacuum chamber and remains fixed,while the analyzer crystals and detector are adjusted to change the Bragg angle,maintaining the Rowland condition.The energy resolution is 0.36-1.30 eV at 2.0-9.0 keV,and the monochromatic flux is approximately 5×10^(5) counts/s at 7040 eV.This study highlights the primary characteristics of the spectrometer and demon-strates its capabilities using selected experimental examples.The successful development of this spectrometer can facilitate research on actinide elements,which are often constrained in synchrotron radiation experiments owing to their radioactivity,thus fostering advancements in related nuclear energy fields.展开更多
Against the backdrop of the digital era,information technology is constantly evolving.Among various technologies,EDA(Electronic Design Automation)technology provides strong support for integrated circuit design and el...Against the backdrop of the digital era,information technology is constantly evolving.Among various technologies,EDA(Electronic Design Automation)technology provides strong support for integrated circuit design and electronic system development,demonstrating significant value.Colleges and universities are key institutions for cultivating computer professionals.By building high-level EDA laboratories,they can effectively improve the effectiveness of teaching and train talents that meet industry demands.From the perspective of computer majors in colleges and universities,this paper discusses the construction objectives of EDA laboratories and proposes specific practical strategies.The purpose is to provide feasible references for the construction of Eda laboratories,effectively enhance the quality of professional talent cultivation,and offer insights for the subsequent teaching reform of computer majors.展开更多
Objective:To explore the application effect of the case-based problem-based learning(PBL)teaching model in clinical microbiology laboratory internship teaching,and provide a reference for the reform of clinical practi...Objective:To explore the application effect of the case-based problem-based learning(PBL)teaching model in clinical microbiology laboratory internship teaching,and provide a reference for the reform of clinical practical teaching.Methods:A total of 36 students who interned in the Clinical Laboratory of the Affiliated Hospital of Youjiang Medical University for Nationalities from May 2023 to April 2025 were selected as the research subjects.They were divided into two groups by the envelope method,with 18 students in each group.The control group adopted the traditional lecture-based teaching model,while the study group used the case-based PBL teaching model.The teaching scores,teaching quality,and satisfaction of the two groups of interns were compared.Results:The theoretical score(65.28±2.78),skill score(26.06±2.34),and total score(91.33±3.54)of the study group were all higher than those of the control group(61.67±3.01,22.28±2.49,83.94±3.72,respectively),and the differences were statistically significant(P<0.05).The results of the questionnaire showed that the scores of students in the study group in terms of autonomous learning,clinical thinking ability,comprehension ability,and learning interest were significantly higher than those in the control group,and all the differences were statistically significant(P<0.05).Meanwhile,the satisfaction rate of students in the study group with the teaching was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:The PBL teaching model can effectively improve the academic performance of interns and the quality of teaching,enhance teaching satisfaction,and thus serve as a powerful auxiliary teaching method in clinical internship education.展开更多
With the continuous advancement of information technology,traditional teaching management models can no longer meet the demands of modern laboratory management.Information management,characterized by efficiency,conven...With the continuous advancement of information technology,traditional teaching management models can no longer meet the demands of modern laboratory management.Information management,characterized by efficiency,convenience,and intelligence,provides new ideas and directions for reforming laboratory teaching management models in higher education.Based on this,this paper explores reform strategies and practical approaches for laboratory teaching management models from the perspective of information management,aiming to offer references for enhancing the modernization and intelligentization of laboratory teaching management.展开更多
Background:Medical laboratory diagnostic services play a critical role in the diagnosis,treatment,and manage-ment of diseases,forming the cornerstone of effective healthcare systems.Despite the crucial role of laborat...Background:Medical laboratory diagnostic services play a critical role in the diagnosis,treatment,and manage-ment of diseases,forming the cornerstone of effective healthcare systems.Despite the crucial role of laboratory services,the quality and accessibility of medical laboratory services in sub-Saharan Africa(SSA)face signifi-cant challenges.Global health development aid has been pivotal in supporting SSA laboratory services.This study aimed to examine global health development aid initiatives that have successfully enhanced the quality of medical laboratory services and the challenges and barriers to effectively improving medical laboratory services through global health development aid in SSA.Methods:We used a narrative review study design.We searched