The dependence of interface structure and mechanical properties on the modulation layer thickness of VN/TiN−Ni nano-multilayered films deposited on Si substrates using a reactive magnetron sputtering technique was sys...The dependence of interface structure and mechanical properties on the modulation layer thickness of VN/TiN−Ni nano-multilayered films deposited on Si substrates using a reactive magnetron sputtering technique was systematically investigated. The films were characterized using X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, transmission electron microscopy, and nanoindentation. The results show that the TiN−Ni layer grows epitaxially on the VN layer, forming a coherent interface between the two sublayers. When the deposition time ratio of the two sublayers (TTiN−Ni꞉TVN) is 10꞉12, the films exhibit remarkable mechanical properties, with hardness, elastic modulus, and fracture toughness values of 25.9 GPa, 317 GPa, and 1.88 MPa·m^(1/2), respectively. Meanwhile, fracture toughness is improved by approximately 50% compared to the VN monolithic film. This enhancement is attributed to the coherent interface between the sublayers and the phase separation in the TiN−Ni layer.展开更多
In order to eliminate the meshing interference between the flexspline and circular spline after the taper deformation of the flexspline,the radial deformation difference method,major and minor axis fitting method,and ...In order to eliminate the meshing interference between the flexspline and circular spline after the taper deformation of the flexspline,the radial deformation difference method,major and minor axis fitting method,and ellipse fitting method are used to modify the tooth thickness of the flexspline and analyze the performance indexes such as the assembly stress,transmission error,and fatigue life.Firstly,the conjugate tooth profile is solved based on the quadruple-circular-arc tooth profile and modified kinematic method.Then,based on the finite element radial deformation of the flexspline,the principle and characteristics of three modification methods are analyzed,and the modification amount of each section of the flexspline tooth is calculated.Finally,the influence of the three modification methods on the performance of the harmonic drive is compared.The results show that the radial deformation difference method can initially determine the modification amount.The minimum static assembly stress is 406.22 MPa by the major and minor axis fitting method.The ellipse fitting method has the best dynamic performance,small transmission error fluctuation,a peak-to-peak value of 3.060",and a maximum fatigue life of 10^(7.558)cycles.展开更多
AIM:To investigate the changes of retinal vascular parameters and retinal layer thickness in patients with multiple sclerosis(MS).METHODS:This single-centered case-control study was performed on a MS group of 42 patie...AIM:To investigate the changes of retinal vascular parameters and retinal layer thickness in patients with multiple sclerosis(MS).METHODS:This single-centered case-control study was performed on a MS group of 42 patients diagnosed with MS and a control group of 43 healthy hospital staff matched in terms of age and sex at Iran University,department of neurology and ophthalmology from March 2020 to March 2021.The ophthalmic parameters of each patient were recorded,and optical coherence tomography was used to evaluate the retinal thickness in the layers.RESULTS:This study enrolled a total of 85 participants,with a mean age of 40.44±11.52 years,including 61 females(72%).The control group consisted of 43 individuals with a mean age of 39.49±11.07 years,while the MS group comprised 42 participants with a mean age of 41.40±12.01 years.The mean disease duration in the MS group was 8.45±6.04 a.The thickness of the ganglion cell layer in the right eye was significantly lower in the MS group compared to the control group(P=0.034).In addition,except for the left nasal sector(P=0.106),the mean peripapillary neurofibrillation in all examined sectors were significantly lower in the MS group than in the control group(P<0.05).The average vessel density in both the deep and superficial capillary plexuses across all regions of both eyes was lower in the MS group than in the control group,with all comparisons for the superficial capillary plexus showing statistical significance(P<0.05 for all except the left nasal sector).CONCLUSION:The thickness of the retina of patients with MS is significantly reduced.Therefore,optical coherence tomography results can be used as a reliable tool to evaluate disease progression and prognosis in MS patients.展开更多
BaFe_(12)O_(19)(BaM)thin films with thicknesses ranging from 15 nm–200 nm were deposited on Al_(2)O_(3)(0001)substrates by pulsed laser deposition(PLD).X-ray diffraction patterns show that a buffer layer with a thick...BaFe_(12)O_(19)(BaM)thin films with thicknesses ranging from 15 nm–200 nm were deposited on Al_(2)O_(3)(0001)substrates by pulsed laser deposition(PLD).X-ray diffraction patterns show that a buffer layer with a thickness of nearly 60 nm forms on the substrate,and then a c-axis perpendicularly oriented Ba M thin film grows on the buffer layer.Atomic force microscopy results indicate that the Ba M thin film exhibits a spiral island growth mode on the buffer layer.Magnetic hysteresis loop results confirm that the buffer layer exhibits no significant magnetic anisotropy,while the Ba M thin film exhibits perpendicular magnetic anisotropy.The out-of-plane coercivity decreases with increasing Ba M thin-film thickness due to the combined effect of grain size growth and lattice strain relaxation.The 200 nm thick film exhibits optimum magnetic properties with M_(s)=319 emu/cm^(3) and H_(c)=1546 Oe.展开更多
In dry-coupled ultrasonic thickness measurement,thick rubber layers introduce high-amplitude parasitic echoes that obscure defect signals and degrade thickness accuracy.Existing methods struggle to resolve overlap-pin...In dry-coupled ultrasonic thickness measurement,thick rubber layers introduce high-amplitude parasitic echoes that obscure defect signals and degrade thickness accuracy.Existing methods struggle to resolve overlap-ping echoes under variable coupling conditions and non-stationary noise.This study proposes a novel dual-criterion framework integrating energy contribution and statistical impulsivity metrics to isolate specimen re-flections from coupling-layer interference.By decomposing A-scan signals into Intrinsic Mode Functions(IMFs),the framework employs energy contribution thresholds(>85%)and kurtosis indices(>3)to autonomously select IMFs containing valid specimen echoes.Hybrid time-frequency thresholding further suppresses interference through amplitude filtering and spectral focusing.Experimental results demonstrate the framework’s robustness,achieving 92.3%thickness accuracy for 5 mm steel specimens with 5 mm rubber coupling,outperforming conventional methods by up to 18.7%.The dual-criterion approach reduces operator dependency by 37%and maintainsΔT<0.03 mm under surface roughness up to 6.3μm,offering a practical solution for industrial nondestructive testing with thick dry-coupled interfaces.展开更多
Lead-free hybrid double perovskites(LFHDPs) have received a lot of attention due to their environmental friendliness and promising attributes. However, studying the effect of film thickness on LFHDPs optoelectronic pr...Lead-free hybrid double perovskites(LFHDPs) have received a lot of attention due to their environmental friendliness and promising attributes. However, studying the effect of film thickness on LFHDPs optoelectronic properties has not yet been investigated. Herein, we synthesized two new Ruddlesden–Popper LFHDPs, namely(C_(5)H_(12)N)_(4)AgBiI_(8)(CAB-1) and(C_(6)H_(14)N)_(4)Ag Bi I8(CAB-2) using cyclopentylamine and cyclohexylamine as monoamine ligands. Indeed, these two Ag(Ⅰ)-Bi(Ⅲ) LFHDPs form smooth and uniform films ranging in thickness from 250 nm to 1 μm, with preferred orientations. Notably, the studies on the optical properties showed that the direct band gap value decreased from 2.17 e V to 1.91 e V for CAB-1 and from 2.05 e V to 1.86 e V for CAB-2 with increasing thickness. Accordingly, photo-current response using a xenon lamp revealed a significant difference of over 1000 n A between light and dark conditions for1 μm-thickness films, suggesting potential for light harvesting. Other than that, thicker films of CAB-1and CAB-2 exhibit high stability for 90 days in a relatively humid environment(RH of 55%), paving the way for promising optoelectronic applications.展开更多
