The dependence of interface structure and mechanical properties on the modulation layer thickness of VN/TiN−Ni nano-multilayered films deposited on Si substrates using a reactive magnetron sputtering technique was sys...The dependence of interface structure and mechanical properties on the modulation layer thickness of VN/TiN−Ni nano-multilayered films deposited on Si substrates using a reactive magnetron sputtering technique was systematically investigated. The films were characterized using X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, transmission electron microscopy, and nanoindentation. The results show that the TiN−Ni layer grows epitaxially on the VN layer, forming a coherent interface between the two sublayers. When the deposition time ratio of the two sublayers (TTiN−Ni꞉TVN) is 10꞉12, the films exhibit remarkable mechanical properties, with hardness, elastic modulus, and fracture toughness values of 25.9 GPa, 317 GPa, and 1.88 MPa·m^(1/2), respectively. Meanwhile, fracture toughness is improved by approximately 50% compared to the VN monolithic film. This enhancement is attributed to the coherent interface between the sublayers and the phase separation in the TiN−Ni layer.展开更多
Leaf thickness in rice critically influences photosynthetic efficiency and yield,yet its genetic basis remains poorly understood,with few functional genes previously characterized.In this study,we employ a pangenome-w...Leaf thickness in rice critically influences photosynthetic efficiency and yield,yet its genetic basis remains poorly understood,with few functional genes previously characterized.In this study,we employ a pangenome-wide association study(Pan-GWAS)on 302 diverse rice accessions from southern China,identifying 49 quantitative trait loci(QTLs)associated with leaf thickness.The most significant locus,qLT9,is fine-mapped to a 79-kb region on chromosome 9.Transcriptomic and genomic sequence analyses identify LOC_Os09g33480,which encodes a protein belonging to Multiple Organellar RNA Editing Factor family,as the key candidate gene.Overexpression and complementation transgenic experiments confirm LOC_Os09g33480(OsLT9)as the functional gene underlying qLT9,demonstrating a 24-bp Indel in its promoter correlates with the expression levels and leaf thickness.Notably,OsLT9 overexpression lines show not only thicker leaf,but also significantly enhanced photosynthetic efficiency and grain yield,establishing a link between leaf thickness modulation and yield enhancement.Population genomic analyses indicate strong selection for OsLT9 during domestication and breeding,with modern cultivars favoring thick leaf haplotype of OsLT9.This study establishes OsLT9 as a key regulator controlling leaf thickness in rice,and provides a valuable genetic resource for molecular breeding of high-yielding rice through optimization of plant architecture.展开更多
In order to optimize the reaming process of the type IV composite hydrogen storage cylinder,the netting theory was employed for the design of stacking sequences,and the thickness in the head section was predicted.A fi...In order to optimize the reaming process of the type IV composite hydrogen storage cylinder,the netting theory was employed for the design of stacking sequences,and the thickness in the head section was predicted.A finite element model of the plastic-lined composite hydrogen storage cylinder,designed to withstand a working pressure of 70.0 MPa,was established by using the wound composite modeler(WCM)in the Abaqus software to analyze the forces acting on the winding layer.The Hashin failure criterion was utilized as the standard for assessing composite failure,and a progressive failure analysis of the cylinder was conducted to predict both the bursting pressure and the failure location of the composite hydrogen storage cylinder.The results indicate that the reaming process can effectively reduce the maximum filament winding thickness in the head section and promote a more uniform transition.At the bursting pressure,the stress within the head liner decreases,thereby enhancing the ultimate bearing capacity of the cylinder.A control system for a four-axis winding machine was designed by utilizing an industrial computer and a programmable multi-axis controller(PMAC).The winding line pattern is designed and the G-code trajectory is generated by the industrial computer.The numerical control system,composed of the PMAC and servo motor,executes the four-axis interpolation motion.展开更多
Objective:To identify predictors of pregnancy and live birth outcomes in assisted reproductive technology(ART)cycles based on patient characteristics,hormonal profile,and embryo transfer variables.Methods:This retrosp...Objective:To identify predictors of pregnancy and live birth outcomes in assisted reproductive technology(ART)cycles based on patient characteristics,hormonal profile,and embryo transfer variables.Methods:This retrospective cohort study included 50 fresh in vitro fertilization(IVF)/intracytoplasmic sperm injection(ICSI)cycles selected from ART participants at a single tertiary ART center.Controlled ovarian stimulation was performed using recombinant follicle stimulating hormone(rFSH),gonadotropin-releasing hormone(GnRH)antagonist,and menotropins;oocyte retrieval occurred 36 h after trigger and embryo transfer was performed on day 3 or 5.Outcomes(chemical pregnancy,ongoing pregnancy,abortion,live birth)were compared across groups stratified by maternal age,antral follicle count(AFC),anti-Müllerian hormone(AMH),baseline luteinizing hormone(LH),estradiol(E2)at trigger,and endometrial thickness.Multivariate regression was used to identify independent predictors of live birth.Results:A total of 124 ART patients were screened during the study period,of whom 50 participants meeting the eligibility criteria were included in the final analysis.The median age of the participants was 35.8 years[interquartile range(IQR)32.5–39.6].The median AFC was 8(IQR 4–14),AMH level was 1.4 ng/mL(IQR 0.7–2.9),and the median endometrial thickness at embryo transfer was 10.2 mm(IQR 9.0–11.3).Chemical,ongoing,abortion,and live birth rates were 62%,32%,12%,and 16%,respectively.Younger maternal age(<35 years),higher AFC(>12),AMH 1–4 ng/mL,and endometrial thickness≥10 mm were associated with more favorable pregnancy outcomes.In multivariate analysis,higher baseline LH(β=0.089;95%CI 0.017–0.162;P=0.02)and greater endometrial thickness(β=0.145;95%CI 0.011–0.278;P=0.04)independently predicted live birth,whereas age,AFC,AMH,and E2 did not.Conclusions:Maternal age,ovarian reserve markers,LH levels,and endometrial thickness collectively influence ART outcomes.Baseline LH and endometrial receptivity are key independent predictors of live birth and may guide individualized treatment strategies.展开更多
The correlation between the Soil Moisture and Ocean Salinity(SMOS)L-band brightness temperature and thin sea ice thickness has been widely exploited using semi-empirical retrieval approaches based on a single-tie poin...The correlation between the Soil Moisture and Ocean Salinity(SMOS)L-band brightness temperature and thin sea ice thickness has been widely exploited using semi-empirical retrieval approaches based on a single-tie point(STP).However,due to pronounced spatial heterogeneity in seawater and sea ice properties across the Arctic,the use of an STP often leads to regionally biased.To address this limitation,this study proposes a multi-tie point(MTP)sea ice thickness retrieval method based on SMOS brightness temperature and sea ice concentration time series.Multiple seawater and sea ice tie-point values are identified through point-by-point time series analysis,quality control,and statistical hypothesis testing,allowing spatial variability in radiometric properties to be explicitly considered.The MTP-based retrieval is applied to Arctic freeze-up conditions.Validation against independent SMOS thin sea ice thickness products shows that the MTP approach yields significantly reduced bias and root mean square error compared with the conventional STP method,with statistically significant improvements confirmed by paired t-tests.While retrieval accuracy stabilizes beyond a certain number of tie points,the preprocessing cost associated with tie-point selection increases substantially.Considering both accuracy and efficiency,the MTP framework provides a practical and robust approach for large-scale Arctic thin sea ice thickness retrieval and enables improved characterization of regional freezing processes and maximum ice thickness.展开更多
