Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and...Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified.展开更多
The third front industrial cultural landscape has the dual attributes of “industry” and “nature”.The special historical background and mountainous environment make it a distinctive industrial cultural landscape.Ta...The third front industrial cultural landscape has the dual attributes of “industry” and “nature”.The special historical background and mountainous environment make it a distinctive industrial cultural landscape.Taking the third front industrial cultural landscape of southern Anhui as an example,this paper uses philosophy of technology to study this industrial cultural landscape with “modernity” characteristics,so as to make its “culture” return to the industrial cultural system and rethink,rather than the previous interpretation in the context of “cultural relics”.Then,under the framework of natural system,technological system and cultural system,the deep-seated cultural philosophy characteristics of the third front industrial cultural landscape are explained from the technological nature of the three line industrial cultural landscape.展开更多
From the perspective of bibliometric analysis, based on the data of 286 related literature retrieved and screened in the CNKI database, coOC software is used for data processing, and the relevant knowledge graphs such...From the perspective of bibliometric analysis, based on the data of 286 related literature retrieved and screened in the CNKI database, coOC software is used for data processing, and the relevant knowledge graphs such as the amount of publication, authors, and keywords in the field of third-line heritage research are plotted. The results show that the attention to third-line heritage research in China is increasing day by day, and the overall volume of publications shows a rapid growth trend;The authors’ clusters are scattered and do not form a broad and close network of cooperation;The research hotspots focus on the protection and reuse of third-line heritage, and the quantitative research methods are insufficient. In the future, the breadth and depth of third-line heritage research need to be expanded.展开更多
In the process of promoting the national territorial spatial planning system in all provinces, cities and counties, the geospatial database of “One Map” has realized the information sharing and collaborative work of...In the process of promoting the national territorial spatial planning system in all provinces, cities and counties, the geospatial database of “One Map” has realized the information sharing and collaborative work of multiple departments. Based on this, this paper intended to provide a set of standardized mapping models for industrial heritage storage, and through the establishment of the database to protect and reuse the status quo of industrial heritage research. This paper took the third-line construction industrial heritage of Mianyang “Two-Bomb City” as the research object, developed the relevant drawing standards of third-line industrial heritage database, and studied the database construction process. GIS technology is used to establish a geospatial database of the third-line industrial heritage in cooperation with the “One Map” system, in order to provide reference for the storage of the third-line industrial heritage in various places, and to protect and reuse the third-line industrial heritage from the perspectives of spatial factors, planning coordination and dynamic assessment.展开更多
文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified.
基金Sponsored by Key Project of Humanities and Social Sciences in Anhui Universities (sk2019a0515)Youth Project of Philosophy and Social Sciences Planning in Anhui Province (ahskq2021d123)。
文摘The third front industrial cultural landscape has the dual attributes of “industry” and “nature”.The special historical background and mountainous environment make it a distinctive industrial cultural landscape.Taking the third front industrial cultural landscape of southern Anhui as an example,this paper uses philosophy of technology to study this industrial cultural landscape with “modernity” characteristics,so as to make its “culture” return to the industrial cultural system and rethink,rather than the previous interpretation in the context of “cultural relics”.Then,under the framework of natural system,technological system and cultural system,the deep-seated cultural philosophy characteristics of the third front industrial cultural landscape are explained from the technological nature of the three line industrial cultural landscape.
文摘From the perspective of bibliometric analysis, based on the data of 286 related literature retrieved and screened in the CNKI database, coOC software is used for data processing, and the relevant knowledge graphs such as the amount of publication, authors, and keywords in the field of third-line heritage research are plotted. The results show that the attention to third-line heritage research in China is increasing day by day, and the overall volume of publications shows a rapid growth trend;The authors’ clusters are scattered and do not form a broad and close network of cooperation;The research hotspots focus on the protection and reuse of third-line heritage, and the quantitative research methods are insufficient. In the future, the breadth and depth of third-line heritage research need to be expanded.
文摘In the process of promoting the national territorial spatial planning system in all provinces, cities and counties, the geospatial database of “One Map” has realized the information sharing and collaborative work of multiple departments. Based on this, this paper intended to provide a set of standardized mapping models for industrial heritage storage, and through the establishment of the database to protect and reuse the status quo of industrial heritage research. This paper took the third-line construction industrial heritage of Mianyang “Two-Bomb City” as the research object, developed the relevant drawing standards of third-line industrial heritage database, and studied the database construction process. GIS technology is used to establish a geospatial database of the third-line industrial heritage in cooperation with the “One Map” system, in order to provide reference for the storage of the third-line industrial heritage in various places, and to protect and reuse the third-line industrial heritage from the perspectives of spatial factors, planning coordination and dynamic assessment.
