Parkinson＇s disease （PD） is a progressive neurodegenerative disease, which is generally considered a multifactorial disorder that arises owing to a combination of genes and environmental factors. While most cases a...Parkinson＇s disease （PD） is a progressive neurodegenerative disease, which is generally considered a multifactorial disorder that arises owing to a combination of genes and environmental factors. While most cases are idiopathic, in about 10% of the patients a genetic cause can be detected, ascribable to mutations in more than a dozen genes. PD is characterized clinically by tremor, rigidity, reduced mo- tor activity （bradykinesia）, and postural instability and pathological- ly by loss of dopaminergic （DA） neurons in the substantia nigra pars compacta, loss of DA innervation in the striatum, and the presence of a-synuclein positive aggregates in the form of Lewy bodies. The symptomatic treatment of PD with levodopa, which aims at replac- ing dopamine, remains the gold standard, and no neuroprotective or disease-modifying therapy is available. During treatment, the disease continues to progress, and long-term use of levodopa has import- ant limitations including motor complications termed dyskinesias. Therefore, a pharmacological therapy able to prevent or halt the neu- rodegenerative process is urgently required.展开更多
A more feasibly convergent synthesis of selective estrogen receptor degrading agent(S)-8-(4-((1-(3-fluoropropyl)-pyrrolidin-3-yl)oxy)phenyl)-7-(4-hydroxyphenyl)-5,6-dihydronaphthalen-2-ol was reported,featured with co...A more feasibly convergent synthesis of selective estrogen receptor degrading agent(S)-8-(4-((1-(3-fluoropropyl)-pyrrolidin-3-yl)oxy)phenyl)-7-(4-hydroxyphenyl)-5,6-dihydronaphthalen-2-ol was reported,featured with concise work up and absence of regioselectivity dilemma.展开更多
The microkinetics of H_2S removal by ZnO desulfurization in H_2O-CO_2-N_2,H_2O-CO-N_2 and H_2O-O_2-N_2 gas mixtures was studied by thermogravimetric analysis. Experimentswere carried out with 100-120 mesh ZnO powder a...The microkinetics of H_2S removal by ZnO desulfurization in H_2O-CO_2-N_2,H_2O-CO-N_2 and H_2O-O_2-N_2 gas mixtures was studied by thermogravimetric analysis. Experimentswere carried out with 100-120 mesh ZnO powder at temperatures from 473 K to 563 K. The results showthat the kinetic behaviors of desulfurization could all be described by an improved shrinking-coremodel. The activation energies of the reaction and the diffusion in different gas atmosphere's wereestimated.展开更多
After trace Sm^3＋ ions and Gd^3＋ ions doping, the emission intensity of red phosphors Y2O2S： Eu^3 ＋ was enhanced and the voltage character （relation between emission intensity and excitation voltage） was improve...After trace Sm^3＋ ions and Gd^3＋ ions doping, the emission intensity of red phosphors Y2O2S： Eu^3 ＋ was enhanced and the voltage character （relation between emission intensity and excitation voltage） was improved while the other properties of physics and chemistry were not changed. The origins of enhancement and improvement are discussed. Probably the distortion and the defect of crystals are decreased by the substitution of Gd^3＋ for Y^3＋ instead of Eu^3＋ for Y^3＋ , and thus the Eu^3＋ crystal field is improved, and radiationless process and energy loss resulted from crystal defect are weakened, which leads to increased luminescence intensity and voltage character improvement. The overlapping fluorescent spectra of Y2O2S： Sm^3＋ emission and Y2O2S：Eu^3＋ excitation as well as Eu^3 ＋ excitation spectra transitions spectra lead to energy transfer from Sm^3 ＋ sensitization of Sm^3＋ ions fectively. containing Sm^3＋ excitation the possibility of resonance ions to Eu^3＋ ions, and the to Eu^3＋ ions is achieved effectively.展开更多
As one of the participants in the Subseasonal to Seasonal(S2S)Prediction Project,the China Meteorological Administration(CMA)has adopted several model versions to participate in the S2S Project.This study evaluates th...As one of the participants in the Subseasonal to Seasonal(S2S)Prediction Project,the China Meteorological Administration(CMA)has adopted several model versions to participate in the S2S Project.This study evaluates the models’capability to simulate and predict the Madden-Julian Oscillation(MJO).Three versions of the Beijing Climate Center Climate System Model(BCC-CSM)are used to conduct historical simulations and re-forecast experiments(referred to as EXP1,EXP1-M,and EXP2,respectively).In simulating MJO characteristics,the newly-developed high-resolution BCC-CSM outperforms its predecessors.In terms of MJO prediction,the useful prediction skill of the MJO index is enhanced from 15 days in EXP1 to 22 days in EXP1-M,and further to 24 days in EXP2.Within the first forecast week,the better initial condition in EXP2 largely contributes to the enhancement of MJO prediction skill.However,during forecast weeks 2–3,EXP2 shows little advantage compared with EXP1-M because the increased skill at MJO initial phases 6–7 is largely offset by the degraded skill at MJO initial phases 2–3.Particularly at initial phases 2–3,EXP1-M skillfully captures the wind field and Kelvin-wave response to MJO convection,leading to the highest prediction skill of the MJO.Our results reveal that,during the participation of the CMA models in the S2S Project,both the improved model initialization and updated model physics played positive roles in improving MJO prediction.Future efforts should focus on improving the model physics to better simulate MJO convection over the Maritime Continent and further improve MJO prediction at long lead times.展开更多
基金supported by the Ministry of Health and Department of Educational Assistance,University and Research of the Autonomous Province of Bolzano
文摘Parkinson＇s disease （PD） is a progressive neurodegenerative disease, which is generally considered a multifactorial disorder that arises owing to a combination of genes and environmental factors. While most cases are idiopathic, in about 10% of the patients a genetic cause can be detected, ascribable to mutations in more than a dozen genes. PD is characterized clinically by tremor, rigidity, reduced mo- tor activity （bradykinesia）, and postural instability and pathological- ly by loss of dopaminergic （DA） neurons in the substantia nigra pars compacta, loss of DA innervation in the striatum, and the presence of a-synuclein positive aggregates in the form of Lewy bodies. The symptomatic treatment of PD with levodopa, which aims at replac- ing dopamine, remains the gold standard, and no neuroprotective or disease-modifying therapy is available. During treatment, the disease continues to progress, and long-term use of levodopa has import- ant limitations including motor complications termed dyskinesias. Therefore, a pharmacological therapy able to prevent or halt the neu- rodegenerative process is urgently required.