In order to eliminate the meshing interference between the flexspline and circular spline after the taper deformation of the flexspline,the radial deformation difference method,major and minor axis fitting method,and ...In order to eliminate the meshing interference between the flexspline and circular spline after the taper deformation of the flexspline,the radial deformation difference method,major and minor axis fitting method,and ellipse fitting method are used to modify the tooth thickness of the flexspline and analyze the performance indexes such as the assembly stress,transmission error,and fatigue life.Firstly,the conjugate tooth profile is solved based on the quadruple-circular-arc tooth profile and modified kinematic method.Then,based on the finite element radial deformation of the flexspline,the principle and characteristics of three modification methods are analyzed,and the modification amount of each section of the flexspline tooth is calculated.Finally,the influence of the three modification methods on the performance of the harmonic drive is compared.The results show that the radial deformation difference method can initially determine the modification amount.The minimum static assembly stress is 406.22 MPa by the major and minor axis fitting method.The ellipse fitting method has the best dynamic performance,small transmission error fluctuation,a peak-to-peak value of 3.060",and a maximum fatigue life of 10^(7.558)cycles.展开更多
Instrumental and expert assessments were used to assess the effect of massage on facial skin blood perfusion,as well as the effects of the long-term use of the two skin health programs on the water content of the stra...Instrumental and expert assessments were used to assess the effect of massage on facial skin blood perfusion,as well as the effects of the long-term use of the two skin health programs on the water content of the stratum corneum,F4,L^(*),dermal and epidermal thickness and density,facial wrinkles,and so on.Sixty healthy Chinese women were selected as the study subjects,which were subsequently divided into G1 non-massage group and G2 massage group.The results show that massage can increase the blood perfusion of facial skin.Group G2 solution is found to be more effective in improving the skin structural barrier(epidermal density),skin elasticity,firmness(dermal thickness)and forehead wrinkles.展开更多
AIM:To investigate the changes of retinal vascular parameters and retinal layer thickness in patients with multiple sclerosis(MS).METHODS:This single-centered case-control study was performed on a MS group of 42 patie...AIM:To investigate the changes of retinal vascular parameters and retinal layer thickness in patients with multiple sclerosis(MS).METHODS:This single-centered case-control study was performed on a MS group of 42 patients diagnosed with MS and a control group of 43 healthy hospital staff matched in terms of age and sex at Iran University,department of neurology and ophthalmology from March 2020 to March 2021.The ophthalmic parameters of each patient were recorded,and optical coherence tomography was used to evaluate the retinal thickness in the layers.RESULTS:This study enrolled a total of 85 participants,with a mean age of 40.44±11.52 years,including 61 females(72%).The control group consisted of 43 individuals with a mean age of 39.49±11.07 years,while the MS group comprised 42 participants with a mean age of 41.40±12.01 years.The mean disease duration in the MS group was 8.45±6.04 a.The thickness of the ganglion cell layer in the right eye was significantly lower in the MS group compared to the control group(P=0.034).In addition,except for the left nasal sector(P=0.106),the mean peripapillary neurofibrillation in all examined sectors were significantly lower in the MS group than in the control group(P<0.05).The average vessel density in both the deep and superficial capillary plexuses across all regions of both eyes was lower in the MS group than in the control group,with all comparisons for the superficial capillary plexus showing statistical significance(P<0.05 for all except the left nasal sector).CONCLUSION:The thickness of the retina of patients with MS is significantly reduced.Therefore,optical coherence tomography results can be used as a reliable tool to evaluate disease progression and prognosis in MS patients.展开更多
The remarkable mechanical and physical characteristics of functionally graded(FG)graphene origami(GOri)-enabled auxetic metamaterial(GOEAM)structures,including their high strength-to-weight ratio,tunable stiffness and...The remarkable mechanical and physical characteristics of functionally graded(FG)graphene origami(GOri)-enabled auxetic metamaterial(GOEAM)structures,including their high strength-to-weight ratio,tunable stiffness and strength,and negative Poisson's ratio(NPR),have demonstrated significant promise for a range of engineering applications.This paper aims to investigate the nonlinear free vibrations behaviors of FG-GOEAM non-uniform thickness skew-microplate with rectangular and elliptical planform and resting on Kerr-elastic foundation in thermal environment.Within the framework of the higher-order shear deformation theory(HSDT),von Kármán assumption,modified couple stress theory(MCST)and by employing Hamilton's principle the nonlinear governing equations of motion are established.By combining an iterative technique with a displacement control strategy,an isogeometric analysis(IGA)approach used to determine the nonlinearity in free vibration,as measured by the nonlinear frequency ratio associated with the center deflection amplitude.The effects of GOri distribution patterns,weight fraction,length-scale parameter,temperature difference,skew-angle,and micro-plate dimensions on the nonlinear free vibrations behaviors of the FG-GOEAM non-uniform thickness skew-microplate are revealed through a thorough parametric study.This result can be applied in studies on the design of micro-electro-mechanical devices operating in various complex environments and conditions.展开更多
BaFe_(12)O_(19)(BaM)thin films with thicknesses ranging from 15 nm–200 nm were deposited on Al_(2)O_(3)(0001)substrates by pulsed laser deposition(PLD).X-ray diffraction patterns show that a buffer layer with a thick...BaFe_(12)O_(19)(BaM)thin films with thicknesses ranging from 15 nm–200 nm were deposited on Al_(2)O_(3)(0001)substrates by pulsed laser deposition(PLD).X-ray diffraction patterns show that a buffer layer with a thickness of nearly 60 nm forms on the substrate,and then a c-axis perpendicularly oriented Ba M thin film grows on the buffer layer.Atomic force microscopy results indicate that the Ba M thin film exhibits a spiral island growth mode on the buffer layer.Magnetic hysteresis loop results confirm that the buffer layer exhibits no significant magnetic anisotropy,while the Ba M thin film exhibits perpendicular magnetic anisotropy.The out-of-plane coercivity decreases with increasing Ba M thin-film thickness due to the combined effect of grain size growth and lattice strain relaxation.The 200 nm thick film exhibits optimum magnetic properties with M_(s)=319 emu/cm^(3) and H_(c)=1546 Oe.展开更多
Water-sand gushing(WSG)disasters in confinedaquifers pose significantchallenges to the utilization of deep underground spaces in soft soil areas.Since few studies have considered the impact of confined aquifer thickne...Water-sand gushing(WSG)disasters in confinedaquifers pose significantchallenges to the utilization of deep underground spaces in soft soil areas.Since few studies have considered the impact of confined aquifer thickness and confinedwater pressure on WSG disasters,a novel visual model test system was developed to investigate the influencingcharacteristics and mechanisms of the two aforementioned factors.The test results showed that the WSG process in clay aquiclude-confinedaquifer composite strata exhibits two prominent stages.First,the sand loss zone expands vertically in an ellipsoid shape.Then,it expands horizontally once the ellipsoid reaches the boundary of the clay layer.The sand loss continues until the overlying clay sinks to the bottom to clog the gushing crack,creating a large sinkhole at the surface.Increasing the confinedaquifer thickness can increase the vertical expansion of the ellipsoid and delay the clay-clogging effects,thereby considerably increasing the severity of sand loss,stratum deformation,and surface settlement.An increase in the confinedwater pressure markedly increases the hydraulic gradient along the seepage path,which contributes to increasing the gushing rates of water and sand.As a result,substantial sand loss occurs before the clay clogs the gushing crack,inducing more cracks and deeper sinkholes at the surface.All the aforementioned results provide insights into the effects of confinedaquifer on WSG disasters in clay aquiclude-confinedaquifer composite strata.展开更多