PubMed,Web of Science and Scopus for articles published in the last 15 years.These three databases are generally considered premier databases for peer-reviewed articles in global health,public health,health systems,and biomedical sciences.The inclusion criteria for this review included research studies,reports,and grey literature.Only articles published in English from 2010 on-ward were considered.The analysis followed a qualitative approach,emphasizing thematic synthesis and critical interpretation.Results:Forty articles were included in this study.Of these,18 were primary research studies,11 were reports,7 were commentaries,and 4 were reviews.Five sub-themes from the successful global health development aid initiative themes were capacity building and training programs,infrastructure development,partnership models,policy advocacy and regulatory support,quality control and standardization of laboratory services.The sub-themes from the challenges and barrier theme were insufficient funding and resource allocation,human resource constraints,inadequate infrastructure and equipment,and political and institutional barriers.This review re-vealed that several factors,including financial sustainability,human resource capacity,institutional support,resilience,and effective monitoring systems,shape the sustainability of improvements in medical laboratory services in SSA.Conclusion:Achieving long-term sustainability requires strategies that ensure financial self-sufficiency,foster a skilled and stable workforce,and integrate laboratory services into national health frameworks.展开更多
In recent years,with the continuous deepening of educational reform in the medical field,standardized training,as an important stage of providing excellent laboratory physicians to the clinic,not only needs to strengt...In recent years,with the continuous deepening of educational reform in the medical field,standardized training,as an important stage of providing excellent laboratory physicians to the clinic,not only needs to strengthen various professional skills of laboratory physicians,but also needs to integrate medical ethics education into the education.Report analysis uses clinical case test reports as teaching content.Under the guidance of attending physicians,resident physicians are the main body of standardized training.Teaching activities for report analysis are carried out by combining theoretical knowledge and case information.Through detailed planning of report analysis teaching activities and adequate preparation,standardized training activities are smoothly carried out.This targeted and comprehensive teaching model can effectively improve the clinical thinking and clinical laboratory professional ability of resident physicians,strengthen medical ethics,and make biochemistry sub-specialty resident physicians in laboratory medicine more adaptable to clinical work,thus achieving teaching goals.展开更多
Background Small-scale research or individual seed cotton samples from breeders and geneticists are ginned using laboratory saws or roller gins.The objective of this study was to examine the effects of two different l...Background Small-scale research or individual seed cotton samples from breeders and geneticists are ginned using laboratory saws or roller gins.The objective of this study was to examine the effects of two different laboratory saw ginning(SG)rates and subsequent mechanical blending on fiber high volume instrument(HVI)and advanced fiber information system(AFIS)quality measurement.Seed cottons from diverse upland cotton cultivars,years,and locations were evaluated.Results As the SG rate was increased,HVI results for uniformity index(UI),short fiber index(SFI),and two non-lint parameters(area%,particle count),as well as AFIS results for some properties,were impacted,with significant effects on HVI UI and AFIS short fiber content(SFC).Apparent fiber blending impacts were observed for HVI UI,strength(STR),reflectance(Rd),SFI,and two trashes as well as for all AFIS parameters,with significant effects on HVI Rd and two trashes and all AFIS parameters except the length and maturity measurements.A combination of ginning and blending processes indicated statistically significant interactions for HVI STR,Rd,SFI,and two trashes,and also for AFIS neps,L(w)CV,UQL(w),L(n)CV,SFC(n),L5%(n),immature fiber content(IFC),fineness,total count,dust count,particle count,and visible foreign matter(VFM).Further analysis implied a few impacts of ginning and blending on correlations between HVI and relevant AFIS qualities.Conclusion Despite the observation,the laboratory saw gin and blending methods should continue to be a practical tool to study the differences when all samples are processed identically.展开更多
Against the backdrop of the rapid intelligent development of medical laboratory technology,vocational education is in urgent need of teaching innovation.This paper explores the integration and practice of information-...Against the backdrop of the rapid intelligent development of medical laboratory technology,vocational education is in urgent need of teaching innovation.This paper explores the integration and practice of information-based teaching methods in vocational education of medical laboratory technology,analyzes the current situation of traditional teaching and the demand for informatization,and elaborates on the practical paths from aspects such as resource construction,model innovation,and evaluation reform.Practice has verified that this integration has improved teaching quality and students’skills,but there are problems such as uneven resources and the need to improve teachers’and students’abilities.Countermeasures such as strengthening co-construction and sharing of resources and carrying out special training are proposed to provide reference for the development of professional education.展开更多