Mg alloy matrix composites reinforced with short carbon fibers(C_(sf)/Mg)are considered as potential candidates for integrated structural-functional electronic parts that satisfy the requirements of lightweight,excell...Mg alloy matrix composites reinforced with short carbon fibers(C_(sf)/Mg)are considered as potential candidates for integrated structural-functional electronic parts that satisfy the requirements of lightweight,excellent mechanical properties,and heat dissipation.However,the different characteristics of C_(sf)and Mg alloy make the interface a critical issue affecting the synergistic improvement of thermal and mechanical properties of the composites.Here,Cu coating with different thicknesses is introduced to modify the C_(sf)/Mg interface,so as to simultaneously enhance the thermal and mechanical performances,which can combine the advantages of coating modification and matrix alloying.Results reveal that thermal diffusivity(TD)of 3-C_(sf)-Cu/Mg composites is as high as 22.12 mm^(2)/s and an enhancement of 52.97%is achieved compared with C_(sf)/Mg composites,as well as 16.3%enhancement of ultimate compressive strength(UCS)in the longitudinal direction,8.84%improvement of UCS in the transverse direction,and 53.08%increasement of ultimate tensile strength(UTS).Such improvement can be ascribed to the formation of intermetallic compounds.The formation of intermetallic compounds can not only effectively alleviate the lattice distortion of the matrix and decrease interfacial thermal resistance,but also bear the loads.Our work is of great significance for designing C_(sf)/Mg composites with integrated structure and function.展开更多
Background:It is found to have association of facial parameters with trisomy 21 fetuses(T 21).We have compared prenasal thickness(PNT),nasal bone length(NBL),and the PNT:NBL ratio of normal fetuses with fetuses with t...Background:It is found to have association of facial parameters with trisomy 21 fetuses(T 21).We have compared prenasal thickness(PNT),nasal bone length(NBL),and the PNT:NBL ratio of normal fetuses with fetuses with trisomy 21(T 21)between 16 and 25 weeks of gestation as a diagnostic tool for T 21.Methods:Facial profile images in the two dimensional(2D)gray scale were assessed to measure fetal NBL and PNT between 16 and 25 weeks of gestation.The PNT:NBL ratio of the fetuses was calculated.Nomograms were constructed from the data of morphologically normal fetuses at live birth.The PNT,NBL,and PNT:NBL ratio of fetuses with confirmed T 21(n=31)and morphologically normal fetuses at live birth(controls,n=3485)were compared.Results:Nomograms for PNT,NBL,and the PNT:NBL ratio were constructed.In T 21 fetuses,PNT(>95th percentile),NBL(<5th percentile),and the PNT:NBL ratio(>95th percentile)showed a sensitivity of 25%,29%,and 45%for PNT,NBL,and PNT:NBL,respectively,and specificity of 95%,96%,and 94%,for PNT,NBL,and PNT:NBL,respectively.All of these markers showed a negative predictive value of 99%.Conclusion:PNT,NBL,and the PNT:NBL ratio have high diagnostic value for fetuses with Down syndrome and can be incorporated easily in the current second trimester screening protocol for T 21.PNT,NBL,and the PNT:NBL ratio are more specific markers for Down syndrome than those used in previous studies.展开更多
Due to the influence of karst cave development and route selection,the location relationship between concealed karst cave and tunnel is more random.In order to explore the influence rule of karst cave location on the ...Due to the influence of karst cave development and route selection,the location relationship between concealed karst cave and tunnel is more random.In order to explore the influence rule of karst cave location on the minimum safe thickness of water-proof rock mass,a simplified calculation model of water-proof rock mass thickness when the karst cave is located at any location around the tunnel is established,and the influence of multiple factors on the overall stability of water-proof rock mass is considered.Based on the cusp catastrophe theory,the analytical expressions for the safety thickness of waterproof rock mass are derived.Based on the finite difference principle,the analytical expressions of the safety thickness of water-proof rock mass are verified.In order to improve the application range of the analytical formula derived in this paper,the analytical formula is optimized based on the instability principle differences between the simplified calculation model and the elastic compressive bar.The research results show that the necessary condition solution is more applicable and much safer than the sufficient condition solution.Tectonic stress,rock beam length and karst cave water pressure are significantly positively correlated with the safe thickness of the waterproof rock mass.The calculated results of the semioptimized formula and the unoptimized formula are constant values,independent of the karst cave location.While the calculated results of the fully optimized formula are variable values,correlated with the karst cave location,the thickness of the waterproof rock mass gradually decreases as the karst cave location moves from the top of the tunnel to the bottom of the tunnel.The unoptimized formula does not consider the influence of the lateral force of the rock beam,and is not suitable for the working condition with large lateral force,the calculation results of the semi-optimized formula and the fully optimized formula are not very different and are biased to safety,so it can be given priority.展开更多
The key factor that controls the genesis of porphyry Cu deposits(PCDs)in collisional orogens remains a debated topic.This study employs whole-rock La/Yb proxies to quantitatively constrain the spatial and temporal var...The key factor that controls the genesis of porphyry Cu deposits(PCDs)in collisional orogens remains a debated topic.This study employs whole-rock La/Yb proxies to quantitatively constrain the spatial and temporal variations in crustal thickness of the South Armenian-Iranian magmatic belt(SAIMB)within the Zagros orogen(central Tethys region)since the Eocene.Our results show that rapid crustal thickening occurred first in the NW section of the SAIMB at~35 Ma,then propagated southeastward into the central and SE sections at~25 Ma and 20 Ma,respectively,indicating that the Arabia-Eurasia collision was diachronous.The formation of the large and giant collision-related PCDs in the SAIMB might have been controlled by the collision process because they developed first in the NW section of the SAIMB and subsequently propagated southeastward into the central and SE sections.More importantly,crustal thickness mapping shows that the PCDs are preferentially developed in the thickened crust areas(>50 km).Our findings propose that thickened crust is critical for the formation of the PCDs in collisional orogens by promoting Fe^(2+)-rich minerals as a fractionating phase,driving magmatic auto-oxidation and releasing Cu into the magmas.The Cu is then partitioned into magmatic fluids,sustaining the porphyry systems.Furthermore,our research highlights that the thickened crust hosting PCDs was characterized by a previously thinner crust(<40 km),where magmas had low oxygen fugacity due to the absence of the auto-oxidation process.Consequently,chalcophile elements(e.g.,Cu)efficiently separated from the melt through sulfide segregation,forming large Cu-bearing lower-crustal cumulates.These cumulates can be mobilized with an increase in oxygen fugacity,incorporating into subsequent porphyry mineralization.We thus propose that the crustal thickness evolution over time controls the formation of the PCDs in collisional orogens.There are two essential stages in the collision-related PCDs formation:the first is high-flux magmatism in the thin crustal setting(<40 km),leading to metal-fertilized lower crust through sulfide segregation,and the second is the intracrustal auto-oxidation during crustal thickening(>50 km)which facilitates pre-enriched sulfides in the lower crust to re-dissolve,releasing Cu into the magmas.展开更多
The undeformed chip thickness and grinding force are key parameters for revealing the material removal mechanism in the grinding process.However,they are difficult to be well expressed due to the ununiformed protrusio...The undeformed chip thickness and grinding force are key parameters for revealing the material removal mechanism in the grinding process.However,they are difficult to be well expressed due to the ununiformed protrusion height and random position distribution of abrasive grains on the abrasive wheel surface.This study investigated the distribution of undeformed chip thickness and grinding force considering the non-uniform characteristics of abrasive wheel in the grinding of K4002 nickel-based superalloy.First,a novel grinding force model was established through a kinematic-geometric analysis and a grain-workpiece contact analysis.Then,a series of grinding experiments were conducted for verifying the model.The results indicate that the distribution of undeformed chip thickness is highly consistent with the Gaussian distribution formula.The increase in the grinding depth mainly leads to an increase in the average value of Gaussian distribution.On the contrary,the increase in the workpiece infeed speed or the decrease in the grinding speed mainly increases the standard deviation of Gaussian distribution.The average and maximum errors of the grinding force model are 4.9%and 14.6%respectively,indicating that the model is of high predication accuracy.展开更多
