Construction of theme park has been launched since the early 1990s in Chengdu City,but ended up as a losing proposition after its short-term prosperity because of similar scale and similarity with those in other citie...Construction of theme park has been launched since the early 1990s in Chengdu City,but ended up as a losing proposition after its short-term prosperity because of similar scale and similarity with those in other cities.As more international well-known theme parks entering the market,theme parks in Chengdu have been faced with the transition,and novel concepts are also introduced into the operation of these parks.To adapt to the market,it is imperative to make marketing strategies and combine marketing elements.Through analyzing current development of local theme parks and introducing successful marketing modes of domestic and overseas theme parks,a favorable marketing mode for theme parks in Chengdu was defined on the basis of fully exploring Ba-Shu culture(Ba and Shu are two ancient kingdoms in the history of Sichuan).By defining a favorable theme,focusing more on visitors'experience,devoting more in developing new products,adopting flexible price strategies,and integrating advertisement marketing,internet marketing,and other marketing methods,outstanding brands will be formed,and tourism cultures with distinguished features of Chengdu will be created.展开更多
Neural stem cells,which are capable of multi-potential differentiation and self-renewal,have recently been shown to have clinical potential for repairing central nervous system tissue damage.However,the theme trends a...Neural stem cells,which are capable of multi-potential differentiation and self-renewal,have recently been shown to have clinical potential for repairing central nervous system tissue damage.However,the theme trends and knowledge structures for human neural stem cells have not yet been studied bibliometrically.In this study,we retrieved 2742 articles from the PubMed database from 2013 to 2018 using "Neural Stem Cells" as the retrieval word.Co-word analysis was conducted to statistically quantify the characteristics and popular themes of human neural stem cell-related studies.Bibliographic data matrices were generated with the Bibliographic Item Co-Occurrence Matrix Builder.We identified 78 high-frequency Medical Subject Heading(MeSH)terms.A visual matrix was built with the repeated bisection method in gCLUTO software.A social network analysis network was generated with Ucinet 6.0 software and GraphPad Prism 5 software.The analyses demonstrated that in the 6-year period,hot topics were clustered into five categories.As suggested by the constructed strategic diagram,studies related to cytology and physiology were well-developed,whereas those related to neural stem cell applications,tissue engineering,metabolism and cell signaling,and neural stem cell pathology and virology remained immature.Neural stem cell therapy for stroke and Parkinson’s disease,the genetics of microRNAs and brain neoplasms,as well as neuroprotective agents,Zika virus,Notch receptor,neural crest and embryonic stem cells were identified as emerging hot spots.These undeveloped themes and popular topics are potential points of focus for new studies on human neural stem cells.展开更多
文摘Construction of theme park has been launched since the early 1990s in Chengdu City,but ended up as a losing proposition after its short-term prosperity because of similar scale and similarity with those in other cities.As more international well-known theme parks entering the market,theme parks in Chengdu have been faced with the transition,and novel concepts are also introduced into the operation of these parks.To adapt to the market,it is imperative to make marketing strategies and combine marketing elements.Through analyzing current development of local theme parks and introducing successful marketing modes of domestic and overseas theme parks,a favorable marketing mode for theme parks in Chengdu was defined on the basis of fully exploring Ba-Shu culture(Ba and Shu are two ancient kingdoms in the history of Sichuan).By defining a favorable theme,focusing more on visitors'experience,devoting more in developing new products,adopting flexible price strategies,and integrating advertisement marketing,internet marketing,and other marketing methods,outstanding brands will be formed,and tourism cultures with distinguished features of Chengdu will be created.
基金supported by the National Natural Science Foundation of China,No.81471308(to JL)the Stem Cell Clinical Research Project in China,No.CMR-20161129-1003(to JL)the Innovation Technology Funding of Dalian in China,No.2018J11CY025(to JL)
文摘Neural stem cells,which are capable of multi-potential differentiation and self-renewal,have recently been shown to have clinical potential for repairing central nervous system tissue damage.However,the theme trends and knowledge structures for human neural stem cells have not yet been studied bibliometrically.In this study,we retrieved 2742 articles from the PubMed database from 2013 to 2018 using "Neural Stem Cells" as the retrieval word.Co-word analysis was conducted to statistically quantify the characteristics and popular themes of human neural stem cell-related studies.Bibliographic data matrices were generated with the Bibliographic Item Co-Occurrence Matrix Builder.We identified 78 high-frequency Medical Subject Heading(MeSH)terms.A visual matrix was built with the repeated bisection method in gCLUTO software.A social network analysis network was generated with Ucinet 6.0 software and GraphPad Prism 5 software.The analyses demonstrated that in the 6-year period,hot topics were clustered into five categories.As suggested by the constructed strategic diagram,studies related to cytology and physiology were well-developed,whereas those related to neural stem cell applications,tissue engineering,metabolism and cell signaling,and neural stem cell pathology and virology remained immature.Neural stem cell therapy for stroke and Parkinson’s disease,the genetics of microRNAs and brain neoplasms,as well as neuroprotective agents,Zika virus,Notch receptor,neural crest and embryonic stem cells were identified as emerging hot spots.These undeveloped themes and popular topics are potential points of focus for new studies on human neural stem cells.