The growing need for sustainable energy solutions,driven by rising energy shortages,environmental concerns,and the depletion of conventional energy sources,has led to a significant focus on renewable energy.Solar ener...The growing need for sustainable energy solutions,driven by rising energy shortages,environmental concerns,and the depletion of conventional energy sources,has led to a significant focus on renewable energy.Solar energy,among the various renewable sources,is particularly appealing due to its abundant availability.However,the efficiency of commercial solar photovoltaic(PV)modules is hindered by several factors,notably their conversion efficiency,which averages around 19%.This efficiency can further decline to 10%–16%due to temperature increases during peak sunlight hours.This study investigates the cooling of PV modules by applying water to their front surface through Computational fluid dynamics(CFD).The study aimed to determine the optimal conditions for cooling the PV module by analyzing the interplay between water film thickness,Reynolds number,and their effects on temperature reduction and heat transfer.The CFD analysis revealed that the most effective cooling condition occurred with a 5 mm thick water film and a Reynolds number of 10.These specific parameters were found to maximize the heat transfer and temperature reduction efficiency.This finding is crucial for the development of practical and efficient cooling systems for PV modules,potentially leading to improved performance and longevity of solar panels.Alternative cooling fluids or advanced cooling techniques that might offer even better efficiency or practical benefits.展开更多
Lead-free hybrid double perovskites(LFHDPs) have received a lot of attention due to their environmental friendliness and promising attributes. However, studying the effect of film thickness on LFHDPs optoelectronic pr...Lead-free hybrid double perovskites(LFHDPs) have received a lot of attention due to their environmental friendliness and promising attributes. However, studying the effect of film thickness on LFHDPs optoelectronic properties has not yet been investigated. Herein, we synthesized two new Ruddlesden–Popper LFHDPs, namely(C_(5)H_(12)N)_(4)AgBiI_(8)(CAB-1) and(C_(6)H_(14)N)_(4)Ag Bi I8(CAB-2) using cyclopentylamine and cyclohexylamine as monoamine ligands. Indeed, these two Ag(Ⅰ)-Bi(Ⅲ) LFHDPs form smooth and uniform films ranging in thickness from 250 nm to 1 μm, with preferred orientations. Notably, the studies on the optical properties showed that the direct band gap value decreased from 2.17 e V to 1.91 e V for CAB-1 and from 2.05 e V to 1.86 e V for CAB-2 with increasing thickness. Accordingly, photo-current response using a xenon lamp revealed a significant difference of over 1000 n A between light and dark conditions for1 μm-thickness films, suggesting potential for light harvesting. Other than that, thicker films of CAB-1and CAB-2 exhibit high stability for 90 days in a relatively humid environment(RH of 55%), paving the way for promising optoelectronic applications.展开更多
The key factor that controls the genesis of porphyry Cu deposits(PCDs)in collisional orogens remains a debated topic.This study employs whole-rock La/Yb proxies to quantitatively constrain the spatial and temporal var...The key factor that controls the genesis of porphyry Cu deposits(PCDs)in collisional orogens remains a debated topic.This study employs whole-rock La/Yb proxies to quantitatively constrain the spatial and temporal variations in crustal thickness of the South Armenian-Iranian magmatic belt(SAIMB)within the Zagros orogen(central Tethys region)since the Eocene.Our results show that rapid crustal thickening occurred first in the NW section of the SAIMB at~35 Ma,then propagated southeastward into the central and SE sections at~25 Ma and 20 Ma,respectively,indicating that the Arabia-Eurasia collision was diachronous.The formation of the large and giant collision-related PCDs in the SAIMB might have been controlled by the collision process because they developed first in the NW section of the SAIMB and subsequently propagated southeastward into the central and SE sections.More importantly,crustal thickness mapping shows that the PCDs are preferentially developed in the thickened crust areas(>50 km).Our findings propose that thickened crust is critical for the formation of the PCDs in collisional orogens by promoting Fe^(2+)-rich minerals as a fractionating phase,driving magmatic auto-oxidation and releasing Cu into the magmas.The Cu is then partitioned into magmatic fluids,sustaining the porphyry systems.Furthermore,our research highlights that the thickened crust hosting PCDs was characterized by a previously thinner crust(<40 km),where magmas had low oxygen fugacity due to the absence of the auto-oxidation process.Consequently,chalcophile elements(e.g.,Cu)efficiently separated from the melt through sulfide segregation,forming large Cu-bearing lower-crustal cumulates.These cumulates can be mobilized with an increase in oxygen fugacity,incorporating into subsequent porphyry mineralization.We thus propose that the crustal thickness evolution over time controls the formation of the PCDs in collisional orogens.There are two essential stages in the collision-related PCDs formation:the first is high-flux magmatism in the thin crustal setting(<40 km),leading to metal-fertilized lower crust through sulfide segregation,and the second is the intracrustal auto-oxidation during crustal thickening(>50 km)which facilitates pre-enriched sulfides in the lower crust to re-dissolve,releasing Cu into the magmas.展开更多
Background Increased backfat thickness of sows in early gestation is negative to reproductive performance.Endometrial receptivity is an important determinant of reproductive success,but it is unclear whether the effec...Background Increased backfat thickness of sows in early gestation is negative to reproductive performance.Endometrial receptivity is an important determinant of reproductive success,but it is unclear whether the effect of sow backfat thickness on litter size is associated with endometrial receptivity and whether melatonin treatment may have benefits.The present study seeks to answer these questions through in vitro and in vivo investigations.Results Excessive lipid deposition and lower melatonin levels in the uterus are detrimental to endometrial receptivity and embryo implantation in high backfat thickness sows.In cells treated with melatonin,the MT2/PI3K/LIF axis played a role in reducing lipid accumulation in porcine endometrial epithelium cells and improved endometrial receptivity.Furthermore,we found a reduction of lipids in the uterus after eight weeks of intraperitoneal administration of melatonin to HFD mice.Notably,melatonin treatment caused a significant reduction in the deposition of endometrial collagen,an increase in the number of glands,and repair of the pinopode structure,ultimately improving endometrial receptivity,promoting embryo implantation,and increasing the number of litter size of mice.Conclusions Collectively,the finding reveals the harmful effects of high backfat thickness sows on embryo implantation and highlight the role of melatonin and the MT2/PI3K/LIF axis in improving endometrial receptivity by enhancing metabolism and reducing the levels of uterine lipids in obese animals.展开更多
Background:It is found to have association of facial parameters with trisomy 21 fetuses(T 21).We have compared prenasal thickness(PNT),nasal bone length(NBL),and the PNT:NBL ratio of normal fetuses with fetuses with t...Background:It is found to have association of facial parameters with trisomy 21 fetuses(T 21).We have compared prenasal thickness(PNT),nasal bone length(NBL),and the PNT:NBL ratio of normal fetuses with fetuses with trisomy 21(T 21)between 16 and 25 weeks of gestation as a diagnostic tool for T 21.Methods:Facial profile images in the two dimensional(2D)gray scale were assessed to measure fetal NBL and PNT between 16 and 25 weeks of gestation.The PNT:NBL ratio of the fetuses was calculated.Nomograms were constructed from the data of morphologically normal fetuses at live birth.The PNT,NBL,and PNT:NBL ratio of fetuses with confirmed T 21(n=31)and morphologically normal fetuses at live birth(controls,n=3485)were compared.Results:Nomograms for PNT,NBL,and the PNT:NBL ratio were constructed.In T 21 fetuses,PNT(>95th percentile),NBL(<5th percentile),and the PNT:NBL ratio(>95th percentile)showed a sensitivity of 25%,29%,and 45%for PNT,NBL,and PNT:NBL,respectively,and specificity of 95%,96%,and 94%,for PNT,NBL,and PNT:NBL,respectively.All of these markers showed a negative predictive value of 99%.Conclusion:PNT,NBL,and the PNT:NBL ratio have high diagnostic value for fetuses with Down syndrome and can be incorporated easily in the current second trimester screening protocol for T 21.PNT,NBL,and the PNT:NBL ratio are more specific markers for Down syndrome than those used in previous studies.展开更多
