The development of water-soluble hexanuclear cluster complexes of low toxicity is a promising task due to their potential biomedical applications such as bioimaging and photodynamic therapy.Herein,we present the synth...The development of water-soluble hexanuclear cluster complexes of low toxicity is a promising task due to their potential biomedical applications such as bioimaging and photodynamic therapy.Herein,we present the syntheses of two new water-soluble hexarhenium cluster complexes with terminal amphiphilic phosphine ligands,and delineate their photoluminescence and X-ray excited optical luminescence(XEOL)properties.These cluster complexes,namely[{Re_(6)Q_(8)}(PPh_(2)CH_(2)CH_(2)COO)_(6)]^(4−)(Q=S(1);Se,(2)),have the least cytotoxicity among all the tested hexanuclear metal-clusters,are capable of penetrating into cells and exhibit moderate photodynamic toxicity toward Hep-2 cells.展开更多
基金supported by the Russian Science Foundation[grant no.15-15-10006]the Czech Science Foundation[grant no.18-05076S]the Ministry of science and higher education of RF[no.0333-2017-0002].
文摘The development of water-soluble hexanuclear cluster complexes of low toxicity is a promising task due to their potential biomedical applications such as bioimaging and photodynamic therapy.Herein,we present the syntheses of two new water-soluble hexarhenium cluster complexes with terminal amphiphilic phosphine ligands,and delineate their photoluminescence and X-ray excited optical luminescence(XEOL)properties.These cluster complexes,namely[{Re_(6)Q_(8)}(PPh_(2)CH_(2)CH_(2)COO)_(6)]^(4−)(Q=S(1);Se,(2)),have the least cytotoxicity among all the tested hexanuclear metal-clusters,are capable of penetrating into cells and exhibit moderate photodynamic toxicity toward Hep-2 cells.