To advance the understanding of the corrosion behavior of stainless steel bellows in marine atmospheric environments and enhance the precision of service life predictions,this study employs finite element simulations ...To advance the understanding of the corrosion behavior of stainless steel bellows in marine atmospheric environments and enhance the precision of service life predictions,this study employs finite element simulations to investigate the pitting corrosion rates and pit morphologies of bellows peaks and troughs under varying electrolyte film thicknesses.The model incorporates localized electrochemical reactions,oxygen concentration,and homogeneous solution reactions.For improved computational accuracy,the fitted polarization curve data were directly applied as nonlinear boundary conditions on the electrode surface via interpolation functions.Simulation results reveal that the peak regions exhibit faster corrosion rates than the trough regions.With increasing electrolyte film thickness(from 10μm to 500μm),corrosion rates at both peaks and troughs decrease progressively,and after 120 hours of simulation,the maximum corrosion rate at the peaks declines from 0.720 mm/a to 0.130 mm/a,and at the troughs from 0.520 mm/a to 0.120 mm/a,with the disparity in corrosion rates diminishing over time.Furthermore,as corrosion progresses,pits propagate deeper into the substrate,exhibiting both vertical penetration and lateral expansion along the passive film interface,ultimately breaching the substrate.This research offers valuable insights into designing corrosion mitigation strategies for stainless steel bellows in marine environments.展开更多
Appreciation of soft-tissue thickness(STT)at surgical sites is an increasingly recognized aspect of arthroplasty procedures as it may potentially impacting postoperative outcomes.Recent research has focused on the pre...Appreciation of soft-tissue thickness(STT)at surgical sites is an increasingly recognized aspect of arthroplasty procedures as it may potentially impacting postoperative outcomes.Recent research has focused on the predictive value of preoperative STT measurements for complications following various forms of arthroplasty,particularly infections,across procedures such as total knee,hip,shoulder,and ankle replacements.Several studies have indicated that increased STT is associated with a higher risk of complications,including infection and wound healing issues.The assessment of STT before surgery could play a crucial role in identifying patients at a higher risk of complications and may be instru-mental in guiding preoperative planning to optimize outcomes in arthroplasty procedures.Standardized measurement techniques and further research are essential to enhance the reliability and clinical utility of STT assessment for arthro-plasty surgery.展开更多
Background Postoperative delirium is one of the most common complications in the older surgical population,but its pathogenesis and biomarkers are largely undetermined.Retinal layer thickness has been demonstrated to ...Background Postoperative delirium is one of the most common complications in the older surgical population,but its pathogenesis and biomarkers are largely undetermined.Retinal layer thickness has been demonstrated to be associated with cognitive function in mild cognitive impairment and patients with Alzheimer’s disease.However,relatively little is known about possible retinal layer thickness among patients with postoperative delirium.Aims We aimed to investigate the relationship between retinal layer thickness and postoperative delirium in this cross-sectional study.Methods The participants(≥65 years old)having elective surgery under general anaesthesia were screened via medical records from Shanghai 10th People’s Hospital.Preoperative macular thickness and peripapillary retinal nerve fibre layer(RNFL)thickness were measured using optical coherence tomography(OCT).The Confusion Assessment Method(CAM)algorithm and CAM-Severity(CAM-S)were used to assess the incidence and severity of postoperative delirium on the first,second and third days after surgery.Results Among 169 participants(mean(standard deviation(SD)71.15(4.36)years),40(24%)developed postoperative delirium.Notably,individuals who developed postoperative delirium exhibited thicker preoperative macular thickness in the right eye compared with those who did not(mean(SD)283.35(27.97)µm vs 273.84(20.14)µm,p=0.013).Furthermore,the thicker preoperative macular thickness of the right eye was associated with a higher incidence of postoperative delirium(adjusted odds ratio 1.593,95%confidence interval(CI)1.093 to 2.322,p=0.015)and greater severity(adjusted mean difference(β)=0.256,95%CI 0.037 to 0.476,p=0.022)after adjustment for age,sex and Mini-Mental State Examination(MMSE)scores.However,such a difference or association did not appear in the left macular or bilateral peripapillary RNFL thicknesses.Conclusions Current findings demonstrated that preoperative macular thickness might serve as a potential non-invasive marker for the vulnerability of developing postoperative delirium in older surgical patients.Further large-scale validation studies should be performed to confirm these results.展开更多
BACKGROUND Despite growing evidence on endoscopic full thickness resection(EFTR),data on segment-specific outcomes in real-world patients remain limited.AIM To investigate segment-specific outcomes of EFTR using a ful...BACKGROUND Despite growing evidence on endoscopic full thickness resection(EFTR),data on segment-specific outcomes in real-world patients remain limited.AIM To investigate segment-specific outcomes of EFTR using a full-thickness resection device(FTRD)for neoplastic colorectal lesions.METHODS In this multicenter,retrospective study,EFTR was conducted in unselected realworld patients referred to participating German centers after colonoscopy confirmed EFTR eligibility.The primary outcome was histologically complete resection(R0)of the lesion,including segment-specific outcomes and adverse events(AE).Additional efficacy and safety parameters were investigated by colonic topography for up to 30 days.RESULTS The analysis included 102 patients(64 males,38 females)with a median age of 70 years.EFTR via FTRD was technically successful in all patients.The R0 rate was 81.4%,segment-specifically ranging from 85.0%(rectum),84.6%(descending colon),84.0%(ascending colon),83.3%(cecum),and 76.5%(sigmoid colon)to 73.3%(transverse colon).Examination time was longer in proximal parts compared to the rectosigmoid(non-significant).Overall,33 patients(32.4%)experienced AE,including only one major complication(0.98%;perforation of sigmoid colon).Abdominal postsurgical pain(18.6%),hematochezia(9.8%),and hemoglobin decline(7.8%)were the most frequent minor complications.Transverse colon lesions had the numerically highest rate of AE,with 8 of 15 patients(53.3%)affected.CONCLUSION EFTR is efficacious for neoplastic colorectal lesions,though R0 rates vary by location.This may impact patient education,selection of the operator,and consideration of laparoscopy surgery.展开更多
While the fire protection function of tree bark has been extensively documented,other critical functions,including storage and mechanical support,have received less attention.In this study we examined:(1)the allometry...While the fire protection function of tree bark has been extensively documented,other critical functions,including storage and mechanical support,have received less attention.In this study we examined:(1)the allometry of bark thickness(and biomass)against wood radius(and biomass)at a disc level,(2)differences in bark allocation between the ratio and the regression approaches,(3)differences between bark thickness and biomass as metrics of bark allocation,and(4)how bark allocation is associated with the evolution of wood from non-porous to diffuse-porous and ring-porous types.Thickness and biomass of bark and wood were measured using trunk discs of 88 individual trees of 36 species in a temperate forest characterized by a long fire interval.Allometric relationships of bark thickness(and biomass)against wood radius(and biomass)explained why both relative bark thickness and biomass decreased with increasing stem diameter.Variations in both among species varied by factors of 3.5 to 7.5 depending on the measurement methods.The ratio approach produced higher estimates of both relative bark thickness and biomass compared to the regression approach,while relative bark thickness was significantly lower than relative bark biomass.Ring-porous species exhibited higher bark thickness based on the ratio approach,which might reflect evolutionary adaptations where ring-porous species have developed thicker bark as protection:thermal insulation against freeze-thaw embolism coupled with carbohydrate reservoirs for hydraulic repair.The regression slope of bark allocation against wood density increased along the wood porosity gradient,demonstrating evolutionary biomechanical coordination between bark and wood.These findings highlight systematic coupling between bark and xylem multifunctionality.展开更多