Objective Blood culture remains the gold standard for diagnosing bloodstream infections.Clinical laboratories must ensure the quality of blood culture processes from receipt to obtaining definitive results.We examined...Objective Blood culture remains the gold standard for diagnosing bloodstream infections.Clinical laboratories must ensure the quality of blood culture processes from receipt to obtaining definitive results.We examined laboratory analytical indicators associated with positive blood culture results.Methods Blood cultures collected from Peking Union Medical College Hospital between January 1,2020,and December 31,2022,were retrospectively analyzed.The mode of transportation(piping logistics delivery vs.staff),source of blood cultures(outpatient/emergency department vs.inpatient department),rotation of personnel,and time of reception(8:00–19:59 vs.20:00–07:59)were compared between blood culture-positive and-negative results.Results Between 2020 and 2022,the total positive rate of blood culture was 8.07%.The positive rate of blood cultures in the outpatient/emergency department was significantly higher than that in the inpatient department(12.46%vs.5.83%;P<0.0001).The time-to-detection of blood cultures was significantly affected by the delivery mode and personnel rotation.The blood culture positive rate of the total pre-analytical time within 1 h was significantly higher than that within 1–2 h or>2 h(P<0.0170).Conclusion Laboratory analytical indicators such as patient source,transportation mode,and personnel rotation significantly impacted the positive detection rate or time of blood culture.展开更多
The clinical application of solid lipid particles(SLPs)is hampered due to the need for advanced nano/micro-suspension production technology.This research aims to establish a pilot-scale production line employing high-...The clinical application of solid lipid particles(SLPs)is hampered due to the need for advanced nano/micro-suspension production technology.This research aims to establish a pilot-scale production line employing high-speed shears as emulsification equipment.The primary purpose is to manufacture nano/micro-suspensions using solid lipid particles(SLPs).The study also exhaustively introduces and analyzes the regulatory schemes for process parameters and formulations at various stages of production.The process and formulation endured optimization through orthog-onal or single-factor tests at various production steps:laboratory research,small-scale trial production,and pilot production.Quality standards for the product were determined,and key parameters were obtained at each stage.The laboratory research demonstrated that the optimal SLPs comprised 15 mL 3%polyvinyl alcohol(PVA)per 1.0 g tilmicosin and 2.5 g carnauba wax(WAX).During small-scale production,modifications were made to the volume of the aqueous phase,emulsifier concentration,and emulsification strength,setting them to 16 mL,5%,and 2200 r/min,respectively.In the pilot production stage,the shear time was considered optimal at eight min.The impurity,content,polydispersion coefficient(PDI),and size of the pilot product were<3%,5%,0385 and 2.64μm,respectively.Among the several parameters studied,heating temperature,drug-lipid ratio,and emulsifier concentration were identified as the main factors affecting product quality,and they were regulated at 100℃,1:3,and 5%,respectively.A novel hot melt emulsification shear method aided the development of a new solid lipid-based suspension from its preliminary stages in the laboratory to pilot production.This innovation is expected to enhance solid lipid-based suspensions'industrial evolution extensively.展开更多
基金China Power Construction Group research project,Grant/Award Number:DJ-HXGG-2023-16National Natural Science Foundation of China-Yalong River Joint Fund Key Project,Grant/Award Number:U1965204+1 种基金National Natural Science Foundation of China,Grant/Award Number:52109143Open Research Fund of State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin(China Institute of Water Resources and Hydropower Research),Grant/Award Number:IWHR-SKL-KF202305。
文摘The Jinping Underground Laboratory is the deepest and largest underground laboratory in the world,with a maximum buried depth of approximately 2400 m.The objective is to study the brittle-ductile transition of marble through a combination of experimental research and constitutive modeling.Triaxial compression and triaxial cyclic loading tests are initially conducted to explore the accumulation of pre-peak plastic strain and the deterioration of stiffness of the marble.Then,a specific constitutive model is developed to accurately reflect the pre-peak plastic hardening and post-peak strain softening behaviors based on the deformation and failure mechanism of the marble.The incremental constitutive relationship of the proposed model is subsequently derived in detail,and the model parameters are calibrated using data obtained from the test results.Finally,the effectiveness of the proposed model is assessed by comparing its results with the experimental results of the marble.The findings show that the proposed model accurately predicts the behavior of the marble,and its results are in good agreement with the test data.