文摘A more feasibly convergent synthesis of selective estrogen receptor degrading agent(S)-8-(4-((1-(3-fluoropropyl)-pyrrolidin-3-yl)oxy)phenyl)-7-(4-hydroxyphenyl)-5,6-dihydronaphthalen-2-ol was reported,featured with concise work up and absence of regioselectivity dilemma.
基金The author would like to express gratitude to the National Key Fundamental Research Project of Science and Technology(973)(No.G1999022104-1)with their financial aid.
文摘The microkinetics of H_2S removal by ZnO desulfurization in H_2O-CO_2-N_2,H_2O-CO-N_2 and H_2O-O_2-N_2 gas mixtures was studied by thermogravimetric analysis. Experimentswere carried out with 100-120 mesh ZnO powder at temperatures from 473 K to 563 K. The results showthat the kinetic behaviors of desulfurization could all be described by an improved shrinking-coremodel. The activation energies of the reaction and the diffusion in different gas atmosphere's wereestimated.
文摘After trace Sm^3＋ ions and Gd^3＋ ions doping, the emission intensity of red phosphors Y2O2S： Eu^3 ＋ was enhanced and the voltage character （relation between emission intensity and excitation voltage） was improved while the other properties of physics and chemistry were not changed. The origins of enhancement and improvement are discussed. Probably the distortion and the defect of crystals are decreased by the substitution of Gd^3＋ for Y^3＋ instead of Eu^3＋ for Y^3＋ , and thus the Eu^3＋ crystal field is improved, and radiationless process and energy loss resulted from crystal defect are weakened, which leads to increased luminescence intensity and voltage character improvement. The overlapping fluorescent spectra of Y2O2S： Sm^3＋ emission and Y2O2S：Eu^3＋ excitation as well as Eu^3 ＋ excitation spectra transitions spectra lead to energy transfer from Sm^3 ＋ sensitization of Sm^3＋ ions fectively. containing Sm^3＋ excitation the possibility of resonance ions to Eu^3＋ ions, and the to Eu^3＋ ions is achieved effectively.
基金supported by the National Natural Science Foundation of China(Grant No.42075161).
文摘As one of the participants in the Subseasonal to Seasonal(S2S)Prediction Project,the China Meteorological Administration(CMA)has adopted several model versions to participate in the S2S Project.This study evaluates the models’capability to simulate and predict the Madden-Julian Oscillation(MJO).Three versions of the Beijing Climate Center Climate System Model(BCC-CSM)are used to conduct historical simulations and re-forecast experiments(referred to as EXP1,EXP1-M,and EXP2,respectively).In simulating MJO characteristics,the newly-developed high-resolution BCC-CSM outperforms its predecessors.In terms of MJO prediction,the useful prediction skill of the MJO index is enhanced from 15 days in EXP1 to 22 days in EXP1-M,and further to 24 days in EXP2.Within the first forecast week,the better initial condition in EXP2 largely contributes to the enhancement of MJO prediction skill.However,during forecast weeks 2–3,EXP2 shows little advantage compared with EXP1-M because the increased skill at MJO initial phases 6–7 is largely offset by the degraded skill at MJO initial phases 2–3.Particularly at initial phases 2–3,EXP1-M skillfully captures the wind field and Kelvin-wave response to MJO convection,leading to the highest prediction skill of the MJO.Our results reveal that,during the participation of the CMA models in the S2S Project,both the improved model initialization and updated model physics played positive roles in improving MJO prediction.Future efforts should focus on improving the model physics to better simulate MJO convection over the Maritime Continent and further improve MJO prediction at long lead times.