Background Backfat thickness(BFT)is a vital economic trait in pigs,reflecting subcutaneous fat levels that affect meat quality and production efficiency.As a complex trait shaped by multiple genetic factors,BFT has be...Background Backfat thickness(BFT)is a vital economic trait in pigs,reflecting subcutaneous fat levels that affect meat quality and production efficiency.As a complex trait shaped by multiple genetic factors,BFT has been studied using genome-wide association studies(GWAS)and linkage analyses to locate fat-related quantitative trait loci(QTLs),but pinpointing causal variants and genes is hindered by linkage disequilibrium and limited regulatory data.This study aimed to dissect the QTLs affecting BFT on Sus scrofa chromosome 1(SSC1),elucidating regulatory variants,effector genes,and the cell types involved.Results Using whole-genome genotyping data from 3,578 pigs and phenotypic data for five BFT traits,we identified a 630.6 kb QTL on SSC1 significantly associated with these traits via GWAS and fine-mapping,pinpointing 34 candidate causal variants.Using deep convolutional neural networks to predict regulatory activity from sequence data integrated with detailed pig epigenetic profiles,we identified five SNPs potentially affecting enhancer activity in specific tissues.Notably,rs342950505(SSC1:161,123,588)influences weak enhancer activity across multiple tissues,including the brain.High-throughput chromosome conformation capture(Hi-C)analysis identified that rs342950505 interacts with eight genes.Chromatin state annotations confirmed enhancer activity at this QTL in the cerebellum.Leveraging these insights,single-cell ATAC-seq revealed a chromatin accessibility peak encompassing rs342950505 that regulates PMAIP1 expression in inhibitory neurons via enhancer-mediated mechanisms,with an adjacent peak modulating CCBE1 expression in neuroblasts and granule cells.Transcriptome-wide association studies(TWAS)confirmed PMAIP1's role in the hypothalamus,and Mendelian randomization(MR)validated PMAIP1 and CCBE1 as key brain expression quantitative trait locus(eQTL)effectors.We propose that the variant rs342950505,located within a regulatory peak,modulates PMAIP1 expression in inhibitory neurons,potentially influencing energy homeostasis via hypothalamic regulation.Similarly,CCBE1 may contribute to this process.Conclusions Our results,through systematic dissection of pleiotropic BFT-associated loci,provide a framework to elucidate regulatory mechanisms of complex traits,offering insights into polygenic control through lipid metabolism and neural signaling pathways.展开更多
Background:Poor sleep quality has been associated with changes in brain volume among veterans,particularly those who have experienced mild traumatic brain injury(mTBI)and post-traumatic stress disorder(PTSD).This stud...Background:Poor sleep quality has been associated with changes in brain volume among veterans,particularly those who have experienced mild traumatic brain injury(mTBI)and post-traumatic stress disorder(PTSD).This study sought to investigate:1)whether poor sleep quality is associated with decreased cortical thickness in Iraq and Afghanistan war veterans,and 2)whether these associations differ topographically depending on the presence or absence of mTBI and PTSD.Methods:A sample of 440 post-9/11 era U.S.veterans enrolled in the Translational Research Center for Traumatic Brain Injury and Stress Disorders study at VA Boston,MA from 2010 to 2022 was included in the study.We examined the relationship between sleep quality,as measured by the Pittsburgh Sleep Quality Index(PSQI),and cortical thickness in veterans with mTBI(n=57),PTSD(n=110),comorbid mTBI and PTSD(n=129),and neither PTSD nor mTBI(n=144).To determine the topographical relationship between subjective sleep quality and cortical thickness in each diagnostic group,we employed a General Linear Model(GLM)at each vertex on the cortical mantle.The extent of topographical overlap between the resulting statistical maps was assessed using Dice coefficients.Results:There were no significant associations between PSQI and cortical thickness in the group without PTSD or mTBI(n=144)or in the PTSD-only group(n=110).In the mTBI-only group(n=57),lower sleep quality was significantly associated with reduced thickness bilaterally in frontal,cingulate,and precuneus regions,as well as in the right parietal and temporal regions(β=-0.0137,P<0.0005).In the comorbid mTBI and PTSD group(n=129),significant associations were observed bilaterally in frontal,precentral,and precuneus regions,in the left cingulate and the right parietal regions(β=-0.0094,P<0.0005).Interaction analysis revealed that there was a stronger relationship between poor sleep quality and decreased cortical thickness in individuals with mTBI(n=186)compared with those without mTBI(n=254)specifically in the frontal and cingulate regions(β=-0.0077,P<0.0005).Conclusions:This study demonstrates a significant relationship between poor sleep quality and lower cortical thickness primarily within frontal regions among individuals with both isolated mTBI or comorbid diagnoses of mTBI and PTSD.Thus,if directionality is established in longitudinal and interventional studies,it may be crucial to consider addressing sleep in the treatment of veterans who have sustained mTBI.展开更多
The Qinghai-Tibet Plateau possesses the thickest continental crust on Earth,yet the timing of its formation remains debated.In this study,we conducted zircon U-Pb isotopic dating,geochemical and Sr-Nd-Pb-Hf isotopic a...The Qinghai-Tibet Plateau possesses the thickest continental crust on Earth,yet the timing of its formation remains debated.In this study,we conducted zircon U-Pb isotopic dating,geochemical and Sr-Nd-Pb-Hf isotopic analyses on the Xuexiumaer biotite quartz monzonite porphyry(BQMP)sampled from the Lake Dajia area in southern Gangdese.This study aims to estimate the paleo-crustal thickness beneath this region during the early India-Asia collision stage using whole-rock Sr/Y and(La/Yb)N ratios as proxies.Results reveal that the Xuexiumaer BQMP was formed at~51 Ma in a collisional tectonic setting following Neo-Tethyan slab breakoff,and is an I-type granitoid derived primarily from partial melting of juvenile mafic lower crust with subordinate ancient crustal input.The estimated paleo-crustal thickness in the Lake Dajia area at~51 Ma is less than 40 km.This indicates that although the Qinghai-Tibet Plateau had already undergone significant crustal thickening and attained an exceptionally thick crust(>50 km)prior to the India-Asia collision as demonstrated by previous studies,some regions still maintained a crust only slightly thicker than the average continental crust(~35 km)at the initial collision stage.This limited crustal thickening likely resulted from underplating of subduction-related mafic magma at the mantle-crust boundary.展开更多
The energy density of thin-film lithium batteries(TFLBs)is predominantly determined by the average voltage and specific capacity,however,the mechanism of regulating the voltage plateaus of the film electrodes is not w...The energy density of thin-film lithium batteries(TFLBs)is predominantly determined by the average voltage and specific capacity,however,the mechanism of regulating the voltage plateaus of the film electrodes is not well understood.In this study,three boride films(Co–B,Fe–B,and Co–Fe–B alloys)with different thick-nesses were fabricated to enhance the specific capacity and voltage stability of TFLBs.By analyzing the cycling performance,redox peak evolution,and capacitive contribution,the thickness-dependent lithiation behavior of the thin/thick films was elucidated.Theoretical simulations and electrochemical analysis were conducted to investigate how the lithiation behaviors affected the voltage profiles of the film electrodes.In addition,the various-thickness CoB films were compared in all-solid-state TFLBs,demonstrating the universality and practicability of this simple regulation strategy to develop high-performance energy storage devices.展开更多
基金financially supported by the National Natural Science Foundation of China(No.51971148)the Key Project Foundation of Hanjiang Normal University,China(No.XJ2024A09)+1 种基金the Excellent Young and Middle-aged Science and Technology Innovation Team Project in Higher Education Institutions of Hubei Province,China(No.T2020024)the Shanghai Engineering Research Center of High-Performance Medical Device Materials,China(No.20DZ2255500)。
文摘The dependence of interface structure and mechanical properties on the modulation layer thickness of VN/TiN−Ni nano-multilayered films deposited on Si substrates using a reactive magnetron sputtering technique was systematically investigated. The films were characterized using X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, transmission electron microscopy, and nanoindentation. The results show that the TiN−Ni layer grows epitaxially on the VN layer, forming a coherent interface between the two sublayers. When the deposition time ratio of the two sublayers (TTiN−Ni꞉TVN) is 10꞉12, the films exhibit remarkable mechanical properties, with hardness, elastic modulus, and fracture toughness values of 25.9 GPa, 317 GPa, and 1.88 MPa·m^(1/2), respectively. Meanwhile, fracture toughness is improved by approximately 50% compared to the VN monolithic film. This enhancement is attributed to the coherent interface between the sublayers and the phase separation in the TiN−Ni layer.