文摘China has achieved a major engineering milestone in the construction of the Beishan Underground Research Laboratory(URL)for geological disposal of high-level radioactive waste(HLW).On December 26,2025,the project team successfully completed the excavation of the world's first deep,continuous small-radius,steep spiral ramp by a tunnel boring machine(TBM)named Beishan No.1,which marked the completion of the underground main structure of Beishan URL.
基金supported by Public Health Talent Training and Surport Plan(National Administration of Disease Prevention and Control)Research and application of new technology for rapid monitoring and tracing of emergent infectious diseases among entry-exit population(2024YFFK0056)Monitoring,Early warning and Response of Major Infectious Diseases(2022ZDZX0017).
文摘Objective This study reports the first imported case of Lassa fever(LF)in China.Laboratory detection and molecular epidemiological analysis of the Lassa virus(LASV)from this case offer valuable insights for the prevention and control of LF.Methods Samples of cerebrospinal fluid(CSF),blood,urine,saliva,and environmental materials were collected from the patient and their close contacts for LASV nucleotide detection.Whole-genome sequencing was performed on positive samples to analyze the genetic characteristics of the virus.Results LASV was detected in the patient’s CSF,blood,and urine,while all samples from close contacts and the environment tested negative.The virus belongs to the lineage IV strain and shares the highest homology with strains from Sierra Leone.The variability in the glycoprotein complex(GPC)among different strains ranged from 3.9%to 15.1%,higher than previously reported for the seven known lineages.Amino acid mutation analysis revealed multiple mutations within the GPC immunogenic epitopes,increasing strain diversity and potentially impacting immune response.Conclusion The case was confirmed through nucleotide detection,with no evidence of secondary transmission or viral spread.The LASV strain identified belongs to lineage IV,with broader GPC variability than previously reported.Mutations in the immune-related sites of GPC may affect immune responses,necessitating heightened vigilance regarding the virus.
文摘With the rapid development of virtual reality(VR)and augmented reality(AR)technologies,their application potential in the field of education has become increasingly significant.For a long time,fire safety education in university laboratories has faced numerous challenges,and traditional teaching methods have been insufficiently effective,with high-risk scenarios difficult to realistically recreate.Especially in special scenarios involving hazardous chemicals,conventional training methods struggle to enable learners to achieve deep understanding and behavioral formation.This study systematically integrates immersive technology theory with safety education needs,providing a replicable technical solution for safety education in high-risk environments.Its modular design approach has reference value for expansion into other professional fields,offering practical evidence for innovation in safety education models in the digital age.
文摘State Key Laboratory of Baiyun Obo Rare Earth Resource Researches and Comprehensive Utilization was approved by the Ministry of Science and Technology to be one of the national key laboratories in November 2022.
文摘State Key Laboratory of Baiyun Obo Rare Earth Resource Researches and Comprehensive Utilization was approved by the Ministry of Science and Technology to be one of the national key laboratories in November 2022.The laboratory was reconstructed based on former State Key Laboratory of Baiyun Obo Rare Earth Resources Researches and Comprehensive Utilization.
文摘State Key Laboratory of Baiyun Obo Rare Earth Resource Researches and Comprehensive Utilization was approved by the Ministry of Science and Technology to be one of the national key laboratories in November 2022.The laboratory was reconstructed based on former State Key Laboratory of Baiyun Obo Rare Earth Resources Researches and Comprehensive Utilization.
文摘Drawing upon self-determination theory,this study examines the effects of vicarious abusive supervision on third-party’s self-efficacy and task performance within organizational contexts.Data were collected via surveys from 337 employees across diverse organizations.The results indicate that vicarious abusive supervision significantly undermines both self-efficacy and task performance among employees who are indirectly exposed to such behavior but not directly targeted.Furthermore,self-efficacy serves as a mediator between vicarious abusive supervision and task performance;however,this mediating effect is attenuated for employees with a high promotion focus.These findings provide valuable theoretical and practical insights,particularly in the domain of organizational behavior,by emphasizing the critical role of promotion focus in mitigating the negative effects of vicarious abusive supervision.This research contributes to the organizational behavior literature by shifting the focus from the traditional supervisor-subordinate dynamic to a third-party perspective,thereby enriching our understanding of how vicarious abusive supervision impacts employees within organizational settings.The study underscores the importance of self-efficacy and promotion focus as key factors in unethical leadership contexts.
