DNA G-quadruplex(G4)structures formed in the telomeric and promoter regions represent attractive drug targets for anticancer therapy.Thus,much effort has been devoted to the development of a variety of G4-binding liga...DNA G-quadruplex(G4)structures formed in the telomeric and promoter regions represent attractive drug targets for anticancer therapy.Thus,much effort has been devoted to the development of a variety of G4-binding ligands,mostly based on rigid planar structures.Here,we investigated the efficacy of inherently flexible anticancer substitution-inert polynuclear platinum(Ⅱ)complexes(SI-PPCs)to stabilize DNA G4s and terminate DNA polymerization on templates containing G4-forming sequences.展开更多
基金supported by the Czech Science Foundation(Grant 20-14082J).
文摘DNA G-quadruplex(G4)structures formed in the telomeric and promoter regions represent attractive drug targets for anticancer therapy.Thus,much effort has been devoted to the development of a variety of G4-binding ligands,mostly based on rigid planar structures.Here,we investigated the efficacy of inherently flexible anticancer substitution-inert polynuclear platinum(Ⅱ)complexes(SI-PPCs)to stabilize DNA G4s and terminate DNA polymerization on templates containing G4-forming sequences.