文摘In order to eliminate the meshing interference between the flexspline and circular spline after the taper deformation of the flexspline,the radial deformation difference method,major and minor axis fitting method,and ellipse fitting method are used to modify the tooth thickness of the flexspline and analyze the performance indexes such as the assembly stress,transmission error,and fatigue life.Firstly,the conjugate tooth profile is solved based on the quadruple-circular-arc tooth profile and modified kinematic method.Then,based on the finite element radial deformation of the flexspline,the principle and characteristics of three modification methods are analyzed,and the modification amount of each section of the flexspline tooth is calculated.Finally,the influence of the three modification methods on the performance of the harmonic drive is compared.The results show that the radial deformation difference method can initially determine the modification amount.The minimum static assembly stress is 406.22 MPa by the major and minor axis fitting method.The ellipse fitting method has the best dynamic performance,small transmission error fluctuation,a peak-to-peak value of 3.060",and a maximum fatigue life of 10^(7.558)cycles.
文摘AIM:To investigate the changes of retinal vascular parameters and retinal layer thickness in patients with multiple sclerosis(MS).METHODS:This single-centered case-control study was performed on a MS group of 42 patients diagnosed with MS and a control group of 43 healthy hospital staff matched in terms of age and sex at Iran University,department of neurology and ophthalmology from March 2020 to March 2021.The ophthalmic parameters of each patient were recorded,and optical coherence tomography was used to evaluate the retinal thickness in the layers.RESULTS:This study enrolled a total of 85 participants,with a mean age of 40.44±11.52 years,including 61 females(72%).The control group consisted of 43 individuals with a mean age of 39.49±11.07 years,while the MS group comprised 42 participants with a mean age of 41.40±12.01 years.The mean disease duration in the MS group was 8.45±6.04 a.The thickness of the ganglion cell layer in the right eye was significantly lower in the MS group compared to the control group(P=0.034).In addition,except for the left nasal sector(P=0.106),the mean peripapillary neurofibrillation in all examined sectors were significantly lower in the MS group than in the control group(P<0.05).The average vessel density in both the deep and superficial capillary plexuses across all regions of both eyes was lower in the MS group than in the control group,with all comparisons for the superficial capillary plexus showing statistical significance(P<0.05 for all except the left nasal sector).CONCLUSION:The thickness of the retina of patients with MS is significantly reduced.Therefore,optical coherence tomography results can be used as a reliable tool to evaluate disease progression and prognosis in MS patients.
文摘BaFe_(12)O_(19)(BaM)thin films with thicknesses ranging from 15 nm–200 nm were deposited on Al_(2)O_(3)(0001)substrates by pulsed laser deposition(PLD).X-ray diffraction patterns show that a buffer layer with a thickness of nearly 60 nm forms on the substrate,and then a c-axis perpendicularly oriented Ba M thin film grows on the buffer layer.Atomic force microscopy results indicate that the Ba M thin film exhibits a spiral island growth mode on the buffer layer.Magnetic hysteresis loop results confirm that the buffer layer exhibits no significant magnetic anisotropy,while the Ba M thin film exhibits perpendicular magnetic anisotropy.The out-of-plane coercivity decreases with increasing Ba M thin-film thickness due to the combined effect of grain size growth and lattice strain relaxation.The 200 nm thick film exhibits optimum magnetic properties with M_(s)=319 emu/cm^(3) and H_(c)=1546 Oe.
基金funded by the National Natural Science Foundation of China,grant number U24A20135Inner Mongolia Natural Science Foundation major project,grant number 2023ZD12+7 种基金Inner Mongolia Autonomous Region key research and development and achievement transformation plan project,grant number 2023YFHH0090Natural Science Foundation of Inner Mongolia,grant number 2022MS05006Inner Mongolia Autonomous Region Talent Development FundUniversity basic research business expenses,grant number 2023RCTD012University basic research business expenses,grant number 2023QNJS075Postgraduate Research Innovation Program and of Inner Mongolia Autonomous Region,grant number KC2024053BUniversity basic research business expenses,grant number 2024YXXS012National Key Laboratory of Special Vehicle Design and Manufacturing Integration Technology,grant number GZ2023KF012.
文摘In dry-coupled ultrasonic thickness measurement,thick rubber layers introduce high-amplitude parasitic echoes that obscure defect signals and degrade thickness accuracy.Existing methods struggle to resolve overlap-ping echoes under variable coupling conditions and non-stationary noise.This study proposes a novel dual-criterion framework integrating energy contribution and statistical impulsivity metrics to isolate specimen re-flections from coupling-layer interference.By decomposing A-scan signals into Intrinsic Mode Functions(IMFs),the framework employs energy contribution thresholds(>85%)and kurtosis indices(>3)to autonomously select IMFs containing valid specimen echoes.Hybrid time-frequency thresholding further suppresses interference through amplitude filtering and spectral focusing.Experimental results demonstrate the framework’s robustness,achieving 92.3%thickness accuracy for 5 mm steel specimens with 5 mm rubber coupling,outperforming conventional methods by up to 18.7%.The dual-criterion approach reduces operator dependency by 37%and maintainsΔT<0.03 mm under surface roughness up to 6.3μm,offering a practical solution for industrial nondestructive testing with thick dry-coupled interfaces.
基金supported by the National Natural Science Foundation of China (Nos. 22375157 and W2433042)the Key Scientific and Technological Innovation Team of Shaanxi Province(No. 2020TD-001)+1 种基金the Fundamental Research Funds for Central Universities, State Key Laboratory of Electrical Insulation and Power Equipment (No. EIPE23409)the Instrument Analysis Center of Xi’an Jiaotong University for assistance。
文摘Lead-free hybrid double perovskites(LFHDPs) have received a lot of attention due to their environmental friendliness and promising attributes. However, studying the effect of film thickness on LFHDPs optoelectronic properties has not yet been investigated. Herein, we synthesized two new Ruddlesden–Popper LFHDPs, namely(C_(5)H_(12)N)_(4)AgBiI_(8)(CAB-1) and(C_(6)H_(14)N)_(4)Ag Bi I8(CAB-2) using cyclopentylamine and cyclohexylamine as monoamine ligands. Indeed, these two Ag(Ⅰ)-Bi(Ⅲ) LFHDPs form smooth and uniform films ranging in thickness from 250 nm to 1 μm, with preferred orientations. Notably, the studies on the optical properties showed that the direct band gap value decreased from 2.17 e V to 1.91 e V for CAB-1 and from 2.05 e V to 1.86 e V for CAB-2 with increasing thickness. Accordingly, photo-current response using a xenon lamp revealed a significant difference of over 1000 n A between light and dark conditions for1 μm-thickness films, suggesting potential for light harvesting. Other than that, thicker films of CAB-1and CAB-2 exhibit high stability for 90 days in a relatively humid environment(RH of 55%), paving the way for promising optoelectronic applications.
基金supported by the National Natural Science Foundation of China(grant no.52231004 and 52072305).