Mg alloy matrix composites reinforced with short carbon fibers(C_(sf)/Mg)are considered as potential candidates for integrated structural-functional electronic parts that satisfy the requirements of lightweight,excell...Mg alloy matrix composites reinforced with short carbon fibers(C_(sf)/Mg)are considered as potential candidates for integrated structural-functional electronic parts that satisfy the requirements of lightweight,excellent mechanical properties,and heat dissipation.However,the different characteristics of C_(sf)and Mg alloy make the interface a critical issue affecting the synergistic improvement of thermal and mechanical properties of the composites.Here,Cu coating with different thicknesses is introduced to modify the C_(sf)/Mg interface,so as to simultaneously enhance the thermal and mechanical performances,which can combine the advantages of coating modification and matrix alloying.Results reveal that thermal diffusivity(TD)of 3-C_(sf)-Cu/Mg composites is as high as 22.12 mm^(2)/s and an enhancement of 52.97%is achieved compared with C_(sf)/Mg composites,as well as 16.3%enhancement of ultimate compressive strength(UCS)in the longitudinal direction,8.84%improvement of UCS in the transverse direction,and 53.08%increasement of ultimate tensile strength(UTS).Such improvement can be ascribed to the formation of intermetallic compounds.The formation of intermetallic compounds can not only effectively alleviate the lattice distortion of the matrix and decrease interfacial thermal resistance,but also bear the loads.Our work is of great significance for designing C_(sf)/Mg composites with integrated structure and function.展开更多
The spatial distribution of overburden layer thickness(OLT)is crucial for landslide susceptibility prediction and slope stability analysis.Due to OLT spatial heterogeneity in hillslope regions,combined with the diffic...The spatial distribution of overburden layer thickness(OLT)is crucial for landslide susceptibility prediction and slope stability analysis.Due to OLT spatial heterogeneity in hillslope regions,combined with the difficulty and time consumption of OLT sample collection,accurately predicting OLT distribution remains a challenging.To address this,a novel framework has been developed.First,OLT samples are collected through field surveys,remote sensing,and geological drilling.Next,the heterogeneity of OLT’s spatial distribution is analyzed using the probability distribution of OLT samples and their horizontal and vertical distributions.The OLT samples are categorized and the small sample categories are expanded using the synthetic minority over-sampling technique(SMOTE).The slope position is selected as a key conditioning factor.Subsequently,16 conditioning factors are applied to construct OLT prediction model using the random forest regression algorithm.Weights are assigned to each OLT sample category to balance the uneven distribution of sample sizes.Finally,the Pearson correlation coefficient,mean absolute error(MAE),root mean square error(RMSE),and Lin’s concordance correlation coefficient(Lin’s CCC)are employed to validate the OLT prediction results.The Huangtan town serves as the case study.Results show:(1)heterogeneity analysis,SMOTE-based OLT sample expansion strategy and slope position selection can significantly mitigate the effect of spatial heterogeneity on OLT prediction.(2)The Pearson correlation coefficient,RMSE,MAE and Lin’s CCC values are 0.84,1.173,1.378 and 0.804,respectively,indicating excellent prediction performance.This research provides an effective solution for predicting OLT distribution in hillslope regions.展开更多
Due to the influence of karst cave development and route selection,the location relationship between concealed karst cave and tunnel is more random.In order to explore the influence rule of karst cave location on the ...Due to the influence of karst cave development and route selection,the location relationship between concealed karst cave and tunnel is more random.In order to explore the influence rule of karst cave location on the minimum safe thickness of water-proof rock mass,a simplified calculation model of water-proof rock mass thickness when the karst cave is located at any location around the tunnel is established,and the influence of multiple factors on the overall stability of water-proof rock mass is considered.Based on the cusp catastrophe theory,the analytical expressions for the safety thickness of waterproof rock mass are derived.Based on the finite difference principle,the analytical expressions of the safety thickness of water-proof rock mass are verified.In order to improve the application range of the analytical formula derived in this paper,the analytical formula is optimized based on the instability principle differences between the simplified calculation model and the elastic compressive bar.The research results show that the necessary condition solution is more applicable and much safer than the sufficient condition solution.Tectonic stress,rock beam length and karst cave water pressure are significantly positively correlated with the safe thickness of the waterproof rock mass.The calculated results of the semioptimized formula and the unoptimized formula are constant values,independent of the karst cave location.While the calculated results of the fully optimized formula are variable values,correlated with the karst cave location,the thickness of the waterproof rock mass gradually decreases as the karst cave location moves from the top of the tunnel to the bottom of the tunnel.The unoptimized formula does not consider the influence of the lateral force of the rock beam,and is not suitable for the working condition with large lateral force,the calculation results of the semi-optimized formula and the fully optimized formula are not very different and are biased to safety,so it can be given priority.展开更多
Type 2 diabetes mellitus(T2DM)promotes a risk of the development of atherosclerosis and potentiates atherosclerotic cardiovascular events.Among these patients,chronic hyperglycemia,dyslipidemia,oxidative stress and sy...Type 2 diabetes mellitus(T2DM)promotes a risk of the development of atherosclerosis and potentiates atherosclerotic cardiovascular events.Among these patients,chronic hyperglycemia,dyslipidemia,oxidative stress and systemic inflammation has been found as triggers for accelerating plaque formation.Additionally,conventionally used risk factors,such as age,overweight/obesity,hypertension,poor glycemic control,renal dysfunction,and metabolic disturbances frequently underestimate the patients at the risk of asymptomatic carotid atherosclerosis.Further interventions may be required to prevent vascular complications.To note,asymptomatic carotid plaque in T2DM is associated with older age,increased body mass index,biomarkers of poor glycemic control(glycated hemoglobin,fasting glucose),kidney dysfunction[urinary albumin-to-creatinine ratio(UACR)],and metabolic abnormalities[high-density lipoprotein cholesterol,serum uric acid(SUA)].However,renal(UACR)and metabolic(SUA)biomarkers are likely to be investigated as promising biomarkers for early stage of asymptomatic coronary atherosclerosis,which as expecting could improve diagnostic value of intima-media thickness.展开更多
基金financially supported by the National Natural Science Foundation of China(No.51971148)the Key Project Foundation of Hanjiang Normal University,China(No.XJ2024A09)+1 种基金the Excellent Young and Middle-aged Science and Technology Innovation Team Project in Higher Education Institutions of Hubei Province,China(No.T2020024)the Shanghai Engineering Research Center of High-Performance Medical Device Materials,China(No.20DZ2255500)。
文摘The dependence of interface structure and mechanical properties on the modulation layer thickness of VN/TiN−Ni nano-multilayered films deposited on Si substrates using a reactive magnetron sputtering technique was systematically investigated. The films were characterized using X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, transmission electron microscopy, and nanoindentation. The results show that the TiN−Ni layer grows epitaxially on the VN layer, forming a coherent interface between the two sublayers. When the deposition time ratio of the two sublayers (TTiN−Ni꞉TVN) is 10꞉12, the films exhibit remarkable mechanical properties, with hardness, elastic modulus, and fracture toughness values of 25.9 GPa, 317 GPa, and 1.88 MPa·m^(1/2), respectively. Meanwhile, fracture toughness is improved by approximately 50% compared to the VN monolithic film. This enhancement is attributed to the coherent interface between the sublayers and the phase separation in the TiN−Ni layer.