文摘As the Philippines celebrated the 2nd Asia Laboratory Animal Day(ALAD)last November 29,2025,the Philippine Association for Laboratory Animal Sciences(PALAS)reflected on a year marked by growth,collaboration,and renewed commitment to ethical and scientific excellence in animal-based research.Throughout 2025,PALAS has continued to strengthen the laboratory animal science community by advancing education,capacity building,policy advocacy,and regional cooperation.These efforts underscore PALAS’vital role in shaping a culture of responsible animal research aligned with international standards.
文摘Rational laboratory layout design and scientific management systems are key to improving overall laboratory efficiency and safety,providing a solid foundation and guarantee for the smooth progress of scientific research.This article addresses a series of issues such as low testing efficiency caused by unreasonable laboratory layouts,incomplete or outdated equipment configurations affecting testing accuracy,and safety hazards arising from the lack of effective laboratory management systems.It conducts an in-depth exploration of the design and planning strategies for physicochemical laboratories.By proposing specific designs and guidelines for the location selection,functional zoning,and layout requirements of physicochemical laboratories,the aim is to optimize laboratory space utilization,enhance testing efficiency,and ensure the advancement of equipment configurations and the accuracy of testing precision.Simultaneously,it emphasizes the establishment of an effective laboratory management system to prevent and control safety hazards,safeguarding the lives of laboratory personnel and ensuring stable laboratory operations.
基金supported by the Instrument and Equipment Development Program of the Chinese Academy of Science(Grant No.YJKYYQ20180066)the National Natural Science Foundation of China(No.22227809)+2 种基金the Shanghai Science and Technology Innovation Action Plan(No.22142200300)the Science and Technology Talents Program of the Shanghai Institute of Applied Physics(No.SINAP-KJZX-202204)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA 0400000).
文摘This study describes the design and performance of a laboratory-based tender X-ray spectrometer for X-ray absorption spectroscopy.The system enables effective absorption spectra to be measured within the 2.0-9.0 keV range using Rowland circle geometry;it covers the K edge of 3d transition metals,the L edge of lanthanides,and the M edge of actinides.The spectrometer is configured with a Rowland circle with a diameter of 500 mm and integrates a 250 W liquid metal jet X-ray source,spherical bent crystal analyzer,and energy-resolving silicon drift detector.The X-ray source is installed outside the vacuum chamber and remains fixed,while the analyzer crystals and detector are adjusted to change the Bragg angle,maintaining the Rowland condition.The energy resolution is 0.36-1.30 eV at 2.0-9.0 keV,and the monochromatic flux is approximately 5×10^(5) counts/s at 7040 eV.This study highlights the primary characteristics of the spectrometer and demon-strates its capabilities using selected experimental examples.The successful development of this spectrometer can facilitate research on actinide elements,which are often constrained in synchrotron radiation experiments owing to their radioactivity,thus fostering advancements in related nuclear energy fields.
基金Research Project on Higher Education Teaching Reform in Heilongjiang Province,Construction of Cloud-based Virtual-Physical Integrated Experimental Environment and Inter-university Collaborative Innovation and Practice(Project No.:SJGYB2024285)。
文摘Against the backdrop of the digital era,information technology is constantly evolving.Among various technologies,EDA(Electronic Design Automation)technology provides strong support for integrated circuit design and electronic system development,demonstrating significant value.Colleges and universities are key institutions for cultivating computer professionals.By building high-level EDA laboratories,they can effectively improve the effectiveness of teaching and train talents that meet industry demands.From the perspective of computer majors in colleges and universities,this paper discusses the construction objectives of EDA laboratories and proposes specific practical strategies.The purpose is to provide feasible references for the construction of Eda laboratories,effectively enhance the quality of professional talent cultivation,and offer insights for the subsequent teaching reform of computer majors.
基金This work was supported by the Reform Project of Degree and Postgraduate Education in Guangxi(JGY2025350)the Reform Project of Youjiang Medical University for Nationalities(J2024-04).
文摘Objective:To explore the application effect of the case-based problem-based learning(PBL)teaching model in clinical microbiology laboratory internship teaching,and provide a reference for the reform of clinical practical teaching.Methods:A total of 36 students who interned in the Clinical Laboratory of the Affiliated Hospital of Youjiang Medical University for Nationalities from May 2023 to April 2025 were selected as the research subjects.They were divided into two groups by the envelope method,with 18 students in each group.The control group adopted the traditional lecture-based teaching model,while the study group used the case-based PBL teaching model.The teaching scores,teaching quality,and satisfaction of the two groups of interns were compared.Results:The theoretical score(65.28±2.78),skill score(26.06±2.34),and total score(91.33±3.54)of the study group were all higher than those of the control group(61.67±3.01,22.28±2.49,83.94±3.72,respectively),and the differences were statistically significant(P<0.05).The results of the questionnaire showed that the scores of students in the study group in terms of autonomous learning,clinical thinking ability,comprehension ability,and learning interest were significantly higher than those in the control group,and all the differences were statistically significant(P<0.05).Meanwhile,the satisfaction rate of students in the study group with the teaching was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:The PBL teaching model can effectively improve the academic performance of interns and the quality of teaching,enhance teaching satisfaction,and thus serve as a powerful auxiliary teaching method in clinical internship education.