文摘Mg alloy matrix composites reinforced with short carbon fibers(C_(sf)/Mg)are considered as potential candidates for integrated structural-functional electronic parts that satisfy the requirements of lightweight,excellent mechanical properties,and heat dissipation.However,the different characteristics of C_(sf)and Mg alloy make the interface a critical issue affecting the synergistic improvement of thermal and mechanical properties of the composites.Here,Cu coating with different thicknesses is introduced to modify the C_(sf)/Mg interface,so as to simultaneously enhance the thermal and mechanical performances,which can combine the advantages of coating modification and matrix alloying.Results reveal that thermal diffusivity(TD)of 3-C_(sf)-Cu/Mg composites is as high as 22.12 mm^(2)/s and an enhancement of 52.97%is achieved compared with C_(sf)/Mg composites,as well as 16.3%enhancement of ultimate compressive strength(UCS)in the longitudinal direction,8.84%improvement of UCS in the transverse direction,and 53.08%increasement of ultimate tensile strength(UTS).Such improvement can be ascribed to the formation of intermetallic compounds.The formation of intermetallic compounds can not only effectively alleviate the lattice distortion of the matrix and decrease interfacial thermal resistance,but also bear the loads.Our work is of great significance for designing C_(sf)/Mg composites with integrated structure and function.
文摘Background:It is found to have association of facial parameters with trisomy 21 fetuses(T 21).We have compared prenasal thickness(PNT),nasal bone length(NBL),and the PNT:NBL ratio of normal fetuses with fetuses with trisomy 21(T 21)between 16 and 25 weeks of gestation as a diagnostic tool for T 21.Methods:Facial profile images in the two dimensional(2D)gray scale were assessed to measure fetal NBL and PNT between 16 and 25 weeks of gestation.The PNT:NBL ratio of the fetuses was calculated.Nomograms were constructed from the data of morphologically normal fetuses at live birth.The PNT,NBL,and PNT:NBL ratio of fetuses with confirmed T 21(n=31)and morphologically normal fetuses at live birth(controls,n=3485)were compared.Results:Nomograms for PNT,NBL,and the PNT:NBL ratio were constructed.In T 21 fetuses,PNT(>95th percentile),NBL(<5th percentile),and the PNT:NBL ratio(>95th percentile)showed a sensitivity of 25%,29%,and 45%for PNT,NBL,and PNT:NBL,respectively,and specificity of 95%,96%,and 94%,for PNT,NBL,and PNT:NBL,respectively.All of these markers showed a negative predictive value of 99%.Conclusion:PNT,NBL,and the PNT:NBL ratio have high diagnostic value for fetuses with Down syndrome and can be incorporated easily in the current second trimester screening protocol for T 21.PNT,NBL,and the PNT:NBL ratio are more specific markers for Down syndrome than those used in previous studies.
基金jointly funded by the guangxi Science and Technology Base and Talent Project(AD23026104)the Key Research and Development Program Project in Guangxi(AB23026121)。
文摘Due to the influence of karst cave development and route selection,the location relationship between concealed karst cave and tunnel is more random.In order to explore the influence rule of karst cave location on the minimum safe thickness of water-proof rock mass,a simplified calculation model of water-proof rock mass thickness when the karst cave is located at any location around the tunnel is established,and the influence of multiple factors on the overall stability of water-proof rock mass is considered.Based on the cusp catastrophe theory,the analytical expressions for the safety thickness of waterproof rock mass are derived.Based on the finite difference principle,the analytical expressions of the safety thickness of water-proof rock mass are verified.In order to improve the application range of the analytical formula derived in this paper,the analytical formula is optimized based on the instability principle differences between the simplified calculation model and the elastic compressive bar.The research results show that the necessary condition solution is more applicable and much safer than the sufficient condition solution.Tectonic stress,rock beam length and karst cave water pressure are significantly positively correlated with the safe thickness of the waterproof rock mass.The calculated results of the semioptimized formula and the unoptimized formula are constant values,independent of the karst cave location.While the calculated results of the fully optimized formula are variable values,correlated with the karst cave location,the thickness of the waterproof rock mass gradually decreases as the karst cave location moves from the top of the tunnel to the bottom of the tunnel.The unoptimized formula does not consider the influence of the lateral force of the rock beam,and is not suitable for the working condition with large lateral force,the calculation results of the semi-optimized formula and the fully optimized formula are not very different and are biased to safety,so it can be given priority.
基金funded by the National Key R&D Program of China(Grant No.2022YFC2905000)the NSFC(Grant No.42230813)+4 种基金the Opening Foundation of State Key Laboratory of Continental Dynamics,Northwest University(Grant No.23LCD12)the Opening Foundation of the Key Laboratory of Continental Dynamics of Ministry of Natural Resources(Grant No.J2408)the Sichuan Province Natural Science Foundation(Grant Nos.2024NSFSC1954,2025ZNSFSC1196)the Open Research Fund Program of Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring(Central South University),Ministry of Education(11300-502401003)the Everest Scientific Research Program of Chengdu University of Technology(Grant No.2024ZF11407).
文摘The key factor that controls the genesis of porphyry Cu deposits(PCDs)in collisional orogens remains a debated topic.This study employs whole-rock La/Yb proxies to quantitatively constrain the spatial and temporal variations in crustal thickness of the South Armenian-Iranian magmatic belt(SAIMB)within the Zagros orogen(central Tethys region)since the Eocene.Our results show that rapid crustal thickening occurred first in the NW section of the SAIMB at~35 Ma,then propagated southeastward into the central and SE sections at~25 Ma and 20 Ma,respectively,indicating that the Arabia-Eurasia collision was diachronous.The formation of the large and giant collision-related PCDs in the SAIMB might have been controlled by the collision process because they developed first in the NW section of the SAIMB and subsequently propagated southeastward into the central and SE sections.More importantly,crustal thickness mapping shows that the PCDs are preferentially developed in the thickened crust areas(>50 km).Our findings propose that thickened crust is critical for the formation of the PCDs in collisional orogens by promoting Fe^(2+)-rich minerals as a fractionating phase,driving magmatic auto-oxidation and releasing Cu into the magmas.The Cu is then partitioned into magmatic fluids,sustaining the porphyry systems.Furthermore,our research highlights that the thickened crust hosting PCDs was characterized by a previously thinner crust(<40 km),where magmas had low oxygen fugacity due to the absence of the auto-oxidation process.Consequently,chalcophile elements(e.g.,Cu)efficiently separated from the melt through sulfide segregation,forming large Cu-bearing lower-crustal cumulates.These cumulates can be mobilized with an increase in oxygen fugacity,incorporating into subsequent porphyry mineralization.We thus propose that the crustal thickness evolution over time controls the formation of the PCDs in collisional orogens.There are two essential stages in the collision-related PCDs formation:the first is high-flux magmatism in the thin crustal setting(<40 km),leading to metal-fertilized lower crust through sulfide segregation,and the second is the intracrustal auto-oxidation during crustal thickening(>50 km)which facilitates pre-enriched sulfides in the lower crust to re-dissolve,releasing Cu into the magmas.
基金financially supported by the National Natural Science Foundation of China(Nos.92160301,92060203,52175415 and 52205475)the Science Center for Gas Turbine Project(Nos.P2022-AB-Ⅳ-002-001 and P2023-B-Ⅳ-003-001)+3 种基金the Jiangsu Key Laboratory of Precision and Micro-Manufacturing Technology(No.JSKL2223K01)the Natural Science Foundation of Jiangsu Province(No.BK20210295)the Superior Postdoctoral Project of Jiangsu Province(No.2022ZB215)the Henan Science and Technology Public Relations Project(No.212102210445).