基金supported by the National Natural Science Foundation of China(32301845)GuangDong Basic and Applied Basic Research Foundation(2022A1515012339)+3 种基金the National Key R&D Program of China(2024YFD1200801)Seed industry revitalization project of special fund for rural revitalization strategy in Guangdong Province(2024-NPY-00-001)Modern Seed Industry Innovation Capacity Enhancement Progject of Guangdong Academy of Agricultural Sciences,Elite Rice Plan of GDRRI(2023YG01)Guangdong Key Laboratory of Rice Science and Technology(2023B1212060042).
文摘Leaf thickness in rice critically influences photosynthetic efficiency and yield,yet its genetic basis remains poorly understood,with few functional genes previously characterized.In this study,we employ a pangenome-wide association study(Pan-GWAS)on 302 diverse rice accessions from southern China,identifying 49 quantitative trait loci(QTLs)associated with leaf thickness.The most significant locus,qLT9,is fine-mapped to a 79-kb region on chromosome 9.Transcriptomic and genomic sequence analyses identify LOC_Os09g33480,which encodes a protein belonging to Multiple Organellar RNA Editing Factor family,as the key candidate gene.Overexpression and complementation transgenic experiments confirm LOC_Os09g33480(OsLT9)as the functional gene underlying qLT9,demonstrating a 24-bp Indel in its promoter correlates with the expression levels and leaf thickness.Notably,OsLT9 overexpression lines show not only thicker leaf,but also significantly enhanced photosynthetic efficiency and grain yield,establishing a link between leaf thickness modulation and yield enhancement.Population genomic analyses indicate strong selection for OsLT9 during domestication and breeding,with modern cultivars favoring thick leaf haplotype of OsLT9.This study establishes OsLT9 as a key regulator controlling leaf thickness in rice,and provides a valuable genetic resource for molecular breeding of high-yielding rice through optimization of plant architecture.
文摘In order to optimize the reaming process of the type IV composite hydrogen storage cylinder,the netting theory was employed for the design of stacking sequences,and the thickness in the head section was predicted.A finite element model of the plastic-lined composite hydrogen storage cylinder,designed to withstand a working pressure of 70.0 MPa,was established by using the wound composite modeler(WCM)in the Abaqus software to analyze the forces acting on the winding layer.The Hashin failure criterion was utilized as the standard for assessing composite failure,and a progressive failure analysis of the cylinder was conducted to predict both the bursting pressure and the failure location of the composite hydrogen storage cylinder.The results indicate that the reaming process can effectively reduce the maximum filament winding thickness in the head section and promote a more uniform transition.At the bursting pressure,the stress within the head liner decreases,thereby enhancing the ultimate bearing capacity of the cylinder.A control system for a four-axis winding machine was designed by utilizing an industrial computer and a programmable multi-axis controller(PMAC).The winding line pattern is designed and the G-code trajectory is generated by the industrial computer.The numerical control system,composed of the PMAC and servo motor,executes the four-axis interpolation motion.
文摘Objective:To identify predictors of pregnancy and live birth outcomes in assisted reproductive technology(ART)cycles based on patient characteristics,hormonal profile,and embryo transfer variables.Methods:This retrospective cohort study included 50 fresh in vitro fertilization(IVF)/intracytoplasmic sperm injection(ICSI)cycles selected from ART participants at a single tertiary ART center.Controlled ovarian stimulation was performed using recombinant follicle stimulating hormone(rFSH),gonadotropin-releasing hormone(GnRH)antagonist,and menotropins;oocyte retrieval occurred 36 h after trigger and embryo transfer was performed on day 3 or 5.Outcomes(chemical pregnancy,ongoing pregnancy,abortion,live birth)were compared across groups stratified by maternal age,antral follicle count(AFC),anti-Müllerian hormone(AMH),baseline luteinizing hormone(LH),estradiol(E2)at trigger,and endometrial thickness.Multivariate regression was used to identify independent predictors of live birth.Results:A total of 124 ART patients were screened during the study period,of whom 50 participants meeting the eligibility criteria were included in the final analysis.The median age of the participants was 35.8 years[interquartile range(IQR)32.5–39.6].The median AFC was 8(IQR 4–14),AMH level was 1.4 ng/mL(IQR 0.7–2.9),and the median endometrial thickness at embryo transfer was 10.2 mm(IQR 9.0–11.3).Chemical,ongoing,abortion,and live birth rates were 62%,32%,12%,and 16%,respectively.Younger maternal age(<35 years),higher AFC(>12),AMH 1–4 ng/mL,and endometrial thickness≥10 mm were associated with more favorable pregnancy outcomes.In multivariate analysis,higher baseline LH(β=0.089;95%CI 0.017–0.162;P=0.02)and greater endometrial thickness(β=0.145;95%CI 0.011–0.278;P=0.04)independently predicted live birth,whereas age,AFC,AMH,and E2 did not.Conclusions:Maternal age,ovarian reserve markers,LH levels,and endometrial thickness collectively influence ART outcomes.Baseline LH and endometrial receptivity are key independent predictors of live birth and may guide individualized treatment strategies.
基金supported by the National Key Research and Development Program of China(Grant nos.2023YFC2809103,2024YFC2813505)the Fundamental Research Funds for the Central Universities(Grant nos.2042025kf0083,2042025gf0014)the Antarctic Zhongshan Ice and Space Environment National Observation and Research Station(Grant no.ZSNORS-20252702).
