Radiopharmaceuticals involve the local delivery of radionuclides to targeted lesions for the diagnosis and treatment of multiple diseases.Radiopharmaceutical therapy,which directly causes systematic and irreparable da...Radiopharmaceuticals involve the local delivery of radionuclides to targeted lesions for the diagnosis and treatment of multiple diseases.Radiopharmaceutical therapy,which directly causes systematic and irreparable damage to targeted cells,has attracted increasing attention in the treatment of refractory diseases that are not sensitive to current therapies.As the Food and Drug Administration(FDA)approvals of[177Lu]Lu-DOTA-TATE,[177Lu]Lu-PSMA-617 and their complementary diagnostic agents,namely,[68Ga]Ga-DOTA-TATE and[68Ga]Ga-PSMA-11,targeted radiopharmaceutical-based theranostics(radiotheranostics)are being increasingly implemented in clinical practice in oncology,which lead to a new era of radiopharmaceuticals.The new generation of radiopharmaceuticals utilizes a targeting vector to achieve the accurate delivery of radionuclides to lesions and avoid off-target deposition,making it possible to improve the efficiency and biosafety of tumour diagnosis and therapy.Numerous studies have focused on developing novel radiopharmaceuticals targeting a broader range of disease targets,demonstrating remarkable in vivo performance.These include high tumor uptake,prolonged retention time,and favorable pharmacokinetic properties that align with clinical standards.While radiotheranostics have been widely applied in tumor diagnosis and therapy,their applications are now expanding to neurodegenerative diseases,cardiovascular diseases,and inflammation.Furthermore,radiotheranostic-empowered precision medicine is revolutionizing the cancer treatment paradigm.Diagnostic radiopharmaceuticals play a pivotal role in patient stratification and treatment planning,leading to improved therapeutic outcomes in targeted radionuclide therapy.This review offers a comprehensive overview of the evolution of radiopharmaceuticals,including both FDA-approved and clinically investigated agents,and explores the mechanisms of cell death induced by radiopharmaceuticals.It emphasizes the significance and future prospects of theranostic-based radiopharmaceuticals in advancing precision medicine.展开更多
To the Editor:Anterior cruciate ligament(ACL)rupture is a frequent knee injury that modifies knee joint kinematics,including intra-articular motions and forces,leading to recurrent functional instability of the knee.W...To the Editor:Anterior cruciate ligament(ACL)rupture is a frequent knee injury that modifies knee joint kinematics,including intra-articular motions and forces,leading to recurrent functional instability of the knee.With an estimated 200,000 ACL ruptures annually in the United States,ACL ruptures are prevalent,especially in young,physically active individuals.[1]Restoring knee morphology,stability,and function is the aim of conventional therapy,which is ACL reconstruction(ACLR).[2]Previous studies have evaluated gait function at different time points before and after ACLR to quantify impairments in movement patterns and knee joint biomechanics.[3]These investigations have consistently revealed substantial alterations in gait patterns induced by ACLR,with recovery persisting for at least 6 months post-procedure.[4]Majewska et al[4]pointed out that most studies focus on short-term follow-up within 6 months after surgery,while time-dependent changes in long-term dynamic functional recovery remain poorly studied.Accordingly,we aimed to perform gait analysis both pre-ACLR and throughout the 12 months postoperatively,complemented by standard assessments of knee joint function.展开更多
基金supported by the National Natural Science Foundation of China(No.82372002)the Nonprofit Central Research Institute Fund of the Chinese Academy of Medical Sciences(No.2022-RC350-04)+5 种基金the CAMS Innovation Fund for Medical Sciences(Nos.2023-I2M-2-006,2023-I2M-QJ-010,02149942,2021-I2M-1-026,2022-I2M-2-002-2,and 2021-I2M-3-001)the National Key Research and Development Programme of China(No.2022YFE0111700)the Beijing Nova Programme to K.H..This work was also supported by the Beijing Natural Science Foundation(Nos.L234044 and L248087)the Fundamental Research Funds for the Central Universities(Nos.3332023044 and 3332023151)the CIRP Open Fund of Radiation Protection Laboratories(No.ZHYLYB2021005)the China National Nuclear Corporation Young Talent Programme.
文摘Radiopharmaceuticals involve the local delivery of radionuclides to targeted lesions for the diagnosis and treatment of multiple diseases.Radiopharmaceutical therapy,which directly causes systematic and irreparable damage to targeted cells,has attracted increasing attention in the treatment of refractory diseases that are not sensitive to current therapies.As the Food and Drug Administration(FDA)approvals of[177Lu]Lu-DOTA-TATE,[177Lu]Lu-PSMA-617 and their complementary diagnostic agents,namely,[68Ga]Ga-DOTA-TATE and[68Ga]Ga-PSMA-11,targeted radiopharmaceutical-based theranostics(radiotheranostics)are being increasingly implemented in clinical practice in oncology,which lead to a new era of radiopharmaceuticals.The new generation of radiopharmaceuticals utilizes a targeting vector to achieve the accurate delivery of radionuclides to lesions and avoid off-target deposition,making it possible to improve the efficiency and biosafety of tumour diagnosis and therapy.Numerous studies have focused on developing novel radiopharmaceuticals targeting a broader range of disease targets,demonstrating remarkable in vivo performance.These include high tumor uptake,prolonged retention time,and favorable pharmacokinetic properties that align with clinical standards.While radiotheranostics have been widely applied in tumor diagnosis and therapy,their applications are now expanding to neurodegenerative diseases,cardiovascular diseases,and inflammation.Furthermore,radiotheranostic-empowered precision medicine is revolutionizing the cancer treatment paradigm.Diagnostic radiopharmaceuticals play a pivotal role in patient stratification and treatment planning,leading to improved therapeutic outcomes in targeted radionuclide therapy.This review offers a comprehensive overview of the evolution of radiopharmaceuticals,including both FDA-approved and clinically investigated agents,and explores the mechanisms of cell death induced by radiopharmaceuticals.It emphasizes the significance and future prospects of theranostic-based radiopharmaceuticals in advancing precision medicine.
基金supported by the National Key Research and Development Program of China(Grant No.2024YFC2510400)Key Research and development projects of Shanxi province(202202150401019)the Central Government Guides Local Science and Technology Development Funds(Grant No.YDZJSX2022B011).
文摘To the Editor:Anterior cruciate ligament(ACL)rupture is a frequent knee injury that modifies knee joint kinematics,including intra-articular motions and forces,leading to recurrent functional instability of the knee.With an estimated 200,000 ACL ruptures annually in the United States,ACL ruptures are prevalent,especially in young,physically active individuals.[1]Restoring knee morphology,stability,and function is the aim of conventional therapy,which is ACL reconstruction(ACLR).[2]Previous studies have evaluated gait function at different time points before and after ACLR to quantify impairments in movement patterns and knee joint biomechanics.[3]These investigations have consistently revealed substantial alterations in gait patterns induced by ACLR,with recovery persisting for at least 6 months post-procedure.[4]Majewska et al[4]pointed out that most studies focus on short-term follow-up within 6 months after surgery,while time-dependent changes in long-term dynamic functional recovery remain poorly studied.Accordingly,we aimed to perform gait analysis both pre-ACLR and throughout the 12 months postoperatively,complemented by standard assessments of knee joint function.