文摘With the continuous advancement of information technology,traditional teaching management models can no longer meet the demands of modern laboratory management.Information management,characterized by efficiency,convenience,and intelligence,provides new ideas and directions for reforming laboratory teaching management models in higher education.Based on this,this paper explores reform strategies and practical approaches for laboratory teaching management models from the perspective of information management,aiming to offer references for enhancing the modernization and intelligentization of laboratory teaching management.
文摘Background:Medical laboratory diagnostic services play a critical role in the diagnosis,treatment,and manage-ment of diseases,forming the cornerstone of effective healthcare systems.Despite the crucial role of laboratory services,the quality and accessibility of medical laboratory services in sub-Saharan Africa(SSA)face signifi-cant challenges.Global health development aid has been pivotal in supporting SSA laboratory services.This study aimed to examine global health development aid initiatives that have successfully enhanced the quality of medical laboratory services and the challenges and barriers to effectively improving medical laboratory services through global health development aid in SSA.Methods:We used a narrative review study design.We searched PubMed,Web of Science and Scopus for articles published in the last 15 years.These three databases are generally considered premier databases for peer-reviewed articles in global health,public health,health systems,and biomedical sciences.The inclusion criteria for this review included research studies,reports,and grey literature.Only articles published in English from 2010 on-ward were considered.The analysis followed a qualitative approach,emphasizing thematic synthesis and critical interpretation.Results:Forty articles were included in this study.Of these,18 were primary research studies,11 were reports,7 were commentaries,and 4 were reviews.Five sub-themes from the successful global health development aid initiative themes were capacity building and training programs,infrastructure development,partnership models,policy advocacy and regulatory support,quality control and standardization of laboratory services.The sub-themes from the challenges and barrier theme were insufficient funding and resource allocation,human resource constraints,inadequate infrastructure and equipment,and political and institutional barriers.This review re-vealed that several factors,including financial sustainability,human resource capacity,institutional support,resilience,and effective monitoring systems,shape the sustainability of improvements in medical laboratory services in SSA.Conclusion:Achieving long-term sustainability requires strategies that ensure financial self-sufficiency,foster a skilled and stable workforce,and integrate laboratory services into national health frameworks.
文摘In recent years,with the continuous deepening of educational reform in the medical field,standardized training,as an important stage of providing excellent laboratory physicians to the clinic,not only needs to strengthen various professional skills of laboratory physicians,but also needs to integrate medical ethics education into the education.Report analysis uses clinical case test reports as teaching content.Under the guidance of attending physicians,resident physicians are the main body of standardized training.Teaching activities for report analysis are carried out by combining theoretical knowledge and case information.Through detailed planning of report analysis teaching activities and adequate preparation,standardized training activities are smoothly carried out.This targeted and comprehensive teaching model can effectively improve the clinical thinking and clinical laboratory professional ability of resident physicians,strengthen medical ethics,and make biochemistry sub-specialty resident physicians in laboratory medicine more adaptable to clinical work,thus achieving teaching goals.
基金supported by the USDA-ARS Research Project(#6054–44000-080-00D)。
文摘Background Small-scale research or individual seed cotton samples from breeders and geneticists are ginned using laboratory saws or roller gins.The objective of this study was to examine the effects of two different laboratory saw ginning(SG)rates and subsequent mechanical blending on fiber high volume instrument(HVI)and advanced fiber information system(AFIS)quality measurement.Seed cottons from diverse upland cotton cultivars,years,and locations were evaluated.Results As the SG rate was increased,HVI results for uniformity index(UI),short fiber index(SFI),and two non-lint parameters(area%,particle count),as well as AFIS results for some properties,were impacted,with significant effects on HVI UI and AFIS short fiber content(SFC).Apparent fiber blending impacts were observed for HVI UI,strength(STR),reflectance(Rd),SFI,and two trashes as well as for all AFIS parameters,with significant effects on HVI Rd and two trashes and all AFIS parameters except the length and maturity measurements.A combination of ginning and blending processes indicated statistically significant interactions for HVI STR,Rd,SFI,and two trashes,and also for AFIS neps,L(w)CV,UQL(w),L(n)CV,SFC(n),L5%(n),immature fiber content(IFC),fineness,total count,dust count,particle count,and visible foreign matter(VFM).Further analysis implied a few impacts of ginning and blending on correlations between HVI and relevant AFIS qualities.Conclusion Despite the observation,the laboratory saw gin and blending methods should continue to be a practical tool to study the differences when all samples are processed identically.