文摘The correlation between the Soil Moisture and Ocean Salinity(SMOS)L-band brightness temperature and thin sea ice thickness has been widely exploited using semi-empirical retrieval approaches based on a single-tie point(STP).However,due to pronounced spatial heterogeneity in seawater and sea ice properties across the Arctic,the use of an STP often leads to regionally biased.To address this limitation,this study proposes a multi-tie point(MTP)sea ice thickness retrieval method based on SMOS brightness temperature and sea ice concentration time series.Multiple seawater and sea ice tie-point values are identified through point-by-point time series analysis,quality control,and statistical hypothesis testing,allowing spatial variability in radiometric properties to be explicitly considered.The MTP-based retrieval is applied to Arctic freeze-up conditions.Validation against independent SMOS thin sea ice thickness products shows that the MTP approach yields significantly reduced bias and root mean square error compared with the conventional STP method,with statistically significant improvements confirmed by paired t-tests.While retrieval accuracy stabilizes beyond a certain number of tie points,the preprocessing cost associated with tie-point selection increases substantially.Considering both accuracy and efficiency,the MTP framework provides a practical and robust approach for large-scale Arctic thin sea ice thickness retrieval and enables improved characterization of regional freezing processes and maximum ice thickness.
文摘In order to eliminate the meshing interference between the flexspline and circular spline after the taper deformation of the flexspline,the radial deformation difference method,major and minor axis fitting method,and ellipse fitting method are used to modify the tooth thickness of the flexspline and analyze the performance indexes such as the assembly stress,transmission error,and fatigue life.Firstly,the conjugate tooth profile is solved based on the quadruple-circular-arc tooth profile and modified kinematic method.Then,based on the finite element radial deformation of the flexspline,the principle and characteristics of three modification methods are analyzed,and the modification amount of each section of the flexspline tooth is calculated.Finally,the influence of the three modification methods on the performance of the harmonic drive is compared.The results show that the radial deformation difference method can initially determine the modification amount.The minimum static assembly stress is 406.22 MPa by the major and minor axis fitting method.The ellipse fitting method has the best dynamic performance,small transmission error fluctuation,a peak-to-peak value of 3.060",and a maximum fatigue life of 10^(7.558)cycles.
文摘Instrumental and expert assessments were used to assess the effect of massage on facial skin blood perfusion,as well as the effects of the long-term use of the two skin health programs on the water content of the stratum corneum,F4,L^(*),dermal and epidermal thickness and density,facial wrinkles,and so on.Sixty healthy Chinese women were selected as the study subjects,which were subsequently divided into G1 non-massage group and G2 massage group.The results show that massage can increase the blood perfusion of facial skin.Group G2 solution is found to be more effective in improving the skin structural barrier(epidermal density),skin elasticity,firmness(dermal thickness)and forehead wrinkles.
文摘AIM:To investigate the changes of retinal vascular parameters and retinal layer thickness in patients with multiple sclerosis(MS).METHODS:This single-centered case-control study was performed on a MS group of 42 patients diagnosed with MS and a control group of 43 healthy hospital staff matched in terms of age and sex at Iran University,department of neurology and ophthalmology from March 2020 to March 2021.The ophthalmic parameters of each patient were recorded,and optical coherence tomography was used to evaluate the retinal thickness in the layers.RESULTS:This study enrolled a total of 85 participants,with a mean age of 40.44±11.52 years,including 61 females(72%).The control group consisted of 43 individuals with a mean age of 39.49±11.07 years,while the MS group comprised 42 participants with a mean age of 41.40±12.01 years.The mean disease duration in the MS group was 8.45±6.04 a.The thickness of the ganglion cell layer in the right eye was significantly lower in the MS group compared to the control group(P=0.034).In addition,except for the left nasal sector(P=0.106),the mean peripapillary neurofibrillation in all examined sectors were significantly lower in the MS group than in the control group(P<0.05).The average vessel density in both the deep and superficial capillary plexuses across all regions of both eyes was lower in the MS group than in the control group,with all comparisons for the superficial capillary plexus showing statistical significance(P<0.05 for all except the left nasal sector).CONCLUSION:The thickness of the retina of patients with MS is significantly reduced.Therefore,optical coherence tomography results can be used as a reliable tool to evaluate disease progression and prognosis in MS patients.
文摘The remarkable mechanical and physical characteristics of functionally graded(FG)graphene origami(GOri)-enabled auxetic metamaterial(GOEAM)structures,including their high strength-to-weight ratio,tunable stiffness and strength,and negative Poisson's ratio(NPR),have demonstrated significant promise for a range of engineering applications.This paper aims to investigate the nonlinear free vibrations behaviors of FG-GOEAM non-uniform thickness skew-microplate with rectangular and elliptical planform and resting on Kerr-elastic foundation in thermal environment.Within the framework of the higher-order shear deformation theory(HSDT),von Kármán assumption,modified couple stress theory(MCST)and by employing Hamilton's principle the nonlinear governing equations of motion are established.By combining an iterative technique with a displacement control strategy,an isogeometric analysis(IGA)approach used to determine the nonlinearity in free vibration,as measured by the nonlinear frequency ratio associated with the center deflection amplitude.The effects of GOri distribution patterns,weight fraction,length-scale parameter,temperature difference,skew-angle,and micro-plate dimensions on the nonlinear free vibrations behaviors of the FG-GOEAM non-uniform thickness skew-microplate are revealed through a thorough parametric study.This result can be applied in studies on the design of micro-electro-mechanical devices operating in various complex environments and conditions.
文摘BaFe_(12)O_(19)(BaM)thin films with thicknesses ranging from 15 nm–200 nm were deposited on Al_(2)O_(3)(0001)substrates by pulsed laser deposition(PLD).X-ray diffraction patterns show that a buffer layer with a thickness of nearly 60 nm forms on the substrate,and then a c-axis perpendicularly oriented Ba M thin film grows on the buffer layer.Atomic force microscopy results indicate that the Ba M thin film exhibits a spiral island growth mode on the buffer layer.Magnetic hysteresis loop results confirm that the buffer layer exhibits no significant magnetic anisotropy,while the Ba M thin film exhibits perpendicular magnetic anisotropy.The out-of-plane coercivity decreases with increasing Ba M thin-film thickness due to the combined effect of grain size growth and lattice strain relaxation.The 200 nm thick film exhibits optimum magnetic properties with M_(s)=319 emu/cm^(3) and H_(c)=1546 Oe.
基金financedby the National Natural Science Foundation of China(Grant No.52090083)the Shanghai Rising-Star Program(Grant No.23QB1404800).
文摘Water-sand gushing(WSG)disasters in confinedaquifers pose significantchallenges to the utilization of deep underground spaces in soft soil areas.Since few studies have considered the impact of confined aquifer thickness and confinedwater pressure on WSG disasters,a novel visual model test system was developed to investigate the influencingcharacteristics and mechanisms of the two aforementioned factors.The test results showed that the WSG process in clay aquiclude-confinedaquifer composite strata exhibits two prominent stages.First,the sand loss zone expands vertically in an ellipsoid shape.Then,it expands horizontally once the ellipsoid reaches the boundary of the clay layer.The sand loss continues until the overlying clay sinks to the bottom to clog the gushing crack,creating a large sinkhole at the surface.Increasing the confinedaquifer thickness can increase the vertical expansion of the ellipsoid and delay the clay-clogging effects,thereby considerably increasing the severity of sand loss,stratum deformation,and surface settlement.An increase in the confinedwater pressure markedly increases the hydraulic gradient along the seepage path,which contributes to increasing the gushing rates of water and sand.As a result,substantial sand loss occurs before the clay clogs the gushing crack,inducing more cracks and deeper sinkholes at the surface.All the aforementioned results provide insights into the effects of confinedaquifer on WSG disasters in clay aquiclude-confinedaquifer composite strata.