文摘The undeformed chip thickness and grinding force are key parameters for revealing the material removal mechanism in the grinding process.However,they are difficult to be well expressed due to the ununiformed protrusion height and random position distribution of abrasive grains on the abrasive wheel surface.This study investigated the distribution of undeformed chip thickness and grinding force considering the non-uniform characteristics of abrasive wheel in the grinding of K4002 nickel-based superalloy.First,a novel grinding force model was established through a kinematic-geometric analysis and a grain-workpiece contact analysis.Then,a series of grinding experiments were conducted for verifying the model.The results indicate that the distribution of undeformed chip thickness is highly consistent with the Gaussian distribution formula.The increase in the grinding depth mainly leads to an increase in the average value of Gaussian distribution.On the contrary,the increase in the workpiece infeed speed or the decrease in the grinding speed mainly increases the standard deviation of Gaussian distribution.The average and maximum errors of the grinding force model are 4.9%and 14.6%respectively,indicating that the model is of high predication accuracy.
基金supported by the National Natural Science Foundation of China(No.52074130)Engineering Research Center of Resource Utilization of Carbon-containing Waste with Carbon Neutrality,Ministry of Education,200237 Shanghai,PR China.
文摘To advance the understanding of the corrosion behavior of stainless steel bellows in marine atmospheric environments and enhance the precision of service life predictions,this study employs finite element simulations to investigate the pitting corrosion rates and pit morphologies of bellows peaks and troughs under varying electrolyte film thicknesses.The model incorporates localized electrochemical reactions,oxygen concentration,and homogeneous solution reactions.For improved computational accuracy,the fitted polarization curve data were directly applied as nonlinear boundary conditions on the electrode surface via interpolation functions.Simulation results reveal that the peak regions exhibit faster corrosion rates than the trough regions.With increasing electrolyte film thickness(from 10μm to 500μm),corrosion rates at both peaks and troughs decrease progressively,and after 120 hours of simulation,the maximum corrosion rate at the peaks declines from 0.720 mm/a to 0.130 mm/a,and at the troughs from 0.520 mm/a to 0.120 mm/a,with the disparity in corrosion rates diminishing over time.Furthermore,as corrosion progresses,pits propagate deeper into the substrate,exhibiting both vertical penetration and lateral expansion along the passive film interface,ultimately breaching the substrate.This research offers valuable insights into designing corrosion mitigation strategies for stainless steel bellows in marine environments.
文摘Appreciation of soft-tissue thickness(STT)at surgical sites is an increasingly recognized aspect of arthroplasty procedures as it may potentially impacting postoperative outcomes.Recent research has focused on the predictive value of preoperative STT measurements for complications following various forms of arthroplasty,particularly infections,across procedures such as total knee,hip,shoulder,and ankle replacements.Several studies have indicated that increased STT is associated with a higher risk of complications,including infection and wound healing issues.The assessment of STT before surgery could play a crucial role in identifying patients at a higher risk of complications and may be instru-mental in guiding preoperative planning to optimize outcomes in arthroplasty procedures.Standardized measurement techniques and further research are essential to enhance the reliability and clinical utility of STT assessment for arthro-plasty surgery.
基金supported by grants from National Natural Science Foundation of China(81720108012,82001118)Ministry of Science and Technology of China(2021ZD0202003)+1 种基金Shanghai‘Rising Stars of Medical Talents’Youth Development Program(SHWSRS(2023)-62)Henry K.Beecher Professorship from Harvard University。
文摘Background Postoperative delirium is one of the most common complications in the older surgical population,but its pathogenesis and biomarkers are largely undetermined.Retinal layer thickness has been demonstrated to be associated with cognitive function in mild cognitive impairment and patients with Alzheimer’s disease.However,relatively little is known about possible retinal layer thickness among patients with postoperative delirium.Aims We aimed to investigate the relationship between retinal layer thickness and postoperative delirium in this cross-sectional study.Methods The participants(≥65 years old)having elective surgery under general anaesthesia were screened via medical records from Shanghai 10th People’s Hospital.Preoperative macular thickness and peripapillary retinal nerve fibre layer(RNFL)thickness were measured using optical coherence tomography(OCT).The Confusion Assessment Method(CAM)algorithm and CAM-Severity(CAM-S)were used to assess the incidence and severity of postoperative delirium on the first,second and third days after surgery.Results Among 169 participants(mean(standard deviation(SD)71.15(4.36)years),40(24%)developed postoperative delirium.Notably,individuals who developed postoperative delirium exhibited thicker preoperative macular thickness in the right eye compared with those who did not(mean(SD)283.35(27.97)µm vs 273.84(20.14)µm,p=0.013).Furthermore,the thicker preoperative macular thickness of the right eye was associated with a higher incidence of postoperative delirium(adjusted odds ratio 1.593,95%confidence interval(CI)1.093 to 2.322,p=0.015)and greater severity(adjusted mean difference(β)=0.256,95%CI 0.037 to 0.476,p=0.022)after adjustment for age,sex and Mini-Mental State Examination(MMSE)scores.However,such a difference or association did not appear in the left macular or bilateral peripapillary RNFL thicknesses.Conclusions Current findings demonstrated that preoperative macular thickness might serve as a potential non-invasive marker for the vulnerability of developing postoperative delirium in older surgical patients.Further large-scale validation studies should be performed to confirm these results.
文摘BACKGROUND Despite growing evidence on endoscopic full thickness resection(EFTR),data on segment-specific outcomes in real-world patients remain limited.AIM To investigate segment-specific outcomes of EFTR using a full-thickness resection device(FTRD)for neoplastic colorectal lesions.METHODS In this multicenter,retrospective study,EFTR was conducted in unselected realworld patients referred to participating German centers after colonoscopy confirmed EFTR eligibility.The primary outcome was histologically complete resection(R0)of the lesion,including segment-specific outcomes and adverse events(AE).Additional efficacy and safety parameters were investigated by colonic topography for up to 30 days.RESULTS The analysis included 102 patients(64 males,38 females)with a median age of 70 years.EFTR via FTRD was technically successful in all patients.The R0 rate was 81.4%,segment-specifically ranging from 85.0%(rectum),84.6%(descending colon),84.0%(ascending colon),83.3%(cecum),and 76.5%(sigmoid colon)to 73.3%(transverse colon).Examination time was longer in proximal parts compared to the rectosigmoid(non-significant).Overall,33 patients(32.4%)experienced AE,including only one major complication(0.98%;perforation of sigmoid colon).Abdominal postsurgical pain(18.6%),hematochezia(9.8%),and hemoglobin decline(7.8%)were the most frequent minor complications.Transverse colon lesions had the numerically highest rate of AE,with 8 of 15 patients(53.3%)affected.CONCLUSION EFTR is efficacious for neoplastic colorectal lesions,though R0 rates vary by location.This may impact patient education,selection of the operator,and consideration of laparoscopy surgery.
基金supported by the National Natural Science Foundation of China(32171765)。
文摘While the fire protection function of tree bark has been extensively documented,other critical functions,including storage and mechanical support,have received less attention.In this study we examined:(1)the allometry of bark thickness(and biomass)against wood radius(and biomass)at a disc level,(2)differences in bark allocation between the ratio and the regression approaches,(3)differences between bark thickness and biomass as metrics of bark allocation,and(4)how bark allocation is associated with the evolution of wood from non-porous to diffuse-porous and ring-porous types.Thickness and biomass of bark and wood were measured using trunk discs of 88 individual trees of 36 species in a temperate forest characterized by a long fire interval.Allometric relationships of bark thickness(and biomass)against wood radius(and biomass)explained why both relative bark thickness and biomass decreased with increasing stem diameter.Variations in both among species varied by factors of 3.5 to 7.5 depending on the measurement methods.The ratio approach produced higher estimates of both relative bark thickness and biomass compared to the regression approach,while relative bark thickness was significantly lower than relative bark biomass.Ring-porous species exhibited higher bark thickness based on the ratio approach,which might reflect evolutionary adaptations where ring-porous species have developed thicker bark as protection:thermal insulation against freeze-thaw embolism coupled with carbohydrate reservoirs for hydraulic repair.The regression slope of bark allocation against wood density increased along the wood porosity gradient,demonstrating evolutionary biomechanical coordination between bark and wood.These findings highlight systematic coupling between bark and xylem multifunctionality.