文摘Against the backdrop of the rapid intelligent development of medical laboratory technology,vocational education is in urgent need of teaching innovation.This paper explores the integration and practice of information-based teaching methods in vocational education of medical laboratory technology,analyzes the current situation of traditional teaching and the demand for informatization,and elaborates on the practical paths from aspects such as resource construction,model innovation,and evaluation reform.Practice has verified that this integration has improved teaching quality and students’skills,but there are problems such as uneven resources and the need to improve teachers’and students’abilities.Countermeasures such as strengthening co-construction and sharing of resources and carrying out special training are proposed to provide reference for the development of professional education.
基金supported by grants from the National High Level Hospital Clinical Research Funding(2022-PUMCH-B-074)Peking Union Medical College Hospital Research Funding for Postdoc(kyfyjj202320).
文摘Objective Blood culture remains the gold standard for diagnosing bloodstream infections.Clinical laboratories must ensure the quality of blood culture processes from receipt to obtaining definitive results.We examined laboratory analytical indicators associated with positive blood culture results.Methods Blood cultures collected from Peking Union Medical College Hospital between January 1,2020,and December 31,2022,were retrospectively analyzed.The mode of transportation(piping logistics delivery vs.staff),source of blood cultures(outpatient/emergency department vs.inpatient department),rotation of personnel,and time of reception(8:00–19:59 vs.20:00–07:59)were compared between blood culture-positive and-negative results.Results Between 2020 and 2022,the total positive rate of blood culture was 8.07%.The positive rate of blood cultures in the outpatient/emergency department was significantly higher than that in the inpatient department(12.46%vs.5.83%;P<0.0001).The time-to-detection of blood cultures was significantly affected by the delivery mode and personnel rotation.The blood culture positive rate of the total pre-analytical time within 1 h was significantly higher than that within 1–2 h or>2 h(P<0.0170).Conclusion Laboratory analytical indicators such as patient source,transportation mode,and personnel rotation significantly impacted the positive detection rate or time of blood culture.
基金supported by the Fundamental Research Funds for the Central Universities(2662020DKPY008)the National Natural Science Foundation of China(grant No.31772797)。
文摘The clinical application of solid lipid particles(SLPs)is hampered due to the need for advanced nano/micro-suspension production technology.This research aims to establish a pilot-scale production line employing high-speed shears as emulsification equipment.The primary purpose is to manufacture nano/micro-suspensions using solid lipid particles(SLPs).The study also exhaustively introduces and analyzes the regulatory schemes for process parameters and formulations at various stages of production.The process and formulation endured optimization through orthog-onal or single-factor tests at various production steps:laboratory research,small-scale trial production,and pilot production.Quality standards for the product were determined,and key parameters were obtained at each stage.The laboratory research demonstrated that the optimal SLPs comprised 15 mL 3%polyvinyl alcohol(PVA)per 1.0 g tilmicosin and 2.5 g carnauba wax(WAX).During small-scale production,modifications were made to the volume of the aqueous phase,emulsifier concentration,and emulsification strength,setting them to 16 mL,5%,and 2200 r/min,respectively.In the pilot production stage,the shear time was considered optimal at eight min.The impurity,content,polydispersion coefficient(PDI),and size of the pilot product were<3%,5%,0385 and 2.64μm,respectively.Among the several parameters studied,heating temperature,drug-lipid ratio,and emulsifier concentration were identified as the main factors affecting product quality,and they were regulated at 100℃,1:3,and 5%,respectively.A novel hot melt emulsification shear method aided the development of a new solid lipid-based suspension from its preliminary stages in the laboratory to pilot production.This innovation is expected to enhance solid lipid-based suspensions'industrial evolution extensively.
