An efficient enantioselective cascade sulfa-Michael/Michael addition reaction of trans-3-(2-mercaptophenyl)-2-propenoic acid ethyl ester with nitroalkenes catalyzed by a chiral squaramide catalyst was disclosed.This c...An efficient enantioselective cascade sulfa-Michael/Michael addition reaction of trans-3-(2-mercaptophenyl)-2-propenoic acid ethyl ester with nitroalkenes catalyzed by a chiral squaramide catalyst was disclosed.This cascade reaction afforded thiochroman derivatives with three contiguous stereocenters in high yields(up to 94%),excellent diastereoselectivities(up to>25∶1 dr)and enantioselectivities(up to 99% ee).展开更多
A C-H sulfurated cyclization protocol starting from thioacetates is developed for straightforward construction of sulfur-containing benzo- heterocyclics. The diversiform functional dihydrobenzothiophenes and thiochrom...A C-H sulfurated cyclization protocol starting from thioacetates is developed for straightforward construction of sulfur-containing benzo- heterocyclics. The diversiform functional dihydrobenzothiophenes and thiochromans were comprehensively achieved through the Pd-catalyzed carbon- sulfur cyclization. Mechanistic studies indicated that C-H bond cleavage was involved in the rate-determining step. [1]Benzothieno-[3,2-b]- [1]benzothiophene （BTBT） and benzo[b]thieno[2,3-d]thiophene （BTT） were efficiently established as the well-known organic field-effect transistor （OFET） material molecules through this methodology.展开更多
基金We are grateful for financial support from the National Natural Science Foundation of China(Grant No.21272024).
文摘An efficient enantioselective cascade sulfa-Michael/Michael addition reaction of trans-3-(2-mercaptophenyl)-2-propenoic acid ethyl ester with nitroalkenes catalyzed by a chiral squaramide catalyst was disclosed.This cascade reaction afforded thiochroman derivatives with three contiguous stereocenters in high yields(up to 94%),excellent diastereoselectivities(up to>25∶1 dr)and enantioselectivities(up to 99% ee).
文摘A C-H sulfurated cyclization protocol starting from thioacetates is developed for straightforward construction of sulfur-containing benzo- heterocyclics. The diversiform functional dihydrobenzothiophenes and thiochromans were comprehensively achieved through the Pd-catalyzed carbon- sulfur cyclization. Mechanistic studies indicated that C-H bond cleavage was involved in the rate-determining step. [1]Benzothieno-[3,2-b]- [1]benzothiophene （BTBT） and benzo[b]thieno[2,3-d]thiophene （BTT） were efficiently established as the well-known organic field-effect transistor （OFET） material molecules through this methodology.