基金supported by the China Postdoctoral Science Foundation[Grant Number BX20240146 and 2024M761230]Key Project of Research and Development Plan in Jiangxi Province[Grant Number 20243BCC31001].
文摘Background Backfat thickness(BFT)is a vital economic trait in pigs,reflecting subcutaneous fat levels that affect meat quality and production efficiency.As a complex trait shaped by multiple genetic factors,BFT has been studied using genome-wide association studies(GWAS)and linkage analyses to locate fat-related quantitative trait loci(QTLs),but pinpointing causal variants and genes is hindered by linkage disequilibrium and limited regulatory data.This study aimed to dissect the QTLs affecting BFT on Sus scrofa chromosome 1(SSC1),elucidating regulatory variants,effector genes,and the cell types involved.Results Using whole-genome genotyping data from 3,578 pigs and phenotypic data for five BFT traits,we identified a 630.6 kb QTL on SSC1 significantly associated with these traits via GWAS and fine-mapping,pinpointing 34 candidate causal variants.Using deep convolutional neural networks to predict regulatory activity from sequence data integrated with detailed pig epigenetic profiles,we identified five SNPs potentially affecting enhancer activity in specific tissues.Notably,rs342950505(SSC1:161,123,588)influences weak enhancer activity across multiple tissues,including the brain.High-throughput chromosome conformation capture(Hi-C)analysis identified that rs342950505 interacts with eight genes.Chromatin state annotations confirmed enhancer activity at this QTL in the cerebellum.Leveraging these insights,single-cell ATAC-seq revealed a chromatin accessibility peak encompassing rs342950505 that regulates PMAIP1 expression in inhibitory neurons via enhancer-mediated mechanisms,with an adjacent peak modulating CCBE1 expression in neuroblasts and granule cells.Transcriptome-wide association studies(TWAS)confirmed PMAIP1's role in the hypothalamus,and Mendelian randomization(MR)validated PMAIP1 and CCBE1 as key brain expression quantitative trait locus(eQTL)effectors.We propose that the variant rs342950505,located within a regulatory peak,modulates PMAIP1 expression in inhibitory neurons,potentially influencing energy homeostasis via hypothalamic regulation.Similarly,CCBE1 may contribute to this process.Conclusions Our results,through systematic dissection of pleiotropic BFT-associated loci,provide a framework to elucidate regulatory mechanisms of complex traits,offering insights into polygenic control through lipid metabolism and neural signaling pathways.
基金supported by the U.S.Department of Veterans Affairs through the Translational Research Center for TBI and Stress Disorders(TRACTS B3001-C),a VA Rehabilitation Research and Development Traumatic Brain Injury National Network Research Center,and the Boston University Chobanian&Avedisian School of Medicine’s Medical Student Summer Research Program,with funding from the Gabriel Family Foundation CTE Research Fund(MA).
文摘Background:Poor sleep quality has been associated with changes in brain volume among veterans,particularly those who have experienced mild traumatic brain injury(mTBI)and post-traumatic stress disorder(PTSD).This study sought to investigate:1)whether poor sleep quality is associated with decreased cortical thickness in Iraq and Afghanistan war veterans,and 2)whether these associations differ topographically depending on the presence or absence of mTBI and PTSD.Methods:A sample of 440 post-9/11 era U.S.veterans enrolled in the Translational Research Center for Traumatic Brain Injury and Stress Disorders study at VA Boston,MA from 2010 to 2022 was included in the study.We examined the relationship between sleep quality,as measured by the Pittsburgh Sleep Quality Index(PSQI),and cortical thickness in veterans with mTBI(n=57),PTSD(n=110),comorbid mTBI and PTSD(n=129),and neither PTSD nor mTBI(n=144).To determine the topographical relationship between subjective sleep quality and cortical thickness in each diagnostic group,we employed a General Linear Model(GLM)at each vertex on the cortical mantle.The extent of topographical overlap between the resulting statistical maps was assessed using Dice coefficients.Results:There were no significant associations between PSQI and cortical thickness in the group without PTSD or mTBI(n=144)or in the PTSD-only group(n=110).In the mTBI-only group(n=57),lower sleep quality was significantly associated with reduced thickness bilaterally in frontal,cingulate,and precuneus regions,as well as in the right parietal and temporal regions(β=-0.0137,P<0.0005).In the comorbid mTBI and PTSD group(n=129),significant associations were observed bilaterally in frontal,precentral,and precuneus regions,in the left cingulate and the right parietal regions(β=-0.0094,P<0.0005).Interaction analysis revealed that there was a stronger relationship between poor sleep quality and decreased cortical thickness in individuals with mTBI(n=186)compared with those without mTBI(n=254)specifically in the frontal and cingulate regions(β=-0.0077,P<0.0005).Conclusions:This study demonstrates a significant relationship between poor sleep quality and lower cortical thickness primarily within frontal regions among individuals with both isolated mTBI or comorbid diagnoses of mTBI and PTSD.Thus,if directionality is established in longitudinal and interventional studies,it may be crucial to consider addressing sleep in the treatment of veterans who have sustained mTBI.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.92155305 and 42103066)the National Key Research and Development Plan(Grant No.2023YFC2908400 and 2024YFC2910102)the Fundamental Research Funds for the Central Universities(Grant No.FRF-TP-24-046A).
文摘The Qinghai-Tibet Plateau possesses the thickest continental crust on Earth,yet the timing of its formation remains debated.In this study,we conducted zircon U-Pb isotopic dating,geochemical and Sr-Nd-Pb-Hf isotopic analyses on the Xuexiumaer biotite quartz monzonite porphyry(BQMP)sampled from the Lake Dajia area in southern Gangdese.This study aims to estimate the paleo-crustal thickness beneath this region during the early India-Asia collision stage using whole-rock Sr/Y and(La/Yb)N ratios as proxies.Results reveal that the Xuexiumaer BQMP was formed at~51 Ma in a collisional tectonic setting following Neo-Tethyan slab breakoff,and is an I-type granitoid derived primarily from partial melting of juvenile mafic lower crust with subordinate ancient crustal input.The estimated paleo-crustal thickness in the Lake Dajia area at~51 Ma is less than 40 km.This indicates that although the Qinghai-Tibet Plateau had already undergone significant crustal thickening and attained an exceptionally thick crust(>50 km)prior to the India-Asia collision as demonstrated by previous studies,some regions still maintained a crust only slightly thicker than the average continental crust(~35 km)at the initial collision stage.This limited crustal thickening likely resulted from underplating of subduction-related mafic magma at the mantle-crust boundary.
基金supported by National Natural Science Foundation of China(Grant Nos.52101273 and U22A20118)Natural Science Foundation of Fujian Province of China(Grant No.2022J01042)Fundamental Research Funds for Central Universities of China(Grant No.20720242002).
文摘The energy density of thin-film lithium batteries(TFLBs)is predominantly determined by the average voltage and specific capacity,however,the mechanism of regulating the voltage plateaus of the film electrodes is not well understood.In this study,three boride films(Co–B,Fe–B,and Co–Fe–B alloys)with different thick-nesses were fabricated to enhance the specific capacity and voltage stability of TFLBs.By analyzing the cycling performance,redox peak evolution,and capacitive contribution,the thickness-dependent lithiation behavior of the thin/thick films was elucidated.Theoretical simulations and electrochemical analysis were conducted to investigate how the lithiation behaviors affected the voltage profiles of the film electrodes.In addition,the various-thickness CoB films were compared in all-solid-state TFLBs,demonstrating the universality and practicability of this simple regulation strategy to develop high-performance energy storage devices.