文摘The growing need for sustainable energy solutions,driven by rising energy shortages,environmental concerns,and the depletion of conventional energy sources,has led to a significant focus on renewable energy.Solar energy,among the various renewable sources,is particularly appealing due to its abundant availability.However,the efficiency of commercial solar photovoltaic(PV)modules is hindered by several factors,notably their conversion efficiency,which averages around 19%.This efficiency can further decline to 10%–16%due to temperature increases during peak sunlight hours.This study investigates the cooling of PV modules by applying water to their front surface through Computational fluid dynamics(CFD).The study aimed to determine the optimal conditions for cooling the PV module by analyzing the interplay between water film thickness,Reynolds number,and their effects on temperature reduction and heat transfer.The CFD analysis revealed that the most effective cooling condition occurred with a 5 mm thick water film and a Reynolds number of 10.These specific parameters were found to maximize the heat transfer and temperature reduction efficiency.This finding is crucial for the development of practical and efficient cooling systems for PV modules,potentially leading to improved performance and longevity of solar panels.Alternative cooling fluids or advanced cooling techniques that might offer even better efficiency or practical benefits.
基金supported by the National Natural Science Foundation of China (Nos. 22375157 and W2433042)the Key Scientific and Technological Innovation Team of Shaanxi Province(No. 2020TD-001)+1 种基金the Fundamental Research Funds for Central Universities, State Key Laboratory of Electrical Insulation and Power Equipment (No. EIPE23409)the Instrument Analysis Center of Xi’an Jiaotong University for assistance。
文摘Lead-free hybrid double perovskites(LFHDPs) have received a lot of attention due to their environmental friendliness and promising attributes. However, studying the effect of film thickness on LFHDPs optoelectronic properties has not yet been investigated. Herein, we synthesized two new Ruddlesden–Popper LFHDPs, namely(C_(5)H_(12)N)_(4)AgBiI_(8)(CAB-1) and(C_(6)H_(14)N)_(4)Ag Bi I8(CAB-2) using cyclopentylamine and cyclohexylamine as monoamine ligands. Indeed, these two Ag(Ⅰ)-Bi(Ⅲ) LFHDPs form smooth and uniform films ranging in thickness from 250 nm to 1 μm, with preferred orientations. Notably, the studies on the optical properties showed that the direct band gap value decreased from 2.17 e V to 1.91 e V for CAB-1 and from 2.05 e V to 1.86 e V for CAB-2 with increasing thickness. Accordingly, photo-current response using a xenon lamp revealed a significant difference of over 1000 n A between light and dark conditions for1 μm-thickness films, suggesting potential for light harvesting. Other than that, thicker films of CAB-1and CAB-2 exhibit high stability for 90 days in a relatively humid environment(RH of 55%), paving the way for promising optoelectronic applications.
基金funded by the National Key R&D Program of China(Grant No.2022YFC2905000)the NSFC(Grant No.42230813)+4 种基金the Opening Foundation of State Key Laboratory of Continental Dynamics,Northwest University(Grant No.23LCD12)the Opening Foundation of the Key Laboratory of Continental Dynamics of Ministry of Natural Resources(Grant No.J2408)the Sichuan Province Natural Science Foundation(Grant Nos.2024NSFSC1954,2025ZNSFSC1196)the Open Research Fund Program of Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring(Central South University),Ministry of Education(11300-502401003)the Everest Scientific Research Program of Chengdu University of Technology(Grant No.2024ZF11407).
文摘The key factor that controls the genesis of porphyry Cu deposits(PCDs)in collisional orogens remains a debated topic.This study employs whole-rock La/Yb proxies to quantitatively constrain the spatial and temporal variations in crustal thickness of the South Armenian-Iranian magmatic belt(SAIMB)within the Zagros orogen(central Tethys region)since the Eocene.Our results show that rapid crustal thickening occurred first in the NW section of the SAIMB at~35 Ma,then propagated southeastward into the central and SE sections at~25 Ma and 20 Ma,respectively,indicating that the Arabia-Eurasia collision was diachronous.The formation of the large and giant collision-related PCDs in the SAIMB might have been controlled by the collision process because they developed first in the NW section of the SAIMB and subsequently propagated southeastward into the central and SE sections.More importantly,crustal thickness mapping shows that the PCDs are preferentially developed in the thickened crust areas(>50 km).Our findings propose that thickened crust is critical for the formation of the PCDs in collisional orogens by promoting Fe^(2+)-rich minerals as a fractionating phase,driving magmatic auto-oxidation and releasing Cu into the magmas.The Cu is then partitioned into magmatic fluids,sustaining the porphyry systems.Furthermore,our research highlights that the thickened crust hosting PCDs was characterized by a previously thinner crust(<40 km),where magmas had low oxygen fugacity due to the absence of the auto-oxidation process.Consequently,chalcophile elements(e.g.,Cu)efficiently separated from the melt through sulfide segregation,forming large Cu-bearing lower-crustal cumulates.These cumulates can be mobilized with an increase in oxygen fugacity,incorporating into subsequent porphyry mineralization.We thus propose that the crustal thickness evolution over time controls the formation of the PCDs in collisional orogens.There are two essential stages in the collision-related PCDs formation:the first is high-flux magmatism in the thin crustal setting(<40 km),leading to metal-fertilized lower crust through sulfide segregation,and the second is the intracrustal auto-oxidation during crustal thickening(>50 km)which facilitates pre-enriched sulfides in the lower crust to re-dissolve,releasing Cu into the magmas.
基金supported by the China Agriculture Research System(CARS-35-PIG)the National Natural Science Foundation of China(32272847,U22A20516)+1 种基金the National Key Research and Development Program of China(No.2021YFF1000602)the Key Research and Development Program of Shaanxi Province(No.2022ZDLNY01–04)。
文摘Background Increased backfat thickness of sows in early gestation is negative to reproductive performance.Endometrial receptivity is an important determinant of reproductive success,but it is unclear whether the effect of sow backfat thickness on litter size is associated with endometrial receptivity and whether melatonin treatment may have benefits.The present study seeks to answer these questions through in vitro and in vivo investigations.Results Excessive lipid deposition and lower melatonin levels in the uterus are detrimental to endometrial receptivity and embryo implantation in high backfat thickness sows.In cells treated with melatonin,the MT2/PI3K/LIF axis played a role in reducing lipid accumulation in porcine endometrial epithelium cells and improved endometrial receptivity.Furthermore,we found a reduction of lipids in the uterus after eight weeks of intraperitoneal administration of melatonin to HFD mice.Notably,melatonin treatment caused a significant reduction in the deposition of endometrial collagen,an increase in the number of glands,and repair of the pinopode structure,ultimately improving endometrial receptivity,promoting embryo implantation,and increasing the number of litter size of mice.Conclusions Collectively,the finding reveals the harmful effects of high backfat thickness sows on embryo implantation and highlight the role of melatonin and the MT2/PI3K/LIF axis in improving endometrial receptivity by enhancing metabolism and reducing the levels of uterine lipids in obese animals.
文摘Background:It is found to have association of facial parameters with trisomy 21 fetuses(T 21).We have compared prenasal thickness(PNT),nasal bone length(NBL),and the PNT:NBL ratio of normal fetuses with fetuses with trisomy 21(T 21)between 16 and 25 weeks of gestation as a diagnostic tool for T 21.Methods:Facial profile images in the two dimensional(2D)gray scale were assessed to measure fetal NBL and PNT between 16 and 25 weeks of gestation.The PNT:NBL ratio of the fetuses was calculated.Nomograms were constructed from the data of morphologically normal fetuses at live birth.The PNT,NBL,and PNT:NBL ratio of fetuses with confirmed T 21(n=31)and morphologically normal fetuses at live birth(controls,n=3485)were compared.Results:Nomograms for PNT,NBL,and the PNT:NBL ratio were constructed.In T 21 fetuses,PNT(>95th percentile),NBL(<5th percentile),and the PNT:NBL ratio(>95th percentile)showed a sensitivity of 25%,29%,and 45%for PNT,NBL,and PNT:NBL,respectively,and specificity of 95%,96%,and 94%,for PNT,NBL,and PNT:NBL,respectively.All of these markers showed a negative predictive value of 99%.Conclusion:PNT,NBL,and the PNT:NBL ratio have high diagnostic value for fetuses with Down syndrome and can be incorporated easily in the current second trimester screening protocol for T 21.PNT,NBL,and the PNT:NBL ratio are more specific markers for Down syndrome than those used in previous studies.
基金supported by the National Natural Science Foundation of China(grant no.52231004 and 52072305).
文摘Mg alloy matrix composites reinforced with short carbon fibers(C_(sf)/Mg)are considered as potential candidates for integrated structural-functional electronic parts that satisfy the requirements of lightweight,excellent mechanical properties,and heat dissipation.However,the different characteristics of C_(sf)and Mg alloy make the interface a critical issue affecting the synergistic improvement of thermal and mechanical properties of the composites.Here,Cu coating with different thicknesses is introduced to modify the C_(sf)/Mg interface,so as to simultaneously enhance the thermal and mechanical performances,which can combine the advantages of coating modification and matrix alloying.Results reveal that thermal diffusivity(TD)of 3-C_(sf)-Cu/Mg composites is as high as 22.12 mm^(2)/s and an enhancement of 52.97%is achieved compared with C_(sf)/Mg composites,as well as 16.3%enhancement of ultimate compressive strength(UCS)in the longitudinal direction,8.84%improvement of UCS in the transverse direction,and 53.08%increasement of ultimate tensile strength(UTS).Such improvement can be ascribed to the formation of intermetallic compounds.The formation of intermetallic compounds can not only effectively alleviate the lattice distortion of the matrix and decrease interfacial thermal resistance,but also bear the loads.Our work is of great significance for designing C_(sf)/Mg composites with integrated structure and function.
基金funded by the Natural Science Foundation of China(No.42407241,42272326 and 52222905)Jiangxi Provincial Natural Science Foundation(Nos.20242BAB20241,20242BAB23052 and 20242BAB24001).
文摘The spatial distribution of overburden layer thickness(OLT)is crucial for landslide susceptibility prediction and slope stability analysis.Due to OLT spatial heterogeneity in hillslope regions,combined with the difficulty and time consumption of OLT sample collection,accurately predicting OLT distribution remains a challenging.To address this,a novel framework has been developed.First,OLT samples are collected through field surveys,remote sensing,and geological drilling.Next,the heterogeneity of OLT’s spatial distribution is analyzed using the probability distribution of OLT samples and their horizontal and vertical distributions.The OLT samples are categorized and the small sample categories are expanded using the synthetic minority over-sampling technique(SMOTE).The slope position is selected as a key conditioning factor.Subsequently,16 conditioning factors are applied to construct OLT prediction model using the random forest regression algorithm.Weights are assigned to each OLT sample category to balance the uneven distribution of sample sizes.Finally,the Pearson correlation coefficient,mean absolute error(MAE),root mean square error(RMSE),and Lin’s concordance correlation coefficient(Lin’s CCC)are employed to validate the OLT prediction results.The Huangtan town serves as the case study.Results show:(1)heterogeneity analysis,SMOTE-based OLT sample expansion strategy and slope position selection can significantly mitigate the effect of spatial heterogeneity on OLT prediction.(2)The Pearson correlation coefficient,RMSE,MAE and Lin’s CCC values are 0.84,1.173,1.378 and 0.804,respectively,indicating excellent prediction performance.This research provides an effective solution for predicting OLT distribution in hillslope regions.
基金jointly funded by the guangxi Science and Technology Base and Talent Project(AD23026104)the Key Research and Development Program Project in Guangxi(AB23026121)。
文摘Due to the influence of karst cave development and route selection,the location relationship between concealed karst cave and tunnel is more random.In order to explore the influence rule of karst cave location on the minimum safe thickness of water-proof rock mass,a simplified calculation model of water-proof rock mass thickness when the karst cave is located at any location around the tunnel is established,and the influence of multiple factors on the overall stability of water-proof rock mass is considered.Based on the cusp catastrophe theory,the analytical expressions for the safety thickness of waterproof rock mass are derived.Based on the finite difference principle,the analytical expressions of the safety thickness of water-proof rock mass are verified.In order to improve the application range of the analytical formula derived in this paper,the analytical formula is optimized based on the instability principle differences between the simplified calculation model and the elastic compressive bar.The research results show that the necessary condition solution is more applicable and much safer than the sufficient condition solution.Tectonic stress,rock beam length and karst cave water pressure are significantly positively correlated with the safe thickness of the waterproof rock mass.The calculated results of the semioptimized formula and the unoptimized formula are constant values,independent of the karst cave location.While the calculated results of the fully optimized formula are variable values,correlated with the karst cave location,the thickness of the waterproof rock mass gradually decreases as the karst cave location moves from the top of the tunnel to the bottom of the tunnel.The unoptimized formula does not consider the influence of the lateral force of the rock beam,and is not suitable for the working condition with large lateral force,the calculation results of the semi-optimized formula and the fully optimized formula are not very different and are biased to safety,so it can be given priority.
文摘Type 2 diabetes mellitus(T2DM)promotes a risk of the development of atherosclerosis and potentiates atherosclerotic cardiovascular events.Among these patients,chronic hyperglycemia,dyslipidemia,oxidative stress and systemic inflammation has been found as triggers for accelerating plaque formation.Additionally,conventionally used risk factors,such as age,overweight/obesity,hypertension,poor glycemic control,renal dysfunction,and metabolic disturbances frequently underestimate the patients at the risk of asymptomatic carotid atherosclerosis.Further interventions may be required to prevent vascular complications.To note,asymptomatic carotid plaque in T2DM is associated with older age,increased body mass index,biomarkers of poor glycemic control(glycated hemoglobin,fasting glucose),kidney dysfunction[urinary albumin-to-creatinine ratio(UACR)],and metabolic abnormalities[high-density lipoprotein cholesterol,serum uric acid(SUA)].However,renal(UACR)and metabolic(SUA)biomarkers are likely to be investigated as promising biomarkers for early stage of asymptomatic coronary atherosclerosis,which as expecting could improve diagnostic value of intima-media thickness.
